Doxycycline Hyclate Capsules

2021 ◽  
Keyword(s):  
Doxycycline Hyclate

Injectable in-situ Forming Depot Of Doxycycline Hyclate/α-Cyclodextrin Complex using PLGA for Periodontitis Treatment: Preparation, Charac-terization, and In-Vitro Evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farhad Eisvand ◽  
Mohammad Sina Nezami ◽  
Seyedeh Nesa Rezaeian Shiadeh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Complex Form ◽  
Docking Studies ◽  
Morphological Properties ◽  
Burst Release ◽  
Cyclodextrin Complex ◽  
Doxycycline Hyclate ◽  
Scanning Calorimetry ◽  
In Situ Forming

Background:: Doxycycline (DOX) is used in treating a bacterial infection, especially for periodontitis treatment. Objective: To reduce irritation of DOX for subgingival administration and increase the chemical stability and against enzy-matic, the complex of α-cyclodextrin with DOX was prepared and loaded into injectable in situ forming implant based on PLGA. Methods:: FTIR, molecular docking studies, X-ray diffraction, and differential scanning calorimetry was performed to char-acterize the DOX/α-cyclodextrin complex. Finally, the in-vitro drug release and modeling, morphological properties, and cellular cytotoxic effects were also evaluated. Results:: The stability of DOX was improved with complex than pure DOX. The main advantage of the complex is the al-most complete release (96.31 ± 2.56 %) of the drug within 14 days of the implant, whereas in the formulation containing the pure DOX and the physical mixture the DOX with α-cyclodextrin release is reached to 70.18 ± 3.61 % and 77.03 ± 3.56 %, respectively. This trend is due to elevate of DOX stability in the DOX/ α-cyclodextrin complex form within PLGA implant that confirmed by the results of stability. Conclusion:: Our results were indicative that the formulation containing DOX/α-cyclodextrin complex was biocompatible and sustained-release with minimum initial burst release.

"Carbopol-olive oil-based bigel drug delivery system of doxycycline hyclate for the treatment of acne"

2021 ◽  
pp. 1-28
Author(s):  
Kumud Soni ◽  
Vishal Gour ◽  
Poornima Agrawal ◽  
Tanweer Haider ◽  
Indu Lata Kanwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Olive Oil ◽  
Drug Delivery System ◽  
Delivery System ◽  
Doxycycline Hyclate

scholarly journals Enhanced antibacterial activity of chitosan, guar gum and polyvinyl alcohol blend matrix loaded with amoxicillin and doxycycline hyclate drugs

2021 ◽  
pp. 103156
Author(s):  
Dure N. Iqbal ◽  
Syed Ehtisham-ul-Haque ◽  
Sundas Ahmad ◽  
Khadija Arif ◽  
Erum Akbar Hussain ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Guar Gum ◽  
Doxycycline Hyclate

scholarly journals Mechanical and biological characterization of resin-modified glass-ionomer cement containing doxycycline hyclate

2012 ◽  
Vol 57 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Aline R.F. de Castilho ◽  
Cristiane Duque ◽  
Thais de C. Negrini ◽  
Nancy T. Sacono ◽  
Andréia B. de Paula ◽  
...  
Keyword(s):  
Glass Ionomer Cement ◽  
Glass Ionomer ◽  
Biological Characterization ◽  
Doxycycline Hyclate ◽  
Resin Modified Glass Ionomer ◽  
Ionomer Cement

scholarly journals Ehrlichia canis (Jaboticabal strain) induces the expression of TNF-α in leukocytes and splenocytes of experimentally infected dogs

2011 ◽  
Vol 20 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Joice Lara Maia Faria ◽  
Thiago Demarchi Munhoz ◽  
Carolina Franchi João ◽  
Giovanny Vargas-Hernández ◽  
Marcos Rogério André ◽  
...  
Keyword(s):  
Acute Phase ◽  
Ehrlichia Canis ◽  
Post Inoculation ◽  
Doxycycline Hyclate ◽  
Blood Leukocytes ◽  
Canine Ehrlichiosis ◽  
Tnf Α ◽  
Study Results ◽  
Splenic Cells ◽  
Ifn Γ

Canine ehrlichiosis is caused by the bacterium Ehrlichia canis and is characterized by a systemic febrile disease of unknown pathogenesis. This study evaluated the expression of cytokines TNF-α, IL-10, IFN-γ, in splenic cells and blood leukocytes during the acute phase of ehrlichiosis and after treatment with doxycycline hyclate in dogs experimentally infected with the E. canis Jaboticabal strain. The study results showed a significant expression of TNF-α 18 days post-inoculation, reducing by approximately 70% after treatment. There was a unique peak of expression of IL-10 and IFN-γ 18 and 30 days post-inoculation, respectively. This study suggests that TNF-α plays a role in the pathogenesis of the acute phase of canine ehrlichiosis and that treatment with doxycycline hyclate reduces the systemic effects of this cytokine, possibly by reducing or eliminating parasitemia.

OPTIMIZATION OF RP-HPLC METHOD BY 32 – CENTRAL COMPOSITE DESIGN FOR THE VALIDATION AND ESTIMATION OF DOXYCYCLINE HYCLATE IN BULK DRUG AND FORMULATIONS

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (11) ◽  
pp. 42-49
Author(s):  
C Dhal ◽  
◽  
F. J. Ahmad ◽  
M. Singhal ◽  
A. Kukrety ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Flow Rate ◽  
High Performance ◽  
Hplc Method ◽  
Array Detector ◽  
Doxycycline Hyclate ◽  
Chromatography Method ◽  
Column Temperature ◽  
Bulk Drug ◽  
Central Composite

An accurate, sensitive, precise, economic and rapid isocratic Reverse Phase High Performance Liquid Chromatography method was developed complying Quality by Design (QbD) trends and validated for determining doxycycline hyclate in bulk drug, tablet and capsule dosage form. The method was optimized using Minitab software with 3 factors (pH of the buffer, flow rate and percentage of buffer in the mobile phase), 2 level (higher limit and lower limit) Central Composite Design (CCD). The results of randomized 20 runs were analyzed for optimum composite desirability to give optimum conditions such as, pH 6.5, flow rate 0.9 mLmin-1 and 30:70 V/V 0.05M potassium dihydrogen orthophosphate buffer adjusted to pH 6.5 using orthophosphoric acid and methanol using C8 column 250 X 4.6 mm X 5.0 μm, injection volume of 10uL, ambient column temperature and ultraviolet detection using photo diode array detector at 360nm as constants. The method was validated as per ICH guidelines and was found linear over a concentration range of 10-100 μg/mL (r2 = 0.999) with the limits of detection and quantification being 2.45 μg/mL and 7.55 μg/mL respectively.

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