Enalapril Maleate and Hydrochlorothiazide Tablets

Keyword(s):  
Hypertension ◽  
1995 ◽  
Vol 25 (6) ◽  
pp. 1345-1350 ◽  
Author(s):  
Alan H. Gradman ◽  
Karen E. Arcuri ◽  
Allan I. Goldberg ◽  
Leila S. Ikeda ◽  
Edward B. Nelson ◽  
...  

2005 ◽  
Vol 79 (2) ◽  
pp. 259-262 ◽  
Author(s):  
E. A. Gómez Pineda ◽  
A. D. Martins Ferrarezi ◽  
J. G. Ferrarezi ◽  
A. A. Winkler Hechenleitner

Author(s):  
Liliya Logoyda

Objective: A simple, rapid high-performance liquid chromatography-mass spectrometry (HPLC MS/MS) method was developed for the determination of enalapril maleate from confluent Caco-2 monolayers and aqueous solution.Methods: Chromatography was achieved on Discovery C18, 50×2.1 mm, 5 μm column. Samples were chromatographed in a gradient mode (eluent A [acetonitrile-water-formic acid, 5: 95:0.1 v/v] and eluent B [acetonitrile-formic acid, 100:0.1 v/v]). The initial content of the eluent B is 0%, which increases linearly by 1.0 min to 100% and 1.01 min returns to the initial 0%. The mobile phase was delivered at a flow rate of 0.4 ml/min into the mass spectrometer ESI chamber. The sample volume was 5 μl.Results: Under these conditions, enalapril maleate was eluted at 1.52 min. According to the Caco-2 test results, enalapril showed low permeability. It should be noted that the recovery value for enalapril is 100.62 %. Low in vitro permeability data for enalapril are in good agreement with the literature data.Conclusion: From results of the analysis, it can be concluded that developed method is simple and rapid for determination of enalapril maleate from confluent Caco-2 monolayers and aqueous solution. Acquired results demonstrate that proposed strategy can be effortlessly and advantageously applied for examination of enalapril from Caco-2 cell monolayers.


2018 ◽  
Vol 6 (6) ◽  
pp. 115-119
Author(s):  
Irene Thomas ◽  
Binu Anand ◽  
Beena P ◽  
Elessy Abraham
Keyword(s):  

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