Essential tremor not just a tremor (review)

2021 ◽  
Vol 1 (223) ◽  
pp. 39-43
Author(s):  
Guzel Shiderova ◽  
◽  
Altynay Karimova ◽  
Gulnaz Kaishibayeva ◽  
Gulmira Amrayeva ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Essential Tremor ◽  
Web Of Science ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Motor Symptoms ◽  
The Past ◽  
Search Terms ◽  
Anxiety Depression ◽  
Non Motor Symptoms

Essential tremor is one of the most common movement disorders. The nature of this disease is not fully understood. It was believed that this pathology manifests itself only by tremor, and symptoms such as depression, anxiety and apathy in patients with essential tremor can only be regarded as a reaction to the presence of tremor. Cognitive impairment is a concomitant pathology that can occur in the elderly, which accounts for a more frequent onset of the disease. But is it really so Purpose of the study. To study the literature data to identify the presence in patients with essential tremor of such signs that can be attributed to the group of "non-motor" symptoms. Material and methods. In order to study the literature data, a search was carried out in the Web of Science, PubMed databases. During the search, all articles published since 2000 were examined and the following terms were used in combination with "essential tremor": "non-motor symptoms", "anxiety", "depression", "apathy", "cognitive impairment", "sleep disorders", "hearing impairment", "hyposmia". The main search terms were studies based on the study of patients with essential tremor: meta-analyzes, original studies, retrospective and cohort studies. Results and discussion. It can be unambiguously argued that symptoms such as anxiety, depression, apathy and cognitive, hearing and smell dysfunctions are characterised to the patients with essential tremor. The first three manifestations were attributed to the response to the presence of tremor. And cognitive functions, hearing and smell dysfunctions was considered a concomitant pathology, which occurs quite often in old age, which accounts for a more frequent onset of the disease. But in reality, everything is not so simple. The literature data, which began to appear over the past 20 years, make it clear that the previously mentioned clinical manifestations may well be regarded as "non-motor" symptoms of essential tremor. Conclusion. Nowadays neurologists are increasingly faced with the problem of differential diagnosis of essential tremor. Despite the fact that everything was very simple and clear on the diagnosis of this disease, in recent years more and more data have appeared in favor of the fact that essential tremor is a heterogeneous disease that manifests not only by tremor. But this is also a disease, which, due to its heterogeneity of pathophysiology, can give great variability in the clinical picture. Keywords: essential tremor, nonmotor symptoms, anxiety, depression, cognitive impairnment, dementia.

NON-MOTOR SYMPTOMS AND QUALITY OF LIFE IN PATIENTS WITH ESSENTIAL TREMOR, PARKINSONS DISEASE AND THE COMBINATION OF ESSENTIAL TREMOR AND PARKINSONS DISEASE

2018 ◽  
Vol 18 (2) ◽  
pp. 63-71 ◽  
Author(s):  
A V Kudrevatykh ◽  
M D Didur ◽  
TV V Sergeev ◽  
D S Bug ◽  
I V Miliukhina
Keyword(s):  
Quality Of Life ◽  
Essential Tremor ◽  
Depressive Disorders ◽  
Clinical Manifestations ◽  
Motor Symptoms ◽  
Parkinsons Disease ◽  
Early Stages ◽  
Wide Range ◽  
Non Motor Symptoms

Aim of the study: to assess non-motor symptoms and quality of life in patients with essential tremor (ET), different stages of Parkinson’s Disease (PD) and combination of ET and PD (ET-PD). Materials and methods of the research: We examined 82 patients with ET, 20 patients with ET-PD, 283 patients with PD, and 72 neurologically healthy volunteers. The neuropsychological status, intensity of motor symptoms, the grade of vegetative dysfunction and dyssomnia, and quality of life of patients were assessed. Results: Patients with ET showed wide range of nonmotor symptoms. The severity of cognitive impairment in group of patients with ET corresponded with the same severity of patients with early stages of PD. It is interesting that patients with ET showed more severe depression than patients with early stages of PD. The maximum severity of anxiety-depressive disorders was observed in patients with the combination of ET-PD. Conclusion: In spite of the fact that it is usual to consider the ET as a monosymptomatic benign disease, we have found significant non-motor disorders in this group of patients and a significant violation of the quality of life. The results of the study also give evidence that patients with ET-PD represent a special group of patients, characterized by special, both motor and non-motor symptoms. The data we obtained made it possible to form a deeper understanding of the generality of the clinical manifestations of ET, PD and ET-PD, which will make it possible to improve the quality of management of patients with these nosologies in clinical practice.

scholarly journals Study of cognitive impairment and genetic polymorphism of SLC41A1 (rs11240569 allele) in Parkinson’s disease in Upper Egypt: case-control study

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Hamdy N. El-Tallawy ◽  
Tahia H. Saleem ◽  
Wafaa M. Farghaly ◽  
Heba Mohamed Saad Eldien ◽  
Ashraf Khodaery ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Motor Symptoms ◽  
And Control ◽  
Non Motor Symptoms ◽  
Control Study

Abstract Background Parkinson’s disease is one of the neurodegenerative disorders that is caused by genetic and environmental factors or interaction between them. Solute carrier family 41 member 1 within the PARK16 locus has been reported to be associated with Parkinson’s disease. Cognitive impairment is one of the non-motor symptoms that is considered a challenge in Parkinson’s disease patients. This study aimed to investigate the association of rs11240569 polymorphism; a synonymous coding variant in SLC41A1 in Parkinson’s disease patients in addition to the assessment of cognitive impairment in those patients. Results In a case -control study, rs11240569 single nucleotide polymorphisms in SLC41A1, genes were genotyped in 48 Parkinson’s disease patients and 48 controls. Motor and non-motor performance in Parkinson's disease patients were assessed by using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). The genotype and allele frequencies were compared between the two groups and revealed no significant differences between case and control groups for rs11240569 in SLC41A1 gene with P value .523 and .54, respectively. Cognition was evaluated and showed the mean ± standard deviation (SD) of WAIS score of PD patients 80.4 ± 9.13 and the range was from 61 to 105, in addition to MMSE that showed mean ± SD 21.96 ± 3.8. Conclusion Genetic testing of the present study showed that rs11240569 polymorphism of SLC41A1 gene has no significant differences in distributions of alleles and genotypes between cases and control group, in addition to cognitive impairment that is present in a large proportion of PD patients and in addition to the strong correlation between cognitive impairment and motor and non-motor symptoms progression.

scholarly journals A Theoretical Framework on the Determinants of Food Purchasing Behavior of the Elderly: A Bibliometric Review with Scientific Mapping in Web of Science

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 688
Author(s):  
Khaled Alhammadi ◽  
Luna Santos-Roldán ◽  
Luis Javier Cabeza-Ramírez
Keyword(s):  
Elderly Population ◽  
Web Of Science ◽  
The Elderly ◽  
Purchasing Behavior ◽  
Food Purchasing ◽  
The Past ◽  
Bibliometric Review ◽  
Food Market ◽  
The Common ◽  
Elderly Consumers

The past few years have seen significant demographic changes in most regions, including an increased elderly population. Subsequently, elderly citizens comprise an important market segment of consumers, with the food industry one of the most affected areas in this context. However, food market managers previously believed that elderly consumers’ needs were stereotyped in nature. The lack of focus on this sector, therefore, left elderly consumers as an untapped market, without realizing the financial independence of this segment regarding their nutrition. This research will attempt to provide the key determinant factors on elderly consumers’ behavior related to food. For that purpose, a complete literature review of more than 123 papers regarding these concepts has been carried out. Once analyzed, we highlight the common insights to give clear guidance for supermarket managers and food manufacturers to have a better knowledge of the reasons behind elderly people’s food acquisitions.

Constipation is Associated with Development of Cognitive Impairment in de novo Parkinson’s Disease: A Longitudinal Analysis of Two International Cohorts

2021 ◽  
pp. 1-11
Author(s):  
Valentina Leta ◽  
Daniele Urso ◽  
Lucia Batzu ◽  
Daniel Weintraub ◽  
Nataliya Titova ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
De Novo ◽  
Motor Dysfunction ◽  
Group Differences ◽  
Motor Symptoms ◽  
Kaplan Meier ◽  
Patients At Risk ◽  
Non Motor Symptoms

Background: Constipation is regarded as one of the prodromal features of Parkinson’s disease (PD) and there is emerging evidence linking gastrointestinal dysfunction and cognitive impairment (CI) in PD. Objective: We explored whether constipation is associated with development of CI in two independent cohorts of de novo PD patients (n = 196 from the Non-motor International Longitudinal Study [NILS] and n = 423 from the Parkinson’s Progression Markers Initiative [PPMI] study). Methods: Constipation was clinically defined using the Non-Motor Symptoms Scale (NMSS) item-21 [NILS] and Scales for Outcomes in PD-Autonomic (SCOPA-AUT) item-5 [PPMI]. We assessed baseline group differences (PD with or without constipation) in CI, global non-motor symptoms burden, motor dysfunction, and striatal dopaminergic denervation. Kaplan-Meier method estimated group differences in cumulative proportion of patients with incident CI over three years. In PPMI, we subsequently performed univariate and multivariate Cox survival analyses to evaluate whether constipation predicts incident mild cognitive impairment or dementia over a 6-year period, including constipation and other known predictors of CI as covariates. Results: Patients with constipation had greater motor and global non-motor burden in both cohorts at baseline (p <  0.05). Kaplan-Meier plots showed faster conversion to CI in patients with constipation in both cohorts (p <  0.05). In PPMI, 37 subjects developed dementia during a mean follow-up of 4.9 years, and constipation was an independent predictor of dementia onset (hazard ratio = 2.311; p = 0.02). Conclusion: Constipation in de novo PD patients is associated with development of cognitive decline and may serve as a clinical biomarker for identification of patients at risk for cognitive impairment.

The association of cognitive impairment and other non-motor symptoms among Thai Parkinson's disease patients

2021 ◽  
Vol 429 ◽  
pp. 119607
Author(s):  
Chayasak Wantaneeyawong ◽  
Kittithatch Booncharoen ◽  
Kanokwan Wattana ◽  
Orawan Ronran ◽  
Siwahdol Chaimano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Motor Symptoms ◽  
Non Motor Symptoms

scholarly journals Assessment of Non-Motor Symptoms in Essential Tremor

2019 ◽  
Vol 9 (4) ◽  
pp. 308-312
Author(s):  
Tatiana Govorova ◽  
Tatiana Popova ◽  
Aleksei Tappakhov ◽  
Michil Andreev
Keyword(s):  
Essential Tremor ◽  
Motor Symptoms ◽  
Non Motor Symptoms

scholarly journals Non-Motor Symptoms of Essential Tremor Are Independent of Tremor Severity and Have an Impact on Quality of Life

2016 ◽  
Vol 6 (0) ◽  
pp. 361 ◽  
Author(s):  
Thomas Musacchio ◽  
Veronika Purrer ◽  
Aikaterini Papagianni ◽  
Anna Fleischer ◽  
Daniel Mackenrodt ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Essential Tremor ◽  
Motor Symptoms ◽  
Non Motor Symptoms

scholarly journals Non motor symptoms in patients with essential tremor

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M Elbelkemy ◽  
A Shalash ◽  
A Mansour ◽  
E Hamed ◽  
H M Abdelalim
Keyword(s):  
Essential Tremor ◽  
Cognitive Assessment ◽  
Rating Scale ◽  
Pittsburgh Sleep Quality Index ◽  
Case Control ◽  
Poor Sleep ◽  
Motor Symptoms ◽  
Egyptian Patients ◽  
Hamilton Anxiety Rating Scale ◽  
Non Motor Symptoms

Abstract Article Outline Abstract Introduction Patients and methods Procedure Statistical analysis Results Discussion Conclusion References Background Essential tremor (ET) is the most prevalent tremor disorder. ET has traditionally been viewed as a monosymptomatic disorder characterized by a kinetic arm tremor but now there is a growing amount of evidence to suggest that besides motor features, patients with essential tremor may exhibit significant non-motor features. The Aim of this study: To assess non-motor features in Egyptian patients with ET in comparison to controls. Patients and Methods This is a Case control observational study in which 30 patients with ET and 30 matched healthy controls ET was assessed using; Fahn Tolosa Marin Tremor Rating Scale (FTM); non-motor symptoms were evaluated using; Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), Hamilton anxiety rating scale (HARS), Pittsburgh Sleep quality index (PSQI). Results ET patients had significant cognitive dysfunction, neuropsychiatric problems including depression, anxiety, poor sleep and other NMS compared to controls. Conclusion The presence of numerous non motor features in ET is increasingly evident. Therefore, NMS should be considered in the clinical evaluation and management of ET.

scholarly journals Relationship between cognition and frailty in elderly: A systematic review

2015 ◽  
Vol 9 (2) ◽  
pp. 110-119 ◽  
Author(s):  
Allan Gustavo Brigola ◽  
Estefani Serafim Rossetti ◽  
Bruna Rodrigues dos Santos ◽  
Anita Liberalesso Neri ◽  
Marisa Silvana Zazzetta ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Search Strategy ◽  
Web Of Science ◽  
The Elderly ◽  
Cross Sectional ◽  
Cognitive Domains ◽  
The Subject ◽  
The Relationship

OBJECTIVE: The aim of this study was to analyze the relationship between cognition and frailty in the elderly. METHODS: A systematic review on the currently existing literature concerning the subject was carried out. The search strategy included LILACS, SCOPUS, SciELO, PsycINFO, PubMed and Web of Science databases. RESULTS: A total of 19 studies were selected for review, from which 10 (52.6%) were cross-sectional and 9 (47.4%) longitudinal, and the majority Brazilian. All of the studies established a link between cognition and frailty. There was a relationship between components of frailty and the cognitive domains. Risk of Mild Cognitive Impairment (MCI), dementia and mortality were all evidenced in the relationship between frailty and cognitive impairment. CONCLUSION: The theory remains limited, but results show the variables that appear to be linked to cognition and frailty in elderly. This data can help in implementing actions to improve the quality of life among elderly.

Non-motor Symptoms in Parkinson’s Disease

US Neurology ◽  
2011 ◽  
Vol 07 (02) ◽  
pp. 113 ◽  
Author(s):  
Ergun Y Uc ◽  
Jon Tippin ◽  
Kelvin L Chou ◽  
Bradley A Erickson ◽  
Kevin C Doerschug ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Cognitive Impairment ◽  
Psychiatric Disorders ◽  
Motor Dysfunction ◽  
Motor Symptoms ◽  
Dopaminergic Systems ◽  
Sleep Abnormalities ◽  
Non Motor Symptoms

In addition to typical motor dysfunction (parkinsonism), diverse non-motor symptoms (NMS) are frequently observed in patients with Parkinson’s disease (PD). Some NMS may antedate the diagnosis of PD. Examples of NMS include cognitive impairment, autonomic dysfunction, visual dysfunction, sleep abnormalities, and psychiatric disorders. NMS are associated with wide-ranging abnormalities in extranigral dopaminergic systems and non-dopaminergic (e.g. cholinergic, noradrenergic, serotoninergic) systems. The type and severity of NMS vary based on age, disease severity, and predominant motor symptoms. NMS can be disabling and reduce quality of life. Treatment of NMS can be challenging. Some NMS are helped by dopaminergic treatment, whereas others can be induced or exacerbated by treatments that help the motor dysfunction. Physicians should probe their PD patients about their NMS and address them for better care. Clinical trials should incorporate NMS as outcomes for more meaningful conclusions on the effect of treatments under investigation.

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