scholarly journals Mechanism of psychoactive substance-induced cognitive disorders: does tau protein play a role?

2022 ◽  
Vol 27 (1) ◽  
pp. 1
Author(s):  
YuYe Wang ◽  
JiaCheng Lv ◽  
JiNing He ◽  
GeHua Wen ◽  
Xu Wu
2014 ◽  
Vol 56 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Xiaoting Lu ◽  
Ruifeng Liang ◽  
Zhijian Jia ◽  
Hao Wang ◽  
Baolong Pan ◽  
...  

2017 ◽  
Vol 20 (3) ◽  
pp. 181-184 ◽  
Author(s):  
Mariia V. Matveeva ◽  
Yulia G. SamoiIova ◽  
Natalia G. Zhukova ◽  
Oksana A. Oleynik ◽  
Maria A. Rotkank

Currently, diabetes mellitus (DM) is the most common metabolic disorder, which is manifested by hyperglycemia and leads to vascular and cognitive impairment. Mechanisms of cognitive dysfunction in patients with DM remain highly unclear, thus complicating the search for effective strategies for the prevention and treatment of dementia. Recently, scientists have discussed the issues regarding the relationship between DM and Alzheimers disease (AD), such as risk factors that trigger the cascade of pathological reactions. Patients with DM show an increased risk of developing AD. Similarly, patients with AD have been shown to have impaired insulin and glucose metabolism. Both these diseases have common nosology, pathology and biochemical basics, including oxidative stress, formation of advanced glycation end products, dysregulation of glucose metabolism and altered insulin signaling pathways. The microtubule-associated tau protein is involved in one of the causative mechanisms underlying the development of AD. We provide an overview of the major domestic and foreign data analyses regarding tau protein and the development of cognitive disorders in experimental DM.


2021 ◽  
Vol 9 (4) ◽  
pp. 96
Author(s):  
Qing Ji ◽  
Xin Li

<span lang="EN-US">Morphine is an opioid drug. Long-term use can cause morphine dependence or addiction, and there are cognitive dysfunction such as abnormal mental behavior, decline in learning and memory, and decline in executive ability. The occurrence of this disease is related to many factors, such as oxidative stress, hippocampal neuronal injury, mitochondrial function injury, etc. Tau protein is a microtubule-associated protein involved in nervous system development. Studies have found that hyperphosphorylation of tau proteins can cause apoptosis of hippocampal neurons<sup>[1]</sup>, and tau proteins can cause oxidative stress<sup>[2]</sup>. Therefore, tau proteins play an important role in the pathogenesis of cognitive disorders. The relationship between morphine dependence and cognitive dysfunction is now reviewed.</span>


2016 ◽  
Vol 21 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Silvia Convento ◽  
Cristina Russo ◽  
Luca Zigiotto ◽  
Nadia Bolognini

Abstract. Cognitive rehabilitation is an important area of neurological rehabilitation, which aims at the treatment of cognitive disorders due to acquired brain damage of different etiology, including stroke. Although the importance of cognitive rehabilitation for stroke survivors is well recognized, available cognitive treatments for neuropsychological disorders, such as spatial neglect, hemianopia, apraxia, and working memory, are overall still unsatisfactory. The growing body of evidence supporting the potential of the transcranial Electrical Stimulation (tES) as tool for interacting with neuroplasticity in the human brain, in turn for enhancing perceptual and cognitive functions, has obvious implications for the translation of this noninvasive brain stimulation technique into clinical settings, in particular for the development of tES as adjuvant tool for cognitive rehabilitation. The present review aims at presenting the current state of art concerning the use of tES for the improvement of post-stroke visual and cognitive deficits (except for aphasia and memory disorders), showing the therapeutic promises of this technique and offering some suggestions for the design of future clinical trials. Although this line of research is still in infancy, as compared to the progresses made in the last years in other neurorehabilitation domains, current findings appear very encouraging, supporting the development of tES for the treatment of post-stroke cognitive impairments.


PsycCRITIQUES ◽  
2015 ◽  
Vol 6060 (1111) ◽  
Author(s):  
Paula Lundberg-Love ◽  
Cecily Luft

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