Effects of Adipose Tissue Stem Cell Concurrent with Greater Omentum on Experimental Long-Bone Healing in Dog

2012 ◽  
Vol 53 (4) ◽  
pp. 334-342 ◽  
Author(s):  
Amin Bigham-Sadegh ◽  
Pezhman Mirshokraei ◽  
Iraj Karimi ◽  
Ahmad Oryan ◽  
Amir Aparviz ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Bone Healing ◽  
Long Bone ◽  
Greater Omentum

Losartan Improves Adipose Tissue-Derived Stem Cell Niche by Inhibiting Transforming Growth Factor-β and Fibrosis in Skeletal Muscle Injury

2012 ◽  
Vol 21 (11) ◽  
pp. 2407-2424 ◽  
Author(s):  
Jin-Kyu Park ◽  
Mi-Ran Ki ◽  
Eun-Mi Lee ◽  
Ah-Young Kim ◽  
Sang-Young You ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Muscle Injury ◽  
Transforming Growth Factor ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Type I ◽  
Skeletal Muscle Injury ◽  
Losartan Treatment

Recently, adipose tissue-derived stem cells (ASCs) were emerged as an alternative, abundant, and easily accessible source of stem cell therapy. Previous studies revealed losartan (an angiotensin II type I receptor blocker) treatment promoted the healing of skeletal muscle by attenuation of the TGF-β signaling pathway, which inhibits muscle differentiation. Therefore, we hypothesized that a combined therapy using ASCs and losartan might dramatically improve the muscle remodeling after muscle injury. To determine the combined effect of losartan with ASC transplantation, we created a muscle laceration mouse model. EGFP-labeled ASCs were locally transplanted to the injured gastrocnemius muscle after muscle laceration. The dramatic muscle regeneration and the remarkably inhibited muscular fibrosis were observed by combined treatment. Transplanted ASCs fused with the injured or differentiating myofibers. Myotube formation was also enhanced by ASC+ satellite coculture and losartan treatment. Thus, the present study indicated that ASC transplantation effect for skeletal muscle injury can be dramatically improved by losartan treatment inducing better niche.

Enhancing therapeutic effects and in vivo tracking of adipose tissue derived mesenchymal stem cells for liver injury using bioorthogonal click chemistry

Nanoscale ◽  
2020 ◽  
Author(s):  
Naishun Liao ◽  
Da Zhang ◽  
Ming Wu ◽  
Huang-Hao Yang ◽  
Xiaolong Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Liver Injury ◽  
Mesenchymal Stem Cell ◽  
Liver Diseases ◽  
Therapeutic Effects

Adipose tissue derived mesenchymal stem cell (ADSC)-based therapy is attractive for liver diseases, but the long-term therapeutic outcome is still far from satisfaction due to low hepatic engraftment efficiency of...

scholarly journals Adipose tissue-derived stem cell therapy in rat cryopreserved ovarian grafts

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Luciana Lamarão Damous ◽  
Juliana Sanajotti Nakamuta ◽  
Ana Elisa Teófilo Saturi de Carvalho ◽  
José Maria Soares-Jr ◽  
Manuel de Jesus Simões ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy

“Bone Morphogenic Protein augmentation for long bone healing” response to “Clinical need for bone morphogenetic protein”

2017 ◽  
Vol 41 (11) ◽  
pp. 2417-2419 ◽  
Author(s):  
Gopal Shankar Krishnakumar ◽  
Alice Roffi ◽  
Davide Reale ◽  
Elizaveta Kon ◽  
Giuseppe Filardo
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Healing ◽  
Bone Morphogenic Protein ◽  
Long Bone ◽  
Healing Response ◽  
Morphogenetic Protein

scholarly journals Safety and Effect of Adipose Tissue-Derived Stem Cell Implantation in Patients With Critical Limb Ischemia

2012 ◽  
Vol 76 (7) ◽  
pp. 1750-1760 ◽  
Author(s):  
Han Cheol Lee ◽  
Sung Gyu An ◽  
Hye Won Lee ◽  
Jin-Sup Park ◽  
Kwang Soo Cha ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Cell Implantation
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