Statin Use and Incident Cataract Surgery: A Case-Control Study

Advancements in surgical techniques and increased life expectancy have made cataract surgery more common among very old patients. However, surgical outcomes seem impaired in patients older than 90 years, especially with ocular comorbidities. A retrospective case-control study of 53 eyes of 53 very old patients (mean 92.6 ± 3.0) and 140 eyes of 140 matched patients (mean 75.2 ± 7.6) was undertaken. Groups were matched in terms of gender and systemic and ocular comorbidities. In very old patients, higher phacoemulsification energy (cumulative dissipated energy [CDE], 25.0 ± 22.4 vs. 16.1 ± 10.7, p = 0.01) and rate of intraoperative floppy iris syndrome (IFIS, 9.4% vs. 1.4%, p = 0.02) were observed compared to controls. Uncorrected (UCVA) and best-corrected distance visual acuity (BCVA) gains were significantly poorer among the very old patients than among the control at postoperative day 30 (0.20 ± 0.70 vs. 0.56 ± 0.61 logMAR, p < 0.001 and 0.27 ± 0.64 vs. 0.55 ± 0.62 logMAR, p = 0.006, respectively). Even after including CDE and IFIS as covariates, age remained an independent factor for poor visual gain at 30 days (p < 0.001). Cataract surgery in very old patients may demand more experienced surgeons due to higher nuclear density and the rates of IFIS. Expectations in visual acuity gains should be aligned with the patient’s age.

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Statin Use Is Associated with Bladder Pain Syndrome/Interstitial Cystitis: A Population-Based Case-Control Study

Urologia Internationalis ◽

10.1159/000431185 ◽

2015 ◽

Vol 95 (2) ◽

pp. 227-232 ◽

Cited By ~ 7

Author(s):

C.Y. Huang ◽

S.D. Chung ◽

L.T. Kao ◽

H.C. Lin ◽

L.H. Wang

Keyword(s):

Case Control Study ◽

Conditional Logistic Regression ◽

Pain Syndrome ◽

Population Based ◽

Case Control ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Epithelial Dysfunction ◽

Control Study ◽

Statin Use

Introduction: Statin may induce epithelial dysfunction of the bladder urothelium. Epithelial dysfunction was proposed as one of the major potential etiologies for bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we examined the association between statin use and BPS/IC using a population-based study. Subjects and Methods: This case-control study used the Taiwan Longitudinal Health Insurance Database. In total, 815 female subjects with BPS/IC and 4075 randomly selected female controls were included. We used a conditional logistic regression to compute the odds ratio (OR) for having previously used statins between cases and controls. Results: A conditional logistic regression analysis showed that the OR of prior statin users for cases was 1.52 (95% confidence interval (CI): 1.19-1.94) compared to controls after adjusting for diabetes, hypertension, coronary heart disease, obesity, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, and asthma. Furthermore, adjusted ORs of regular and irregular statin use for cases were 1.58 (95% CI: 1.20-2.08) and 1.53 (95% CI: 1.02-2.31), respectively, compared to controls. Conclusion: We concluded that there was an association between statin use and BPS/IC.

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Statin Use Reduces Risk of Esophageal Adenocarcinoma in US Veterans With Barrett’s Esophagus: A Nested Case-Control Study

Gastroenterology ◽

10.1053/j.gastro.2015.07.009 ◽

2015 ◽

Vol 149 (6) ◽

pp. 1392-1398 ◽

Cited By ~ 24

Author(s):

Theresa Nguyen ◽

Zhigang Duan ◽

Aanand D. Naik ◽

Jennifer R. Kramer ◽

Hashem B. El-Serag

Keyword(s):

Barrett’S Esophagus ◽

Esophageal Adenocarcinoma ◽

Barrett's Esophagus ◽

Case Control Study ◽

Case Control ◽

Us Veterans ◽

Nested Case Control ◽

Control Study ◽

Statin Use

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Statin use and risk of cataract: A nested case-control study within a healthcare database

Atherosclerosis ◽

10.1016/j.atherosclerosis.2016.06.020 ◽

2016 ◽

Vol 251 ◽

pp. 153-158 ◽

Cited By ~ 9

Author(s):

Manuela Casula ◽

Davide Soranna ◽

Giovanni Corrao ◽

Luca Merlino ◽

Alberico Luigi Catapano ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Healthcare Database ◽

Nested Case Control ◽

Control Study ◽

Statin Use

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Statin use and risk for ovarian cancer: a Danish nationwide case–control study

British Journal of Cancer ◽

10.1038/bjc.2014.574 ◽

2014 ◽

Vol 112 (1) ◽

pp. 157-161 ◽

Cited By ~ 25

Author(s):

L Baandrup ◽

C Dehlendorff ◽

S Friis ◽

J H Olsen ◽

S K Kjær

Keyword(s):

Ovarian Cancer ◽

Case Control Study ◽

Case Control ◽

Control Study ◽

Statin Use

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Association between Statin and Fibrate Use and Venous Thromboembolism: A Case-Control Study.

Blood ◽

10.1182/blood.v104.11.2594.2594 ◽

2004 ◽

Vol 104 (11) ◽

pp. 2594-2594

Author(s):

Karine Lacut ◽

Gregoire Le Gal ◽

Emmanuel Oger ◽

Dominique Mottier

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Protective Effect ◽

Case Control Study ◽

Case Control ◽

Increased Risk ◽

Venous Thromboembolic ◽

The Difference ◽

Control Study ◽

Statin Use

Abstract Background: Previous studies of selected patients have suggested a reduction in the risk of venous thromboembolism (VTE) with the use of statins, and no effect of fibrates. Objective: To evaluate the influence of statin and fibrate use on the risk of venous thromboembolic events. Design: Case-control study (EDITH) designed to investigate genetic and environmental risk factors of VTE. Setting: Brest University Hospital. Participants: 857 patients consecutively hospitalized for a documented venous thromboembolic event were included between May 2000 and May 2004. Controls were matched on age, sex and the main risk factors of VTE (cancer, surgery, pregnancy…). Results: The mean age of patients was 67.7 year. No significant difference was found between cases and controls concerning the main characteristics, except for smocking and body mass index. Controls had more often previous vascular events (coronary heart disease, stroke or arteriopathy of the lower limbs) than cases but the difference was no significant. Statin use was associated with a significant decreased risk of VTE (odds ratio (OR) = 0.58; 95% confidence interval (CI), 0.41–0.82), whereas fibrate use was associated with a significant increased risk of VTE (OR = 1.60; 95% CI, 1.09–2.34). After adjustment on the main confounding factors including aspirin use and cardiovascular disease, these associations remained significant. Among pleiotropic effects of statins, some antithrombotic mechanisms could be proposed to explain their possible protective effect. Concerning the possible negative effect of fibrates, some authors found that the most prescribed fibrates, but not statins, caused hyperhomocysteinemia. In our study, analyses of homocysteinemia are ongoing. Conclusion: In this case-control study of hospitalized patients, statin use was associated with a significant decreased risk of VTE, whereas fibrate use was associated with a significant increased risk. Homocysteinemia may be involved in the difference between the effects of these two categories of lipid-lowering drugs on VTE. Because our study was observational, the protective effect of statins as regards the risk of VTE remains questionable and further prospective studies are needed.

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