Ovarian Response to Exogenous Gonadotropins in Infant Cynomolgus Monkeys Hidenobu Sameshima

1996 ◽  
Vol 15 (3) ◽  
pp. 194-204 ◽  
Author(s):  
Satoru Oneda ◽  
Toshio Ihara ◽  
Katsumi Hamana
Keyword(s):  
Ovarian Function ◽  
Single Injection ◽  
Histopathological Examination ◽  
Ovarian Response ◽  
The Other ◽  
Human Menopausal Gonadotropin ◽  
Serum Estradiol ◽  
Cynomolgus Monkeys ◽  
Adult Females ◽  
Other Hand

The response of the ovaries to exogenous gonadotropins was examined by determining serum estradiol (E2) and progesterone (P) levels and by observing the development of follicles by using 5-to 7-month-old cynomolgus females. The serum E2 levels began to increase 2 h after a single injection of 15 IU of human menopausal gonadotropin (h MG) and reached peak levels at 6 h after dosing, but the E2levels decreased to near predosing values at 24 h. The serum E2 levels increased markedly due to the repeated injections of 15 IU h MG for 10 days (days 0-9), but the P levels were low and equal to the levels observed at the follicular stage in adult females. The E2 levels decreased after an injection of 1,000 IU h CG on day 10, and the levels on day 21 were almost equal to the predosing values on day 0. On the other hand, the P levels increased transiently on day 16, which suggested ovulation. In the histopathological examination of the ovaries obtained on day 10, large antrum follicles were observed. These results confirmed that the ovary of infant cynomolgus monkeys reacted in the same way as the ovary of adult monkeys to exogenous gonadotropins and suggested that this method could become a useful means of evaluating the ovarian function of infant females.

CORTICOTROPIN-BESTIMMUNG ANHAND DES CORTICOSTERONANSTIEGES IM NEBENNIEREN-VENENBLUT HYPOPHYSEKTOMIERTER RATTEN

1962 ◽  
Vol 41 (2) ◽  
pp. 211-218 ◽  
Author(s):  
K. Retiene ◽  
H. Ditschuneit ◽  
M. Fischer ◽  
K. Kopp ◽  
E. F. Pfeiffer
Keyword(s):  
Peripheral Blood ◽  
Single Injection ◽  
Venous Blood ◽  
Corticosterone Level ◽  
The Other ◽  
Adrenal Vein ◽  
Major Surgery ◽  
Other Hand ◽  
Hypophysectomized Rats

ABSTRACT Corticotrophin has been measured by using the corticotrophin-induced increase of corticosterone in adrenal venous blood of rats, the corticotrophin secretion of which has been blocked by preliminary injection of dexamethasone. Sensitivity and precision of this technique have not been higher than in the simpler procedure using corticosterone increase in peripheral blood. Single injection of dexamethasone on the other hand did not prevent release of endogenous corticotrophin following major surgery, required for canulation of the adrenal vein. In hypophysectomized rats corticotrophin can be measured by using adrenal venous blood. 0.05 mU corticotrophin (US-P-Standard) has been determined with an index of precision of λ = 0.13. The consistent relation between initial and elevated corticosterone level following corticotrophin in both peripheral and adrenal venous blood makes it highly unlikely that other modifications of this kind of assay will increase sensitivity.

scholarly journals γA-BLOOD GROUP ANTIBODIES

1966 ◽  
Vol 123 (5) ◽  
pp. 951-967 ◽  
Author(s):  
M. Adinolfi ◽  
P. L. Mollison ◽  
Margaret J. Polley ◽  
Jane M. Rose
Keyword(s):  
Blood Group ◽  
Single Injection ◽  
Deae Cellulose ◽  
Red Cells ◽  
The Other ◽  
Intravenous Injections ◽  
Other Hand

The serological characteristics of γA-anti-A and anti-B were studied using, as a source, either colostrum, or fractions relatively rich in γA obtained from selected potent antisera. γA-anti-A and anti-B were never hemolytic nor did they sensitize red cells to agglutination by anticomplement globulin sera. γA-anti-A, like γG-anti-A and unlike γM-anti-A was unaffected by heating at 56°C for 3 hr. On the other hand in the following three characteristics the behavior of γA fell between that of γG- or γM-anti-A: sensitivity to inactivation by 2-mercaptoethanol, ease of neutralization by A substance and degree of enhancement of agglutination in a medium of serum rather than saline. The agglutination produced by γA-anti-A was regularly enhanced by addition of anti-γA-globulin serum. In searching for γA-blood group antibodies of other specificities the following sera were tested: anti-D (32 examples); anti-c (2 examples); anti-Lea or -Leb (3 examples); anti-K (3 examples); anti-Fya (3 examples), and anti-Jka (3 examples). Only 3 sera, all containing anti-D, sensitized red cells to agglutination by anti-γA. There were no discrepancies between results obtained with four different anti-γA-globulin sera. Approximately half the sera were fractionated on DEAE-cellulose, and the fractions rich in γA tested for their ability to sensitize red cells to agglutination by anti-γA; no additional examples of γA-antibodies were detected. One of the three examples of γA-anti-D appeared in the serum of a woman during the course of deliberate reimmunization. γA-anti-D appeared only after three intravenous injections of red cells although the γG-anti-D titer rose considerably after a single injection. 3 yr after a fourth injection of Rh-positive cells γA-anti-D, as well as γG-anti-D, was still present in the serum.

scholarly journals Testicular Response to Exogenous Gonadotropins in Infant Cynomolgus Monkeys

1996 ◽  
Vol 15 (5) ◽  
pp. 371-380
Author(s):  
Hidenobu Sameshima ◽  
Katsumi Hamana
Keyword(s):  
Leydig Cells ◽  
Histopathological Examination ◽  
Serum Testosterone ◽  
Human Menopausal Gonadotropin ◽  
Testicular Function ◽  
Histopathological Changes ◽  
Cynomolgus Monkeys ◽  
The Mean ◽  
The One ◽  
Germinal Cells

The response of the testis to exogenous gonadotropins was examined by determining serum testosterone (T) levels and by observing histopathological changes of the testes using 5–7 month-old males. After a single combined injection of 100 IU plus 15 IU human menopausal gonadotropin (hMG) or 500 IU human chorionic gonadotropin (hCG) plus 15 IU hMG, the serum T levels reached peak values 72 h after administration. During repeated aministration of the combined injection of 100 IU hCG plus 15 IU hMG at five 3-day intervals (Day 0, 3, 6, 9, 12), the serum T levels reached peak values 3 days after the first injection, which were about 3 times higher than the mean serum T levels of adult monkeys. The serum T levels decreased gradually on subsequent days of treatment. Three days after the fifth injection (Day 15), the T levels were equal to the T levels of adult monkeys. The testicular volumes on Day 15 were significantly higher than those on the first day of injection. The histopathological examination of the testes (210, 238 mg) obtained from two treated males revealed hyperplasia and hypertrophy of the Leydig cells and spermatogonias, spermatocytes, and mitotic germinal cells were observed in the seminiferous tubule. Only spermatogonia were found in the one testis (150 mg) obtained from an untreated male. From the above results, it was confirmed that the testes of infant cynomolgus monkeys produced T levels in the same way as the testes of adult monkeys in response to the administration of exogenous gonadotropins. Additionally, the initiation of the spermatogenetic process in the testes of infant monkeys was stimulated by exogenous gonadotropins, therefore suggesting that this method could become a useful means to evaluate the testicular function of infant males.

Effects of a spring snowstorm on behavior, reproduction, and survival of Belding's ground squirrels

1978 ◽  
Vol 56 (12) ◽  
pp. 2578-2590 ◽  
Author(s):  
Martin L. Morton ◽  
Paul W. Sherman
Keyword(s):  
Body Size ◽  
Sierra Nevada ◽  
Ground Squirrels ◽  
The Other ◽  
High Altitudes ◽  
Adult Females ◽  
Early Emergence ◽  
Other Hand ◽  
Body Weights ◽  
Spermophilus Beldingi

From 30 April to 26 May 1977 a snowstorm occurred in the Sierra Nevada where we were studying Spermophilus beldingi. The storm began 8 days after ground squirrels began emerging from hibernation. During the storm, emergence nearly ceased and mating was suspended, body weights decreased sharply, locomotor abilities became impaired, and nocturnal burrow sharing increased. The animals became more susceptible to predation, and one case of intraspecific killing and cannibalism was observed. At least four animals starved; they were totally depleted of fat and had atrophied livers. During the storm, more adult females than males perished; 60% of females disappeared in 1977 vs. 32 and 26% in 1975 and 1976, respectively. Furthermore, when compared with 1975 and 1976, fewer 1977 females mated, conceived, or weaned young.During 1969–1977 at Tioga Pass, first emergence of S. beldingi varied up to 6 weeks with the animals emerging earliest in years of lightest snowpacks. At high altitudes where summers are brief, early emergence may increase the likelihood that young will reach appropriate body size before winter. On the other hand, avoidance of the effects of unpredictable spring storms favors later emergence. In 1977, because of the snowstorm, late emergers were favored.

scholarly journals A CUTANEOUS HORN MIMICKING POLYDACTYLY: A CASE REPORT

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Funda Tamer ◽  
Mehmet Eren Yuksel
Keyword(s):  
Congenital Anomaly ◽  
Case Report ◽  
Histopathological Examination ◽  
The Other ◽  
Caucasian Male ◽  
Cutaneous Horn ◽  
Other Hand

A cutaneous horn is a general name for cornified material protruding from skin. On the other hand, polydactyly is a common congenital anomaly of the hand and foot which is characterized by extra finger or toe. A cutaneous horn might mimick polydactyly by resembling an extra toe. Hereby, we present a 72-year-old white Caucasian male with an extra toe-like projection on his fourth toe. Initially, polydactyly was suspected, however a cutaneous horn was also considered. The lesion was surgically removed. The histopathological examination of the specimen revealed hyperkeratosis, and thus confirmed the  lesion to be a cutaneous horn. 

A study of cometary eruptions through OH radio-lines

1999 ◽  
Vol 173 ◽  
pp. 249-254
Author(s):  
A.M. Silva ◽  
R.D. Miró
Keyword(s):  
Short Duration ◽  
Growth Curves ◽  
The Other ◽  
Initial Mass ◽  
Radio Lines ◽  
Other Hand ◽  
Sudden Rise

AbstractWe have developed a model for theH2OandOHevolution in a comet outburst, assuming that together with the gas, a distribution of icy grains is ejected. With an initial mass of icy grains of 108kg released, theH2OandOHproductions are increased up to a factor two, and the growth curves change drastically in the first two days. The model is applied to eruptions detected in theOHradio monitorings and fits well with the slow variations in the flux. On the other hand, several events of short duration appear, consisting of a sudden rise ofOHflux, followed by a sudden decay on the second day. These apparent short bursts are frequently found as precursors of a more durable eruption. We suggest that both of them are part of a unique eruption, and that the sudden decay is due to collisions that de-excite theOHmaser, when it reaches the Cometopause region located at 1.35 × 105kmfrom the nucleus.

Closing the GAP—A 5Å Scanning Microscope

1969 ◽  
Vol 27 ◽  
pp. 6-7
Author(s):  
A. V. Crewe
Keyword(s):  
Normal Form ◽  
The Other ◽  
Resolving Power ◽  
Scanning Microscope ◽  
Conventional Microscope ◽  
Other Hand ◽  
Closing The Gap ◽  
Thermal Sources ◽  
Better Than ◽  
Transmission Microscope

We have become accustomed to differentiating between the scanning microscope and the conventional transmission microscope according to the resolving power which the two instruments offer. The conventional microscope is capable of a point resolution of a few angstroms and line resolutions of periodic objects of about 1Å. On the other hand, the scanning microscope, in its normal form, is not ordinarily capable of a point resolution better than 100Å. Upon examining reasons for the 100Å limitation, it becomes clear that this is based more on tradition than reason, and in particular, it is a condition imposed upon the microscope by adherence to thermal sources of electrons.

Life Beyond 1MeV

1980 ◽  
Vol 38 ◽  
pp. 30-33
Author(s):  
K.H. Westmacott
Keyword(s):  
Electron Microscopy ◽  
Past Experience ◽  
The Other ◽  
Good Case ◽  
Other Hand ◽  
The U.S

Life beyond 1MeV – like life after 40 – is not too different unless one takes advantage of past experience and is receptive to new opportunities. At first glance, the returns on performing electron microscopy at voltages greater than 1MeV diminish rather rapidly as the curves which describe the well-known advantages of HVEM often tend towards saturation. However, in a country with a significant HVEM capability, a good case can be made for investing in instruments with a range of maximum accelerating voltages. In this regard, the 1.5MeV KRATOS HVEM being installed in Berkeley will complement the other 650KeV, 1MeV, and 1.2MeV instruments currently operating in the U.S. One other consideration suggests that 1.5MeV is an optimum voltage machine – Its additional advantages may be purchased for not much more than a 1MeV instrument. On the other hand, the 3MeV HVEM's which seem to be operated at 2MeV maximum, are much more expensive.

Can the Academic Self-Concept be Positive and Realistic?

2005 ◽  
Vol 19 (3) ◽  
pp. 129-132 ◽  
Author(s):  
Reimer Kornmann
Keyword(s):  
Academic Performance ◽  
Opposite Effect ◽  
Self Esteem ◽  
Point Of View ◽  
The Other ◽  
Self Concept ◽  
High Ability ◽  
Self Image ◽  
Other Hand

Summary: My comment is basically restricted to the situation in which less-able students find themselves and refers only to literature in German. From this point of view I am basically able to confirm Marsh's results. It must, however, be said that with less-able pupils the opposite effect can be found: Levels of self-esteem in these pupils are raised, at least temporarily, by separate instruction, academic performance however drops; combined instruction, on the other hand, leads to improved academic performance, while levels of self-esteem drop. Apparently, the positive self-image of less-able pupils who receive separate instruction does not bring about the potential enhancement of academic performance one might expect from high-ability pupils receiving separate instruction. To resolve the dilemma, it is proposed that individual progress in learning be accentuated, and that comparisons with others be dispensed with. This fosters a self-image that can in equal measure be realistic and optimistic.

Stories and the Self

2020 ◽  
Vol 32 (2) ◽  
pp. 47-58 ◽  
Author(s):  
Stefan Krause ◽  
Markus Appel
Keyword(s):  
Meta Analysis ◽  
The Self ◽  
The Other ◽  
Lower Degree ◽  
Contrast Effects ◽  
Self Perception ◽  
Self Perceptions ◽  
Other Hand ◽  
The One ◽  
Implicit And Explicit

Abstract. Two experiments examined the influence of stories on recipients’ self-perceptions. Extending prior theory and research, our focus was on assimilation effects (i.e., changes in self-perception in line with a protagonist’s traits) as well as on contrast effects (i.e., changes in self-perception in contrast to a protagonist’s traits). In Experiment 1 ( N = 113), implicit and explicit conscientiousness were assessed after participants read a story about either a diligent or a negligent student. Moderation analyses showed that highly transported participants and participants with lower counterarguing scores assimilate the depicted traits of a story protagonist, as indicated by explicit, self-reported conscientiousness ratings. Participants, who were more critical toward a story (i.e., higher counterarguing) and with a lower degree of transportation, showed contrast effects. In Experiment 2 ( N = 103), we manipulated transportation and counterarguing, but we could not identify an effect on participants’ self-ascribed level of conscientiousness. A mini meta-analysis across both experiments revealed significant positive overall associations between transportation and counterarguing on the one hand and story-consistent self-reported conscientiousness on the other hand.

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