Variations of Serum Alkaline Phosphatase and Plasma Uric Acid During Child's Growth

1964 ◽  
Vol 72 (4) ◽  
pp. 599-605 ◽  
Author(s):  
J. G. Henrotte ◽  
G. A. Heuse ◽  
G. E. Jaeger
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Serum Alkaline Phosphatase ◽  
Plasma Uric Acid

scholarly journals Serum uric acid, lipid profile and alkaline phosphatase levels in ischemic cerebrovascular accident patients

2021 ◽  
Vol 8 (8) ◽  
pp. 1171
Author(s):  
Gaurav Gupta ◽  
Saurabh Kishor ◽  
Aditya Kumar
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Ischemic Stroke ◽  
Serum Uric Acid ◽  
Cerebrovascular Accident ◽  
Serum Alkaline Phosphatase ◽  
Multiple Logistic Regression Analysis ◽  
Elevated Serum ◽  
Control Group ◽  
Significant Difference

Background: Stroke or cerebrovascular accident (CVA) is noted as the second cause of mortality, especially in the elderly population. Recent studies indicated that higher concentrations of uric acid are involved in various vascular diseases. The findings of previous investigations suggest that, elevated serum alkaline phosphatase (ALP) levels may have a pathophysiological character in the occurrence of atherosclerotic vascular disease (AVD) of the heart and brain. This study evaluated the association between serum uric acid (SUA) levels, serum lipid levels, serum alkaline phosphatase (ALP) levels, and changes in ischemic cerebrovascular accident patients.Methods: All patients with Ischemic cerebrovascular accident age >50 years were included based on their clinical, laboratory, and radiological findings (including computed tomography (CT)/magnetic resonance imaging (MRI)) those admitted in our hospital. As control group 200 healthy individuals matched for sex and age were recruited from the same demographic area.Result: Multiple logistic regression analysis findings proposed four components as significant predictors in ischemic cerebrovascular accident (serum uric acid, serum ALP, LDL and HDL. In this study, it was found, that patients with ischemic cerebrovascular accident had significant difference (p<0.001) in serum uric acid and serum ALP than normal patients (non-ischemic cerebrovascular accident patients).Conclusions: Patients with ischemic cerebrovascular accident had significant difference (p<0.001) in SUA and serum ALP than normal patients (non-ischemic cerebrovascular accident patients). High SUA levels were observed to be associated significantly with ischemic stroke. On the basis of our study design, we cannot clarify that the elevated levels are the risk of ischemic stroke and it requires further studies.

scholarly journals Evalution of Anti-Diabetic Potential of Aqueous Extract of “Luffa cylindrica” (Native Sponge/Sponge Gourd) Leaf and Seed on Alloxan Induced Diabetic Wistar Rats

2019 ◽  
pp. 1-8
Author(s):  
Luka, C. D. Abigail ◽  
E. A. Metuaghan
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Normal Control ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Serum Alkaline Phosphatase ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Luffa Cylindrica ◽  
Leaf Extracts

The study was carried out to evaluate the anti-diabetic effect of Luffa cylindrical (native sponge /sponge gourd) seed and leaf extracts in alloxan- induced diabetic rats. Sixteen experimental rats were divided into four groups of four rats each: a, diabetic control; b, normal control; c, diabetic rats treated with seed extract (400 mg/kg) and d, diabetic rats treated with leaf extract (400 mg/kg). The groups A, C and D rats were induced with diabetes intraperitoneally with alloxan (150 mg/kg bw). Phytochemical screening was carried out on the plant seed and leaf extracts and the following biochemical tests were carried out: blood glucose, serum lipid profile, serum alanine aminotransferase, serum aspartate aminotransferase, serum alkaline phosphatase, total protein, albumin, creatinine, urea, uric acid and some electrolytes like Na+, K+, HCO3-, and Cl- the administration of alloxan to experimental rats resulted in an increased level of most biochemical parameters; blood glucose, serum alanine aminotransferase, serum aspartate aminotransferase and serum alkaline phosphatase, serum total cholesterol, triglyceride, low density lipoprotein, creatinine, urea and uric acid. Luffa cylindrica seed and leaf extracts was administered to groups c and d diabetic rats respectively for two weeks, results were compared with normal control and diabetic control rats these parameters were found to be significantly (p<0.05) high in the diabetic groups than in the normal control groups. Treatment with the plant extract significantly (p<0.05) reduced elevated blood levels of glucose, cholesterol, triglyceride, alkaline phosphatase, amylase, aspartate aminotransferase, alanine aminotransferase, creatinine, urea, uric acid associated with alloxan-induced diabetic rats. The plant tested positive for alkaloids, flavonoids, saponins and tannins, negative for cardiac glycosides, phenols, resins, terpenes and steroids. Extracts of Luffa cylindrica seed and leaf has shown to have anti-diabetic and anti-lipidemic effects generally on alloxan induced diabetic rats. The study’s findings has shown that the plant possess hypoglycaemic and hypolipidaemic property and has supported the traditional use of Luffa cylindrica plant in the management of diabetes and its complications.

scholarly journals Effect of Oral Supplementation for Rabbits of Pomegranate seed Extract on Some Serum Biochemical Parameters in Relation to oral Inflammation, oxidative stress, and wound healing

2019 ◽  
Vol 31 (2) ◽  
pp. 14-19
Author(s):  
Rezan M Omer ◽  
Dilyar A Baban ◽  
Bakhtiar M Ahmed
Keyword(s):  
Wound Healing ◽  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Serum Alkaline Phosphatase ◽  
Seed Extract ◽  
Total Proteins ◽  
Time Intervals ◽  
Oral Supplementation ◽  
Pomegranate Seed ◽  
Anti Inflammatory

Background: Pomegranate (punicagranatum L, Punicaceae), is an edible fruit consumed around the world. The edible part of pomegranate is rich in compounds that possess antioxidant and anti-inflammatory activities. The aim of this study is to investigate the antioxidant; anti-inflammatory and gingival wound healing effects of Punicagrantum L. seed extract oral supplementation in rabbit. Methods and Methods: Forty five male rabbits were divided into 3 groups, base line (5 rabbits) left without buccal gingival wound as( group 1),study group, 20 rabbits (group2) with buccal gingival wound treated with ethanolic extract of Punicagranatum L. seed extract and control, 20 rabbits (group 3) with buccal gingival wound only. Buccal gingival wounds were created on lower right central incisor and sutured removed after (7) days. Blood biopsies by cardiocentesis were collected at times (0, 3h, 1, 3 and 7days) for estimation of serum alkaline phosphatase activity, serum total proteins, and serum uric acid. Results: The results showed a significant increase in serum Alkaline phosphatase, total proteins and uric acid in all time intervals after buccal gingival wound, in rabbits receiving water, while their levels increased significantly only at time intervals of 3 hours and 1 day after gingival wound, in rabbits receiving pomegranate seed extraction. Conclusions: It has been concluded that oral Supplementation of pomegranate seed extract in rabbits can expedite the rate of healing of gingival wound

P0817SMOKING WAS ASSOCIATED WITH LOWER SERUM LEVEL OF SOLUBLE ALPHA KLOTHO IN PATIENTS WITH NON-DIALYSIS CHRONIC KIDNEY DISEASE:RESULTS FROM THE KOREAN COHORT STUDY FOR OUTCOMES IN PATIENTS WITH CHRONIC KIDNEY DISEASE (KNOW-CKD)

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
DONG-WAN CHAE ◽  
Yong Jin Yi ◽  
Jong Chul Cheong
Keyword(s):  
Alkaline Phosphatase ◽  
Uric Acid ◽  
Cohort Study ◽  
Serum Level ◽  
Linear Regression ◽  
Serum Alkaline Phosphatase ◽  
Enzyme Linked Immunosorbent Assay ◽  
Lower Serum ◽  
Never Smokers ◽  
Renal Tubular

Abstract Background and Aims Soluble αklotho (sklotho) in systemic circulation, which is mainly derived from renal tubule, has been reported to play important roles in mineral bone disorders, cardiovascular complications and renal progression in CKD. Although decreased renal parenchymal mass is thought to be a main cause of decreased serum level of sklotho in CKD, various factors causing renal tubular injury such as hypoxia, oxidative stress, proinflammatory cytokines and uremic toxins are also known to decrease the renal tubular expression of αklotho. Because smoking contributes to hypoxia and oxidative damage, we hypothesized that smoking might be related to decreased sklotho in patients with non-dialysis CKD. Method To test this hypothesis, we analysed data of 2,101 subjects with non-dialysis CKD from a currently on-going Korean multi-centers prospective cohort study of CKD (KNOW-CKD, NCT01630486 at www.clinicaltrials.gov) in whom serum klotho was measured using an enzyme-linked immunosorbent assay kit (Immuno-Biological Laboratories Co, Gunma, Japan). The intra-assay and inter-assay coefficients of variations were 0.57-1.78% and 3.01-6.12% respectively. Results Mean age was 53.6±12.2 years and 1282 (61.0%) were men. The number of current, former and never smokers were 338 (16.1%), 642 (30.6%), and 1118 (53.2%) respectively. The median pack-year was 20.0 (interquartile range: 10.0-35.0). Mean eGFR by CKD-EPICr equation was 53.0±30.7 ml/min/1.73m2 and mean UACR was 903.9±1423.8 mg/g. Median serum sklotho was 536.0 (IQR: 419.5 – 667.0) pg/ml. In multivariable linear regression with backward stepwise adjustment by all significant factors for sklotho in univariate linear regression, smoking pack-year was independent variable for sklotho. (β= -0.786, p=0.032 95% CI for β: -1.504 to -0.069). Age and serum uric acid were also negatively associated with sklotho, while eGFR, serum alkaline phosphatase, and serum hemoglobin were positively associated with sklotho in the same analysis. Median sklotho of never, former, and current smokers were 551.0 (IQR:430 – 689.3) pg/ml, 509.5 (IQR: 407.8 – 645.3) pg/ml, and 521. (IQR: 397.8 – 645.0) pg/ml respectively. Linear mixed model adjusted by sex, age, eGFR, hemoglobin, alkaline phosphatase, and uric acid demonstrated that sklotho in never smokers was significantly higher than former (p=0.004) and current smokers (p=0.001). But there was no difference in sklotho between former and current smokers. Conclusion Smoking was associated with lower serum sklotho in non-dialysis CKD. But no difference in sklotho between former and current smoker casted doubt on causal relationship between smoking and serum sklotho

The Origin of Elevation of Serum Alkaline Phosphatase in Hepatic Disease

1962 ◽  
Vol 42 (4) ◽  
pp. 431-438 ◽  
Author(s):  
Stanton G. Polin ◽  
Mitchell A. Spellberg ◽  
Lloyd Teitelman ◽  
Makoto Okumura
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Hepatic Disease

SUBACUTE THYROIDITIS WITH ELEVATED SERUM ALKALINE PHOSPHATASE LEVEL

1960 ◽  
Vol XXXIV (II) ◽  
pp. 256-260
Author(s):  
Jörgen Herman Vogt
Keyword(s):  
Alkaline Phosphatase ◽  
Alkaline Phosphatase Level ◽  
Serum Alkaline Phosphatase ◽  
Thyroid Tissue ◽  
Elevated Serum ◽  
Subacute Thyroiditis ◽  
Serum Alkaline Phosphatase Level ◽  
Transient Rise

ABSTRACT A case of subacute thyroiditis is recorded, in which a transient rise in serum alkaline phosphatase values leads to the hypothesis of a transient parathyroid hyper-activity induced by the inflammation of the thyroid tissue in which the parathyroid may be embedded.

The validity of serum alkaline phosphatase to identify nutritional rickets in Nigerian children on a calcium-deprived diet

2019 ◽  
Author(s):  
Tom Thacher ◽  
Christopher Sempos ◽  
Ramon Durazo-Arvizu ◽  
Craig Munns ◽  
Philip Fischer ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Nigerian Children ◽  
Nutritional Rickets

Paget’s disease: clinical update

2011 ◽  
Vol 152 (33) ◽  
pp. 1337-1346
Author(s):  
Judit Donáth ◽  
Gyula Poór
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Etiologic Role ◽  
Osteoblast Activity ◽  
Chronic Disorder ◽  
Abnormal Increase ◽  
Osteoclast Function ◽  
High Level

Paget’s disease is a chronic disorder of bone remodeling, characterized by an abnormal increase of osteoclast and, hence, osteoblast activity. The imbalance of bone turnover results in the formation of unhealthy and fragile bone. It also leads to impairment of adjacent joints and to a risk of various complications. Current research focuses on the elucidation of the etiologic role viral infection and predisposing genetic factors. Paget’s disease is commonly discovered by chance; its suspicion is raised either by high level of alkaline phosphatase or by the X-ray of the pathological bone. Bisphosphonates have proven to be effective in controlling disease activity because they inhibit osteoclast function. Their use is recommended when bone-derived serum alkaline phosphatase is high and/or when disease localizations are highly suspected for the development of complications. Orv. Hetil., 2011, 152, 1337–1346.

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