Clinical Presentation and Prognostic Factors in Sodium Monofluoroacetate Intoxication

IntroductionThere is global concern about the increasing prevalence of autism spectrum disorders (ASDs), which are early-onset and long-lasting disorders. Although ASDs are considered to comprise a unique syndrome, their clinical presentation and outcome vary widely. Large-scale and long-term cohort studies of well-phenotyped samples are needed to better understand the course of ASDs and their determinants. The primary objective of the multicEntric Longitudinal study of childrEN with ASD (ELENA) study is to understand the natural history of ASD in children and identify the risk and prognostic factors that affect their health and development.Methods and analysisThis is a multicentric, longitudinal, prospective, observational cohort in which 1000 children with ASD diagnosed between 2 and 16 years of age will be recruited by 2020 and followed over 6 years. The baseline follow-up starts with the clinical examination to establish the ASD diagnosis. A battery of clinical tools consisting of the Autism Diagnostic Observation Schedule, the revised version of the Autism Diagnostic Interview, measures of intellectual functioning, as well as large-scale behavioural and developmental measurements will allow us to study the heterogeneity of the clinical presentation of ASD subtypes. Subsequent follow-up at 18 months and at 3, 4.5 and 6 years after the baseline examination will allow us to explore the developmental trajectories and variables associated with the severity of ASD. In addition to the children’s clinical and developmental examinations, parents are invited to complete self-reported questionnaires concerning perinatal and early postnatal history, congenital anomalies, genetic factors, lifestyle factors, medical and psychiatric comorbidities, and the socioeconomic environment. As of 1 November 2018, a total of 766 participants have been included.Ethics and disseminationEthical approval was obtained through the Marseille Mediterranean Ethics Committee (ID RCB: 2014-A01423-44), France. We aim to disseminate the findings through national and international conferences, international peer-reviewed journals, and social media.Trial registration numberNCT02625116; Pre-results.

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Necrotizing soft-tissue infections in New Caledonia: Epidemiology, clinical presentation, microbiology, and prognostic factors

Asian Journal of Surgery ◽

10.1016/j.asjsur.2015.10.008 ◽

2017 ◽

Vol 40 (4) ◽

pp. 290-294 ◽

Cited By ~ 5

Author(s):

Pauline Kha ◽

Julien Colot ◽

Shirley Gervolino ◽

Gilles Guerrier

Keyword(s):

Prognostic Factors ◽

Soft Tissue ◽

Clinical Presentation ◽

New Caledonia ◽

Soft Tissue Infections ◽

Necrotizing Soft Tissue Infections

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Rapidly Progressive IgA Nephropathy: A Case Report With Review of Clinical Presentation, Prognostic Factors and Therapeutic Modalities

Journal of Medical Cases ◽

10.14740/jmc2498w ◽

2016 ◽

Vol 7 (6) ◽

pp. 230-233 ◽

Cited By ~ 1

Author(s):

Isaac Akkad ◽

Alberto Ortiz ◽

Melvyn Hecht

Keyword(s):

Prognostic Factors ◽

Case Report ◽

Iga Nephropathy ◽

Clinical Presentation ◽

Therapeutic Modalities

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Acute transverse myelitis and intramedullary spinal cord tumors in children – clinical presentation, differential diagnosis and prognostic factors

Child Neurology ◽

10.20966/chn.2017.52.391 ◽

2017 ◽

Vol 26 (52) ◽

pp. 39-45

Author(s):

Ilona Kopyta ◽

◽

Marek Mandera ◽

Beata Wesolek-Kaminska ◽

Joanna Sordyl ◽

...

Keyword(s):

Spinal Cord ◽

Differential Diagnosis ◽

Prognostic Factors ◽

Clinical Presentation ◽

Transverse Myelitis ◽

Spinal Cord Tumors ◽

Intramedullary Spinal Cord ◽

Acute Transverse Myelitis

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Pulmonary Embolism: Treatment Outcomes and Prognostic Factors of Mortality in University Hospital

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2021.02.11545 ◽

2021 ◽

Vol 104 (2) ◽

pp. 225-232

Keyword(s):

Pulmonary Embolism ◽

Prognostic Factors ◽

Respiratory Failure ◽

Hospital Mortality ◽

Treatment Outcomes ◽

Sofa Score ◽

Clinical Presentation ◽

University Hospital ◽

The Mean ◽

Overall Mortality

Objective: To determine the treatment outcomes, and to identify the prognostic factors of hospital mortality of pulmonary embolism (PE) patients. Materials and Methods: A retrospective cohort study was conducted in a 1,400-bed university hospital. Demographic, Medical history, clinical data and treatment outcomes were collected. Logistic regression was performed to identify prognostic factors for all-cause of hospital mortality. Results: One hundred fifty-eight patients with PE were included, 47.5% were male and the mean age was 59.2±14.7 years. The most common of clinical presentation are dyspnea 125 (79.1%), tachycardia 72 (45.6%), and hypotension 39 (24.7%). Forty patients (25.3%) had acute massive PE. The overall mortality rate (MR) was 19.6% and intensive care unit (ICU) MR was found in 34.5%. The prognostic factors of mortality were massive PE (adjusted odds ratio [AOR] 5.44, 95% confidence interval [CI] 1.10 to 27.06, p=0.039), cancer (AOR 4.45, 95% CI 1.52 to 12.98, p=0.006), respiratory failure (AOR 3.63, 95% CI 1.10 to 12.10, p=0.019), and SOFA score of 5 or greater (AOR 3.46, 95% CI 1.11 to 10.80, p=0.032). Conclusion: PE is associated with high mortality in hospital, especially in ICU. The prognostic factors for hospital mortality were massive PE, respiratory failure, cancer comorbidity and SOFA score of 5 or greater. Keywords: Pulmonary embolism, Prognostic factor, Mortality, Treatment outcomes

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