The test results of graduates transport universities for knowledge of regulatory requirements documents on the safety of movement of trains

2020 ◽  
pp. 15-22
Author(s):  
N.O. Berestok ◽  
◽  
V.A. Kobzev ◽  
E.A. Ovchinnikova ◽  
S.P. Shumsky ◽  
...  
Keyword(s):  
Test Results ◽  
Regulatory Requirements ◽  
Requirements Documents

Conducting a comparison of violations committed by employees of the movement economy and errors made during testing for knowledge of PTE.

Laboratory performance and regulatory requirements.

1987 ◽  
Vol 33 (6) ◽  
pp. 1087-1102 ◽  
Author(s):  
M L Kenney
Keyword(s):  
Linear Regression ◽  
Proficiency Test ◽  
Clinical Laboratory ◽  
Group Practice ◽  
Federal Regulations ◽  
Test Results ◽  
Regulatory Requirements ◽  
Service Levels ◽  
Z Scores ◽  
Log Normal

Abstract We compared performance levels of four clinical laboratory groups defined by federal regulatory characteristics, to assess the appropriateness of selected regulations: laboratories in JCAH-accredited hospitals; non-doctoral-directed independent laboratories; state-regulated but federally exempt group-practice laboratories; and unregulated laboratories in physicians' offices (POLs). Federal regulations evaluated were those dealing with the doctoral directorship requirement and exemption of POLs from regulation. Quantitative analytes were compared by using linear regression on log-normal transformations of mean absolute-z scores of proficiency test results. The scope of services offered by laboratories was statistically related to performance in quantitative analytes. Confounding effects of scope-of-service levels were statistically controlled. Proportions of errors in qualitative analytes were compared. No pattern of statistically discernible differences in performance was found between hospital laboratories and non-doctoral-directed laboratories. Both regulated non-doctoral-directed laboratories and state-regulated but federally exempt group-practice laboratories demonstrated higher levels of performance than unregulated POLs.

Carcinogenicity testing of IL-10: principles and practicalities

2002 ◽  
Vol 21 (7) ◽  
pp. 347-358 ◽  
Author(s):  
I Y Rosenblum ◽  
A D Dayan
Keyword(s):  
Immune System ◽  
Critical Evaluation ◽  
Carcinogenic Risk ◽  
Test Results ◽  
Scientific Evaluation ◽  
Regulatory Requirements ◽  
Candidate Drug ◽  
Detailed Evaluation ◽  
Rational Consideration ◽  
Practical Feasibility

IL-10 is a cytokine with actions at many levels of the immune system. In the course of development of recombinant human IL-10 (rhuIL-10) as a potential treatment for a number of chronic diseases of man, the question `What about its carcinogenicity testing?’ was repeatedly asked, based on scientific evaluation by toxicologists, beliefs about regulatory requirements, and questions considered likely to be raised by physicians, patients, and lawyers. The feasibility of various approaches to the carcinogenicity testing of rhuIL-10 is critically discussed here as a contribution to rational consideration of the general need for and value of such testing, and its particular feasibility for a recombinant human protein with profound effects on the immune system. The physiological functions of IL-10 in man and rodents are reviewed in detail, as there are notable differences between species in its normal activities, followed by detailed evaluation of the potential procedures and practical problems of its carcinogenicity testing as a heterologous, immunogenic protein in rodents. The value of information that might be obtained from transgenic mice is also evaluated, and so are the results of studies exploring its actions on human tumour cell biopsies and rodent and human cell lines. It is concluded that despite the probable popular and regulatory expectations that carcinogenicity test results would be provided, all the physiological and pathological information reveals no indication that rhuIL10 would pose a carcinogenic risk to humans on prolonged administration, and that it would not be feasible to undertake such experimentation. It is argued that in this, as in other instances, professional and popular expectations have run beyond practical feasibility or theoretical justification. Cautious and critical evaluation should be made every time shorter or longer term toxicity studies of any candidate drug are planned or even considered, especially if it is a recombinant protein, to decide on objective grounds whether the studies are really necessary and whether they can be done in a way that will give meaningful results that will help in risk assessment.

Soot Wear in Diesel Engines

2006 ◽  
Vol 220 (5) ◽  
pp. 463-469 ◽  
Author(s):  
E. S. Yamaguchi ◽  
M Untermann ◽  
S. H. Roby ◽  
P. R. Ryason ◽  
S. W. Yeh
Keyword(s):  
Photoelectron Spectroscopy ◽  
Sliding Wear ◽  
Wear Test ◽  
Test Results ◽  
Regulatory Requirements ◽  
Low Wear ◽  
Stribeck Curves ◽  
Gas Recirculation ◽  
Lubrication Conditions ◽  
Ball On Disc

In response to regulatory requirements, lubricant manufacturers are seeking oils that minimize soot thickening and the accompanying soot wear. Formulation technology is being developed by additive manufacturers to satisfy these requirements. For example, such work is in progress at Chevron Oronite Company LLC, using the Cummins M-11 exhaust gas recirculation (EGR) engine test as a surrogate for the anticipated soot wear test for PC-10. Simultaneously, the authors developed bench tests to screen candidate formulations and reduce costs. A ball-on-disc sliding wear test, using a PCS Instruments MTM® tribometer, has been investigated. Sliding conditions at high pressure are required for soot polishing wear. Conditions that correlate tribometer test results with M-11 engine results at high soot concentrations (∼9 per cent) have been found. Both ball wear and Stribeck curves were determined in these tests. The high-wear oil progresses from mixed lubrication conditions to boundary lubrication at higher sliding speeds than the low-wear oil. X-ray photoelectron spectroscopy experiments were also conducted on the ball wear scars, revealing differences in the chemical constitution of the tribofilms from the two oils.

Regulation of Laboratory Genetic Testing

2017 ◽  
Author(s):  
Barbara Zehnbauer ◽  
W. Andrew Faucett
Keyword(s):  
Genetic Testing ◽  
Clinical Laboratory ◽  
Genetic Counselor ◽  
Professional Standards ◽  
Test Results ◽  
Regulatory Requirements ◽  
Clinical Genetic ◽  
Regulatory Oversight ◽  
Laboratory Staff ◽  
Phenotypic Information

Laboratory regulations provide rules to establish consistency and to evaluate performance. They also set out the qualifications and experience needed for laboratory staff to fulfill regulatory requirements and meet professional standards. Clinical genetic counselors play a significant role in determining which tests to offer patients, which laboratories to consider for testing, and which phenotypic information to provide to the clinical laboratory to improve the interpretation of test results. This chapter discusses laboratory regulations pertinent to the type of genetic testing offered and specimens received in the laboratory. The goal is to help the laboratory genetic counselor understand the regulatory oversight of genetic testing and the quality management of clinical laboratory operations.

scholarly journals Design and Implementation of Mechanical Instrument for Flight Simulator

2019 ◽  
Vol 291 ◽  
pp. 01007
Author(s):  
Li Huiru
Keyword(s):  
Design Principle ◽  
Delay Testing ◽  
Flight Simulator ◽  
Test Results ◽  
Regulatory Requirements ◽  
Mechanical Simulation ◽  
Working Principle ◽  
Visual Error ◽  
Diagram Design ◽  
Angle Calculation

The mechanical simulation instrument of flight simulator can meet the display visual error specified by the new regulations. By studying the working principle of the flight simulator mechanical simulation instrument, it can be seen that the mechanical simulation instrument can be quickly converted into other instruments of the same series by changing the dial. Taking the oxygen pressure indicating instrument of flight simulator as an example, this paper introduces the design principle, design circuit diagram, design angle calculation and software architecture of the instrument. It was installed on the CJ1 flight simulator for transmission delay testing. Test results show that the simulation instrument can fully meet the regulatory requirements

Preliminary Research on the Elimination of OBE in the Seismic Design of NPP

2013 ◽  
Author(s):  
Qiang Li ◽  
Jian Zhang
Keyword(s):  
Seismic Design ◽  
Nuclear Power ◽  
Power Plants ◽  
Nuclear Power Plants ◽  
User Requirements ◽  
Regulatory Requirements ◽  
Standard Design ◽  
Explicit Analysis ◽  
Design Analyses ◽  
Requirements Documents

Two levels of seismic, i.e. OBE and SSE, are conventionally considered in the seismic design of nuclear power plants. OBE is formerly set to equal to one half of SSE. In Advanced Light Water Reacter User Requirements Documents (ALWR-URD), US EPRI recommented to decrease OBE to one third of SSE. In the standard design of third generation of nuclear power plants, such as AP1000 of Westinghouse and EPR of AREVA, OBE was eliminated and substituted by lower level earthquake. In AP1000 standard design, OBE was decreased to one third of SSE and explicit analysis on OBE in the seimic design analyses is not required. Literatures and reports related to the regulatory requirements of seismic design are reviewed to study the reasons and means to be taken to address the issue of elimination of OBE from the design analyses of NPP. It will provide guidelines on the issue of elimination of OBE from seimic analysis of NPP design in China.

Analysis of Influence of Fine Aggregate on Void Ratio of Asphalt Mixture

2014 ◽  
Vol 587-589 ◽  
pp. 1079-1083
Author(s):  
Guan Jing
Keyword(s):  
Bulk Density ◽  
Void Ratio ◽  
Coarse Aggregate ◽  
Asphalt Mixture ◽  
Fine Aggregate ◽  
Test Results ◽  
Regulatory Requirements ◽  
Aggregate Gradation

Using molding with different fine aggregate, gradation, asphalt, aggregate forming and forming method, and calculate the sample porosity. The test results show that: The basalt coarse-fine aggregate molding, specimen void ratio was larger, are beyond the regulatory requirements; basalt coarse aggregate molding and limestone fine aggregate molding, specimen porosity is small, can meet the requirements of specification range. The main reason is that the basalt thin bulk density is big, and its not easy compaction.

Using Conventional Articulation Tests With Highly Unintelligible Children

1992 ◽  
Vol 23 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Pamela G. Garn-Nunn ◽  
Vicki Martin
Keyword(s):  
Test Results ◽  
Phonological Processes ◽  
Rule Based ◽  
Severity Level ◽  
Error Sensitivity ◽  
Conventional Tests ◽  
Severity Levels ◽  
Conventional Test ◽  
Impaired Children

This study explored whether or not standard administration and scoring of conventional articulation tests accurately identified children as phonologically disordered and whether or not information from these tests established severity level and programming needs. Results of standard scoring procedures from the Assessment of Phonological Processes-Revised, the Goldman-Fristoe Test of Articulation, the Photo Articulation Test, and the Weiss Comprehensive Articulation Test were compared for 20 phonologically impaired children. All tests identified the children as phonologically delayed/disordered, but the conventional tests failed to clearly and consistently differentiate varying severity levels. Conventional test results also showed limitations in error sensitivity, ease of computation for scoring procedures, and implications for remediation programming. The use of some type of rule-based analysis for phonologically impaired children is highly recommended.

Vestibular Function and Motion Sickness Susceptibility: Videonystagmographic Evidence From Oculomotor and Caloric Tests

2020 ◽  
Vol 29 (2) ◽  
pp. 188-198
Author(s):  
Cynthia G. Fowler ◽  
Margaret Dallapiazza ◽  
Kathleen Talbot Hadsell
Keyword(s):  
Phase Velocity ◽  
Motion Sickness ◽  
Repeated Measures ◽  
Short Form ◽  
Vestibular Function ◽  
Slow Phase ◽  
Test Results ◽  
Normal Range ◽  
Slow Phase Velocity ◽  
Caloric Tests

Purpose Motion sickness (MS) is a common condition that affects millions of individuals. Although the condition is common and can be debilitating, little research has focused on the vestibular function associated with susceptibility to MS. One causal theory of MS is an asymmetry of vestibular function within or between ears. The purposes of this study, therefore, were (a) to determine if the vestibular system (oculomotor and caloric tests) in videonystagmography (VNG) is associated with susceptibility to MS and (b) to determine if these tests support the theory of an asymmetry between ears associated with MS susceptibility. Method VNG was used to measure oculomotor and caloric responses. Fifty young adults were recruited; 50 completed the oculomotor tests, and 31 completed the four caloric irrigations. MS susceptibility was evaluated with the Motion Sickness Susceptibility Questionnaire–Short Form; in this study, percent susceptibility ranged from 0% to 100% in the participants. Participants were divided into three susceptibility groups (Low, Mid, and High). Repeated-measures analyses of variance and pairwise comparisons determined significance among the groups on the VNG test results. Results Oculomotor test results revealed no significant differences among the MS susceptibility groups. Caloric stimuli elicited responses that were correlated positively with susceptibility to MS. Slow-phase velocity was slowest in the Low MS group compared to the Mid and High groups. There was no significant asymmetry between ears in any of the groups. Conclusions MS susceptibility was significantly and positively correlated with caloric slow-phase velocity. Although asymmetries between ears are purported to be associated with MS, asymmetries were not evident. Susceptibility to MS may contribute to interindividual variability of caloric responses within the normal range.

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