Features of therapy of alcoholic liver disease in persons of young age

The aim of this study was to study the eff ects of using the infusion drug Remaxol in young patients with alcoholic liver disease.Materials and methods: the clinical and laboratory data of 80 young patients with alcoholic liver disease were analyzed, divided depending on the treatment regimen into 2 groups: the main (n = 44) who received Remaxol according to the scheme: 400 ml iv, drip, at a rate 40–60 drops per minute daily, course No. 5–10, and control (n = 36) — received basic therapy. In all patients, the dynamics in blood serum was studied: lipid peroxidation indices (malondialdehyde, diene conjugates), antioxidant protection enzymes (catalase, SOD, glutathione peroxidase), markers of cytolysis, cholestasis and lipid metabolism.Results: initially there was a significant increase in lipid peroxidation processes, accompanied by slight stimulation of the antioxidant system of the liver and pronounced signs of cytolysis and cholestasis. The inclusion of Remaxol in treatment regimens leads to a significant decrease in the level of malondialdehyde and diene conjugates, and the restoration of the antioxidant system (increase in catalase, SOD, and glutathione peroxidase). At the same time, a marked decrease in the syndromes of cytolysis and cholestasis was noted, which was accompanied by an improvement in the condition of the patients: cessation of nausea, restoration of appetite and sleep, and improvement of well-being.

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Alcoholic liver disease: a modern look at diagnosis and treatment

Medical Council ◽

10.21518/2079-701x-2019-14-64-71 ◽

2019 ◽

pp. 64-71

Author(s):

R. G. Myazin ◽

D. N. Emel’yanov

Keyword(s):

Lipid Peroxidation ◽

Lipid Metabolism ◽

Liver Disease ◽

Antioxidant System ◽

Alcoholic Liver Disease ◽

Energy Requirement ◽

Stress Factors ◽

Energy Potential ◽

Diene Conjugates ◽

History Of

Alcohol is one of the leading etiological factors in liver damage. In alcoholic liver disease (ALD), hypoxia occurs due to an imbalance between the energy requirement of hepatocytes and energy production in the mitochondrial oxidative phosphorylation system. Diagnosis of ALD includes the taking of an anamnesis, questioning of patients, clinical examination data, laboratory and instrumental study. For the treatment of ALD, agents are used that protect cell membranes from oxidative stress factors and restore the energy potential of cells under conditions of tissue hypoxia. One such hepatotropic infusion is Remaxol®, the original polyionic succinatemethionine complex based on succinic acid. Aim of the study: to consider the effects of using Remaxol® infusion drug in the group of ALD patients. Materials and methods: treatment of 40 patients (male) with ALD was carried out, all of whom had a distinct history of the disease with regular and prolonged alcohol abuse. The duration of the disease in the group was 4.8 ± 0.7 years. Initially, all of them showed increased lipid peroxidation, depression of antioxidant protection, as well as pronounced sings of cytolysis, cholestasis and lipid metabolism. Then, all patients in the group were treated with Remaxol®. The course of treatment ranged from 5 to 10 daily intravenous drip infusions. After treatment, the parameters of lipid peroxidation malondialdehyde (MDA), diene conjugates (DC), enzymes of antioxidant system catalase (Cat), superoxide dismutase (SOD), glutathione peroxidase (GP), markers of cytolysis, cholestasis and lipid metabolism were again investigated in the serum of patients. Results of the study: a positive effect after monotherapy with Remaxol® was observed in 34 patients, which amounted to 85% of the group. They recorded a significant decrease in lipid peroxidation and a compensatory increase in antioxidant system enzymes. The indicators of cytolysis and cholestasis syndromes significantly decreased, lipid metabolism was restored, and the subjective status of patients improved. There were no side effects during the treatment with Remaxol® in the group of patients with ALD. Conclusions: It was noted that therapy with Remaxol® caused positive laboratory dynamics in 34 patients, which amounted to 85% of all treated patients with ALD. Thus, it has been shown that therapy with Remaxol® is an effective method of treating alcoholic liver disease.

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Lipid peroxidation and antioxidative system in the blood of alcoholic liver disease patients

Journal of Hepatology ◽

10.1016/s0168-8278(98)81055-6 ◽

1998 ◽

Vol 28 ◽

pp. 220

Author(s):

Carmen Fierbinteanu Braticevici ◽

D. Andronescu ◽

R. Chirila ◽

I. Greceanu ◽

Maria Mohora ◽

...

Keyword(s):

Lipid Peroxidation ◽

Liver Disease ◽

Alcoholic Liver Disease ◽

Antioxidative System

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Resistance of Erythrocytes to Lipid Peroxidation in Alcoholic Liver Disease

Clinical Science ◽

10.1042/cs076010p ◽

1989 ◽

Vol 76 (s20) ◽

pp. 10P-10P

Author(s):

N.A. Punchard ◽

R.M. Berry ◽

P. Mine ◽

R.P.H. Thompson

Keyword(s):

Lipid Peroxidation ◽

Liver Disease ◽

Alcoholic Liver Disease

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Вплив хлориду кадмію на стан антиоксидантної системи у печінці щурів

Вісник Полтавської державної аграрної академії ◽

10.31210/visnyk2013.02.28 ◽

2013 ◽

pp. 102-103

Author(s):

Б. В. Гутий

Keyword(s):

Lipid Peroxidation ◽

Superoxide Dismutase ◽

Enzyme Activity ◽

Glutathione Peroxidase ◽

Antioxidant System ◽

Cadmium Chloride

Розкрито особливості антиоксидантної системиорганізму щурів за хронічного кадмієвого токсикозу.Встановлено, що хлорид кадмію у токсичній дозісприяє зниженню активності ферментної й нефер-ментної системи антиоксидантного захисту, на щовказує зниження ферментів глутатіонпероксидази,глутатіонредуктази, супероксиддисмутази, катала-зи та відновленого глутатіону у печінці щурів. Ре-зультати досліджень вказують на те, що хронічнийкадмієвий токсикоз призводить до посиленої акти-вації процесів ліпопероксидації. The features of the antioxidant system of rats with chronic cadmium toxicosiare disclosed. It wasresearched that cadmium chloride in toxic doses reduces enzyme activity of antioxidant system, asindicated by the decrease in enzyme glutathione peroxidase, hlutationreduktazy, superoxide dismutase,catalase and restored glutathione in the liver and blood of rats. The results indicate that chroniccadmium toxicosis leads to enhanced activation of lipid peroxidation.

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Lipid peroxidation and hepatic antioxidants in alcoholic liver disease.

Gut ◽

10.1136/gut.31.11.1311 ◽

1990 ◽

Vol 31 (11) ◽

pp. 1311-1317 ◽

Cited By ~ 47

Author(s):

R D Situnayake ◽

B J Crump ◽

D I Thurnham ◽

J A Davies ◽

J Gearty ◽

...

Keyword(s):

Lipid Peroxidation ◽

Liver Disease ◽

Alcoholic Liver Disease

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Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease

Free Radical Biology and Medicine ◽

10.1016/s0891-5849(01)00757-2 ◽

2002 ◽

Vol 32 (1) ◽

pp. 38-45 ◽

Cited By ~ 105

Author(s):

Elisa Mottaran ◽

Stephen F Stewart ◽

Roberta Rolla ◽

Daria Vay ◽

Valentina Cipriani ◽

...

Keyword(s):

Lipid Peroxidation ◽

Liver Disease ◽

Alcoholic Liver Disease ◽

Immune Reactions

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The study of influence of the extracts obtained from prunus domestica fruits on lipid peroxydation and antioxidant system indicators in liver

Farmatsevtychnyi zhurnal ◽

10.32352/10.32352/0367-3057.6.19.10 ◽

2019 ◽

pp. 85-93

Author(s):

Bashar Jabbar Ali Al-Sahlanee ◽

I. V. Senyuk ◽

L. V. Lenchyk ◽

T. V. Upyr

Keyword(s):

Lipid Peroxidation ◽

Free Radical ◽

Phenolic Compounds ◽

Effective Dose ◽

Rat Liver ◽

Antioxidant System ◽

Antioxidant Properties ◽

Diene Conjugates ◽

Reference Drug ◽

Wide Range

The study of pharmacological properties and experimental substantiation of application possibilities of the plum fruits extracts in the treatment of the gastrointestinal tract and hepatobiliary system diseases is relevant, because plum is source of phenolic compounds with a wide range of action and is used in folk medicine for treating diseases of digestive system. The aim of the present work was an experimental study of anti free radical activity by lipid peroxidation indicators and antioxidant properties by the antioxidant system (AOS) indicators of two Plum extracts, detecting the most effective extract and determining its effective dose. The objects of research were extracts obtained from the fresh plum fruits: plum extract containing fibers (PEF) and extract containing plum polysaccharide complex (PEPC). Research methods: pharmacological (modeling of alcoholic damage to rat liver), biochemical (determination of the level of diene conjugates, TBA-AP, lipid hydroxyperoxides, reduced glutathione and α-tocopherol in rat liver homogenate) and statistical (using the program «Statistica 6.0», Student’s t-test). Experimental data on the study of the anti free radical properties of the plum extracts showed inhibitory effects on lipid peroxidation, reducing the content of diene conjugates, TBAs, and lipid hydroxyperoxides under conditions of alcoholic liver damage. Regarding the effect of the investigated extracts on the markers of the antioxidant system of hepatocytes, there was an increase in the content of reducing glutathione and α-tocopherol on the alcoholic hepatitis model. The fiber-containing extract (PEF) was the most effective in normalizing the functional state of the liver at a dose of 200 mg/kg. Thus, it was determined that an effective dose of extract with fibers (PEF) was 200 mg/kg. The investigated effects of PEF in 200 mg/kg exceeded the effects of PEPS at the tested doses and were at the level of activity of reference drug «Silibor» in the dose of 25 mg/kg. Anti free radical and antioxidant properties of the PEF are probably related to its chemical composition namely phenolic compounds (anthocyanins and hydroxycinnamic acids). Considering the results of screening, the most promising subject for further in-depth pharmacological study is plum extract PEF at dose 200 mg/kg.

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A RANDOMIZED CLINICAL ENDPOINT STUDY TO EVALUATE THE SAFETY AND EFFICACY OF CLEARLIV TABLETS IN PATIENTS WITH ALCOHOLIC LIVER DISEASE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i1.29921 ◽

2019 ◽

Vol 12 (1) ◽

pp. 297

Author(s):

Ramesh Kannan S ◽

Sivaraman V ◽

Mirunalini C ◽

Sakthibalan M ◽

Jayashree S ◽

...

Keyword(s):

Liver Disease ◽

Liver Function ◽

Liver Function Test ◽

Liver Damage ◽

Alcoholic Liver Disease ◽

Well Being ◽

Study Phase ◽

Clinical Endpoint ◽

Significant Difference ◽

Function Test

Objective: The objective of this study was to evaluate and compare the hepatoprotective effect of clearliv tablets with silymarin in patients with alcoholic liver disease.Methods: This was a prospective, randomized, multicenter, open-label, parallel group interventional clinical endpoint study (Phase IIa). Patients attending general medicine outpatient department were screened for alcoholic liver disease using the serum biochemical liver function test and ultrasonogram abdomen and tested whether they satisfy the selection criteria, and 24 patients were then enrolled in the study. The study drug, namely clearliv tablets of Apex Laboratories Pvt. Ltd., was administered to Group A and tablet silymarin was administered to Group B from day 1 to day 56. Patients were reviewed once in 2 weeks. Liver function test was repeated, and patients were enquired of their well-being and any adverse events.Results: The demographic characters and body weight of the subjects showed no significant difference between the groups. There is a significant improvement (p<0.05) in the aspartate transaminase (AST), alanine transaminase (ALT), and total bilirubin (TB) levels on 28th and 56th days in both silymarin and clearliv groups. Of the 2 groups, there is higher significance of improvement in clearliv group (p<0.001), compared to silymarin group. Clearliv group started showing a significant reduction in AST and ALT levels in the first 14 days of the study period. On comparing the mean percentage reduction in the levels of AST (35.7% and 35%), ALT (26.7% and 24.3%), and TB (26.7% and 25%), it was found that clearliv is showing a better percentage of reduction of the above parameters compared to silymarin. There were reports of adverse effects such as loss of appetite and gastritis in both the groups.Conclusion: This clinical study proves that clearliv is functioning as a hepatoprotective drug. It is offering a better hepatoprotection compared to silymarin. Clearliv tablets can be indicated for the management of liver dysfunction, which occurs due to alcoholic liver damage. It may also be used in similar manner in cases of viral hepatitis, drug-induced liver damage, acute and chronic hepatitis.

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