scholarly journals Algorithm for diagnosing the latent form of celiac disease in adults

2021 ◽  
pp. 188-193
Author(s):  
S. V. Fedorenko ◽  
E. G. Kovaleva ◽  
O. G. Grankina ◽  
T. P. Levina ◽  
A. N. Chumel
Keyword(s):  
Celiac Disease ◽  
Clinical Case ◽  
Clinical Course ◽  
Lactase Deficiency ◽  
Trigger Factors ◽  
Latent Form

The article presents a clinical case of the latent course of celiac disease with diagnosis in the adult period, reflects the role of trigger factors, the features of the clinical course, the formation of concomitant lactase deficiency and the need for all diagnostic stages for diagnosis.

scholarly journals Lactase Deficiency and Colonic Mucosal Eosinophilia (P19-014-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Meenal Singh ◽  
Craig Friesen ◽  
Vivekanand Singh
Keyword(s):  
Abdominal Pain ◽  
Celiac Disease ◽  
Colonic Mucosa ◽  
Inflammatory Cells ◽  
Duodenal Mucosa ◽  
Reference Laboratory ◽  
Lactase Deficiency ◽  
Funding Sources ◽  
Pathology Reports

Abstract Objectives Immunological studies in patients with lactase deficiency (LD) have suggested a role of colonic mucosal inflammatory cells in causation of some of the symptoms. We hypothesized that since eosinophils are associated with symptoms of abdominal pain and diarrhea; and patients with LD frequently manifest these symptoms, there may be an increase of eosinophils in LD. Thus, our objective was to study children with LD to assess eosinophils in their colonic mucosa. Methods We reviewed the pathology reports of mucosal biopsies of 86 children with LD who underwent esophagogastroduodenoscopy (EGD) and colonoscopy or only EGD. Data was abstracted from the pathology reports and analyzed. Lactase enzyme testing was performed at a reference laboratory on the mucosal biopsy specimen obtained from duodenum. The reference laboratory defined the normal range of lactase enzyme as 24.5+/− 8 micromoles per minute per gram of protein (micromoles/min), and abnormal level as <15 micromoles/min. Results The subjects ranged in age from 1 to 17 years and 47 (55%) were female and all subjects had abdominal pain. The lactase enzyme levels in the study subjects ranged from 0 to 13.9. All 86 subjects underwent EGD, 6 (7%) of whom had celiac disease and 10 (12%) showed increased mucosal eosinophils in the duodenal mucosa. All subjects with celiac disease had very low (<7 micromoles/min) levels of lactase. There were 52 subjects who had colonoscopy as well, and 16 (31%) of them had increased colonic mucosal eosinophils (CME), whereas 32 (62%) showed no histopathological abnormality of colonic mucosa. Conclusions Our study found that 31% of children with lactase deficiency manifest increased colonic mucosal eosinophils. Chemical mediators secreted by eosinophils are known to mediate abdominal pain. However, to fully understand the role of other inflammatory cells in the clinical presentation of children with LD, future studies on larger numbers of subjects that assess eosinophils and mast cells are needed. Funding Sources Intra-departmental Funding.

ROLE OF THE NOVEL INTRODUCED PAN-INTESTINAL CAPSULE ENDOSCOPY SYSTEM IN CELIAC DISEASE

2019 ◽  
Author(s):  
F Foerster ◽  
K Mönkemüller ◽  
PR Galle ◽  
H Neumann
Keyword(s):  
Celiac Disease ◽  
Capsule Endoscopy ◽  
The Novel

Modern methods of treating rosacea

2019 ◽  
Vol 1 (7) ◽  
pp. 65-71
Author(s):  
O. A. Egorova ◽  
K. A. Novikov
Keyword(s):  
Clinical Manifestations ◽  
Treatment Method ◽  
Current Data ◽  
Trigger Factors ◽  
Laser Technology ◽  
Individual Approach ◽  
Modern Methods ◽  
Methods Of Treatment ◽  
Choice Of Therapy

Presented current data on the etiology of rosacea, the main aspects of pathogenesis, clinical forms of the disease. Reflects trigger factors leading to rosacea, as well as complicating its course. Modern methods of treatment are described, including the use of new safe preparations of ivermectin and brimonidine, providing a good, lasting effect of clinical manifestations of rosacea. The role of laser technology, actively occupying a leading place in the choice of physiotherapeutic treatment method, is noted. The need for an individual approach in the choice of therapy for each patient with rosacea is emphasized.

Are Viruses and Parasites Linked to Celiac Disease? A Question that Still has no Definite Answer

2019 ◽  
Vol 20 (14) ◽  
pp. 1181-1193 ◽  
Author(s):  
Aref Shariati ◽  
Hamid R. Aslani ◽  
Mohammad R.H. Shayesteh ◽  
Ali Taghipour ◽  
Ahmad Nasser ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Multiple Roles ◽  
Barr Virus ◽  
The People ◽  
Intestinal Infections ◽  
Inflammatory Bowel ◽  
Epstein Barr ◽  
Irritable Bowel ◽  
Related Proteins

Celiac Disease (CD) is a complex autoimmune enteropathy of the small intestine that commonly occurs in genetically predisposed individuals due to intake of gluten and related proteins. Gluten consumption, duration of breast-feeding, various infections, especially frequent intestinal infections, vaccinations and use of antibiotics can be linked to CD. It is predicted that it affects 1% of the global population and its incidence rate is increasing. Most of the people with the HLA-DQ2 or HLADQ8 are at a higher risk of developing this disease. The link between infections and autoimmune diseases has been very much considered in recent years. In several studies, we explained that pathogenic and non-pathogenic microorganisms might have multiple roles in initiation, exacerbation, and development of Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD). In various studies, the relationship between infections caused by viruses, such as Epstein-Barr Virus (EBV), Rotavirus, Hepatitis C (HCV), Hepatitis B virus (HBV), Cytomegalovirus (CMV), and Influenza virus, and parasites including Giardia spp. and Toxoplasma gondii with CD has been raised. However, increasing evidence proposes that some of these microorganisms, especially helminths, can also have protective and even therapeutic roles in the CD process. Therefore, in order to determine the role of microorganisms in the process of this disease, we attempted to summarize the evidence suggesting the role of viral and parasitic agents in pathogenesis of CD.

scholarly journals The role of prophylactic antibiotics in hepatitis B virus-related acute-on-chronic liver failure patients at risk of bacterial infection: a retrospective study

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiao-Qin Liu ◽  
Xue-Yun Zhang ◽  
Yue Ying ◽  
Jian-Ming Zheng ◽  
Jian Sun ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Course ◽  
Prophylactic Antibiotics ◽  
Third Generation ◽  
Chronic Liver Failure ◽  
Free Survival ◽  
B Virus ◽  
Third Generation Cephalosporins

Abstract Background Acute-on-chronic liver failure (ACLF) is characterized by an excessive systemic inflammatory response and organ failure and has high mortality. Bacterial infections (BIs) worsen the clinical course of ACLF and carry a poor prognosis in ACLF patients. The efficacy of third-generation cephalosporins has been challenged in recent years. The aim of this study was to characterize the difference between ACLF patients with and without BIs and to provide a reference for medical intervention. Methods A total of 140 patients with hepatitis B virus-related ACLF (HBV-ACLF) hospitalized at the Department of Infectious Diseases, Huashan Hospital, Fudan University (Shanghai, China) between May 2013 and January 2020 were enrolled. Mann-Whitney U test was used to compare the baseline characteristics of HBV-ACLF patients with and without BIs. Univariate and multivariate analyses were performed to find predictors of BIs. The characteristics of BIs and the role of prophylactic antibiotics were profiled. Results A total of 97 episodes of BIs occurred in patients during the course of HBV-ACLF. Patients with and without BIs differed in clinical characteristics. The incidence of BIs showed a positive correlation with the ACLF grade (P = 0.003) and the clinical course (P = 0.003). The 90-day transplant-free survival of patients with BIs was lower than those without BIs (P < 0.0001). Patients administered prophylactic antibiotics showed a lower incidence of BIs and had a higher transplant-free survival probability than those who did not (P = 0.046). No statistical differences in antibiotic efficacy between third-generation and other antibiotics were observed (P = 0.108). Conclusions BIs affected the clinical course and prognosis of patients with HBV-ACLF. Prophylactic antibiotics were of potential clinical importance in the prevention of BIs and improving the clinical course and prognosis in HBV-ACLF patients. Third-generation cephalosporins were qualified for use in antibiotic prophylaxis.

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