scholarly journals DETERMINATION OF PRO12ALA POLYMORPHISM OF PPAR-γ2 GENE AS PREDICTOR OF EFFICACY OF PYOGLITAZONE ANTI-INFLAMMATORY THERAPY OF BRONCHIAL ASTHMA IN COMBINATION WITH CORONARY HEART DISEASE

2018 ◽  
Vol 99 (1) ◽  
pp. 65-70
Author(s):  
O.V. Byelan ◽  
O.A. Shlykova ◽  
Т.V. Mamontova ◽  
I.P. Kaidashev
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bronchial Asthma ◽  
Pro12ala Polymorphism ◽  
Anti Inflammatory ◽  
Γ2 Gene

scholarly journals GASTROESOPHAGEAL REFLUX DISEASE AND BRONCHIAL ASTHMA: MECHANISMS OF COMORBID FORMATION AND COURSE.

2020 ◽  
Vol 2 ◽  
pp. 3-7
Author(s):  
Aleksey Oparin ◽  
Givi Akhvlediani ◽  
Anatoliy Oparin ◽  
Sergei Pavlov
Keyword(s):  
Bronchial Asthma ◽  
Interleukin 4 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Clear Correlation ◽  
The Third ◽  
Gender And Age ◽  
Galectin 3 ◽  
Degree Of Certainty ◽  
Anti Inflammatory

The aim of the study: To estimate the level of Galectin-3 with the parallel tracing of the content of pro- and anti-inflammatory cytokines Interleukin-6 (IL-6) and Interleukin-4 (IL-4) for patients with GERD and BA both in case of separate nosologies, and in case of their combined course during the period of exacerbation of the diseases. Methods. The study was conducted in three groups of patients, homogeneous by gender and age. The first group included 18 patients with GERD. The second group included 19 patients with intermittent or persistent-mild bronchial asthma. The third group included 22 patients suffering from GERD with concomitant BA intermittent or persistent-mild severity. Determination of the level of galectin-3 and interleukins (IL-4 and IL-6) in the blood serum was carried out by enzyme-linked immunosorbent assay. Results. Analyzing the results of the study, we found that the level of galectin - 3 was increased on average in both groups of patients with isolated GERD (and in patients with BA). In patients of the third group with comorbid pathology, the level of galectin-3 was statistically significantly higher than not only the norm, but also the average of patients with isolated BA and GERD. At the same time, we found the rise in the level of pro-inflammatory (IL-6) and anti-inflammatory (IL-4) cytokines. Moreover, in patients with GERD, the level of IL-6 was increased with a higher degree of reliability, and the level of IL-4 was increased with a lower degree of reliability. In patients with BA, on the contrary, the level of IL-4 was determined more often and higher, and the level of IL-6 was lower. Conclusions. Analyzing result of the study, a clear correlation and features of changes in the level of galectin-3, IL-4, IL-6 in patients with isolated GERD, BA, as well as with the comorbidity of these diseases, were revealed. In patients with BA, the level of galectin-3 increases with the same degree of certainty as in the group of patients with GERD. In the cytokine system, on the contrary, the level of anti-inflammatory (IL-4) cytokines increases with a greater degree of certainty than the level of pro-inflammatory (IL-6) cytokines. In patients with GERD with concomitant BA, the level of galectin-3 increases with a greater degree of certainty. It is observed also a higher rising of pro-inflammatory (IL-6) cytokines and a slightly pronounced increasing of the level of anti-inflammatory (IL-4) cytokines in comparison with the group of patients with isolated GERD.

COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease

2003 ◽  
Vol 12 (1) ◽  
pp. 12
Author(s):  
W.A. Ray ◽  
C.M. Stein ◽  
J.R. Daugherty ◽  
K. Hall ◽  
P.G. Arbogast ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory

On Sharp Boundary Problem in Rule Based Expert Systems in the Medical Domain

2010 ◽  
Vol 5 (3) ◽  
pp. 14-26
Author(s):  
Oladipupo O. Olufunke ◽  
Uwadia O. Charles ◽  
Ayo K. Charles
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Expert System ◽  
Boundary Problem ◽  
System Approach ◽  
Disease Risk ◽  
Fuzzy Expert System ◽  
Sharp Boundary ◽  
Rule Based

Recently, the application of the conventional rule based expert system for disease risk determination in medical domains has increased. However, a major limitation to the effectiveness of the rule based expert system approach is the sharp boundary problem that leads to underestimation or overestimation of boundary cases, which ultimately affects the accuracy of their recommendation. In this paper, an expert driven approach is used to investigate the viability of a fuzzy expert system in the determination of risk associated with coronary heart disease with regards to the sharp boundary problem in rule based expert system.

Concentrations of lipids, lipoprotein, and apolipoproteins in serum of Zimbabwean Africans.

1985 ◽  
Vol 31 (8) ◽  
pp. 1390-1392 ◽  
Author(s):  
Z A Gomo
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Reference Ranges ◽  
European Populations

Abstract The subjects in this study were volunteers from a Zimbabwean population: 794 men and 705 women, ages between 20 and 65 years. They were receiving no medication and had no disease that could influence lipid metabolism. For determination of high-density lipoprotein cholesterol and apolipoproteins, they were screened for the known risk factors for coronary heart disease, to exclude factors known to influence those analytes. The results showed a significant sex- and age-dependence. The means and ranges for cholesterol, apolipoprotein B, and triglycerides were lower than those found in European populations. The high-density lipoprotein cholesterol and apolipoprotein A concentrations, on the other hand, were higher than in the European populations. This study established the reference ranges of the analytes studied and suggests that the prevalence of coronary heart disease may be low in Zimbabwean Africans.

An Acridinium Ester for Determination of Serum Arylesterase Activity in Patients with Coronary Heart Disease

2013 ◽  
Vol 781-784 ◽  
pp. 812-817
Author(s):  
Yu Hua Gong ◽  
Xiao Jing Mu ◽  
Zhi Tao Chen ◽  
Zulipiyan Abulimite ◽  
Min Liu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Diseases ◽  
Negative Correlation ◽  
Phenyl Acetate ◽  
Serum Samples ◽  
Significant Difference ◽  
Acridinium Ester

Paraoxonase (PON) is a hydrolyase correlated with many chronic diseases. The use of 9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate ester (CPOCMA) as a substrate for determination of serum arylesterase PON activity had been reported. It is meaningful to compare this substrate with phenyl acetate further with serum samples of patients with coronary heart disease (CHD, n=104). Correlations of PON arylesterase activity with CHD and also with age were analyzed. There was no significant difference in serum arylesterase activity (based on the CPOCMA or the phenyl acetate) between of the CHD inpatients and controls at same age level (45-60 years old). Statistically negative correlation of serum PON CPOCMAase activity (p=0.020) but not the activity based on phenyl acetate (p>0.05) with age was observed. Based on the both substrates, significant decrease in PON activity was found in the old CHD inpatients (≥60 years old), compared with that in the young CHD inpatients (<60 years old), or with that in the young controls. The methods based on CPOCMA substrate and based on the phenyl acetate demonstrated consistent results in correlation with CHD, but different results in correlation of PON activity with age.

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