scholarly journals Development of a Systematic Review Protocol and a Scoping Review of Ultrasound-Induced Immune Effects in Peripheral Tumors

2021 ◽  
Author(s):  
Anne Rix ◽  
Renée Girbig ◽  
Céline Porte ◽  
Wiltrud Lederle ◽  
Cathalijn Leenaars ◽  
...  
Keyword(s):  
Systematic Review ◽  
Scoping Review ◽  
Meta Analysis ◽  
Research Question ◽  
Relevant Literature ◽  
Selection Strategy ◽  
Tumor Type ◽  
Systematic Review Protocol ◽  
Study Characteristics ◽  
Review Protocol

Abstract Purpose Publication numbers reporting that ultrasound can stimulate immune reactions in tumors steadily increase. However, the presented data are partially conflicting, and mechanisms are difficult to identify from single publications. These shortcomings can be addressed by a systematic review and meta-analysis of current literature. As a first step, we here present the methodology and protocol for a systematic review to answer the following research question: Does ultrasound alter the immune reaction of peripheral solid tumors in humans and animals compared to control conditions without ultrasound? Procedures We designed a protocol to perform a systematic review and meta-analysis. The suitability of the protocol to detect and sort relevant literature was tested using a subset of publications. We extracted study characteristics, ultrasound parameters, and study outcomes to pre-evaluate the differences between publications and present the data as a scoping review. Results From 6532 publications detected by our preliminary literature search, 320 were selected for testing our systematic review protocol. Of the latter, 15 publications were eligible for data extraction. There, we found large differences between study characteristics (e.g., tumor type, age) and ultrasound settings (e.g., wavelength 0.5–9.5 MHz, acoustic pressure 0.0001–15,000 W/cm2). Finally, study outcomes included reports on cells of the innate (e.g., dendritic cells, macrophages) and adaptive immune system (e.g., CD8-/CD4-positive T cells). Conclusion We designed a protocol to identify relevant literature and perform a systematic review and meta-analysis. The differences between extracted features between publications show the necessity for a comprehensive search and selection strategy in the systematic review to get a complete overview of the literature. Meta-analyses of the extracted outcomes can then enable evidence-based conclusions.

Effectiveness of Physiotherapy to Promote Motor Recovery in Individuals with Stroke: A Systematic Review Protocol

2022 ◽  
Author(s):  
Shehong Zhang ◽  
Hongyu Xie ◽  
Chuanjie Wang ◽  
Fengfeng Wu ◽  
Xin Wang
Keyword(s):  
Systematic Review ◽  
Motor Function ◽  
Systematic Reviews ◽  
Evaluation System ◽  
Meta Analysis ◽  
Primary Data ◽  
Cochrane Library ◽  
Systematic Review Protocol ◽  
Qualitative Synthesis ◽  
Review Protocol

Abstract Introduction: Motor function is essential in our daily lives, one of the most common impairments caused by stroke is loss of functional movement. Over 70% of stroke survivors have motor or other neurological functional disabilities. However, rehabilitation of motor function suffered from a stroke can be rather difficult due to the complexity of organs and systems related to motor function, as well as the neural system that supported motor function. In particularly, previous evidence for the effectiveness of physiotherapy, a commonly prescribed intervention method for people with stroke, that recover motor function in people following a stroke is varied and limited in the chronic rehabilitation phase and therefore has never been reviewed systematically. With the progress of study in neurology and the development of novel tools for rehabilitation, results from more and more clinical trials are now available, thus here justifying conducting a systematic review. Methods and analysis: This systematic review protocol is developed in accordance with the methodology recommended by the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols, as well as the Cochrane handbook for systematic reviews of interventions. Relevant studies will be identified by searching the databases. We will perform searches for relevant studies in databases, including PubMed, Embase, CINAHL, and Web of Science, Physiotherapy Evidence Database and Cochrane Library databases. The reference lists of included articles and reviews will be searched manually. The date range parameters used in searching all databases will be restricted between January 2001 and January 2021. Randomized controlled trials (RCTs) published will be included. The language used in the articles included was restricted to English. The GRADE (Grading of Recommendations, Assessment, Development and Evaluation system from the Cochrane Handbook for Systematic Reviews of Interventions) approach will be used to systematically appraise the quality of methodology. We will assess the risk of bias of the RCTs included using the Cochrane Collaboration’s tool and provide a qualitative synthesis. After that, we will consider conducting a meta-analysis if the final data across outcomes shows sufficient homogeneity. Ethics and dissemination: No ethical approval is needed as the proposed study does not involve the collection of primary data, and the results of this review will be disseminated via peer-reviewed publications and conference presentations. Trial registration number: CRD42021267069.

scholarly journals Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e026612 ◽  
Author(s):  
Humphrey Mulenga ◽  
Erick Wekesa Bunyasi ◽  
Stanley Kimbung Mbandi ◽  
Simon C Mendelsohn ◽  
Benjamin Kagina ◽  
...  
Keyword(s):  
Systematic Review ◽  
Messenger Rna ◽  
Literature Search ◽  
Meta Analysis ◽  
Systematic Review Protocol ◽  
Cross Sectional ◽  
Review Protocol ◽  
Randomised Controlled ◽  
Host Blood ◽  
True False

IntroductionOne-quarter of the global population, including the majority of adults in tuberculosis (TB) endemic countries, are estimated to beMycobacterium tuberculosis(MTB) infected. An estimated 10 million new TB cases occurred in 2017. One of the biggest challenges confronting TB control is the lack of accurate diagnosis and prediction of prevalent and incident TB disease, respectively. Several host blood transcriptomic messenger RNA (mRNA) signatures that reflect the host immune response following infection with MTB and progression to TB disease in different study populations have recently been published, but these TB biomarkers have not been systematically described. We will conduct a systematic review of the performance of host blood transcriptional signatures for TB diagnosis and prediction of progression to TB disease.Methods and analysisThis systematic review will involve conducting a comprehensive literature search of cohort, case–control, cross-sectional and randomised-controlled studies of the performance of host blood transcriptomic signatures for TB diagnosis and prediction of progression to TB disease. We will search Medline via PubMed, Scopus, Web of Science and EBSCO libraries, complemented by a search of bibliographies of selected articles for other relevant articles. The literature search will be restricted to studies published in English from 2005 to 2018 and conducted in HIV-uninfected adults and adolescents (≥12 years old). Forest plots and a narrative synthesis of the findings will be provided. The primary outcomes will be sensitivity, specificity, as well as true/false positives and true/false negatives. Heterogeneity resulting from differences in the design, composition and structure of individual signatures will preclude meta-analysis and pooling of results.Ethics and disseminationEthics approval is not required for this systematic review protocol. The results of this review will be disseminated through a peer-reviewed journal as well as conference presentations.PROSPERO registration numberCRD42017073817.

scholarly journals Association between bipolar spectrum disorder and bone health: a meta-analysis and systematic review protocol

BMJ Open ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. e013981 ◽  
Author(s):  
Vinoomika Chandrasekaran ◽  
Sharon L Brennan-Olsen ◽  
Amanda L Stuart ◽  
Julie A Pasco ◽  
Michael Berk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Health ◽  
Meta Analysis ◽  
Spectrum Disorder ◽  
Bipolar Spectrum ◽  
Systematic Review Protocol ◽  
Bipolar Spectrum Disorder ◽  
Review Protocol

scholarly journals An assessment of the extent to which the contents of PROSPERO records meet the systematic review protocol reporting items in PRISMA-P

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 773
Author(s):  
Alison Booth ◽  
Alex S. Mitchell ◽  
Andrew Mott ◽  
Sophie James ◽  
Sarah Cockayne ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
A Priori ◽  
Health Interventions ◽  
Systematic Review Protocol ◽  
Eligibility Criteria ◽  
Single Entry ◽  
Review Protocol ◽  
The Mean ◽  
Source Of Information

Background: PROSPERO is an international prospective register for systematic review protocols. Many of the registrations are the only available source of information about planned methods. This study investigated the extent to which records in PROSPERO contained the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Methods: A random sample of 439 single entry PROSPERO records of reviews of health interventions registered in 2018 was identified. Using a piloted list of 19 PRISMA-P items, divided into 63 elements, two researchers independently assessed the registration records. Where the information was present or not applicable to the review, a score of 1 was assigned. Overall scores were calculated and comparisons made by stage of review at registration, whether or not a meta-analysis was planned and whether or not funding/sponsorship was reported. Results: Some key methodological details, such as eligibility criteria, were relatively frequently reported, but much of the information recommended in PRISMA-P was not stated in PROSPERO registrations. Considering the 19 items, the mean score was 4.8 (SD 1.8; median 4; range 2-11) and across all the assessed records only 25% (2081/8227) of the items were scored as reported. Considering the 63 elements, the mean score was 33.4 (SD 5.8; median 33; range 18-47) and overall, 53% (14,469/27,279) of the elements were assessed as reported. Reporting was more frequent for items required in PROSPERO than optional items. The planned comparisons showed no meaningful differences between groups. Conclusions: PROSPERO provides reviewers with the opportunity to be transparent in their planned methods and demonstrate efforts to reduce bias. However, where the PROSPERO record is the only available source of a priori reporting, there is a significant shortfall in the items reported, compared to those recommended. This presents challenges in interpretation for those wishing to assess the validity of the final review.

scholarly journals Effectiveness of Auricular Acupuncture in Treating Depressive Disorders: a Systematic Review Protocol

2021 ◽  
Author(s):  
Karla Natally Santos ◽  
Mayk Rodolfo de Jesus Santana ◽  
Giselle de Carvalho Brito ◽  
Luciana Pereira Lobato
Keyword(s):  
Systematic Review ◽  
Depressive Disorder ◽  
Systematic Reviews ◽  
Depressive Disorders ◽  
Functional Disability ◽  
Meta Analysis ◽  
Auricular Acupuncture ◽  
World Population ◽  
Systematic Review Protocol ◽  
Review Protocol

Abstract Background: Depression is a chronic condition of high prevalence in the world population and associated with functional disability and compromises the physical health of affected individuals. According to Traditional Chinese Medicine (TCM), depression is associated with disability, there is not enough energy for positive feelings or associated with stagnation, when there is energy, but the flow of energy and emotions is blocked. Deficiency is also associated with excess in manic depression or irregularity in depression associated with anxiety. Auricular acupuncture, also known as auriculotherapy, it is part of a set of techniques based on TCM. For this, the auricular pavilion is related to 12 meridians, stimulating points in the ear and restoring the balance between blood and Qi (energy or vital force).Methods: This is a systematic review protocol for clinical trials prepared in accordance with the guidelines of the protocol Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA-P). Studies in which participants have any depressive disorder, diagnosed through standardized criteria such as the Diagnostic and Statistical Manual of Mental Disorders (DSM), the International Classification of Diseases (ICD) and other diagnostic criteria used internationally will be included. There will be no restrictions on age, gender, ethnicity, education or economic status. Studies will be accepted that have as experimental intervention any type of auricular acupuncture (using needles, seeds, magnetic stones, lasers, ultrasound, bleeding or electrical treatment). The control interventions that will be considered for the studies will be conventional medical treatment for each depressive disorder, no treatment, placebo and other active therapies. Discussion: Auricular acupuncture can be a potential alternative complementary treatment, it is low cost and has minimal side effects presented until now. With this review we hope to complete gaps in the knowledge of auricular acupuncture, promoting an updated and comprehensive synthesis of research on this topic. Record of systematic review: In accordance with the guidelines, our systematic review protocol was registered with the International Prospective Registry of systematic reviews (PROSPERO) on 10/27/2020 (registration number CRD42020211302).

scholarly journals Smoking cessation programmes for women living in disadvantaged communities, “We Can Quit 2”: A systematic review protocol

2019 ◽  
Vol 2 ◽  
pp. 10
Author(s):  
Emma Burke ◽  
Fiona Dobbie ◽  
Nadine Dougall ◽  
Mary Adebolu Oluwaseun ◽  
David Mockler ◽  
...  
Keyword(s):  
Systematic Review ◽  
Smoking Cessation ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Future Research ◽  
Successful Implementation ◽  
Systematic Review Protocol ◽  
Socially Disadvantaged ◽  
Review Protocol

Tobacco use is the leading cause of preventable death in Ireland with almost 6,000 smokers dying each year from smoking-related diseases. Amongst younger Irish women, smoking rates are considerably higher in those from socially disadvantaged areas compared to women from affluent areas. Women from poorer areas also experience higher rates of lung cancer. To our knowledge, there are no peer reviewed published systematic reviews on the effectiveness of interventions tailored to reduce smoking rates in women from disadvantaged areas. This systematic review protocol will aim to examine the effectiveness of such interventions and to describe trial processes such as recruitment, follow-up and dropout prevention strategies, as well as barriers and enablers of successful implementation.    A systematic review will be conducted of peer-reviewed randomised controlled trials and associated process evaluations of smoking cessation interventions designed for women living in socially disadvantaged areas. If the search returns, less than five studies are review criteria will expand to include quasi-experimental studies. A number of databases of scholarly literature will be searched from inception using a detailed search strategy. Two independent reviewers will screen titles, abstracts and full-text articles to identify relevant studies using a pre-defined checklist based on PICOS. In the case of disagreement, a third reviewer will be consulted. The quality of included studies will be assessed using the ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) criteria. Quantitative data will be extracted and, if comparable, will be assessed using meta-analysis. A narrative meta-synthesis of qualitative data will be conducted.   This review aims to synthesise information from relevant studies on smoking cessation interventions tailored for women from socially disadvantaged areas. The evidence obtained from studies and presented in this review will help guide future research in this area. Registration: This review will be registered with International Prospective Register of Systematic Reviews (PROSPERO).

scholarly journals Self-mutilation and suicide in the military: a systematic review protocol

2020 ◽  
Vol 4 (1) ◽  
pp. 137-144
Author(s):  
Marcelo Montebello Ribeiro ◽  
M. M. Fernandes ◽  
T. F. B. X. Trajano ◽  
E. A. M. M. Costa
Keyword(s):  
Systematic Review ◽  
Suicide Attempts ◽  
Meta Analysis ◽  
Cochrane Collaboration ◽  
Relevant Information ◽  
Systematic Review Protocol ◽  
Self Mutilation ◽  
Study Selection ◽  
Review Protocol ◽  
The Military

As one of the three leading causes of death in people between the ages of 15 and 44 years old, suicide is, according to data from WHO, responsible annually for a million deaths. These numbers do not include suicide attempts, that are usually 10 to 20 times more frequent than suicide itself. This systematic review proposes to gather relevant information on the topic of self-harm and suicide in the Army, following the PRISMA-P statement for systematic review and meta-analysis protocols. This systematic review protocol was developed to present suitable guidelines for the development of research that can provide results to fulfil the sought objective. The search will cover the dates between 2014 and May 2019. Five databases will be accessed (SCOPUS, PubMed, Science Direct, EBSCOhost and Web of Science) with a total of six keyword combinations. The Cochrane Collaboration Tool will assess study selection and quality for determining the risk of bias.

scholarly journals Smoking cessation programmes for women living in disadvantaged communities, “We Can Quit 2”: A systematic review protocol

2019 ◽  
Vol 2 ◽  
pp. 10
Author(s):  
Emma Burke ◽  
Fiona Dobbie ◽  
Nadine Dougall ◽  
Mary Adebolu Oluwaseun ◽  
David Mockler ◽  
...  
Keyword(s):  
Systematic Review ◽  
Smoking Cessation ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Future Research ◽  
Successful Implementation ◽  
Systematic Review Protocol ◽  
Socially Disadvantaged ◽  
Review Protocol

Tobacco use is the leading cause of preventable death in Ireland with almost 6,000 smokers dying each year from smoking-related diseases. Amongst younger Irish women, smoking rates are considerably higher in those from socially disadvantaged areas compared to women from affluent areas. Women from poorer areas also experience higher rates of lung cancer. To our knowledge, there are no peer reviewed published systematic reviews on the effectiveness of interventions tailored to reduce smoking rates in women from disadvantaged areas. This systematic review protocol will aim to examine the effectiveness of such interventions and to describe trial processes such as recruitment, follow-up and dropout prevention strategies, as well as barriers and enablers of successful implementation.    A systematic review will be conducted of peer-reviewed randomised controlled trials and associated process evaluations of smoking cessation interventions designed for women living in socially disadvantaged areas. If the search returns, less than five studies are review criteria will expand to include quasi-experimental studies. A number of databases of scholarly literature will be searched from inception using a detailed search strategy. Two independent reviewers will screen titles, abstracts and full-text articles to identify relevant studies using a pre-defined checklist based on PICOS. In the case of disagreement, a third reviewer will be consulted. The quality of included studies will be assessed using the ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) criteria. Quantitative data will be extracted and, if comparable, will be assessed using meta-analysis. A narrative meta-synthesis of qualitative data will be conducted.   This review aims to synthesise information from relevant studies on smoking cessation interventions tailored for women from socially disadvantaged areas. The evidence obtained from studies and presented in this review will help guide future research in this area. Registration: This review will be registered with International Prospective Register of Systematic Reviews (PROSPERO).

scholarly journals Use of metabolomics for predicting spontaneous preterm birth in asymptomatic pregnant women: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e026033 ◽  
Author(s):  
Renato T Souza ◽  
Rafael Bessa Galvão ◽  
Debora Farias Batista Leite ◽  
Renato Passini Jr ◽  
Philip Baker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Preterm Birth ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Research Question ◽  
Case Control Studies ◽  
Spontaneous Preterm Birth ◽  
Ethical Approval ◽  
Registration Number ◽  
Review Protocol

IntroductionPreterm birth (PTB) is the leading cause of neonatal mortality and short- and long-term morbidity. The aetiology and pathophysiology of spontaneous PTB (sPTB) are still unclear, which makes the identification of reliable and accurate predictor markers more difficult, particularly for unscreened or asymptomatic women. Metabolomics biomarkers have been demonstrated to be potentially accurate biomarkers for many disorders with complex mechanisms such as PTB. Therefore, we aim to perform a systematic review of metabolomics markers associated with sPTB. Our research question is ‘What is the performance of metabolomics for predicting spontaneous preterm birth in asymptomatic pregnant women?’Methods and analysisWe will focus on studies assessing metabolomics techniques for predicting sPTB in asymptomatic pregnant women. We will conduct a comprehensive systematic review of the literature from the last 10 years. Only observational cohort and case-control studies will be included. Our search strategy will be carried out by two independent reviewers, who will scan title and abstract before carrying out a full review of the article. The scientific databases to be explored include PubMed, MedLine, ScieLo, EMBASE, LILACS, Web of Science, Scopus and others.Ethics and disseminationThis systematic review protocol does not require ethical approval. We intend to disseminate our findings in scientific peer-reviewed journal, the Preterm SAMBA study open access website, specialists’ conferences and to our funding agencies.PROSPERO registration numberCRD42018100172.

Sign in / Sign up

Export Citation Format

Share Document