A Modified Trier Social Stress Test to Investigate Social Anxiety using Videoconferencing Software: A Proof-of-Concept study
Social anxiety disorder (SAD) is one of the most common mental disorders and can be significantly disabling. New treatments are needed as the remission rate for SAD is the lowest of all the anxiety disorders. Experimental medicine models, in which features resembling a clinical disorder are experimentally induced, can be a cost-effective and timely approach to explore potential novel treatments for psychiatric disorders. One such model is the Trier Social Stress Test (TSST), which induces social-evaluative threat and subsequent stress responses in participants. However, following the emergence of SARS-CoV-2, there is a need to develop protocols that can be carried out remotely. We developed a novel modified TSST to investigate SAD that can be carried out entirely online (the Internet-based Trier Stress test for Social Anxiety Disorder; iTSSAD). Our protocol involves a naturalistic social interaction task to explore social anxiety symptoms. The observing panel was also artificial which allows the entire protocol to be carried out by a single investigator, reducing costs and improving internal reliability. The iTSSAD induced significant subjective anxiety and reduced positive affect (F’s > 4.41, p’s < 0.02). Further, social anxiety symptoms correlated with anxiety during the social interaction task (r = 0.65, p = 0.0032). This protocol needs further validation with physiological measures. The iTSSAD is a new tool for researchers to investigate mechanisms underlying social anxiety disorder.