scholarly journals Anti-diabetic effect of combined treatment with Aloe vera gel and Metformin on alloxan-induced diabetic rats

2018 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
F.O. Atanu ◽  
◽  
O.J. Avwioroko ◽  
S. Momoh ◽  
◽  
...  
Keyword(s):  
Combined Treatment ◽  
Aloe Vera ◽  
Diabetic Rats ◽  
Atherogenic Index ◽  
Control Group ◽  
Diabetic Patients ◽  
Aloe Vera Gel ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Aim: The present study investigated the effects of intensive glucose regulation with combined treatment of Aloe vera gel (a herbal agent) and Metformin in an alloxan-induced diabetic rat model. Methods: Forty rats were assigned to the following groups and treated for 21 days: Group 1 (normal untreated control), Group 2 (untreated diabetic rats, DR), Group 3 (DR + 300 mg/kg PE of Aloe vera ), Group 4 (DR + 2 mg/kg Metformin) and Group 5 (DR + 300 mg/kg PE of Aloe vera + 2 mg/kg Metformin). The effect of the treatments on fasting blood glucose (FBG) level, lipid profile, renal function, atherogenic index, pancreas and kidney histopathologies were assessed. Results: FBG level in Group 5 rats decreased by 28.4, 38.0 and 69.0% at Day 7, 14 and 21, respectively. Hyperlipidaemia, high atherogenic index, increased plasma creatinine and urea levels observed in the diabetic rats were ameliorated by the single and combined treatments with Aloe vera and Metformin. Reduced level of HDL-cholesterol in the untreated diabetic rats significantly improved by 160.0, 89.8 and 178.7% respectively in Group 3, 4 and 5 animals. The pancreas and kidney histopathologies indicated signs of recovery in Group 5 rats unlike those of Group 2 that had evidence of necrotic cells in both the acini and islet in pancreas and total glomeruli erosion in kidney. Conclusion: Aloe vera in combination with Metformin for treatment of diabetic patients could avert diabetes-associated dyslipidaemia, improve cellular integrity and increase, thereby preventing patients from risk of cardiovascular diseases and kidney failure.

scholarly journals The antimicrobial and wound healing effect of Aloe Vera in induced diabetic rats

2014 ◽  
Vol 13 (1) ◽  
pp. 7
Author(s):  
R. A.M. Jawad
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Skin Wound ◽  
Diabetic Rats ◽  
Wound Management ◽  
Control Group ◽  
Leaf Extracts ◽  
Fibroblast Migration ◽  
Aloe Vera Gel ◽  
Group 2

The study was conducted on sixteen streptozotocin induced diabetic rats to investigate whether the topical application of Aloe Vera gel and alcoholic Aloe Vera leaf extract could improve the wound healing in diabetic rats. The rats were weight, matched, and placed in to four groups 4 rats of each group. Full thickness circular skin wound (2cm in diameter) was experimentally created dorsal to the neck area of each rat. Animals in group (1) left without dressing as a control group. Animals in group (2 and 3) were treated topically with Aloe Vera gel (100%) and alcoholic Aloe Vera leaf extracts (100%) respectively, while the animals of group (4) were treated with povidone iodine (4%). Treated groups were dresses twice daily for 14 successive days. The treated wound in groups 2, and 3 were significantly healed faster in comparison to the wound of control group. The effect produced by the Aloe Vera with reference to the wound contraction, wound closure, decreased in surfaces area of wound, and tissue regeneration at the wound site. Histologically wounds treated with Aloe Vera show increase in macrophages, fibroblast migration, collagen regeneration and epithelialization compared with the control group. The wet, dry granulation tissue weight, and hydroxyproline content increased significantly when compared to control. Aloe Vera was seen exhibited antimicrobial activity against some pathogenic microorganism. In conclusion Aloe Vera have strong wound healing property and effective as topical preparation and formulated as fairly economical therapeutic agent for wound management.

scholarly journals Effectiveness of medical treatment in overcoming the ureteral double-J stent related symptoms

2012 ◽  
Vol 6 (6) ◽  
pp. 234 ◽  
Author(s):  
Ugur Kuyumcuoglu ◽  
Bilal Eryildirim ◽  
Murat Tuncer ◽  
Gokhan Faydaci ◽  
Fatih Tarhan ◽  
...  
Keyword(s):  
The Body ◽  
Control Group ◽  
Group 4 ◽  
Double J Stent ◽  
Urinary Tract Symptoms ◽  
Stone Treatment ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Background: We investigated whether the frequency of lower urinary tract symptoms (LUTS) increased in patients in whom double-J stents were applied. We also evaluated several medical therapy protocols to treat symptoms related with ureteral stents.Materials and Methods: A total of 108 patients, in whom unilateral double-j stent was applied during ureteral stone treatment, were included. Before the double-J stent was applied, all patients completed storage components of the “International Prostate Symptom Score” (IPSSs), quality of life components of the IPSS (IPSS-QOL) and “Overactive Bladder Questionnaire” (OABq) forms and scores were calculated. After the procedure, cases were randomized into 5 groups, an antiinflammatory was given to Group 1, spasmolytic to Group 2, anticholinergic to Group 3 and α-blocker to Group 4. No additional drug was given to Group 5 as this control group. During the fourth week of the procedure, IPSSs, IPSS-QOL and OABq forms were again completed and scores were compared with the previous ones.Results: When all the cases were evaluated, the IPSSs, IPSS-QOLand OABq scores of patients in whom the double-J stent was applied were statistically significantly higher the procedure. Compared to the control group, the cases where the double-J stent was applied showed a higher IPSSs, IPSS-QOL and OABq scores and none of the medical therapies could prevent this increase.Interpretation: The frequency of LUTS increased in cases where the ureteral stent was applied and discomfort continued as long as the stent stayed in the body.

scholarly journals Zingerone Ameliorates Hepatotoxicity

2020 ◽  
Vol 11 (1) ◽  
pp. 280-284 ◽  
Author(s):  
Julietpoornamathy J ◽  
Parameswari C.S.
Keyword(s):  
The Body ◽  
Control Group ◽  
Medical Sciences ◽  
Toxic Compounds ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Insight Into ◽  
Group 1

In medical sciences, toxicity is an area wherein extensive studies have been carried to improve the diseases as well as to prevent. So, there is a high requirement for novel and improved alternative therapeutic strategies to manage diseases. The liver is the largest gland in the body, which executes several important mechanisms; it stores minerals and vitamins and releases them in periods of need. The main aim of this study was to give a closer insight into potent non- toxic compounds that is capable of modifying the responses. Animals were divided into five equal groups viz control (Group 1), administered with food and water ad libitum, (Group 2) administered with olive oil, (Group 3) administered with zingerone, (Group 4) administered with concanavalin A, (Group 5) administered with cyclosporine A followed by zingerone. Our results revealed significant changes in liver marker enzymes and liver histology of zingerone treated rats when compared to control rats.  A corollary, zingerone has no toxic effect on hepatocytes and was found to be safe at a dose of 10mg/kg b wt and also ameliorates hepatotoxicity.

scholarly journals Anti-Inflammatory and Antioxidative Potential of Aloe vera on the Cartap and Malathion Mediated Toxicity in Wistar Rats

2020 ◽  
Vol 17 (14) ◽  
pp. 5177 ◽  
Author(s):  
Vivek Kumar Gupta ◽  
Abhishek Kumar ◽  
Maria de Lourdes Pereira ◽  
Nikhat Jamal Siddiqi ◽  
Bechan Sharma
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Biological Effects ◽  
Aloe Vera ◽  
Control Group ◽  
Alternative Agent ◽  
Group 5 ◽  
Pre Treatment ◽  
Group 2 ◽  
Histopathological Results

Aloe vera has been the most useful medicinal herb in the world since ancient times due to its vast biological effects. The presence of high content of bioactive compounds make Aloe vera a promising complementary and alternative agent in disease prevention. The effectiveness of A. vera-based medicines against pesticide toxicity has never been evaluated. It was therefore envisaged to develop an A. vera-based strategy to protect the non-target animals from adverse effects of the pesticides. This article illustrates the ameliorating effect of aqueous extract (AE) of A. vera leaves against the cartap and malathion toxicity. To evaluate the protective impact of A. vera against cartap (Ctp), malathion (Mtn) and a mixture of both pesticides, the animals were divided in eight groups, each containing six rats: Group 1- C (control), Group 2- AE + C, Group 3- Ctp, Group 4- Mtn, Group 5- Ctp + Mtn, Group 6- AE + Ctp, Group 7- AE + Mtn, Group 8- AE + Ctp + Mtn. Wistar rats exposed to Ctp, Mtn and Ctp + Mtn, displayed significant change in body weight. It was observed that the WBC level increased significantly in Mtn and Ctp + Mtn challenged groups. The contents of TNF-α and IL-6 in serum increased expressively in the Ctp, Mtn and Ctp + Mtn challenged groups. Rats treated with Ctp, Mtn and Ctp + Mtn displayed significant alterations in the levels of antioxidative indices (MDA, GSH, GST, GPx, SOD and CAT). Significant alterations were recorded in the activities of AST, ALT, ACP and ALP in Ctp, Mtn and Ctp + Mtn challenged groups. The histopathological results of liver supported the biochemical data. The pre-treatment of rats with the aqueous extract of A. vera leaves significantly protected them from the toxicity of pesticides. These results suggested that A. vera extract may be used as a promising natural agent for the management of pesticide induced toxicity.

scholarly journals FE-SEM Evaluation of Dental Specimens Prepared by Different Methods forIn VitroContamination

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Vitor Cesar Nakamura ◽  
Simony Hidee Hamoy Kataoka ◽  
Giulio Gavini ◽  
Patrícia Helena Ferrari ◽  
Silvana Cai
Keyword(s):  
Control Group ◽  
Buffer Solution ◽  
Morphological Alterations ◽  
Ultrasonic Bath ◽  
Group 4 ◽  
Cement Removal ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Objective. To evaluate through FE-SEM the cleanliness and dentinal alterations promoted by different methods of dental sample preparation.Methods. Twenty-five human single-rooted teeth were used. The teeth were cleaned and autoclaved in wet medium and randomly divided into 5 groups (), according to the preparation methods employed—control group: no solutions applied; group 1: cement removal and irrigation with 5.25% % EDTA for 4 minutes each; group 2: 17%  % NaOCl (4 minutes ultrasonic bath); group 3: cement removal and 17%     buffer solution + distilled water (10 minutes ultrasonic); group 4: 17%   NaOCl (3 minutes ultrasonic bath). Specimens were analyzed by field emission scanning electron microscope (FE-SEM), at 1500x magnification. Data were submitted to qualitative analysis according to a scoring system and submitted to Kruskal-Wallis test.Results. In ascending order, as to bind parameters, (i) cleanliness: control, group 2, group 3, group 5, and group 4, (ii) dentinal alterations: group 1, group 5, group 2, group 3, and group 4.Conclusion. The proposed protocol was suitable for subsequent microbiological contamination, because it showed less dentinal morphological alterations with increased removal of organic waste.

scholarly journals The Evaluation of Various Restoration Techniques on Internal Adaptation of Composites in Class V Cavities

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
D. Dionysopoulos ◽  
C. Papadopoulos ◽  
E. Koliniotou-Koumpia
Keyword(s):  
Room Temperature ◽  
Control Group ◽  
Class V ◽  
Group 4 ◽  
Restoration Techniques ◽  
Group 3 ◽  
Internal Adaptation ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Aim.The aim of this study was to evaluate the effect of different restoration techniques on the formation of internal microgaps between materials and dentin in class V restorations.Materials and Methods.Twenty-five extracted human premolars were prepared with standardized class V cavity outlines (3 mm × 2 mm × 2 mm). The cavities were randomly divided into 5 groups of 10 cavities each and restored according to manufacturer’s instructions: Group 1: preheating (55°C) conventional composite (Filtek Z250), Group 2: flowable composite (Filtek Flow), Group 3: Filtek Flow + Filtek Z250 light-cured separately, Group 4: Filtek Flow + Filtek Z250 light-cured simultaneously, and Group 5 (control): Filtek Z250 at room temperature (23°C). The specimens were then thermocycled and cross-sectioned through the center of the restoration. Subsequently, impressions were taken, and epoxy resin replicas were made. The internal adaptation of the materials to the axial wall was analyzed under SEM.Results.The preheated Filtek Z250 (Group 1) showed better internal adaptation than the room temperature groups(P<0.05). The combination of Filtek Flow with Filtek Z250 which was light-cured separately (Group 3) exhibited better internal adaptation than control group(P<0.05).Conclusion.Different restoration techniques exhibit different behavior regarding internal adaptation to dentin after photopolymerization.

scholarly journals Treatment of ovarian cysts in sows – a field trial

2008 ◽  
Vol 52 (No. 9) ◽  
pp. 413-418 ◽  
Author(s):  
S. Cech ◽  
R. Dolezel
Keyword(s):  
The Other ◽  
Ovarian Cysts ◽  
Control Group ◽  
Initial Examination ◽  
Interval Group ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Different procedures of treatment of large follicular ovarian cysts in 177 sows using GnRH, hCG and PGF2α are evaluated in this study. Ovarian cysts were diagnosed by transcutaneous ultrasonography, which was a part of routine pregnancy diagnosis. No treatment was performed in the control group (Group 1, <i>n</i> = 29); the method of treatment used in the other groups immediately after the diagnosis was intramuscular administration of lecirelin in doses 50 µg (Group 2, <i>n</i> = 28), 100 µg (Group 3, <i>n</i> = 27) and 200 µg divided into 2 equal doses administered at a 12-hour interval (Group 4, <i>n<i> = 25) and of hCG in doses 1 500 IU (Group 5, <i>n</i> = 23), 3 000 IU (Group 6, <i>n</i> = 21), and 250 µg of cloprostenol (Group 7, <i>n</i> = 24). Insemination rate (IR), conception rate (CR) in inseminated sows, pregnancy rate (PR = recovery rate), treatment-insemination interval (TII) and treatment-pregnancy interval (TPI) within 42 days after the initial examination were evaluated. In addition PR in groups of sows divided according to parity (1–3, 4–6 and ≥ 7) were also evaluated. IR and PR were higher in Group 4 (84.0% and 44.0%) and lower in Group 1 (17.2% and 6.9%) in comparison with the other groups (<i>P</i> < 0.001 and <i>P</i> < 0.05). CR, TII and TPI did not differ between the experimental groups. PR were similar in sows with different parity. The study proved a positive response in sows with large follicular ovarian cysts to the treatment consisting of 2 administrations of 100 µg GnRH at a 12-hour interval.

scholarly journals Effects of a probiotic in combination with prebiotics on intestinal lactobacilli and coliforms and activities of bacterial enzymes in 1,2-dimethylhydrazine exposed rats

2011 ◽  
Vol 56 (No. 3) ◽  
pp. 99-106 ◽  
Author(s):  
L. Strojný ◽  
A. Bo ◽  
E. Hijová ◽  
A. Chmelárová ◽  
G. Mojžišová ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Control Group ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Beta Glucosidase ◽  
Alpha Glucosidase ◽  
Beta Galactosidase ◽  
Group 1

Effects of the probiotic (PRO) Lactobacillus plantarum and of the combination of PRO and the prebiotic (PRE) inulin enriched with oligofructose (2%), and PRO with Lini oleum virginale (O) on counts of lactobacilli and coliforms and enzymatic activities in faeces of rats were studied. The rats (n = 60) were divided into 5 groups of 12 subjects. The animals were fed on a high fat diet (10%) for 8 weeks of experiment. Colon cancer was induced by the application of 1,2-dimethylhydrazine (DMH) twice a week in a dose of 20 mg/kg s.c. in groups G2-G5. The rats in group 1 (control 1) received a diet without any supplements. The rats in group 2 (control 2) received 1,2 DMH without any supplements. The rats in group 3 received PRO, group 4 PRO and PRE, and group 5 received PRO and O. A significant decrease (P &lt; 0.05) of coliforms was found out after the application of PRO, PRO-O, and PRO-PRE in comparison with control group G2. Significantly higher (P &lt; 0.05) counts of lactobacilli were determined after the application of PRO-O and PRO-PRE. Significantly lower (P &lt; 0.001) activities of &beta;-galactosidase, &beta;-glucuronidase and &alpha;-glucosidase were observed in PRO, PRO-PRE and PRO-O, while in the case of the enzyme &beta;-glucosidase the activity was lower only after the addition of PRO-O. The protective effect of lactobacilli was observed in the order PRO-O, PRO-PRE, and PRO. It was shown that combinations of PRO-O and PRO-PRE had a synergistic effect which was higher than the effect of administering only PRO.

scholarly journals Clinical and Microbiological Outcomes of Topical Aloe Vera Gel vs. Photochemotherapy as an Adjunct to Non-surgical Periodontal Treatment in Periodontitis

2020 ◽  
Vol 07 (03) ◽  
pp. e100-e105
Author(s):  
Mohamed Farouk Elsadek ◽  
Badreldin Mohamed Ahmed ◽  
Rayan M. Eskandrani ◽  
Tasneem Sobhy Fahmy
Keyword(s):  
Photodynamic Therapy ◽  
Aloe Vera ◽  
Antimicrobial Photodynamic Therapy ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Aloe Vera Gel ◽  
Group 3 ◽  
Group 2 ◽  
Attachment Level ◽  
Group 1

AbstractThe present clinical trial aimed to assess the effectiveness of antimicrobial photodynamic therapy versus Aloe vera gel as an adjunct to scaling and root planing on periodontal and microbial outcomes in patients with periodontitis. Eligible patients undergoing nonsurgical periodontal treatment were divided into 3 groups: group 1: antimicrobial photodynamic therapy; group 2: Aloe vera gel application; and group 3: scaling and root planing only. Clinical periodontal variables included the assessment of plaque scores, bleeding on probing, probing depth, and clinical attachment level gain. Plaque samples were collected to estimate microbial counts of Tannerella forsythia (T. forsythia) and Porphyromonas gingivalis (P. gingivalis). All measurements were recorded at baseline, 3 mo, and 6 mo. Statistical analysis of the given data was performed using the chi-squared test and ANOVA for clinical periodontal and microbiological data. Eighty-seven patients completed the trial. Bleeding on probing showed a significant reduction in group 2 compared with the other groups (p < 0.001). Group 1 showed a statistically significant reduction in probing depth and gain in clinical attachment level when compared to group 2 and group 3 (p < 0.05). Group 1 showed a statistically significant reduction in the counts of T. forsythia and P. gingivalis over a period of 3 mo (p < 0.05). The reduction was seen for T. forsythia only following 6 mo (p < 0.05). Group 2 showed a significant reduction for only T. forsythia at 3 mo (p < 0.05). Both antimicrobial photodynamic therapy and Aloe vera gel helped in reducing periodontal inflammation. Aloe vera gel showed additional benefit in reducing bleeding scores, while antimicrobial photodynamic therapy showed additional enhanced activity against periodontal pathogens and periodontal attachment level gain.

scholarly journals Ruellia tuberosa L. Extract Improves Histopathology and Lowers Malondialdehyde Levels and TNF Alpha Expression in the Kidney of Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Anna Roosdiana ◽  
Fajar Shodiq Permata ◽  
Riera Indah Fitriani ◽  
Khairul Umam ◽  
Anna Safitri
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Diabetic Rats ◽  
Tnf Alpha ◽  
Root Extracts ◽  
Male Wistar Rats ◽  
Streptozotocin Induced Diabetes ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Ruellia tuberosa L. is a therapeutic plant that is generally consumed in Indonesian traditional medicine to prevent or cure various illnesses, i.e., diabetes. The current study was conducted to investigate the effects of hydroethanolic root extracts of Ruellia tuberosa L. on the kidney of streptozotocin-induced diabetic Wistar rats. In this study, male Wistar rats were divided into 5 groups: healthy rats (group 1), diabetic rats (group 2), and treated rats which received extract at dosages of 250 (group 3), 375 (group 4), and 500 (group 5) mg/kg body weight for 21 days. Diabetes mellitus was experimentally induced by the administration of five doses of streptozotocin 20 mg/kg body weight within five consecutive days. Significant increases in the value of TNF alpha expression and malondialdehyde (MDA) levels were observed in streptozotocin-induced diabetes rats. Furthermore, severe histological alterations of kidney tissues occurred in the diabetic rats group. After treatment was applied, the value of TNF alpha expression and MDA levels on the kidney decreased considerably p < 0.05 in groups 3, 4, and 5. The optimum dosage was obtained at a dose of 250 mg/kg body weight (group 3), which had 42.24% and 52.70% decrease in TNF alpha expression and MDA levels, respectively. The histopathological profiles of the kidney also showed significant improvements in treated groups. The most prominent recoveries were also shown in group 3. The treatments induced repairment in the glomerular and renal tubular damages in the kidney tissues. To conclude, these results emphasize potentially health valuable properties of hydroethanolic root extracts of R. tuberosa L. in rats with streptozotocin-induced diabetes.

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