ABO blood groups as determinants to patient outcomes in SARS-CoV-2

Background: Blood group antigens are present on the red blood cell surface. O, A, and B are the major blood groups. A, B, AB, and A1 are the antigens. An ample amount of research supports the close association of blood groups with diseases. A new school of thought and finding seems to be indicating that certain blood groups are more susceptible to the COVID-19 infection in comparison to others. Current evidence suggests that SARS-CoV-2 positive cases are more prevalent in individuals with blood group A as compared to those with blood group O. This finding, however, was only relevant for the Rh (+ve) positive blood types. Genetic association reveals that the ABO blood group locus and a chromosome 3 gene cluster are associated with severe acute respiratory syndrome in coronavirus (SARS-CoV-2) respiratory failure patents. This was found in an Italian- Spanish genome-wide association analysis. Various associations between the patients' blood groups when comparing the data with that of physiologically healthy individuals from the same geographical region helped to get a clear comparative picture. Associations that were cross-replicating in nature were determined at chromosome 3p21.31 and chromosome 9q34. The association at chromosome 9q34 was identified at the ABO blood group locus. The difference in the susceptibility could be correlated to the circulating anti‐A antibodies, which inhibit or interfere with the virus-cell adhesion process. Conclusion: It is evident that the research conducted to date is supportive and does suggest that humans of the Blood group O are less likely to be infected in the COVID-19 pandemic as when compared to other blood groups. The SARS-CoV-2 situation is evolving rapidly, discoveries and anomalies are being reported daily. Therefore, it is advised that more definitive and consolidatory research is to be conducted to further elucidate the underlying mechanism of action for the protection in blood group O.

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Distribution and Association of ABO and Rh Blood Group Antigens with BMI Among Nepalese and Indian Students Studied in a Medical College of Nepal

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v17i3.24448 ◽

2021 ◽

Vol 17 (3) ◽

pp. 265-278

Author(s):

Kalipada Kar ◽

Sujata Kar

Keyword(s):

Body Mass Index ◽

Medical Students ◽

Blood Group ◽

Body Mass ◽

Blood Groups ◽

Blood Group Antigens ◽

Medical College ◽

Indian Origin ◽

Overweight Group ◽

The Difference

Introduction: Blood group antigens and body mass index of human are gaining importance for many diseases. Some attempts were reported to find any relationship between BMI and Blood groups with some contradictions. The possible association between BMI and blood groups of Nepalese and Indian medical students is yet to be established. Methods: Blood groups, ABO and Rh systems and body mass index (BMI) of participants, medical students of Nepalese and Indian origin were determined and analyzed statistically. Results: The distribution frequencies of 10.56%, 17.08%, 3.06%, and 20.28% females and 9.03%, 16.39%, 3.61% and 20.0% males of both the countries were present in A, B, AB and O blood groups, respectively. Rh-negative participants were predominantly present in O blood group. The observed frequencies of participants with different BMI group were distributed as 56.11%, 24.72%, 10.69% and 8.47% in Normal, Overweight, Underweight and Obese groups, respectively. Underweight participants were prevalent in O group and in females. The difference between the distribution of Nepalese females and males with Normal BMI was found significant in A and O. A distribution pattern of B>O>A>AB was observed for Overweight group. The occurrence of Obese is few folds higher among Indian participants than Nepalese and prevalent in males. Obese participants were found more associated with B and O blood group. Conclusions: Participants with A were more prevalent among Nepalese in respect to Indian. Rh-negative participants were distributed as 1.67% and 5.0% in Nepalese and Indians, respectively and predominantly present in O (4.44%) and are more prevalent in Indian males. In Normal BMI Nepalese were significantly more as compared to Indians. In the Underweight group females were significantly more prevalent as compared to males and found maximally associated with O blood group and most of them are Nepalese. In Overweight group males were more than females. Participants with obesity were mostly present in B and O blood group and most of them are Indian.

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Association of ABO blood groups with SARS-COV-2 infection

10.21203/rs.3.rs-37570/v1 ◽

2020 ◽

Cited By ~ 1

Author(s):

Juan Zhou ◽

Yingzheng Tan ◽

Llingli Hu ◽

Dan Li ◽

Xiaojin He ◽

...

Keyword(s):

Infectious Diseases ◽

Electronic Medical Records ◽

Blood Group ◽

Medical Records ◽

Demographic Data ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group Antigens ◽

Abo Blood Groups ◽

Asymptomatic Carriers

Abstract In view of the influence of ABO blood group antigens on infectious diseases, we explore the effect of ABO blood types on SARS-COV-2 infection. In this report, demographic data of 80 COVID-19 patients and 26 SARS-COV-2 asymptomatic carriers were collected based on electronic medical records. The results indicated that the distribution of ABO blood group in the confirmed patients was significantly different from asymptomatic carriers; importantly, antigen A carrier have significantly higher risk of developing into severe or critically cases than other types. These data present further evidence for the association of the blood groups to susceptibility to SARS-COV-2 infection.

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ABO, Rhesus blood groups and transfusion-transmitted infections among blood donors in Gabon

Sudan Journal of Medical Sciences ◽

10.18502/sjms.v13i1.1685 ◽

2018 ◽

Vol 13 (1) ◽

pp. 12 ◽

Cited By ~ 1

Author(s):

Christ-Dominique Ngassaki-Yoka ◽

Jophrette Mireille Ntsame Ndong ◽

Cyrille Bisseye

Keyword(s):

Blood Group ◽

Blood Donor ◽

Representative Sample ◽

Blood Donors ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group Antigens ◽

Abo Blood Groups ◽

Donor Population ◽

Monospecific Antisera

Background: Few studies focused on the study of blood groups in Gabon. This study aimed to determine the phenotypic frequency of ABO and Rhesus antigens in blood donors of Libreville and to assess the association between ABO blood groups and transfusion-transmitted infections.Materials and Methods: The study of ABO and Rhesus blood groups concerned 4,744 blood donors. ABO and Rhesus phenotyping were obtained using monoclonal monospecific antisera: anti-A, anti-B, anti-AB, anti-D, anti-E, anti-C, anti-c, and anti-e with an automate (QWALYS® 3, DIAGAST, France) or a card gel (ID Card, BIO-RAD) according to manufacturer’s instructions.Results: The phenotypic frequency of blood group antigens A, B, AB and O were respectively 21.0%; 17.6%; 2.6% and 58.9%. Those of rhesus antigens D, d, C, c, E and e were 97.7%; 2.3%; 15.9%; 99.9%; 17.6%; 99.3%, respectively. The prevalence of ABO and Rh antigens in Gabonese donors reported here are significantly different from those of neighboring countries. No association was found between the prevalence of HIV, HCV and syphilis and ABO blood groups. Instead, HBV seroprevalence was twice as high among non-O blood groups donors compared with blood group O donors [OR = 2 (CI 1.26 to 3.2), p = 0.003].Conclusions: This study provides new data on phenotypic frequency of ABO and Rh blood groups in a representative sample of the Gabonese blood donor population. It suggests a significant association between ABO blood group and HBV infection.

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ABO blood group and skin cancers

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-211290 ◽

2021 ◽

pp. 1-13

Author(s):

Khaldun Jacoub ◽

Zaynab Al-Eisawi

Keyword(s):

Blood Group ◽

Blood Groups ◽

Blood Type ◽

Cell Maturation ◽

Abo Blood Group ◽

Blood Group Antigens ◽

Skin Cancers ◽

Human Disorders ◽

And Control

Beside the role of ABO group in immunohaematology, there is accumulating evidence that the ABO blood group also plays a key role in various human disorders. The interest in blood groups and their association with disease stems from the awareness that blood group antigens are incredibly important components in the process of cell maturation and control. Studies have indicated a link between cancer and the ABO blood group. The appearance or disappearance of blood type antigens is now considered a hallmark of malignancy in many common cancers. Several tumour markers are in fact known blood group antigens. The aim of this review is to describe the history and possible functions of the ABO group and then summarize the association between blood groups and skin cancers.

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HUMAN ABO BLOOD GROUP ANTIGENS ON SPERMATOZOA FROM SECRETORS AND NON-SECRETORS

Reproduction ◽

10.1530/jrf.0.0090267 ◽

1965 ◽

Vol 9 (2) ◽

pp. 267-268 ◽

Cited By ~ 27

Author(s):

B. BOETTCHER

Keyword(s):

Blood Group ◽

Abo Blood Group ◽

Blood Group Antigens

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Correlation of ABO Blood Groups and Rh Factor with The Severity of Generalized Chronic Periodontitis: Across Sectional Study in Riyadh, Saudi Arabia

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.044 ◽

2019 ◽

Vol 7 (4) ◽

pp. 617-622 ◽

Cited By ~ 2

Author(s):

Diana Mostafa ◽

Essam I. Elkhatat ◽

Pradeep Koppolu ◽

Muna Mahgoub ◽

Esam Dhaifullah ◽

...

Keyword(s):

Saudi Arabia ◽

Blood Group ◽

Chronic Periodontitis ◽

Periodontal Diseases ◽

Blood Groups ◽

Blood Group Antigens ◽

Abo Blood Groups ◽

Sectional Study ◽

Cross Sectional ◽

Group I

BACKGROUND: The development of periodontal diseases depends on the presence of causative microorganisms, host immunity and risk factors. Although variability present among the types of periodontal diseases, all are represented to a shared interaction between host and bacteria. ABO blood groups are the most investigated erythrocyte antigen system. However, limited investigations have been conducted to explore the alliance between ABO blood groups and periodontal diseases. AIM: Our purpose was to explore any possible association between the severity of chronic periodontitis with ABO blood groups and Rh factor. METHODS: A cross-sectional study was carried out on 205 patients out of 1126 generalised chronic periodontitis patients (GCP) who were referred to Al-Farabi Colleges, Riyadh, Saudi Arabia. They were categorized into; group I (mild), group II (moderate) and group III (sever). RESULTS: The patients with blood group O were at a greater risk to develop GCP irrespective of its severity, followed by those with blood group A, B, and AB. The dispensation of the Rh factor in all groups exhibited a significantly greater distribution of Rh positive. CONCLUSION: Genetic factors such as ABO blood group antigens may act as a risk influencer that affects the progression and severity of the chronic periodontitis.

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Assessing ABO/Rh Blood Group Frequency and Association with Asymptomatic Malaria among Blood Donors Attending Arba Minch Blood Bank, South Ethiopia

Malaria Research and Treatment ◽

10.1155/2016/8043768 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Getaneh Alemu ◽

Mohammedaman Mama

Keyword(s):

Blood Group ◽

Malaria Infection ◽

Blood Donors ◽

Blood Groups ◽

High Rate ◽

Abo Blood Group ◽

Asymptomatic Malaria ◽

Abo Blood Groups ◽

Group Frequency ◽

Rh Blood Group

Background. Determination of the various ABO/Rh blood group distributions and their association with malaria infection has paramount importance in the context of transfusion medicine and malaria control. Methods. Facility based cross-sectional study was conducted from February to June, 2015, to assess ABO/Rh blood groups distribution and their association with asymptomatic malaria. A structured questionnaire was used to collect data. Blood grouping was done using monoclonal antibodies. Thin and thick blood films were examined for Plasmodium parasites. Data were analyzed using SPSS version 20.0. Results. A total of 416 blood donors participated with median age of 22±0.29 (median ± standard error of the mean). Distribution of ABO phenotypes, in decreasing order, was O (175, 42.1%), A (136, 32.7%), B (87, 20.9%), and AB (18, 4.3%). Most of them were Rh+ (386, 92.8%). The overall malaria prevalence was 4.1% (17/416). ABO blood group is significantly associated with malaria infection (P=0.022). High rate of parasitemia was seen in blood group O donors (6.899, P=0.003) compared to those with other ABO blood groups. Conclusion. Blood groups O and AB phenotypes are the most and the least ABO blood groups, respectively. There is significant association between ABO blood group and asymptomatic malaria parasitemia.

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