scholarly journals A Clinico-histopathological Correlation of Elective Abdominal Hysterectomy in University Hospital

2018 ◽  
Vol 1 (2) ◽  
pp. 18-22
Author(s):  
Sarada Duwal Shrestha ◽  
R. Shrestha ◽  
R. Pradhan
Keyword(s):  
Ovarian Tumor ◽  
Preoperative Diagnosis ◽  
Clinical Symptoms ◽  
Abdominal Hysterectomy ◽  
Atypical Hyperplasia ◽  
University Hospital ◽  
Histopathological Diagnosis ◽  
Histopathological Correlation ◽  
Fibroid Polyp ◽  
Chronic Cervicitis

Introduction: The objective of this study was to correlate preoperative indications of abdominal hysterectomy with histopathological findings. Methods: This cross-sectional study was conducted in Patan Hospital from April 2016 to March 2018 in all the patients who underwent elective abdominal hysterectomy. Demographic characteristics, clinical symptoms, preoperative diagnosis and final histopathological diagnosis were studied. Preoperative indications were correlated with histopathological diagnosis. Results: A total of 203 elective abdominal hysterectomies were performed. Menorrhagia was the leading symptom found in 67 (33.00%) patients followed by pain abdomen in 62 (30.54%) patients. Leiomyoma was the most common preoperative diagnosis seen in 105 (51.72%) patients followed by ovarian tumor in 34 (16.75%) patients. The most common histopathological diagnosis was leiomyoma observed in 87 (42.86%) patients followed by ovarian tumor in 35 (17.24%) patients. Clinical and histopathological correlation was 100% in cases of ovarian tumor, complex endometrial atypical hyperplasia, pelvic inflammatory disease (PID), fibroid polyp and chronic cervicitis. Only 40% of preoperatively diagnosed postmenopausal bleeding cases were correlated histopathologically while the rest were missed preoperatively which included endometrial polyp (40%) and adult granulosa cell tumor (20%). Conclusions: Leiomyoma was the most common preoperative and histopathological diagnosis. Clinical and histopathological correlation was 100% in cases of ovarian tumor, complex endometrial atypical hyperplasia, PID, fibroid polyp and chronic cervicitis.

Clinical to Histopathological Correlation of the Diagnosis of Dementia

1991 ◽  
Vol 3 (S1) ◽  
pp. 69-74 ◽  
Author(s):  
I. Alafuzoff ◽  
A.-L. Rönnberg ◽  
S. Asikainen-Gustafsson
Keyword(s):  
Clinical Diagnosis ◽  
Clinical Investigation ◽  
Clinical Signs ◽  
University Hospital ◽  
Vascular Lesions ◽  
Cortical Atrophy ◽  
Histopathological Diagnosis ◽  
Exact Nature ◽  
Histopathological Correlation ◽  
Diagnostic Decision

Between January 1988 and December 1989, 1,600 autopsies were performed at Huddinge University Hospital, representing approximately 40% of the 4,000 deceased patients. In 40% (647) of the autopsy cases, patients showed clinical signs of CNS dysfunction.Of these cases, 58% (380) were subject to neuropathological evaluation, including both macro- and microscopic examination. Only macroscopic examination by general pathologists was performed on the remaining cases. Clinical signs of dementia were seen in 10% (169 cases) of the autopsied patients. Neuropathological evaluations were performed on 70% (118) of these patients. Of these, 60% (70) showed degenerative changes and 36% (43) vascular alterations. Macroscopic examinations alone were performed in 30% of the cases. Of these, signs of severe cortical atrophy were seen in 21%, vascular lesions in 12%, and no macroscopic changes in 67%. The completeness of clinical and postmortem examinations of the 169 demented patients was variable. Approximately 40% of the patients lacked any diagnostic decision. In approximately 50% of the cases with diagnostic decision, the clinical diagnosis correlated with the histopathological diagnosis. This low correlation between the clinical diagnosis and the exact nature of the disease was primarily based on the variable completeness of the clinical examinations. In order to improve this situation, it is important to perform both a complete clinical investigation and a neuropathological verification of the nature of the disease.

scholarly journals How does Histopathology Correlate with Clinical and Operative Findings in Abdominal Hysterectomy?

1970 ◽  
Vol 6 (2) ◽  
pp. 17-20 ◽  
Author(s):  
R Khan ◽  
H Sultana
Keyword(s):  
Clinical Presentation ◽  
Abdominal Hysterectomy ◽  
Uterine Bleeding ◽  
Histopathological Diagnosis ◽  
Dysfunctional Uterine Bleeding ◽  
Histopathological Findings ◽  
Benign Ovarian Tumours ◽  
Ovarian Tumours ◽  
Operative Findings ◽  
Chronic Cervicitis

Many a times the clinical and per operative diagnosis does not correlate with histopathological diagnosis. Aim of this study was to compare the clinical, peroperative and histopathological findings of different cases of fibroid uterus, dysfunctional uterine bleeding and chronic cervicitis which needed abdominal hysterectomy. In this prospective study 100 cases of abdominal hysterectomy were done over a period of two years. Among them 38% cases were of leiomyoma uterus and 20%, 18%, 12%, 7% and 5% were of dysfunctional uterine bleeding, chronic cervicitis, pelvic inflammatory disease, benign ovarian tumours and endometriosis (external and adenomyosis) respectively. Cases studied on the basis of history, clinical examination and per operative findings. Specimens were sent for histopathology and reports were analyzed. It was thus co-related with the clinical presentation and per operative findings. Among 100 cases, 38 cases were of myoma diagnosed clinically but histopathological findings of 8 patients were different (adenomyosis in 6 cases and normal finding in 2 cases). Among 20 cases of clinically diagnosed dysfunctional uterine bleeding, 6 cases were found to have myoma and adenomyosis on histopathological examination.Key words: Histopathology findings; hysterectomy; diagnosis DOI: 10.3329/jafmc.v6i2.7268JAFMC Bangladesh. Vol 6, No 2 (December) 2010 pp.17-20

F.N.A.C. AS DIAGNOSTIC TOOL OF PAROTID TUMORS AND ASSOCIATED PITFALLS IN CORRELATION WITH HISTOPATHOLOGY

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Bhawana Pant ◽  
Sanjay Gaur ◽  
Prabhat Pant
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Clinical Information ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Cytological Diagnosis ◽  
Tertiary Referral Centre ◽  
Clear Cut ◽  
Parotid Tumors

F.NA.C has been used for ages as a safe and economical tool for fast preoperative diagnosis of parotid tumors. It has certain pitfall which sometimes leads to misdiagnosis and consequently it may have affect on treatment of the tumors. Keeping in view of the diverse classification of parotid tumors’ information from cytology should be combined with radiology as well as clinical diagnosis. Aim: To discuss some cases where there was discrepancy between cytological diagnosis and histopathological result and also suggest measures to improve the efficacy of F.N.A.C. Material and methods: The study includes 50 cases of parotid tumours who presented to the  department of ENT at Government medical college Haldwani which is a tertiary referral centre during 2009 to 2016. Only adult patients were included and inflammatory swelling were excluded from the study. All patients evaluated  Contrast enhanced computerized tomography(CECT) and  Magnetic resonance imaging (MRI) followed by Fine needle aspiration cytology .Preoperative diagnosis was made upon the findings of the above investigations and different types of  parotid surgeries  were done. . Final diagnosis was made on  histopathological  examination. Result :The most common tumour  came out to be pleomorphic adenoma (23 cases-46%) followed by mucoepidermoid carcinoma(12cases-24%). In ten  cases there was no clear cut  association between cytological diagnosis and final histopathological diagnosis. Conclusion: FNAC is highly sensitive and specific technique for diagnosis of many salivary gland swellings. FNAC can be used preoperatively to avoid unnecessary surgery and biopsy. Details of clinical information and radiologic features may help the pathologist to arrive at the appropriate diagnosis and reduce false interpretation. Pitfalls may also occur with improper technique of FNAC which can be overcome by proper caution.

CLINICAL SYMPTOMS, ULTRASOUND AND HISTOPATHOLOGY OF TUMORLIKE LESIONS OF THE BLADDER.

2017 ◽  
pp. 41-46
Author(s):  
Van Mao Nguyen ◽  
Thi Bich Chi Nguyen
Keyword(s):  
Bladder Cancer ◽  
Bladder Tumor ◽  
Clinical Symptoms ◽  
Bladder Wall ◽  
Lower Abdominal Pain ◽  
University Hospital ◽  
Wall Thickening ◽  
Health Examination ◽  
Ultrasound Images ◽  
Key Words Bladder Cancer

Background: Bladder cancer is one of the most frequent type of urinary cancer which has been ever increasing. For the better treatment, the early discovery and definite diagnosis of this disease played an important role. Objective: To describe some clinical symptoms and ultrasound features of tumorlike lesions of the bladder. To diagnose and classify the histopathology of tumorlike lesions of the bladder. Materials, method: cross - sectional study on 64 cases in Hue University Hospital and Hue central hospital from April, 2016 to February, 2017. Results: Hematuria was the most common reason that patients went to hospital (79.7%). Lower abdominal pain and irritation during urination accounting for 9.4% and 6.2% respectively. Only 3 patients with bladder cancer were accidentally discovered through periodic health examination (4.7%). The characteristics of hematuria in bladder tumor was flesh red urine (62.5%) and total hematuria (60.7%). With ultrasonography, the results of 64 patients were divided in 3 groups as follow: bladder tumor, which was the highest rate 87.5%, bladder polyp was 3.1% and focal bladder wall thickening was 9.4%. Of which, the vast majority of these ultrasound images was tumor - like lesions protruding in the lumen of the bladder (75%), the rest was wall thickening lesions (25%). Tumors were different in size, the biggest tumor was 7cm in diameter and the smallest was 0.6cm. Those with the diameter 3cm or bigger accounting for 42.2%, the smaller was 57.8%. Most cases have only one lesion (62.5%) and at lateral wall (46.6%). Histopathologically, cancer was 59/64 case (92.2%): urothelial carcinoma was 98.3 %, squamous cell carcinomawas 1.7% and 5 cases (7.8%) were benign. Most cancerous cases were poorly differentiated, grade II (50.9%) and grade III (32.2%). The stage T1NxMx was 20.3% and worse than T2MxNx was 79.7%. Conclusion: hematuria was the most popular symptom, suggesting bladder cancer. Clinical diagnosing bladder cancer was not high sensitive (61.01%). Ultrasound could detect bladder tumor with high sensitive (89.8%). These patients also needed histopathology classification to diagnose and finally choose the best method for the appropriate treatment. Key words: bladder cancer, histopathology, ultrasound, uroepithelial carcinoma, hematuria

scholarly journals Correlation of FNAC and histopathology in diagnosis of salivary gland lesions

2014 ◽  
Vol 4 (8) ◽  
pp. 654-657 ◽  
Author(s):  
S Koirala ◽  
G Sayami ◽  
AD Pant
Keyword(s):  
Salivary Gland ◽  
Preoperative Diagnosis ◽  
Needle Aspiration ◽  
University Teaching ◽  
Malignant Neoplasms ◽  
Histopathological Diagnosis ◽  
Institute Of Medicine ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity ◽  
Diagnostic Pitfalls

Background: Value of fine needle aspiration cytology in preoperative diagnosis of salivary gland lumps has been established in various studies. This study aims to calculate sensitivity, specificity accuracy of FNAC, correlate FNAC findings with histopathology and find out reasons for common diagnostic pitfalls in FNAC.Materials and methods: This study was performed in 67 patients that presented with salivary gland lumps at Department of pathology, Tribhuvan University Teaching Hospital, Institute of medicine, Kathmandu, Nepal from January 2009 to June 2010. FNAC was performed and was correlated with histopathological diagnosis to judge the sensitivity, specificity and accuracy of FNAC.Results: Out of 36 cases there was cyto-histological correlation in 28 cases. Pleomorphic adenoma was the most frequent lesion in this study. Parotid gland was the most common site affected by salivary gland lesions. The sensitivity, specificity and accuracy for non-neoplastic lesions was 100%, 89.28%, 91.67%, for benign neoplasms was 100%, 86.95%, 91.67% and for malignant neoplasms was 57.14%, 100%, 83.33% respectively.Conclusion: FNAC is a useful tool in preoperative diagnosis of salivary gland lesions and can be crucial for the management of the patient. Aspiration and reporting of salivary gland lesions demands a competent pathologist who considers all the possible diagnostic pitfalls in mind.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11593 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 654-657

scholarly journals Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jinyao Ni ◽  
Junwu Zhang ◽  
Yanxia Chen ◽  
Weizhong Wang ◽  
Jinlin Liu
Keyword(s):  
Information System ◽  
Lichen Planus ◽  
Hospital Information System ◽  
Clinical Characteristics ◽  
Opportunistic Infections ◽  
Clinical Symptoms ◽  
University Hospital ◽  
Ivig Treatment ◽  
Good’S Syndrome ◽  
Laboratory Results

Abstract Background Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed. Methods We used the hospital information system to retrospectively screen thymoma and hypogammaglobulinemia patients at the First Affiliated Hospital of Wenzhou Medical University from Apr 2012 to Apr 2020. The clinical, laboratory, treatment, and outcome data for these patients were collected and analyzed. Results Among the 181 screened thymoma patients, 5 thymoma patients with hypogammaglobulinemia were identified; 3 patients had confirmed diagnoses of GS, and the other 2 did not have a diagnosis of GS recorded in the hospital information system. A retrospective review of the clinical characteristics, laboratory results, and follow-up data for these 2 undiagnosed patients confirmed the diagnosis of GS. All 5 GS patients presented with pneumonia, 2 patients presented with recurrent skin abscesses, 2 patients presented with recurrent cough and expectoration, 1 patient presented with recurrent oral lichen planus and diarrhea, and 1 patient presented with tuberculosis and granulomatous epididymitis. In the years after the diagnosis of hypogammaglobulinemia with mild symptoms, all 5 patients had received irregular intravenous immunoglobulin (IVIG) treatment. As the course of the disease progressed, the clinical symptoms of all patients worsened, but the symptoms were partly resolved with IVIG in these patients. However, 4 patients died due to comorbidities. Conclusion GS should be investigated as a possible diagnosis in thymoma patients who present with hypogammaglobulinemia, especially those with recurrent opportunistic infections, recurrent skin abscesses, chronic diarrhea, or recurrent lichen planus.

Rate of Prophylaxis Oophorectomy and Associated Factors at the Time of Hysterectomy in Premenopausal Women with Benign Diseases

2021 ◽  
Vol 104 (5) ◽  
pp. 709-714
Keyword(s):  
Associated Factors ◽  
Premenopausal Women ◽  
Abdominal Hysterectomy ◽  
University Hospital ◽  
Benign Diseases ◽  
Prophylactic Oophorectomy ◽  
Gynecologic Oncologist ◽  
Menstrual History ◽  
History Of ◽  
Operative Notes

Objective: To determine the rate of oophorectomy and associated factors at the time of hysterectomy in premenopausal women with benign diseases. Materials and Methods: The medical records of the premenopausal women that underwent hysterectomy with or without oophorectomy due to benign gynecologic conditions between January 1, 2012 and December 31, 2017 at Khon Kaen University Hospital (Thailand) were retrospectively reviewed. The data collected included age, BMI, parity, indication for surgery, family history of carcinoma, route of hysterectomy, procedure, specialization of the surgeon, operative notes, and histopathological reports of the ovaries. Results: Six hundred thirty-eight subjects underwent hysterectomy due to benign gynecologic conditions. Bilateral salpingo-oophorectomy (BSO) was performed in 57.37% (366) of the cases. In 81.97% (300) of these cases, either one or both patient’s ovaries were grossly normal. The rate of prophylactic oophorectomy among all cases was 47.02% (300 in 638). The strongest associated factor with BSO was age (odds ratio 8.421, 95% CI 5.488 to 12.921). Other associated factors were irregular menstrual history, the surgeon being a gynecologic oncologist, and abdominal hysterectomy. No cases of ovarian cancer were found. Conclusion: Nearly half of premenopausal women that underwent hysterectomy due to benign conditions underwent prophylactic oophorectomy. Associated factors were age, irregular menstruation, the surgeon being a gynecologic oncologist, and abdominal hysterectomy. Keywords: Hysterectomy, Premenopausal women, Prophylactic oophorectomy

scholarly journals Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Valéria C. Sandrim ◽  
Mayara Caldeira-Dias ◽  
Heloisa Bettiol ◽  
Marco Antonio Barbieri ◽  
Viviane Cunha Cardoso ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Heme Oxygenase ◽  
Clinical Symptoms ◽  
Severe Preeclampsia ◽  
Urine Samples ◽  
University Hospital ◽  
Enzyme Linked Immunosorbent Assay ◽  
Heme Oxygenase 1 ◽  
Study Cohort ◽  
Potential Biomarker

Preeclampsia is the major cause of maternal and fetal deaths worldwide. Circulating biomarker concentrations to predict preeclampsia must be determined. Therefore, the objective was to evaluate heme oxygenase-1 (HO-1) concentration in both plasma and urine samples from pregnant women before the development of preeclampsia and to identify a potential biomarker for preeclampsia development. We performed a case-control study nested in a prospective study cohort at University Hospital of the Ribeirao Preto Medical School, University of São Paulo (HCFMRP-USP), Ribeirao Preto, Brazil. Of 1400 pregnant women evaluated at 20–25 weeks of gestation, 460 delivered in hospitals outside our institution. Of 940 pregnant women who completed the protocol, 30 developed preeclampsia (cases, 14 cases of severe preeclampsia and 16 cases of mild preeclampsia). Healthy pregnant women (controls, n=90) were randomly selected from the remaining 910 participants. HO-1 concentration was evaluated in plasma/urine samples by using a commercial enzyme-linked immunosorbent assay kit. We found similar HO-1 levels in the plasma and urine for case and control groups. In the subgrouped preeclampsia, lower plasma HO-1 levels were found in mild compared with severe preeclampsia. We conclude that plasma HO-1 levels were not altered at 20–25 weeks of gestation before the manifestation of preeclampsia symptoms. Pregnant women who subsequently develop severe preeclampsia show higher expression of HO-1. This may be indicative of important underlying pathophysiologic mechanisms that differentiate between mild and severe preeclampsia and may possibly be related to a higher prooxidative status even before the development of clinical symptoms.

scholarly journals A rare case of adult Ileo-ileal intussusception due to inflammatory fibroid polyp

2017 ◽  
Vol 4 (2) ◽  
pp. 813
Author(s):  
Nitin Kalaskar ◽  
Sharad M. Tanga ◽  
Ravindra B. Dhaded ◽  
Puneeth Thalasta
Keyword(s):  
Small Bowel ◽  
Rare Case ◽  
Clinical Symptoms ◽  
Inflammatory Fibroid Polyp ◽  
Clinical Challenge ◽  
Neoplastic Condition ◽  
Fibroid Polyp ◽  
Inflammatory Fibroid Polyps

Inflammatory fibroid polyps are uncommon; moreover, that polyp causing secondary intussusception in an adult are still rarer. Here, we report a case of inflammatory fibroid polyp of the small bowel that presented as just vague pain in the abdomen in a 48-year-old woman. Even though investigations reported Ileo-ileal intussusception caused by a polyp, the patient did not have clinical symptoms that could be correlated. The rareness of the disease made it a clinical challenge to subject the patient to laparotomy. The rareness of non-neoplastic condition being the cause for adult ileo-ileal intussusception and the clinical challenge associated with it makes it a case worth reporting.

scholarly journals A Rare Case of Bilateral Malignant Brenner Tumors of the Ovaries Associated with Peritoneal Effusion

2020 ◽  
Author(s):  
Jianing Tong ◽  
Jianmin Niu ◽  
Qiaoyun Li ◽  
Li Hu ◽  
Hui Zhang
Keyword(s):  
Preoperative Diagnosis ◽  
Vaginal Bleeding ◽  
Rare Case ◽  
Clinical Symptoms ◽  
Ovarian Tumors ◽  
Case Presentation ◽  
Brenner Tumor ◽  
Peritoneal Effusion ◽  
Brenner Tumors ◽  
The Masses

Abstract Background: Malignant ovarian Brenner tumors are extremely rare worldwide, accounting for only 1% of malignant ovarian tumors. Their clinical symptoms and pathology are complex and erratic, and the images are mostly non-specific. This poses difficulties in preoperative diagnosis and distinguishing them from other cystic solid ovarian tumors. Here this study has reported on a case of bilateral malignant ovarian Brenner tumor with peritoneal effusion. Case presentation: A 54-year-old woman presented with intermittent vaginal bleeding for more than two months and abdominal pain for one month. Two hard mass of five centimeters with poor movement could be touched at each side of the ovarian areas. The CT findings indicated the presence of two large cystic and solid masses in both adnexal regions. The operation had watched the size of the masses in the bilateral ovarian was both 6cmx6cmx5cm and their surface ulceration showed rotten fleshy tissue. After the operation, combined with morphological and immunohistochemical features, the ovarian specimens were consistent with bilateral ovarian malignant Brenner tumors.Conclusions: Although the incidence of bilateral malignant OBT is extremely low and this disease is extremely rare clinically, the gynecologists should be more informed of its diagnosis and treatment.

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