scholarly journals Histopathological changes in gallbladder mucosa associated with cholelithiasis

1970 ◽  
Vol 2 (3) ◽  
pp. 224-225 ◽  
Author(s):  
R Baidya ◽  
B Sigdel ◽  
NL Baidya
Keyword(s):  
Retrospective Study ◽  
Intestinal Metaplasia ◽  
Gastrointestinal Disorder ◽  
Gallstone Formation ◽  
Epithelial Hyperplasia ◽  
Pathological Changes ◽  
Histopathological Changes ◽  
Gallbladder Epithelium ◽  
Gallbladder Mucosa ◽  
Gross Examination

Background: Gallstone is a very common gastrointestinal disorder. It is known to produce histopathological changes in the gallbladder. It is also one of the predisposing factors for the development of cancer of gallbladder. Materials and Methods: This was a retrospective study carried out in the Department of Histopathology, B and B Hospital during a period of 1 year from April 2010 to May 2011. The study included 396 cases of cholecystectomy specimens. Results: On gross examination, outer gallbladder surface was congested in 116 patients (28%), wall thickness was increased in 181 (45.7%) and mucosal abnormalities were present in 126 (31.6%) patients. At microscopy, epithelial hyperplasia was observed in 183 (46.2%), intestinal metaplasia in 112 (28.2%), dysplasia in 5 (1.3%) and cholesterolosis in 56 (14%) patients. Conclusion: The pathological changes of the gallbladder epithelium may play an important role in the process of gallstone formation. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6027 JPN 2012; 2(3): 224-225

Enhanced fluid transport across gallbladder mucosa in experimental cholelithiasis.

1978 ◽  
Vol 234 (6) ◽  
pp. E575
Author(s):  
S P Lee
Keyword(s):  
Cell Proliferation ◽  
Guinea Pig ◽  
Fluid Transport ◽  
Stone Formation ◽  
Gallstone Formation ◽  
Gallbladder Epithelium ◽  
Histological Features ◽  
Gallbladder Mucosa ◽  
Fluid Transfer

Fluid transport of the gallbladder has been studied in two models of experimental cholelithiasis: dihydrocholesterol-induced gallstones in the rabbit and lincomycin-induced gallstones in the guinea pig. Using the noneverted explained gallbladder of the rabbit and the guinea pig, the transport of luminal to serosal fluid has been quantitated before, during, and after stone formation. The everted gallbladder preparation of the rabbit has also been used to measure fluid transport before and during gallstone formation. In both models, an increased fluid transport was observed in the phase of gallstone induction and a return to normal after stones were formed. This abnormality preceded the appearance of conventional histological features of cholecystitis. There was also a coincidental increase in glycoprotein production from and cell proliferation of the gallbladder epithelium. This enhancement of fluid transfer may play a contributing role in the genesis of gallstones.

Pretein kinase C isoforms α, βII and δ are expressed in gallbladder epithelium during gallstone formation

2001 ◽  
Vol 120 (5) ◽  
pp. A386-A386 ◽  
Author(s):  
S NARINS ◽  
E PARK ◽  
X SU ◽  
P SMITH ◽  
M ABEDIN
Keyword(s):  
Gallstone Formation ◽  
Gallbladder Epithelium ◽  
Kinase C

scholarly journals Histopathological changes in pigs infected with ileitis

2020 ◽  
Vol 10 (4) ◽  
pp. 72-77
Author(s):  
O.M. Yermolenko ◽  
O.Y. Ayshpur ◽  
I.Yu. Mushtuk
Keyword(s):  
Histological Examination ◽  
Severe Disease ◽  
Gastrointestinal Diseases ◽  
Pathological Changes ◽  
Histopathological Changes ◽  
Lawsonia Intracellularis ◽  
Early Diagnostics ◽  
Chronic Effect ◽  
Anatomical Changes ◽  
Proliferative Enteropathy

Nowadays, the ileitis (proliferative enteropathy of pigs) is one of the most common gastrointestinal diseases. The intracellular bacterium Lawsonia intracelluaris causes several forms of the disease. Histological examinations are the important stages in diagnosing and detecting profound pathological changes in sick pig organs, decreasing their productivity and causing the deaths. Swine proliferative enteropathy (SPE) has reported for the Ukraine since 2008. For SPE the early diagnostics with different test systems is relevant. We evaluated the sick, forcibly killed and dead piglets of different ages in Ukrainian pig farms during 2018-2019 in animal fattening groups. Materials were taken from piglets aged 120-150 days in farms where the ileitis was diagnosed. To assess the complex of pathological and anatomical changes detected during autopsies of piglets, V.P. Shishkov’s methods were used. Thus, we revealed a characteristic morphology of proliferative lesions. We believed that the histological examination can serve as an important diagnostic method and an alternative to direct isolation of Lawsonia intracellularis, which is very difficult to cultivate. We determined that the histopathological changes in pig organs indicated a chronic effect caused by animal pathogen. We revealed that Lawsonia intracellularis caused the profound pathological changes in pig digestive tracts, which affected the functioning of all organs and tissues of animals and lead to severe disease and possible animal death. We suggested that the histological examination is an important step in diagnosing and detecting profound pathological changes in the organs of sick pigs, which caused the decrease in their productivity and deaths.

A Retrospective Study of Histopathological Changes in Electrocution in Tertiary Hospital

2017 ◽  
Vol 10 (2) ◽  
pp. 78-82
Author(s):  
Radha R. Kabbur ◽  
◽  
Shivarurappa A. Siddalingappa ◽  
Sumana B.S. ◽  
◽  
...  
Keyword(s):  
Retrospective Study ◽  
Tertiary Hospital ◽  
Histopathological Changes

Histopathological changes of gallbladder mucosa in silent gallstone diseases

2016 ◽  
Vol 65 ◽  
pp. S60
Author(s):  
Pratima Baisakh ◽  
M. Baisakh ◽  
B. Mohanty ◽  
S. Panda ◽  
S. Das ◽  
...  
Keyword(s):  
Histopathological Changes ◽  
Gallbladder Mucosa

Relevance of Otopathological Findings in the Treatment of Dizzy Patients

1984 ◽  
Vol 93 (4_suppl) ◽  
pp. 12-16 ◽  
Author(s):  
Pierre B. Montandon ◽  
Rudolf Häusler
Keyword(s):  
Retrospective Study ◽  
Endolymphatic Hydrops ◽  
Vestibular Neuritis ◽  
Common Symptom ◽  
Vestibular Disorders ◽  
Histopathological Changes ◽  
The Brain

Dizziness is a common symptom in disorders of the brain and the ear. In a retrospective study of 1,000 cases, dizziness is attributed to a peripheral disorder in 25%, to a CNS disorder in 46%, and to undetermined causes in 29% of the cases. Peripheral disorders can be defined in terms of histopathological changes; the most frequent is cupulolithiasis, followed by endolymphatic hydrops and vestibular neuritis. These vestibular disorders are reviewed and discussed in connection with accepted facts and current hypotheses.

scholarly journals Failure of Added Dietary Gluten to Induce Small Intestinal Histopathological Changes in Patients with Watery Diarrhea and Lymphocytic Colitis

1996 ◽  
Vol 10 (7) ◽  
pp. 436-439 ◽  
Author(s):  
Hugh James Freeman
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Microscopic Colitis ◽  
Lymphocytic Colitis ◽  
Watery Diarrhea ◽  
Pathological Changes ◽  
Histopathological Changes ◽  
Proximal Small Bowel ◽  
Colorectal Biopsies ◽  
Small Intestinal

Lymphocytic colitis is a form of microscopic colitis usually characterized by watery diarrhea and often associated with biopsy-defined celiac disease. Two patients with lymphocytic colitis and normal small intestinal biopsies who were administered 40 g of added dietary gluten for four consecutive weeks are presented. Small intestinal biopsies from multiple sites in the proximal small bowel were done after three and four weeks to determine whether pathological changes in latent celiac disease could be induced in these patients with a high gluten-containing diet. In addition, colorectal biopsies were done to determine whether the colitis was sensitive to oral gluten. No alterations in the small intestinal biopsies were detected in either patient and no changes occurred in colitis severity. Although microscopic forms of colitis have been linked to celiac disease, this study indicates that lymphocytic colitis is a heterogeneous clinicopathological disorder that, in some patients, is independent of any gluten-induced intestinal pathological changes.

Sodium transport in the diseased human gallbladder and the effects of indomethacin

1988 ◽  
Vol 75 (2) ◽  
pp. 147-149 ◽  
Author(s):  
M. R. Jacyna ◽  
P. E. Ross ◽  
D. Hopwood ◽  
I. A. D. Bouchier
Keyword(s):  
Sodium Transport ◽  
Sodium Ion ◽  
Slight Reduction ◽  
Gallbladder Epithelium ◽  
Principal Function ◽  
Na Transport ◽  
Flux Chamber ◽  
Human Gallbladder ◽  
Gallbladder Mucosa

1. Sodium ion (Na+) transport, a principal function of the gallbladder epithelium, was studied by measuring the flux of 22Na across isolated, inflamed human gallbladder mucosa maintained in a modified ‘Ussing’ flux chamber. Tissue was obtained from cholecystectomy specimens in symptomatic patients with cholelithiasis. 2. In 30 gallbladders studied, 57% had a net Na+ flux from mucosa to serosa (Na+ absorption), while 23% had a net Na+ flux from serosa to mucosa (Na+ secretion). The remaining 20% showed no overall net Na+ flux. 3. Indomethacin added to the serosal fluid reversed the direction of net Na+ flux in secreting gallbladders and caused an absorption of Na+. In Na+-absorbing gallbladders, indomethacin caused a slight reduction in Na+ absorption. No change in Na+ flux was induced in gallbladders with no initial net Na+ flux. 4. These results demonstrate that instead of absorbing Na+, some inflamed human gallbladders may secrete Na+. As this secretion can be reversed to the more usual absorption by indomethacin, it is likely that this secretion is mediated by prostaglandins.

Tu1725 Predilection Sites of Intestinal Metaplasia in the Stomach: a Retrospective Study Based on Endoscopic Results of 78,335 Cases

2015 ◽  
Vol 81 (5) ◽  
pp. AB573
Author(s):  
Xin-Yi Mao ◽  
Qing Liu ◽  
Hai-Han Zhang ◽  
Shun-Fu Xu ◽  
Jian-Xia Jiang
Keyword(s):  
Retrospective Study ◽  
Intestinal Metaplasia

scholarly journals INCIDENCE AND PATHOLOGICAL CHANGES IN FASCIOLIASIS (FASCIOLA GIGANTICA) OF DOMESTICATED DEER

2012 ◽  
Vol 3 (1) ◽  
pp. 67-70
Author(s):  
M Masuduzzaman ◽  
ML Raman ◽  
MA Hossain
Keyword(s):  
Bile Ducts ◽  
Fibrous Tissue ◽  
Fasciola Gigantica ◽  
Age Group ◽  
Post Mortem ◽  
Pathological Changes ◽  
Hepatic Bile ◽  
Faecal Examination ◽  
Tissue Proliferation ◽  
Gross Examination

An investigation was carried out on incidence and pathology of fascioliasis in deer of Chittagong Zoo and some houses of Chittagong city during the period from January 2001 to June 2004. A total of 57 domesticated deer of various types were examined to diagnose the fascioliasis in Chittagong zoo and some house deer of Chittagong city. By faecal examination out of 44 cases 34 (77.3%) were positive for fascioliasis, of which, 15 (34.1%) cases were recorded in Chittra deer, 12 (27.3%) in Maya deer, 05 (11.4%) in Shambar deer and 02 (4.5%) in Nathrini deer. In post mortem examination, fascioliasis found in 13 (100%) cases, of which, 08 (61.5%) from Chittra deer and 05 (38.5%) from Maya deer. The overall incidence of fascioliasis in deer was 82.5%. In relation to sex the fasciolasis was significantly (p < 0.05) higher in female (82.6%) than male (71.4%) deer. The incidence of fascioliasis in various types of deer in relation to age was significantly (p < 0.05) higher in age group of above 2 years old than in age group below 2 years old. The gross examination revealed enlarged livers with round edges and thickened capsule with numerous haemorrhagic spots on the parietal surface (subacute form). In chronic form, the livers were cirrhotic and reduced in size. The affected intra-hepatic bile ducts were protruded and were engorged with flukes. Microscopically the migratory tracts were represented by the presence of haemorrhagic, oedema and infiltration with numerous eosinophils mixed with few lymphocytes. The wall of the bile ducts was thickened with fibrous tissue proliferation and the lining epithelium showed hyperplastic changes.

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