Relevance of Otopathological Findings in the Treatment of Dizzy Patients

1984 ◽  
Vol 93 (4_suppl) ◽  
pp. 12-16 ◽  
Author(s):  
Pierre B. Montandon ◽  
Rudolf Häusler
Keyword(s):  
Retrospective Study ◽  
Endolymphatic Hydrops ◽  
Vestibular Neuritis ◽  
Common Symptom ◽  
Vestibular Disorders ◽  
Histopathological Changes ◽  
The Brain

Dizziness is a common symptom in disorders of the brain and the ear. In a retrospective study of 1,000 cases, dizziness is attributed to a peripheral disorder in 25%, to a CNS disorder in 46%, and to undetermined causes in 29% of the cases. Peripheral disorders can be defined in terms of histopathological changes; the most frequent is cupulolithiasis, followed by endolymphatic hydrops and vestibular neuritis. These vestibular disorders are reviewed and discussed in connection with accepted facts and current hypotheses.

scholarly journals Proceedings of the GDR Vertige 2019 annual meeting devoted to endolymphatic hydrops

2021 ◽  
pp. 1-3
Author(s):  
Christian Chabbert ◽  
Anne Charpiot
Keyword(s):  
Annual Meeting ◽  
Research Group ◽  
Endolymphatic Hydrops ◽  
Clinical Manifestations ◽  
Vestibular Function ◽  
Therapeutic Strategies ◽  
Vestibular Disorders ◽  
Special Issue ◽  
Clinical Imaging ◽  
New Methods

The GDR Vertige is a federative research group gathering the different components of the French neuro-otology community. The annual meeting of the GDR Vertige is an opportunity for interactive exchanges between scientists, clinicians and industrialists, on basic issues related to vestibular function, as well as translational questions regarding the management of vestibular disorders. For its fifth edition, the annual meeting of the GDR Vertige, which took place in September 2019 in Marseille (France), was devoted to one of the most peculiar phenomena of neuro-otology: endolymphatic hydrops. For two days, international scientists and clinicians presented the most recent advances regarding the biophysical correlates of endolymphatic hydrops, the genetic and endocrine tableaux that favor its manifestation, new methods of clinical imaging, and current and upcoming therapeutic strategies to overcome the associated clinical manifestations. This special issue of the Journal of Vestibular Research aims at providing the proceedings of this meeting.

scholarly journals Effects of COVID-19 Lockdown on Otitis Media With Effusion in Children: Future Therapeutic Implications

2021 ◽  
pp. 019459982098745
Author(s):  
Mirko Aldè ◽  
Federica Di Berardino ◽  
Paola Marchisio ◽  
Giovanna Cantarella ◽  
Umberto Ambrosetti ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Otitis Media ◽  
Outpatient Clinic ◽  
Otitis Media With Effusion ◽  
Tertiary Level ◽  
Vestibular Disorders ◽  
Therapeutic Implications ◽  
History Of ◽  
Clinic Population

Objective To evaluate the role of social isolation during the lockdown due to the SARS-CoV-2 outbreak (severe acute respiratory syndrome coronavirus 2) in modifying the prevalence of otitis media with effusion (OME) and the natural history of chronic OME. Study Design Retrospective study. Setting Tertiary level referral audiologic center. Methods We assessed the prevalence of OME among children aged 6 months to 12 years who attended the outpatient clinic for hearing or vestibular disorders during 2 periods before the lockdown, May-June 2019 (n = 350) and January-February 2020 (n = 366), and the period immediately after the lockdown, May-June 2020 (n = 216). We also compared the disease resolution rates between a subgroup of children with chronic OME (n = 30) who were diagnosed in summer 2019 and reevaluated in May-June 2020 and a similar subgroup (n = 29) assessed in 2018-2019. Results The prevalence of OME in this clinic population was 40.6% in May-June 2019, 52.2% in January-February 2020, and 2.3% in May-June 2020. Children with chronic OME had a higher rate of disease resolution in May-June 2020 (93.3%) than those examined in May-June 2019 (20.7%, P < .001). Conclusion Closure of schools and the physical distancing rules were correlated with a reduction in the prevalence of OME and favored the resolution of its chronic forms among children who attended the outpatient clinic. These data could suggest that in the presence of chronic OME, keeping young children out of group care settings for a period might be beneficial to allow for OME resolution.

The Interrelations Between Different Causes of Dizziness: A Conceptual Framework for Understanding Vestibular Disorders

2019 ◽  
Vol 128 (9) ◽  
pp. 869-878 ◽  
Author(s):  
Richard T. Zhu ◽  
Vincent Van Rompaey ◽  
Bryan K. Ward ◽  
Raymond Van de Berg ◽  
Paul Van de Heyning ◽  
...  
Keyword(s):  
Conceptual Framework ◽  
Meniere’S Disease ◽  
Vestibular Migraine ◽  
Menière’S Disease ◽  
Vestibular Neuritis ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Vestibular Disorders ◽  
Menière's Disease ◽  
Ménière's Disease

Background:According to population-based studies that estimate disease prevalence, the majority of patients evaluated at dizziness clinics receive a single vestibular diagnosis. However, accumulating literature supports the notion that different vestibular disorders are interrelated and often underdiagnosed.Objective:Given the complexity and richness of these interrelations, we propose that a more inclusive conceptual framework to vestibular diagnostics that explicitly acknowledges this web of association will better inform vestibular differential diagnosis.Methods:A narrative review was performed using PubMed database. Articles were included if they defined a cohort of patients, who were given specific vestibular diagnosis. The interrelations among vestibular disorders were analyzed and placed within a conceptual framework.Results:The frequency of patients currently receiving multiple vestibular diagnoses in dizziness clinic is approximately 3.7% (1263/33 968 patients). The most common vestibular diagnoses encountered in the dizziness clinic include benign paroxysmal positional vertigo (BPPV), vestibular migraine, vestibular neuritis, and Ménière’s disease.Conclusions:A review of the literature demonstrates an intricate web of interconnections among different vestibular disorders such as BPPV, vestibular migraine, Ménière’s disease, vestibular neuritis, bilateral vestibulopathy, superior canal dehiscence syndrome, persistent postural perceptual dizziness, anxiety, head trauma, and aging, among others.

Rapid correction of severe hyponatremia in the rat: histopathological changes in the brain

1985 ◽  
Vol 248 (5) ◽  
pp. F711-F719 ◽  
Author(s):  
J. C. Ayus ◽  
R. K. Krothapalli ◽  
D. L. Armstrong
Keyword(s):  
Serum Sodium ◽  
Brain Lesions ◽  
The Other ◽  
Histopathological Changes ◽  
Water Restriction ◽  
Severe Hyponatremia ◽  
Group Iii ◽  
Group I ◽  
The Brain ◽  
Rapid Correction

The purpose of the present studies was to examine the effects of rapid correction of severe hyponatremia (serum sodium less than 120 meq/liter) either to mildly hyponatremic levels (serum sodium = 130 meq/liter) or to normonatremic levels (serum sodium = 150 meq/liter) on the brain histology of rats. In group I, 13% of the rats revealed brain lesions following correction to mildly hyponatremic levels by the administration of 855 mM NaCl. All the rats (100%) in group II had brain lesions following correction to normonatremic levels by 24 h of water restriction. Similarly, all the rats in group III showed brain lesions following correction to normonatremic levels by the administration of 855 mM NaCl. Severe hyponatremia by itself did not cause any brain lesions in another group. We conclude that rapid correction of severe hyponatremia to mildly hyponatremic levels by the administration of 855 mM NaCl does not cause significant brain lesions. On the other hand, rapid correction to normonatremic levels either by water restriction or by the administration of 855 mM NaCl results in significant brain lesions.

A cross-sectional study on the guideline adherence to antiemetic regimens for chemotherapy-induced nausea and vomiting: A single center retrospective study of 1000 patients.

2021 ◽  
Author(s):  
Cong Luo ◽  
Lei Chen ◽  
Qi Xu ◽  
Jingjing Li ◽  
Qing Wei ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Dose Intensity ◽  
Cross Sectional Study ◽  
Nausea And Vomiting ◽  
Common Symptom ◽  
Single Center ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Complete Control ◽  
Delayed Cinv

Abstract Background Chemotherapy-induced nausea and vomiting (CINV) is a common symptom in patients who undergoing chemotherapy, it is very important to control CINV to maintain dose intensity and patients' quality of life. To analyze the current situation of CINV for the tumor patients who undergoing chemotherapy, we used a cross-sectional survey to assess CINV status in those patients, and whether the drugs used by doctors in each department met the guidelines, and compared the incidence of acute and delayed CINV overall post-chemotherapy periods. Methods This was a single-center, cross-sectional retrospective study of patients with chemotherapy discharged from different departments of Zhejiang Cancer Hospital in China. Participants reported the occurrence, severity, and impact on daily life of nausea and vomiting from the day of chemotherapy administration up to 5 days, and physicians collected the clinical data from the medical records. Results Data were collected from 875 responses totally. In this study, the overall incidence rate of CINV was 44.34%, acute CINV was 24.57%, and delayed CINV was 39.66%. 19.89% patients had both acute and delayed CINV. The consistency rates of antiemetic with guideline in different departments showed significant gap between the actual usage of drugs and the recommended guidelines (P=0.001). In 875 patients, 518 patients received guideline recommended antiemetic regimen, the CINV rates of complete control (CC), defined as the absence of any symptoms, were 61.58%. While the CC rates in other 357 patients were 47.06%(P<0.001). Conclusion Overall, clinician adherence to antiemetic guideline recommendations in different departments remained poorly characterized with varying degrees. Future studies should focus on the complete rate as a primary end point rather than complete remission. The standardized management of CINV in patients need to be further strengthened and doctors need to use drugs more regularly to reduce the occurrence of CINV in patients.

scholarly journals Neural Mechanisms of Inflammation-Induced Fever

2018 ◽  
Vol 24 (4) ◽  
pp. 381-399 ◽  
Author(s):  
Anders Blomqvist ◽  
David Engblom
Keyword(s):  
Peripheral Nerves ◽  
Circumventricular Organs ◽  
Neural Mechanisms ◽  
Prostaglandin E ◽  
Receptor Subtype ◽  
Common Symptom ◽  
Immune Challenge ◽  
Brain Endothelial Cells ◽  
Efferent Limb ◽  
The Brain

Fever is a common symptom of infectious and inflammatory disease. It is well-established that prostaglandin E2 is the final mediator of fever, which by binding to its EP3 receptor subtype in the preoptic hypothalamus initiates thermogenesis. Here, we review the different hypotheses on how the presence of peripherally released pyrogenic substances can be signaled to the brain to elicit fever. We conclude that there is unequivocal evidence for a humoral signaling pathway by which proinflammatory cytokines, through their binding to receptors on brain endothelial cells, evoke fever by eliciting prostaglandin E2 synthesis in these cells. The evidence for a role for other signaling routes for fever, such as signaling via circumventricular organs and peripheral nerves, as well as transfer into the brain of peripherally synthesized prostaglandin E2 are yet far from conclusive. We also review the efferent limb of the pyrogenic pathways. We conclude that it is well established that prostaglandin E2 binding in the preoptic hypothalamus produces fever by disinhibition of presympathetic neurons in the brain stem, but there is yet little understanding of the mechanisms by which factors such as nutritional status and ambient temperature shape the response to the peripheral immune challenge.

A Clinicopathological Review of Adnexal Masses in a Tertiary Care Centre of Rural Haryana - A Retrospective Study

2021 ◽  
Vol 8 (30) ◽  
pp. 2719-2723
Author(s):  
Shivani Khandelwal ◽  
Lakra Pinkey ◽  
Sangwan Vijayata ◽  
Mahendru Rajiv ◽  
Siwach Sunita ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Tertiary Care ◽  
Serous Cystadenoma ◽  
Common Symptom ◽  
Tertiary Care Centre ◽  
Adnexal Masses ◽  
Sexually Transmitted ◽  
Medical College ◽  
Wide Range ◽  
Ectopic Pregnancies

BACKGROUND There is a wide range of adnexal masses ranging from functional cyst to infection and even malignancy. Epithelial ovarian tumours are the most common benign ovarian lesion. The purpose of this study was to study the pattern of adnexal masses in rural area and plan the preventive steps according to the pattern. METHODS It was a retrospective study of patients who presented with adnexal masses in Bhagat Phool Singh Medical College (Women), Khanpur, Sonepat, Haryana, India over a period of 5.5 years from September 2012 to August 2018. The file records of the patients who underwent surgery for adnexal masse were evaluated to identify the risk factors, presenting complaints, examination findings, serological markers and radiological findings. The histopathological reports were reviewed. The cases excluded were ectopic pregnancies. Frequency distribution tables were used and data was analyzed using percentages. RESULTS Out of total 180 adnexal masses, 167 (92.77 %) cases were of ovarian origin. Out of these, 150 (83.33 %) cases were benign and 17 (9.44 %) were malignant. Among the benign lesions, serous cystadenoma was the most common lesion counting for 54 cases i.e., 30 %. In our study, most common symptom was vague abdominal pain- 63.88 %. Maximum adnexal masses were in the age group of 41 - 50 years i.e., 53 (29.44 %). Different types of surgeries were done. Maximum were bilateral oophorectomies with transabdominal hysterctomy 88 (48.88 %). CONCLUSIONS By proper education about personal and perineal hygiene, use of contraceptives, we can at least prevent some sexually transmitted diseases causing pelvic inflammatory disease (PID) and adnexal masses. KEYWORDS Adnexal Mass, Benign, Malignant, Serous Cystadenoma

A Retrospective Study of Histopathological Changes in Electrocution in Tertiary Hospital

2017 ◽  
Vol 10 (2) ◽  
pp. 78-82
Author(s):  
Radha R. Kabbur ◽  
◽  
Shivarurappa A. Siddalingappa ◽  
Sumana B.S. ◽  
◽  
...  
Keyword(s):  
Retrospective Study ◽  
Tertiary Hospital ◽  
Histopathological Changes

scholarly journals Histopathological changes in gallbladder mucosa associated with cholelithiasis

1970 ◽  
Vol 2 (3) ◽  
pp. 224-225 ◽  
Author(s):  
R Baidya ◽  
B Sigdel ◽  
NL Baidya
Keyword(s):  
Retrospective Study ◽  
Intestinal Metaplasia ◽  
Gastrointestinal Disorder ◽  
Gallstone Formation ◽  
Epithelial Hyperplasia ◽  
Pathological Changes ◽  
Histopathological Changes ◽  
Gallbladder Epithelium ◽  
Gallbladder Mucosa ◽  
Gross Examination

Background: Gallstone is a very common gastrointestinal disorder. It is known to produce histopathological changes in the gallbladder. It is also one of the predisposing factors for the development of cancer of gallbladder. Materials and Methods: This was a retrospective study carried out in the Department of Histopathology, B and B Hospital during a period of 1 year from April 2010 to May 2011. The study included 396 cases of cholecystectomy specimens. Results: On gross examination, outer gallbladder surface was congested in 116 patients (28%), wall thickness was increased in 181 (45.7%) and mucosal abnormalities were present in 126 (31.6%) patients. At microscopy, epithelial hyperplasia was observed in 183 (46.2%), intestinal metaplasia in 112 (28.2%), dysplasia in 5 (1.3%) and cholesterolosis in 56 (14%) patients. Conclusion: The pathological changes of the gallbladder epithelium may play an important role in the process of gallstone formation. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6027 JPN 2012; 2(3): 224-225

Sign in / Sign up

Export Citation Format

Share Document