scholarly journals Clinico-bacterial correlation of bacterial index in Hansen’s disease

2016 ◽  
Vol 6 (12) ◽  
pp. 998-1000
Author(s):  
SM Jha ◽  
AKS Dangol ◽  
S Shakya ◽  
B Jha
Keyword(s):  
Clinical Manifestations ◽  
Clinical Information ◽  
Accurate Diagnosis ◽  
Cross Sectional ◽  
Hansen's Disease ◽  
Hansen’S Disease ◽  
Tuberculoid Leprosy ◽  
Classi Cation ◽  
Leprosy Patients ◽  
Bacterial Index

Background: Leprosy has a broad spectrum of clinical manifestations. Clinical information along with Bacterial evidence is necessary to achieve accurate diagnosis. The present study was carried out to nd out clinical and bacterial correlation in various presentations according to Ridley Jopling classi cation of Hansen’s Disease. Materials and Methods: It was a hospital based cross-sectional comparative study of 72 leprosy patients over a period of 1 year and it’s clinico-Bacterial correlation was done with the help of Slit Skin Smear and clinical classi cation. Results: This study included 72 leprosy patients at various stages according to Ridley Jopling classi cation. Maximum cases belonged to Borderline Tuberculoid leprosy 28(38.88%) followed by Tuberculoid leprosy 15(20.83%). Slit Skin Smear showed 12(42.85%) of Borderline Tuberculoid and 3(20%) of Tuberculoid cases had disparity and didn’t match corresponding clinical subtype. Conclusion: Clinical features along with Bacterial index is useful in making accurate diagnosis so that appropriate treatment could be started and hence deformity and disability could be prevented. 

scholarly journals Acceptability of Immunoprophylaxis and/or Chemoprophylaxis for Household Contacts of Patients with Hansen’s Disease: A Prospective, Single-Center, Mixed Methods Study

2020 ◽  
Vol 54 (3) ◽  
Author(s):  
Armi D.V. Espiridion-Calma ◽  
Belen L. Dofitas ◽  
Maria Elinor Grace Q. Sison
Keyword(s):  
Mixed Methods ◽  
Tertiary Hospital ◽  
Mixed Methods Study ◽  
Urban Setting ◽  
Single Center ◽  
Cross Sectional ◽  
Hansen's Disease ◽  
Household Contacts ◽  
Hansen’S Disease ◽  
Leprosy Patients

Objectives. Leprosy is an infectious disease affecting the skin and nerves caused by Mycobacterium leprae. Closer physical distance was found to increase risk transmission. Thus, targeted provision of prophylactic medications to household contacts of patients with leprosy could possibly aid in decreasing its incidence in a cost-effective manner. This study aimed to determine the attitudes towards disclosure of the diagnosis of leprosy and acceptance of immuno- and chemoprophylaxis for household contacts of patients undergoing treatment in a dermatology outpatient clinic of a tertiary hospital in the Philippines. Methods. We conducted a prospective, single-center, cross-sectional and mixed methods study at a dermatology clinic of a tertiary hospital. All diagnosed leprosy patients, household contacts of leprosy patients, and individuals with no leprosy and no known contact with a leprosy case were invited. Eligible participants who gave consent were included in the cross-sectional survey, followed by in-depth interviews of selected participants. STATA 12 was used to analyze the data. Descriptive statistics were used to summarize information. Chi-square was computed to obtain a measure of association of important variables. The field notes and the verbatim transcriptions of the interviews and narratives were filed using an analytic memo system. Results. Fifty-five participants (22 Hansen’s disease patients, 13 household contacts, and 20 individuals unaffected by and unexposed to leprosy) were enrolled. Mean age of respondents was 38 years, 60% were female, and 85% were living in an urban setting. Majority of the patients with leprosy were borderline lepromatous (45%) to lepromatous type (27%) with mean treatment duration of 13 months. Overall, the respondents were willing to disclose the diagnosis of leprosy to their household members to facilitate provision of prophylaxis. They were also generally willing to receive prophylaxis despite potential side effects, expense, incomplete protection, and the need for yearly assessment for the development of leprosy. All respondents felt hopeful about the availability of medications that can prevent the development of leprosy and its complications, with some feeling anxious and only a few being embarrassed about receiving them. Conclusions. Prophylactic medications were found to be generally acceptable despite some concerns. There is also a willingness to disclose the diagnosis of leprosy to facilitate the targeted provision of prophylaxis to household contacts.

scholarly journals Clinico-histopathological correlation of skin biopsies in leprosy

2013 ◽  
Vol 3 (6) ◽  
pp. 452-458 ◽  
Author(s):  
U Manandhar ◽  
RC Adhikari ◽  
G Sayami
Keyword(s):  
Clinical Information ◽  
Lepromatous Leprosy ◽  
Cross Sectional ◽  
Histopathological Correlation ◽  
Granulomatous Lesions ◽  
Tuberculoid Leprosy ◽  
Special Stain ◽  
Different Types ◽  
Skin Biopsies

Background: In leprosy, there is a range of varied clinicopathologic manifestations and the diagnosis is made from adequate clinical information combined with bacilloscopy and histopathology which helps in diagnosing different types of leprosy and separating it from other granulomatous lesions. Aim of the study was to classify leprosy according to Ridley Jopling classification and perform the clinicopathological correlation. Materials and Methods: A cross sectional comparative study of skin biopsies of newly diagnosed leprosy recieved over a period of 18 months from January 2009 to June 2010 and clinicopathologic correlation was done along with special stain. Results: This study included 75 patients diagnosed clinically as leprosy. Skin biopsy revealed evidence of leprosy in 72 cases. Maximum number of patient clinically belonged to tuberculoid leprosy which constituted 25 (33%) cases followed by borderline tuberculoid 19 (25.33%). On the contrary, histologically borderline tuberculoid was the most common type (40%, n=30) cases and tuberculoid leprosy constituted (13.33%, n=10) cases. Three cases of clinically diagnosed tuberculoid leprosy showed no features of leprosy histologically. Clinical and histopathological correlation was seen in 34 cases (45.33%). The correlation was highest in borderline tuberculoid (63.15%) followed by borderline lepromatous and lepromatous leprosy. Slit skin smear was positive in 31 cases (43.05%). Fite Farraco stain was positive in 18 cases (25%). Conclusion: The classification of leprosy requires attention to the histopathological criteria and correlation with clinicalinformationand bacteriological examination so as to facilitate accurate therapy to prevent undesirable complication. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8992   Journal of Pathology of Nepal (2013) Vol. 3, 452-458

Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients

2005 ◽  
Vol 59 (10) ◽  
pp. 1121-1128 ◽  
Author(s):  
R Vijayaraghavan ◽  
C S Suribabu ◽  
B Sekar ◽  
P K Oommen ◽  
S N Kavithalakshmi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Protective Role ◽  
Hansen's Disease ◽  
Hansen’S Disease ◽  
Leprosy Patients

scholarly journals Treatment for leprosy patients in Japan. Chemotherapy of Hansen's disease in Japan-present status.

1998 ◽  
Vol 67 (2) ◽  
pp. 305-311
Author(s):  
Masamichi Goto ◽  
Shigeki Miyagi ◽  
Hideo Takizawa ◽  
Shin-ichi Kitajima
Keyword(s):  
Present Status ◽  
Hansen's Disease ◽  
Hansen’S Disease ◽  
Leprosy Patients

scholarly journals Peripheral Neuropathy in Leprosy: Clinical Manifestations and Disability in a Colombian National Referral Center

2021 ◽  
Author(s):  
Laura Trujillo-Ramirez ◽  
María Alejandra Palacios-Ariza ◽  
Ivan Pradilla ◽  
Luis Arturo Gamboa
Keyword(s):  
Disease Onset ◽  
Clinical Manifestations ◽  
Disease Diagnosis ◽  
Lepromatous Leprosy ◽  
Nerve Trunk ◽  
Lower Limbs ◽  
Hansen's Disease ◽  
Referral Center ◽  
Hansen’S Disease ◽  
Degree Of Disability

Objective: To describe the neurological features of the physical examination in patients with Hansen’s disease who were treated in Bogotá, Colombia.Methods: We carried out a descriptive study of all patients with a Hansen’s disease diagnosis treated at a referral center between 2003-2018.Results: There were 327 eligible electronic health records (EHRs) with a final sample of 282 subjects. Leprosy was most common in males (57.45%), median age at the diagnosis was 54 years, and lesions of the lower limbs were more common (75.1%). The median time from disease onset to consult was 12 months. Most of them were classified as having lepromatous leprosy (39.7%). Pain over the median nerve trunk was the most common manifestation of disease (28%), followed by pain over the radial trunk (22%). Sensitive alterations were more common than motor ones. Specifically, the posterior tibial nerve was affected in nearly half of subjects. Dual impairment was more common in the ulnar nerve (13.8%). Some disability was apparent in 23.8% of subjects; predominantly grade 1 disability.Conclusion: Findings regarding age, leprosy type, and the frequency of individual nerve compromise were consistent with reports from other countries. Nerve trunk thickening was infrequent, which might be a consequence of subjectiveness in the examination and sample differences in sex distribution, degree of disability and time since disease onset. The frequency of morbidity and disability found in this sample, though low when compared with other series, fails to meet public health goals, including those limiting disability in younger subjects.

Tuberculoid leprosy (Hansen’s disease) in native usa child lacking intrafamily infection

2004 ◽  
Vol 50 (3) ◽  
pp. P48
Author(s):  
Thanh D. Nguyen ◽  
Judy O’Haver ◽  
Karen Warschaw ◽  
Ronald Hansen
Keyword(s):  
Hansen's Disease ◽  
Hansen’S Disease ◽  
Tuberculoid Leprosy

scholarly journals Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Patricia Dian Putri ◽  
Luh Made Mas Rusyati ◽  
Made Swastika Adiguna
Keyword(s):  
Risk Factor ◽  
Negative Correlation ◽  
Sampling Method ◽  
Interleukin 2 ◽  
Serum Levels ◽  
Strong Negative Correlation ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
The Mean ◽  
Bacterial Index

Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the tuberculoid type of leprosy.Objective: Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy.Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Sample was taken using a consecutive sampling method. IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of bacterial index affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high bacterial index 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001).Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.

scholarly journals Clinical Profile of Leprosy Patients in DMCH

2017 ◽  
Vol 6 (1) ◽  
pp. 3-7
Author(s):  
Masuda Khatun ◽  
MM Abu Sayed ◽  
Tahmina Sultana
Keyword(s):  
Infectious Disease ◽  
Peripheral Nerves ◽  
Clinical Manifestations ◽  
Mycobacterium Leprae ◽  
Clinical Profile ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
The Mean ◽  
The Cross

Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae, primarily affecting the skin and peripheral nerves. To find out the clinical profile of leprosy patients the cross sectional observational type of study was carried out in outpatient Dept of Dermatology and Venereology at DMCH, Dhaka. Total 30 cases were included in this study. The mean age was found 28.7±11.3 years. Male were 21(70.0%) and female were 9(30.0%). It was observed that 10(33.3%) patients were diagnosed as having borderline tuberculoid, 5(16.7%) as tuberculoid, 1(3.3%) as borderline, 6(20.0%) as borderline lepromatous and 8(26.7%) as lepromatous. Eighteen (60.0%) patients had mutibacillary and 12(40.0%) had paucibacillary. 28(93.3%) patients had hypopigmented, 27(90.0%) had marked anaesthesia, 26(86.7%) had macule & patch, 18(60.0%) had obvious margin and 9(30.0%) had plaque. Majority patients had symptoms during 6 months to 1 year. Common clinical manifestations of leprosy were obvious margin, hypopigmented, marked anaesthesia, macule and ear lobe enlargement. CBMJ 2017 January: Vol. 06 No. 01 P: 03-07

Hansen's disease: tuberculoid leprosy

1968 ◽  
Vol 97 (5) ◽  
pp. 594-596
Author(s):  
S. L. Moschella
Keyword(s):  
Hansen's Disease ◽  
Hansen’S Disease ◽  
Tuberculoid Leprosy

scholarly journals A Study of Selenium in Leprosy

2018 ◽  
Vol 6 (3) ◽  
pp. 485-487 ◽  
Author(s):  
Donna Partogi ◽  
Dina Arwina Dalimunthe ◽  
Cut Putri Hazlianda
Keyword(s):  
General Hospital ◽  
Sampling Method ◽  
Venous Blood ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Protective Role ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
Low Selenium ◽  
Bacterial Index

INTRODUCTION: Leprosy is a chronic infection caused by Mycobacterium leprae. Selenium, on the other hand, is a substance, which is needed for its protective role against microorganism infection.AIM: This study aims to know the association between selenium serum levels with bacteriological index.METHODS: This is an analytical cross-sectional study model. Sampling was done with consecutive sampling method in Pirngadi General Hospital, Lau Simomo Leprosy Hospital and H. Adam Malik General Hospital. Samples were taken from patients’ venous blood serum then selenium levels were measured.RESULTS: This study found 30 leprosy patients consisted of 19 patients with paucibacillary (PB) leprosy and 11 patients with multibacillary (MB) leprosy. Selenium serum levels of patients with PB leprosy (mean = 97.16 µg/dL) were found to be significantly higher than MB leprosy (mean = 77.27 µg/dL) with p = 0.008 using t-test. The negative correlation between selenium serum levels with bacterial index in patients with leprosy was also found in this study using Spearman’s rho test (r = - 0.499, p = 0.005).CONCLUSIONS: Selenium serum levels of patients with PB leprosy are higher than patients with MB leprosy, and high bacteriological index in patients with leprosy were correlated with low selenium serum levels.

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