scholarly journals Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Patricia Dian Putri ◽  
Luh Made Mas Rusyati ◽  
Made Swastika Adiguna
Keyword(s):  
Risk Factor ◽  
Negative Correlation ◽  
Sampling Method ◽  
Interleukin 2 ◽  
Serum Levels ◽  
Strong Negative Correlation ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
The Mean ◽  
Bacterial Index

Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the tuberculoid type of leprosy.Objective: Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy.Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Sample was taken using a consecutive sampling method. IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of bacterial index affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high bacterial index 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001).Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.

scholarly journals A Study of Selenium in Leprosy

2018 ◽  
Vol 6 (3) ◽  
pp. 485-487 ◽  
Author(s):  
Donna Partogi ◽  
Dina Arwina Dalimunthe ◽  
Cut Putri Hazlianda
Keyword(s):  
General Hospital ◽  
Sampling Method ◽  
Venous Blood ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Protective Role ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
Low Selenium ◽  
Bacterial Index

INTRODUCTION: Leprosy is a chronic infection caused by Mycobacterium leprae. Selenium, on the other hand, is a substance, which is needed for its protective role against microorganism infection.AIM: This study aims to know the association between selenium serum levels with bacteriological index.METHODS: This is an analytical cross-sectional study model. Sampling was done with consecutive sampling method in Pirngadi General Hospital, Lau Simomo Leprosy Hospital and H. Adam Malik General Hospital. Samples were taken from patients’ venous blood serum then selenium levels were measured.RESULTS: This study found 30 leprosy patients consisted of 19 patients with paucibacillary (PB) leprosy and 11 patients with multibacillary (MB) leprosy. Selenium serum levels of patients with PB leprosy (mean = 97.16 µg/dL) were found to be significantly higher than MB leprosy (mean = 77.27 µg/dL) with p = 0.008 using t-test. The negative correlation between selenium serum levels with bacterial index in patients with leprosy was also found in this study using Spearman’s rho test (r = - 0.499, p = 0.005).CONCLUSIONS: Selenium serum levels of patients with PB leprosy are higher than patients with MB leprosy, and high bacteriological index in patients with leprosy were correlated with low selenium serum levels.

Relationship of Sense of Coherence to Other Psychosocial Indices

2004 ◽  
Vol 20 (4) ◽  
pp. 227-236 ◽  
Author(s):  
Sara Holmberg ◽  
Anders Thelin ◽  
Eva-Lena Stiernström
Keyword(s):  
Social Support ◽  
Psychosocial Factors ◽  
Sense Of Coherence ◽  
Living Conditions ◽  
Strong Negative Correlation ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Work Related ◽  
Job Demand ◽  
The Mean

Summary: The concept of “sense of coherence” (SOC) has been widely recognized since it was first introduced by Antonovsky. The originality and usefulness of the SOC scale and its relation to other psychosocial measures has been the subject of lively debate. The aim of this paper was to test for associations between SOC and work-related psychosocial factors (mainly the Job Demand-Control model), general living conditions, education, and social network factors. Cross-sectional data from a population-based sample of 1782 rural males from nine counties in Sweden were analyzed with a multiple regression technique. The subjects were occupationally active at inclusion and the mean age was 50 years (range 40-60). SOC was assessed with the original 29-item questionnaire. Psychosocial variables and lifestyle factors were assessed using questionnaires and structured interviews. The mean SOC among the subjects was 152.3 (standard deviation, 19.4). A strong negative correlation was found between SOC and job demand, whereas a positive correlation with job control was demonstrated. A positive correlation with general living conditions and with social support was also found. However, there was no correlation to education and occupation. Thus, SOC was shown to be strongly correlated to work-related psychosocial factors and social support, but independent of sociodemographic factors.

scholarly journals Clinico-bacterial correlation of bacterial index in Hansen’s disease

2016 ◽  
Vol 6 (12) ◽  
pp. 998-1000
Author(s):  
SM Jha ◽  
AKS Dangol ◽  
S Shakya ◽  
B Jha
Keyword(s):  
Clinical Manifestations ◽  
Clinical Information ◽  
Accurate Diagnosis ◽  
Cross Sectional ◽  
Hansen's Disease ◽  
Hansen’S Disease ◽  
Tuberculoid Leprosy ◽  
Classi Cation ◽  
Leprosy Patients ◽  
Bacterial Index

Background: Leprosy has a broad spectrum of clinical manifestations. Clinical information along with Bacterial evidence is necessary to achieve accurate diagnosis. The present study was carried out to nd out clinical and bacterial correlation in various presentations according to Ridley Jopling classi cation of Hansen’s Disease. Materials and Methods: It was a hospital based cross-sectional comparative study of 72 leprosy patients over a period of 1 year and it’s clinico-Bacterial correlation was done with the help of Slit Skin Smear and clinical classi cation. Results: This study included 72 leprosy patients at various stages according to Ridley Jopling classi cation. Maximum cases belonged to Borderline Tuberculoid leprosy 28(38.88%) followed by Tuberculoid leprosy 15(20.83%). Slit Skin Smear showed 12(42.85%) of Borderline Tuberculoid and 3(20%) of Tuberculoid cases had disparity and didn’t match corresponding clinical subtype. Conclusion: Clinical features along with Bacterial index is useful in making accurate diagnosis so that appropriate treatment could be started and hence deformity and disability could be prevented. 

scholarly journals Child-Free Lifestyle and the Need for Parenthood and Relationship with Marital Satisfaction among Infertile Couples

2021 ◽  
Author(s):  
Razhan Chehreh ◽  
Giti Ozgoli ◽  
Khadijeh Abolmaali ◽  
Malihe Nasiri ◽  
Zolaykha Karamelahi
Keyword(s):  
Marital Satisfaction ◽  
Sampling Method ◽  
Statistical Tests ◽  
Pearson Correlation ◽  
Cross Sectional Study ◽  
Satisfaction Scale ◽  
Cross Sectional ◽  
The Mean ◽  
Convenience Sampling ◽  
Infertile Couples

Objective: Marital satisfaction is considered as satisfaction with a marital relationship on which the presence of a child has different effects. Concerns about a childfree life and its effect on marital satisfaction in infertile couples are very critical. Therefore, this study was intended to characterize and compare concerns about a childfree lifestyle and the need for parenthood and their relationship with marital satisfaction in infertile couples. Method: A total of 200 men and 200 women who referred to fertility centers in Tehran participated in this cross-sectional study. Convenience sampling method was used for sampling. Demographic survey, ENRICH Marital Satisfaction Scale, and Fertility Problem Inventory were used for data collection. The resulting data were analyzed using descriptive and analytical statistical tests (Pearson Correlation Coefficient and Stepwise Regression). Results: The mean scores for concern about a childfree lifestyle and the need for parenthood in women were significantly higher than in men. The variables rejection of a childfree lifestyle and the need for parenthood were respectively predictors of marital satisfaction in women and men. Conclusion: Since marital satisfaction in infertile couples is affected by their feelings about having a child and becoming a parent, it is therefore suggested that appropriate counseling be provided in supportive healthcare programs for infertile couples to promote their marital satisfaction.

scholarly journals Central and Peripheral Obesity on Severity Knee Osteoarthritis

2021 ◽  
Vol 1 (3) ◽  
pp. 64
Author(s):  
Refangga Lova Nusantara Efendi ◽  
Zulfachmi Wahab ◽  
M. Riza Setiawan
Keyword(s):  
Knee Osteoarthritis ◽  
Sampling Method ◽  
Simple Random Sampling ◽  
Statistical Test ◽  
Coefficient Of Determination ◽  
Mean Deviation ◽  
Cross Sectional ◽  
Linear Pattern ◽  
Different Types ◽  
The Mean

Background: Obesity can affect severity of knee osteoarthritis sufferers. Several studies have examined relationship between obesity and osteoarthritis, but no one has examined the different types of obesity on osteoarthritis, therefore, researchers wanted to know differences of central and peripheral obesity on severity osteoarthritis.Methods: A retrospective studi, with cross-sectional, simple random sampling method, conducted between 1 August 2014 and 30 September 2014 in Semarang City. Samples people > 50 years old. Data were analyzed by rank Spearman and Anova correlation.Results: In this study, 45.7% (n = 32) reported severe osteoarthritis. The results of the statistical test obtained p1 = 0,000 (reject Ho). The correlation coefficient (r) is 0.857 (strong), and the linear pattern is positive. The coefficient of determination (r2) is obtained (0.857) 2 = 0.73 = 73%. And 37.1% (N = 26) reported being obese. p2 = 0.043 (reject Ho). The mean deviation (MD) was 0.048 (not significant) between central obesity and peripheral obesity.Conclusion: Obesity affects severity of knee osteoarthritis. The greater body mass index, greater severity of knee osteoarthritis. 73% of severity of knee osteoarthritis is influenced by obesity, but there is no significant effect between central and peripheral obesity on the occurrence of knee osteoarthritis.

scholarly journals Prevalence and Predictors of Stress among Bankers in Enugu State South-East Nigeria

2020 ◽  
Vol 32 (2) ◽  
pp. 68-79
Author(s):  
T.J. Okwor ◽  
A.C. Ndu ◽  
S.U. Arinze-Onyia ◽  
I.J. Ogugua ◽  
I.M. Obionu ◽  
...  
Keyword(s):  
Sampling Method ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Eastern State ◽  
Management Standards ◽  
The Mean ◽  
Enugu State ◽  
Multistage Sampling ◽  
High Level

Background: The work environment is rapidly changing and in recent times, occupational stress poses a threat to the health, morale and productivity of workers and the organization. This study sought to determine the prevalence and predictors of stress among bankers in a south-eastern state of Nigeria. Methods: A descriptive cross-sectional study was carried out among 370 bankers in Enugu State, Nigeria using the Health, Safety, Executive (HSE) management standards indicator tool. Multistage sampling method was used to select participants. Statistical analysis was done using SPSS 22.0. Level of statistical significance was set at p< 0.05.Results: The mean age of the participants was 34.54±6.3 years while the mean years of work was 6.01±4.7years. One hundred and seventy-four (47%) reported high level of stress due to relationship at work while 318 (85.9%) reported low level of stress due to roles. Being 35 years or less was found to a predictor of high (AOR 0.55, CI 0.30-1.02) level of stress due to control.Work experience of 5 years or less was found to be a predictor of both high (AOR 0.74, CI 0.40--1.37) and low (AOR 0.99, CI 0.40-1.37) levels of stress due to control.Conclusion: This study has shown that the prevalence of stress was high among bankers in Enugu State, South-East Nigeria. There is, therefore, the need for routine stress assessment and interventions in the banking industry especially for those at high risk. Keywords: Bankers; HSE Stress Questionnaire; Stress; Workplace; Southeast Nigeria

scholarly journals Correlation between Osteoprotegerin Serum Level and Coronary Calcification Using Coronary Artery Calcium Score in Patient with Moderate–Severe Cardiovascular Risk Factor

2017 ◽  
Vol 26 (04) ◽  
pp. 234-237 ◽  
Author(s):  
Widorini Widorini ◽  
J. Nugroho
Keyword(s):  
Computed Tomography ◽  
Risk Factor ◽  
Coronary Artery ◽  
Serum Level ◽  
Coronary Artery Calcium ◽  
Coronary Artery Calcification ◽  
Calcium Score ◽  
Coronary Calcification ◽  
Cross Sectional ◽  
The Mean

AbstractCoronary artery calcification is a part of atherosclerosis process associated with coronary heart disease. Recently, coronary artery calcification assessment using computed tomography (CT) is still the best noninvasive imaging with high sensitivity and specificity. Osteoprotegerin (OPG) is one of vascular calcification marker that through its role to bind receptor activator of nuclear factor-κβ ligand and inhibit osteoclastogenesis is suspected of playing a role for coronary calcification in atherosclerosis process. The objective of this study was to prove a positive correlation between OPG serum level and coronary calcification using coronary artery calcium (CAC) score in patient with moderate–severe cardiovascular (CV) risk factor. This is a cross-sectional study with purposive sampling technique. Thirty-three subjects participate in this research and each subject underwent a multislice computed tomography (MSCT) examination to assess coronary calcification and their blood samples were collected for OPG measurement. This study is analyzed with Spearman's correlation test. The mean of OPG serum level in this study was 5.89 ± 2.1 pmol/L for moderate-risk Framingham risk score (FRS) and the mean of OPG serum level for high-risk FRS was 7.27 ± 3.4. There was a positive, moderate, and significant correlation between OPG serum level and coronary calcification using CAC score in patient with moderate–severe CV risk factor (r = 0.694; p < 0.001).

scholarly journals Levels of molecular angiogenic and antiangiogenic in pregnant women with risk of preeclampsia

2019 ◽  
Vol 8 (10) ◽  
pp. 4034
Author(s):  
Diah Wulandari ◽  
Mohamad Sulchan ◽  
Syarief Thaufik Hidayat
Keyword(s):  
Risk Factor ◽  
Pregnant Women ◽  
Molecular Level ◽  
Elisa Method ◽  
Cross Sectional ◽  
Primary Health ◽  
The Mean ◽  
Cross Sectional Design ◽  
Plgf Ratio ◽  
Risk Of Preeclampsia

Background: Angiogenic and antiangiogenic imbalances play a major role in the pathogenesis of preeclampsia. Increased production of sFlt-1 by the placenta causes free circulating PIGF and VEGF concentrations to lower because it is bound by sFlt-1. Measuring levels of angiogenic and antiangiogenic proteins as biomarkers indicates placental dysfunction and distinguishes preeclampsia from other disorders. This study aims to analyze the levels of angiogenic and antiangiogenic molecules in pregnant women at risk for preeclampsia.Methods: The study with a cross-sectional design was carried out in 11-15 weeks gestational age whom had a risk of preeclampsia with 30 samples in primary health care starting April-August 2018. Blood serum was measured by molecular levels of VEGF, PlGF, sFlt-1, and sFlt-1/PlGF ratio using the ELISA method. Data analysis used Pearson product moment test.Results: The mean of VEGF levels are 15.5±21.6, PlGF 89.7±55.5, sFlt-1 11519.4±5126.0 and the ratio sFlt-1/PlGF 166.7±102.1. Correlation value of risk factors for preeclampsia with molecular levels of VEGF r= -0.05; p = 0.76, PlGF r= -0.21; p = 0.26, sFlt r= 0.01; p =0.99 and ratio sFlt-1/PlGF r = 0.10; p = 0.58.Conclusions: The higher the total score of preeclampsia risk factor, the lower the molecular level of VEGF and PlGF is. Moreover, the higher the total score of preeclampsia risk factor, the higher the molecular level sFlt-1 and the sFlt-1/PlGF ratio is. There are no significant correlation between total score of preeclampsia risk factor and levels of molecule VEGF, PlGF, sFlt-1 and sFlt-1/PlGF ratio.

Plasma Cholesterol Esterification in Normal and Hyperlipoproteinemic Subjects

1973 ◽  
Vol 51 (5) ◽  
pp. 550-555 ◽  
Author(s):  
Hélène D. Fabien ◽  
Jean Davignon ◽  
Yves L. Marcel
Keyword(s):  
Total Cholesterol ◽  
Negative Correlation ◽  
Plasma Cholesterol ◽  
Relative Rate ◽  
Plasma Lipid ◽  
Normal Subjects ◽  
Cholesterol Esterification ◽  
Strong Negative Correlation ◽  
Total Group ◽  
The Mean

Plasma lipid values and the initial rates of plasma cholesterol esterification in vitro have been studied in seven normal subjects and in 34 patients with primary hyperlipoproteinemia of the different types.Compared with that of normal subjects, the mean rate of cholesterol esterification (nanomoles cholesterol esterified per hour per milliliter of plasma) is significantly increased in type II (p < 0.05), whereas the mean increases noted in types III, IV, and V are not significant. The mean relative rate (percentage cholesterol esterified per hour) is decreased in type III (p < 0.05).The correlations between plasma lipid values and cholesterol esterification have been calculated in each type as well as in normal and hyperlipoproteinemic subjects taken as a group (total group). In the total group, plasma cholesterol esterification (nanomoles per hour per milliliter) is weakly correlated with unesterified cholesterol (r = 0.384), with triglycerides (r = 0.416), and with the ratio of triglycerides to total cholesterol (r = 0.439). Only in the group of normal subjects is the rate of cholesterol esterification strongly correlated with triglycerides (r = 0.896) and with the ratio of triglycerides to total cholesterol (r = 0.885). Finally, there is a strong negative correlation (r = −0.792, p < 0.001) between the rate of cholesterol esterification expressed in the percentage of cholesterol esterified per hour and the ponderal index in the total group. This negative correlation indicates a positive correlation between cholesterol esterification and obesity. In all subjects, we have also found that negative or positive caloric balances caused the rates of cholesterol esterification to be, respectively, decreased or increased as compared with the mean of the group considered.

scholarly journals Salivary pH and Taste Sensitivity among Geriatric and Non-Geriatric Patients in a Tertiary Hospital: A Cross Sectional Study

2019 ◽  
Vol 34 (2) ◽  
pp. 11-15
Author(s):  
Miguel Crisostomo ◽  
Celso Ureta
Keyword(s):  
Citric Acid ◽  
Negative Correlation ◽  
Geriatric Patients ◽  
Cross Sectional Study ◽  
Taste Sensitivity ◽  
Sectional Study ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Salivary Ph ◽  
The Mean

Objective: To evaluate the association of salivary pH and taste sensitivity among geriatric and non-geriatric patients in an otorhinolaryngology - head and neck surgery out-patient clinic. Methods: Design:           Cross-Sectional Study Setting:           Tertiary Government Training Hospital Participants: 40 otorhinolaryngology out-patients   Results: Of the 40 patients aged 24 to 92-years-old (mean age 59.8 years), 21 were geriatric and 19 were non-geriatric. The mean salivary pH was 6.66 (range 5 to 8) and 6.63 (range 5 to 7) for geriatric and non-geriatric groups; the difference in mean salivary pH was not statistically significant (p = .87). The salivary pH in the geriatric group showed a negative correlation with age (r=0.06), while the salivary pH in the non-geriatric group had a positive correlation with age (r=0.14). Overall, increases in age among the non-geriatric group were correlated with increase in salivary pH which were not observed in the geriatric patients. In the geriatric group, among the 4 tastants, the strongest correlation between taste sensitivity and salivary pH was observed for quinine followed by sucrose and NaCl, but no correlation for citric acid. In the non-geriatric group, the strongest correlation between taste sensitivity and salivary pH was observed for NaCl, followed by quinine, citric acid and sucrose. Conclusion: There was no significant difference between the mean salivary pH of geriatric and non-geriatric patients, and both means were within normal. There was a negative correlation between age and salivary pH in the geriatric group, and a positive correlation in the non-geriatric group.  Salivary pH had the strongest correlation with taste sensitivity for quinine and NaCl among geriatric and non-geriatric participants, respectively, but the reasons for, and significance of this cannot be inferred from the present study. Keywords: salivary pH; taste sensitivity; gustatory function; geriatric 

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