scholarly journals Serum Vitamin D and B12 Levels in Alcoholic Male Patients: A Cross-sectional Study

2021 ◽  
Vol 9 (01) ◽  
pp. 47-51
Author(s):  
Archana Jayan ◽  
Buddhi Raj Pokhrel ◽  
Narayan Gautam ◽  
Amit Chandra Jha ◽  
Binaya Tamang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Function ◽  
Alcohol Dependence ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels

INTRODUCTION Alcohol dependence is a global problem and is rapidly increasing in developing countries. We aimed to analyze the serum levels of vitamin B12 and vitamin D in chronic alcoholic patients and their association with parameters of liver function. MATERIAL AND METHODS A cross-sectional study was carried out in Universal College of Medical Sciences, Bhairahawa, Nepal from March 2020 to September 2020 on patients visiting the Psychiatric Out Patient Department (OPD) for the treatment of alcohol dependence. The patients were categorized as excessive and moderate drinkers. Serum vitamin B12, vitamin D, and hepatic function parameters were measured. RESULTS The median serum vitamin B12 and vitamin D levels were 467.8 pg/ml and 24.9 ng/ml respectively. Excessive drinkers had significantly higher B12   levels than moderate drinkers. Vitamin B12   levels correlated positively with liver function parameters, as well as alcohol amount and duration of consumption. Vitamin D levels were insufficient in 57 (71.25%) of the overall participants. CONCLUSION Serum levels of vitamin B12 are not affected in patients with alcohol dependence. Alcohol consumption, however, reduces serum concentrations of vitamin D. Vitamin B12  concentration is positively associated with liver enzymes and other parameters of liver function.  

The Biochemical Parameters and Vitamin D Levels in ICU Patients with Covid-19: A Cross-Sectional Study

2021 ◽  
Vol 21 ◽  
Author(s):  
Hamed Abdollahi ◽  
Farahnaz Salehinia ◽  
Mostafa Badeli ◽  
Elmira Karimi ◽  
Hossein Gandomkar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Immune System ◽  
Liver Enzymes ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elevated Liver Enzymes ◽  
Vitamin D Levels

Background: In Covid-19 infection, leukopenia, inflammation, and elevated liver enzymes are found in most patients. Also, vitamin D deficiency attenuate the immune system and predispose a person more susceptible to infection. In this context, we aimed to evaluate vitamin D, Electrolytes, Complete blood count, Liver enzymes, Urea, Creatinine, Albumin, CRP and ESR levels in patients with Covid-19. Methods: We conducted a cross-sectional study on 118 patients with Covid-19 who were hospitalized from 2020/2/19 to 2020/4/3 in ICU. Serum levels of electrolytes, liver enzymes, blood factors, urea, creatinine, CRP and ESR as well as anthropometric parameters and serum vitamin D concentration were measured. Results: A total of 118 patients (80 male and 38 female) was enrolled in the study (65.05±15.75 years). Only 5.08% of patients had no risk factors and 55.9% had ≥ 2 risk factors. Diabetes (44.1%) and obesity (23.7%) were more common among patients. Laboratory finding showed that 80.50% of patients had hyponatremia, but other electrolytes included K, Mg, Ca and P were normal in majority of participants as well as CBC, Cr, Urea, Alb, ALT and ALKP. The AST concentration increased in most patients (66.94%). All patients had high levels of inflammatory factors such as CRP and ESR. The mean of 25-hydroxy-vitamin D levels in participants (25.95 ± 14.56 ng/mL) was lower than its levels in general papulation. However, it was not statistically significant (P= 0.88). A significant negative correlation found between vitamin D and ALT (P= 0.02, -0.21) as well as vitamin D and CRP (P= 0.05, -0.17). Conclusion: Regarding to the regulatory role of vitamin D in immune system and low levels of vitamin D in Covid-19 infected patients, the evaluation of vitamin D levels and prescribe supplements if necessary is suggested.

Association between serum vitamin D levels and neuropathic pain in rheumatoid arthritis patients: A cross-sectional study

2017 ◽  
Vol 21 (2) ◽  
pp. 431-439 ◽  
Author(s):  
Hilal Yesil ◽  
Ulas Sungur ◽  
Sedef Akdeniz ◽  
Gulcan Gurer ◽  
Basak Yalcın ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Neuropathic Pain ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1075
Author(s):  
Masliza Hanuni Mat Ali ◽  
Tuan Salwani Tuan Ismail ◽  
Wan Norlina Wan Azman ◽  
Najib Majdi Yaacob ◽  
Norhayati Yahaya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Thyroid Diseases ◽  
Z Score ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls (n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.

scholarly journals Does Vitamin D Have a Role in the Inception of Childhood Asthma? - A Comparative Cross-Sectional Study

2021 ◽  
Vol 8 (17) ◽  
pp. 1157-1162
Author(s):  
Mohan Jayabal ◽  
Rashmi Ramanathan ◽  
Arun Kumar ◽  
Pavithra Vyshnavi Yogisparan ◽  
Manishankar Subramaniyam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Function ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels

BACKGROUND Global prevalence of paediatric asthma has shown a sharp increase in last three decades. Recently vitamin D has been linked with lung function and vitamin D supplementation can lessen the acute exacerbations in asthmatic children. The purpose of the study was to compare lung parameters and vitamin D levels in asthmatic and non-asthmatic children and assess the correlation between vitamin D levels and pulmonary function parameters in children. METHODS A cross-sectional study was conducted among 40 asthmatic children and 42 healthy volunteers between the age group of 5 and 18 years attending the paediatric outpatient department (OPD) in a tertiary care centre in Coimbatore. Pulmonary functions were assessed using computerized spirometer and the serum 25-hydroxy vitamin D levels were estimated by Diazyme EZ vitamin D assay latex enhanced immunoturbidimetric method. The results were compared between asthmatics and non-asthmatics to find out the association. RESULTS The average age of the study participants was 10.5 ± 2.5 years. Lung parameters and mean vitamin D levels are reduced in asthmatics. There is a positive significant correlation between serum vitamin D levels and forced expiratory volume FEV1 / forced vital capacity (FVC) (P < 0.05, r = 0.781), and also between vitamin D and FEV1 (P < 0.05, r = 0.28). Lung parameters like FEV1, FEV1 / FVC ratio and peak expiratory flow rate (PEFR) are significantly decreased in asthmatic children. CONCLUSIONS Majority of the asthmatics have insufficient vitamin D levels than the normal peers with no asthma. Our study confirms the positive association between vitamin D and FEV1 and FEV1 / FVC ratio. KEYWORDS Vitamin D, Asthma, Pulmonary Function, Lung Parameters

scholarly journals Serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study

2020 ◽  
Author(s):  
Qinqiu Wang ◽  
Xiao-ying Shi ◽  
Jinghua Wang ◽  
Juanwen Zhang ◽  
Cheng-Fu Xu
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Obese People ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Lean Nafld ◽  
Low Serum

Abstract Background: Low serum vitamin D concentrations have been reported to be associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). However, whether slim or obese people show a similar association between vitamin D and NAFLD remains speculative. This study aimed to explore the relationship between serum vitamin D concentrations and NAFLD in lean and obese Chinese adults.Methods: This cross-sectional study included 2538 participants (1360 men and 1178 women) who underwent their health checkups at the First Affiliated Hospital of Zhejiang University School of Medicine in 2019. NAFLD was diagnosed by liver ultrasound excluding other causes. The association of serum vitamin D concentrations with NAFLD was analyzed in lean and obese participants.Results: The overall prevalence of NAFLD was 33.61% (13.10% in lean and 53.32% in obese) in this study population. The serum vitamin D levels of obese NAFLD patients were lower than that of the obese NAFLD-free controls. However, the serum vitamin D levels of lean NAFLD patients were comparable to that of the lean NAFLD-free controls. Serum vitamin D levels were negatively correlated with the prevalence of NAFLD in obese but not lean participants. Serum vitamin D levels were independently associated with the risk of NAFLD in obese participants, with an adjusted odd ratio (95% CI) of 0.986 (0.979–0.992). However, the serum vitamin D levels were not related to the risk of NAFLD in lean participants.Conclusions: Low serum vitamin D levels are associated with NAFLD in obese but not lean participants.

scholarly journals The Association of 25 (OH) Vitamin D Levels and Severity and Outcome of COVID-19: A Cross-sectional Study

2021 ◽  
Author(s):  
Maryam Vasheghani ◽  
Nasrin Jannati ◽  
Parvaneh Baghaei ◽  
Mitra Rezaei ◽  
Majid Marjani
Keyword(s):  
Vitamin D ◽  
Severe Disease ◽  
Serum Levels ◽  
Multivariate Regression Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Icu Admission ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Abstract BackgroundCoronavirus disease 2019 (COVID-19) is a pandemic disease. Experiments with influenza and severe acute respiratory syndrome (SARS) have shown supplemental vitamin D can reduce the risk of infection and death.AimThis study was performed to evaluate the relationship between vitamin D levels and the severity and outcome of admitted patients with COVID-19.Material and MethodsThis cross-sectional study was performed on COVID-19 cases diagnosed by examining RT-PCR assay for SARS-CoV-2 or a set of symptoms and typical findings in lung CT scan. Based on clinical and radiologic characteristics, the patients were categorized as mild, moderate, severe, and critical. Calcium, phosphorus, albumin, creatinine, and serum 25 hydroxy vitamin D were measured and their correlation with the severity and outcome were analyzed.ResultsFrom May 1 to June 31, 2020, 508 patients ((442 patients in general wards and 66 patients in intensive care unit (ICU)) were included in this study. The participants were 56±17 years old (mean ±SD) (range from 14 to 95 years) and 52% were male. According to the past medical history, 190 (37.4%) of them had comorbidity. Concerning severity, 13.2%, 42.3%, 35.4%, and 9.1% had the mild, moderate, severe, and critical disease, respectively. The in-hospital mortality rate was 10.8%. In the multivariate regression analysis, age had a positive correlation and use of vitamin D supplement, serum level of 25 OH vitamin D, calcium, and albumin had a negative correlation with disease severity and admission to ICU. Poor outcome was inversely related to serum levels of vitamin D, calcium, albumin, and renal function. Vitamin D deficiency increased the rate of ICU admission by 2.7 times (95%CI=1.288-5.91, P=0.009).ConclusionIn patients who are hospitalized due to COVID-19, low 25-hydroxyvitamin D, hypocalcemia, and hypoalbuminemia are associated with severe disease, ICU admission, and an increase in mortality.

scholarly journals Serum vitamin D levels in Berliners of Turkish descent –a cross-sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lilian Krist ◽  
Theresa Keller ◽  
Heiko Becher ◽  
Karl-Heinz Jöckel ◽  
Martin Schlaud ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Evaluation of the Relationship Between Vitamin D Levels and Related Serum Markers as Well as Disease Activity in Patients With Rheumatoid Arthritis: A Cross-sectional Study in Western Iran

2020 ◽  
Author(s):  
Nasrin Moghimi ◽  
Ali Faridfar ◽  
Reza Shahriarirad ◽  
Mohsen Nikandish ◽  
Amirhossein Salimi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Marker ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
The Relationship

Abstract Introduction: Many studies have reported the role of vitamin D in rheumatoid arthritis (RA) which is related to several serum autoantibodies such as RF and Anti CCP. It also has been shown that vitamin D deficiency affect the DAS28 and VAS score inversely. Therefore, we aim to assess the relationship between vitamin D deficiency and RA-related autoantibodies including Anti CCP and RF levels and also evaluate the association between these parameters and the severity of disease.Methods: In this cross-sectional study, RA patients over 16 years of age were enrolled. The severity of diseases was assessed via the DAS28 scoring system. Serum levels of 25(OH) vitamin D were determined by the ELISA method, along with other rheumatoid related laboratory evaluations including Anti CCP, RF and CRPResults: A total of 100 patients with a mean age of 45.27± 14.14 were included and evaluated; of them, 75% were female and 77% lived in the city. Most of the patients (66%) had moderate DAS28 levels; however, no substantial relationship was observed between DAS28 and vitamin D levels. A significant positive relation between serum 25(OH)D level and disease duration, as well as the level of education, was observed. There was also no significant correlation between RA-related autoantibodies and inflammatory serum marker with 25(OH)D.Conclusion: Due to vitamin deficiency in the majority of cases (73%) and the relationship between serum 25(OH)D levels and the duration of disease, it can be concluded that vitamin D levels should be checked in those patients.

scholarly journals Vitamin D, vitamin D binding protein, vitamin D receptor levels and cardiac dysautonomia in patients with multiple sclerosis: a cross-sectional study

2019 ◽  
Vol 77 (12) ◽  
pp. 848-854 ◽  
Author(s):  
Tülin Aktürk ◽  
Yaşar Turan ◽  
Nermin Tanik ◽  
Müjgan Ercan Karadağ ◽  
Hikmet Sacmaci ◽  
...  
Keyword(s):  
Vitamin D ◽  
Orthostatic Hypotension ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Vitamin D Binding Protein ◽  
Cross Sectional ◽  
Supine Hypertension ◽  
Serum Vitamin D

ABSTRACT Vitamin D is a pleiotropic steroid hormone that modulates the autonomic balance. Its deficiency has been described as an environmental risk factor for multiple sclerosis (MS). The aim of this study was to investigate the serum levels of vitamin D, vitamin D binding protein (VDBP) and vitamin D receptors (VDR) and to evaluate cardiac dysautonomia in MS patients due to bidirectional interaction between vitamin D and the autonomic nervous system. Methods: The current cross-sectional study was conducted on 26 patients with relapsing-remitting MS and on 24 healthy controls. Twenty-four-hour ambulatory blood pressure variability (BPV) was calculated and the participants were evaluated for orthostatic hypotension and supine hypertension. Serum levels of vitamin D, VDBP and VDR were measured. Results: The mean serum vitamin D level was significantly lower in MS patients than in controls (p = 0.044); however there was no significant difference in terms of VDR and VDBP levels between the groups. Supine hypertension and orthostatic hypotension were significant and the 24-hour systolic BPV was significantly decreased in patients with MS (p < 0.05) compared to controls. No correlation was found between vitamin D, VDBP and VDR with supine hypertension, orthostatic hypotension and systolic BPV values (p > 0.05). Also, there was a negative correlation between VDBP and the EDSS (p = 0.039, r = −0.406). Conclusion: There was no correlation between orthostatic hypotension, supine hypertension and systolic BPV values and serum vitamin D, VDBP and VDR in MS patients. Future prospective studies with large number of patients may help us to better understand the relationship between vitamin D and the autonomic nervous system.

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