scholarly journals ГУМОРАЛЬНИЙ ІМУНІТЕТ У ДІТЕЙ ШКІЛЬНОГО ВІКУ ЗІ ПОЗАШПИТАЛЬНОЮ ПНЕВМОНІЄЮ

World Science ◽  
2018 ◽  
Vol 2 (8(36)) ◽  
pp. 8-10
Author(s):  
Бабік І. В.
Keyword(s):  
Immunoglobulin A ◽  
Serum Levels ◽  
Secretory Immunoglobulin A ◽  
Pathogenic Microorganisms ◽  
First Line ◽  
Upper Respiratory Infection ◽  
Immune Systems ◽  
Potential Risk Factors ◽  
Upper Respiratory ◽  
Secretory Immunoglobulin

Secretory immunoglobulin A (sIgA) is often characterized as a component of the immune systems “first-line of defense” against pathogenic microorganisms, viruses, and bacteria. A lower concentration of sIgA in saliva has been conceptualized as a risk factor for upper respiratory infection in children. Also, individual differences in sIgA levels in response to infection have been identified as potential risk factors. No gender differences in SIgA levels have been reported. sIgA in saliva is not directly related to serum levels of sIgA.

scholarly journals INFLUENCE OF LACTOBACILLUS SPP. ON COLONIZATION AND ANTI-INFECTIOUS RESISTANCE OF THE MUCOUS MEMBRANES OF THE UPPER RESPIRATORY TRACT

2017 ◽  
Author(s):  
S. V. Kalinichenko ◽  
O. O. Korotkykh ◽  
S. I. Pokhil ◽  
M. G. Bakumenko
Keyword(s):  
Staphylococcus Aureus ◽  
Respiratory Tract ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
Upper Respiratory Tract ◽  
Colonization Resistance ◽  
Mucous Membranes ◽  
Upper Respiratory ◽  
Lactobacillus Spp ◽  
Secretory Immunoglobulin

Background. Lactobacilli are very important for the formation of colonization resistance and have pronounced antagonistic effect against a wide range of microorganisms. That is why the lactobacilli have extensive use as a component of classic probiotic agents that are widely used to prevent and treat dysbiotic conditions of digestive and genital systems of people.Objective. The aim of the research was to study the effect of lactobacilli on anti-infectious resistance of mucous membranes of upper respiratory tract.Methods. The colonization degree (lg CFU / g) of nasal mucosal membranes by Lactobacillus spp. and S. aureus was determined in all carriers before the experiment. Also, the level of lysozyme and secretory immunoglobulin A (sIgA) in nasal secretions cavities was identified.Results. It was established a clear dysfunction of anti-infectious resistance in carriers of Staphylococcus aureus - a decrease of colonization resistance and local immunity of mucous membranes of upper respiratory tract. As for the anti-infectious resistance of nasal mucosal of S. aureus carriers, the level of lysozyme and secretory immunoglobulin A gradually increased after the application of probiotic strain L. rhamnosus GG, and in 21 days it reached rates of healthy individuals.Conclusions. It was found out that probiotics for nasal passages sanitation in Staphylococcus aureus carriers lead to gradual eradication of the pathogen (S. aureus) with restoration of colonization and anti-infectious resistance, mucous membranes and upper respiratory tract.

High serum levels of secretory immunoglobulin a (sIgA) in advanced chronic pancreatitis (CP)

1998 ◽  
Vol 114 ◽  
pp. A459
Author(s):  
L. Frulloni ◽  
M. Negri ◽  
M. Zanini ◽  
P. Bovo ◽  
S. Brunelli ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Immunoglobulin A ◽  
Serum Levels ◽  
High Serum ◽  
Secretory Immunoglobulin A ◽  
Secretory Immunoglobulin

Structure of the secretory immunoglobulin A core

Science ◽  
2020 ◽  
Vol 367 (6481) ◽  
pp. 1008-1014 ◽  
Author(s):  
Nikit Kumar ◽  
Christopher P. Arthur ◽  
Claudio Ciferri ◽  
Marissa L. Matsumoto
Keyword(s):  
Immunoglobulin A ◽  
Secretory Component ◽  
Polymeric Immunoglobulin Receptor ◽  
Secretory Immunoglobulin A ◽  
First Line ◽  
Immunoglobulin Receptor ◽  
Host Protection ◽  
Luminal Side ◽  
Mucosal Pathogens ◽  
Secretory Immunoglobulin

Secretory immunoglobulin A (sIgA) represents the immune system’s first line of defense against mucosal pathogens. IgAs are transported across the epithelium, as dimers and higher-order polymers, by the polymeric immunoglobulin receptor (pIgR). Upon reaching the luminal side, sIgAs mediate host protection and pathogen neutralization. In recent years, an increasing amount of attention has been given to IgA as a novel therapeutic antibody. However, despite extensive studies, sIgA structures have remained elusive. Here, we determine the atomic resolution structures of dimeric, tetrameric, and pentameric IgA-Fc linked by the joining chain (JC) and in complex with the secretory component of the pIgR. We suggest a mechanism in which the JC templates IgA oligomerization and imparts asymmetry for pIgR binding and transcytosis. This framework will inform the design of future IgA-based therapeutics.

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