The effect of locally delivered Tualang honey on healing of periodontal tissues during non-surgical periodontal therapy

Honey is a sweet, viscous natural substance made from flower nectar by bees. Honey has been used not only as a nutritional source but also for wound healing and to reduce tissue inflammation. Nevertheless, the use of honey in the treatment of periodontitis is not well established. This study aimed to evaluate the effect of locally delivered Tualang honey on periodontal tissue healing by a randomized controlled split-mouth clinical trial involving 20 chronic periodontitis patients with a periodontal pocket depth of ? 5 mm. Each site was randomly treated either by scaling and root debridement alone (Control Group) or scaling and root debridement with locally delivered Tualang honey (Test Group). Assessment of probing pocket depth (PPD) and clinical attachment level (CAL) was recorded at baseline and after 6 weeks interval. Gingival crevicular fluid samples were collected from treated pockets at baseline and along with periodontal reassessment to evaluate the level of Matrix Metalloproteinase 8 (MMP-8) and Osteoprotegerin (OPG). Data were analysed by using Wilcoxon Signed Rank Test and Paired Sample t-Test. PPD and CAL were significantly improved after the 6 weeks review (P=0.001) in both groups. However, there was no significant difference in the changes of the PPD, CAL, MMP-8 and OPG levels after the 6 weeks review and in between the groups. In conclusion, within the limitations of this study, the effect of locally delivered Tualang honey on periodontal tissue healing is not evident. Nevertheless, all pockets achieved good periodontal healing.

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An Evaluation of the Effect of Therapeutic Ultrasound on Healing of Mandibular Fracture

Craniomaxillofacial Trauma & Reconstruction ◽

10.1055/s-0034-1544104 ◽

2015 ◽

Vol 8 (4) ◽

pp. 299-306 ◽

Cited By ~ 5

Author(s):

Kiran Patel ◽

Sanjeev Kumar ◽

Nishtha Kathiriya ◽

Sonal Madan ◽

Ankit Shah ◽

...

Keyword(s):

Pain Perception ◽

Mandibular Fracture ◽

Periodontal Pocket ◽

Control Group ◽

Mandibular Fractures ◽

Study Group ◽

Pulsed Ultrasound ◽

Pocket Depth ◽

Significant Difference ◽

Experimental Group

The mandible is the most frequently fractured bone in maxillofacial trauma, the treatment of which consists of reduction and fixation of dislocated fragments by open or closed approach. Innovative techniques toward reducing the period of the postoperative intermaxillary fixation (IMF) are being researched. A relatively unknown treatment that may have an effect on fracture healing is ultrasound. Recent clinical trials have shown that low-intensity pulsed ultrasound (LIPUS) has a positive effect on bone healing. The aim of this study was to evaluate the effect of LIPUS on healing by its application in fresh, minimally displaced or undisplaced mandibular fracture in young and healthy individuals. A total of 28 healthy patients were selected randomly from the outpatient department needing treatment of mandibular fractures. They were then randomly allocated to either of the following two groups—experimental group and study group. After IMF, patients in experimental group received pulsed ultrasound signals with frequency of 1 MHz, with temporal and spatial intensity of 1.5 W/cm2, pulsed wave for 5 minutes on every alternate day for 24 days, whereas patients in control group received no therapy except IMF. Radiographic density at the fracture zone was assessed from the radiograph by Emago (Emago, Amsterdam, Netherlands) Image Analysis software before IMF then at 1st to 5th weeks post-IMF. The amount of clinical mobility between fracture fragments was assessed by digital manipulation of fractured fragment with the help of periodontal pocket depth measuring probe in millimeters at pre-IMF and after 3 weeks. Pain was objectively measured using a visual analogue scale at weekly interval. The data collected were subjected to unpaired “ t“ test. The experimental group showed significant improvement in radiographic density compared with control group at 3- and 5-week interval; pain perception was significantly reduced in experimental group compared with study group in the subsequent weeks. No significant difference was found in clinical mobility between fracture fragments at 3-week interval. The present study provides a basis for application of therapeutic controlled ultrasound as an effective treatment modality to accelerate healing of fresh, minimally displaced mandibular fracture.

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Periodontal status and salivary flow rate among diagnostic radiology department workers

Journal of Baghdad College of Dentistry ◽

10.26477/jbcd.v31i3.2694 ◽

2019 ◽

Vol 31 (3) ◽

pp. 17-20

Author(s):

Ghadah N. Alhusaini ◽

Ahlam T Mohammed

Keyword(s):

Flow Rate ◽

Salivary Flow ◽

Salivary Flow Rate ◽

Diagnostic Radiology ◽

Periodontal Pocket ◽

Control Group ◽

Pocket Depth ◽

Clinical Attachment Loss ◽

Periodontal Status ◽

Significant Difference

Background: diagnostic radiology field workers are at elevated risk level for systemic and oral diseases like periodontal diseases. This study was aimed to estimate the periodontal condition and salivary flow rate among diagnostic radiology workers. Material and method: The sample for this study consisted of a study group radiographers (forty subjects) working for 5 years at least and control group consisted of nurses and laboratory workers away from radiation (forty subjects) in Baghdad hospitals. All the 80 subjects aged 30-40 year-old and looking healthy without systemic diseases. Plaque, gingival, periodontal pocket depth and clinical attachment loss indices were used for recording the periodontal conditions. Under standardized conditions, collection of unstimulated salivary samples was done and salivary flow rate was measured. Results: Although not significant statistically (p>0.01), analysis of the present study data showed that plaque and gingival indices were higher among radiographers. While periodontal pocket depth and clinical attachment loss were higher among radiographers than control group with statistically highly significant difference (p<0.01). On the other hand salivary flow rate was lower among radiographers than control group with statistically highly significant difference (p<0.01). Conclusions: Ionizing radiation affects salivary flow rate and this in turn will affect periodontal status.

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Lack of Correlation between Periodontitis and Renal Dysfunction in Systemically Healthy Patients

European Journal of Dentistry ◽

10.1055/s-0039-1698853 ◽

2011 ◽

Vol 05 (01) ◽

pp. 008-018 ◽

Cited By ~ 11

Author(s):

Renata Squariz Brotto ◽

Regina Célia Vendramini ◽

Iguatemy Lourenço Brunetti ◽

Rosemary Adriana Chierici Marcantonio ◽

Adriana Pelegrino Pinho Ramos ◽

...

Keyword(s):

Kidney Function ◽

Test Group ◽

Severity Index ◽

Reference Intervals ◽

Control Group ◽

Pocket Depth ◽

Albumin Creatinine Ratio ◽

Probing Pocket Depth ◽

Severe Periodontitis ◽

Significant Difference

ABSTRACTObjectives: The aim of this study was to assess a suggested association between periodontitis and renal insufficiency by assaying kidney disease markers. Methods: Variables used to diagnose periodontitis were: (i) probing pocket depth (PPD), (ii) attachment loss (AL), (iii) bleeding on probing (BOP), (iv) plaque index (PI) and (v) extent and severity index. Blood and urine were collected from 60 apparently healthy non-smokers (men and women), consisting of a test group of 30 subjects with periodontitis (age 46±6 yrs) and a control group of 30 healthy subjects (age 43±5 yrs). Kidney function markers (urea, creatinine, uric acid and albumin contents) were measured in the serum and urine. Also, the glomerular filtration rate was estimated from creatinine clearance, from the abbreviated Modification of Diet in Renal Disease formula and from the albumin : creatinine ratio in a 24–h sample of urine. Results: It was found that the control group had a greater mean number of teeth than the test group and that the two groups also differed in PPD, AL, BOP and PI, all these variables being higher in the test group (P=0.006). For the extent and severity index of both PPD and AL, the test group had much higher medians of both extent and severity than the control group (P=0.001). With regard to kidney function, none of the markers revealed a significant difference between the control and test groups and all measured values fell within the reference intervals. Conclusions: It is proposed that severe periodontitis is not associated with any alteration in kidney function. (Eur J Dent 2011;5:8-18)

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Identification of Periopathogenes from Dental Plaque in Periodontal Patients with PCR Technique and Their Association with Composite Interleukin-1 Genotype

PRILOZI ◽

10.2478/prilozi-2019-0019 ◽

2019 ◽

Vol 40 (2) ◽

pp. 89-97

Author(s):

Aneta Atanasovska Stojanovska ◽

Saska Todoroska ◽

Mirjana Popovska ◽

Ilijana Muratovska ◽

Linda Zendeli Bedzeti

Keyword(s):

Chronic Periodontitis ◽

Dental Plaque ◽

Bacterial Species ◽

Interleukin 1 ◽

Strong Association ◽

Periodontal Pocket ◽

Control Group ◽

Pocket Depth ◽

Significant Difference ◽

Healthy Control

Abstract Introduction: The present study aimed to assess the presence of main types of microorganisms involved in the aetiopathogenesis of chronic periodontitis with PCR technique and determinates the presence of composite IL-1 genotype and their associations with founded bacteria. Material and method: The examined group was consisted from 20 subjects with diagnosed chronic periodontitis and 20 healthy control without periodontitis. Clinical parameters like gingival index (GI), plaque index (PI), bleeding on probing (BOP), periodontal pocket depth (PPD) and clinical attachment lost (CAL) were determinates. Subgingival dental plaque was collected using a sterilized paper point. We used Parodontose Plus test, reverse hybridization kit, for the detection of periodontal marker bacteria, as well as for the detection of composite Interleukin -1 Genotype Results: The most present bacterial species detected from subgingival dental plaque was Treponema denticola and Porfiromonas gingivalis which was present in 65% of examined patients. In relation to the presence of positive genotype in patients, there was no significant difference between the test and control group for p> 0.05 (p = 1.00). For χ2=8,17 (p=0,06, p<0,05) there is an association between Prevotella intermedia, and composite genotype. Between positive genotype and analyzed bacterial species A. actinomycetem comitans for p> 0.05 (p = 1.00), P. gingivalis for p> 0.05 (p = 0.16), T. Forsythia for p> 0.05 (p = 0.20), T. Denticola for p> 0.05 (p = 0.64) no association was found. Conclusion. This investigations confirmed the strong association of these five examined periopathogenes with periodontitis.

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Adjunctive air-polishing with erythritol in nonsurgical periodontal therapy – a randomized clinical trial

10.21203/rs.3.rs-47863/v1 ◽

2020 ◽

Author(s):

Holger F.R. Jentsch ◽

Christian Flechsig ◽

Benjamin Kette ◽

Sigrun Eick

Keyword(s):

Test Group ◽

Periodontal Therapy ◽

Periodontal Pocket ◽

Clinical Variable ◽

Control Group ◽

Clinical Variables ◽

Air Polishing ◽

Probing Depth ◽

Nonsurgical Periodontal Therapy ◽

Significant Difference

Abstract Background: This study was aimed to investigate if the adjunctive use of erythritol air-polishing powder applied with the nozzle-system during subgingival instrumentation (SI) has an effect on the outcome of non-surgical periodontal treatment in patients with moderate to severe periodontitis. Methods: Fourty-two individuals with periodontitis receiving nonsurgical periodontal therapy by SI without (controls, n=21) and with adjunctive air-polishing using nozzle + erythritol powder (test, n=21) were analyzed for clinical variables, four selected microorganisms and two biomarkers at baseline, before SI as well as three and six months after SI. Statistical analysis included nonparametric tests for intra- and intergroup comparisons. Results: In both groups, the clinical variables probing depth (PD), attachment level and BOP significantly improved three and six months after SI. The number of sites with PD ≥ 5 mm was significantly lower in the test group than in the control group after six months. At six months vs. baseline, there were significant reductions of Tannerella forsythia and Treponema denticola counts as well as lower levels of MMP-8 in the test group but not in the controls. There was no further significant difference of any clinical and non-clinical variable between both groups at three and six months after SI. Conclusions: Subgingival instrumentation with adjunctive erythritol air-polishing powder may add beneficial effects like reducing the probing depth measured as number of residual periodontal pocket with PD ≥ 5 mm when compared with subgingival instrumentation only. Clinical relevanceThe adjunctive use of erythritol air-polishing powder applied with the nozzle-system during SI may improve the clinical outcome of SI. Trial registration: The study was retrospectively registered in the German register of clinical trials, DRKS00015239 on 6th August 2018, https://www.drks.de/drks_web/navigate.do?navigationId =trial.HTML&TRIAL

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The Effects of 6-Month Vitamin D Supplementation during the Non-Surgical Treatment of Periodontitis in Vitamin-D-Deficient Patients: A Randomized Double-Blind Placebo-Controlled Study

Nutrients ◽

10.3390/nu12102940 ◽

2020 ◽

Vol 12 (10) ◽

pp. 2940

Author(s):

Marina Perić ◽

Dominique Maiter ◽

Etienne Cavalier ◽

Jérôme F. Lasserre ◽

Selena Toma

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

Test Group ◽

Controlled Study ◽

Control Group ◽

Controlled Clinical Trial ◽

Pocket Depth ◽

Double Blind ◽

Double Blind Placebo ◽

Significant Difference

Background: This study assessed the effects of weekly vitamin D (VD) supplementation on clinical and biological parameters after scaling and root planning (SRP) in the treatment of periodontitis and served to validate the VD dosage regimen. Methods: It was a monocentric, randomized, double-blind, placebo-controlled clinical trial with 6 months follow-up. Healthy Caucasian periodontitis patients presenting serum 25(OH) vitamin D3 below 30 ng/mL were randomly allocated to test group (SRP + VD 25,000 international units (IU)/week) or the control group (SRP + placebo). Results: A total of 59 patients were screened, 27 were included and 26 completed 3 months (M) and 21 completed 6M control. Test (n = 13) and control groups (n = 14) had similar 25(OH) vitamin D3 levels at baseline (17.6 ± 7.4 vs. 14.4 ± 5.2, respectively). After one month, there was a significant difference between groups (32.9 ± 5.2 vs. 16.1 ± 4.7), also seen at M3 and M6 (t-test, p < 0.001). Periodontal treatment was successful in both groups, since it resulted in a reduction of all measured clinical parameters at M3 and M6 (probing pocket depth (PPD), full mouth bleeding and plaque). However, the reduction in PPD was greater in the test group. Conclusions: In this short-term pilot study, no significant differences were observed between two groups. However, supplementation with VD tended to improve the treatment of periodontitis in patients with initial 25(OH) vitamin D3 < 30 ng/mL and proved safe and efficacious. NCT03162406.

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Early Clinical Effectiveness of ER:Yag Laser in Association with the Red Complex of Bacteria in the Initial Treatment of Moderate Chronic Periodontitis

Acta Medica Bulgarica ◽

10.2478/amb-2014-0005 ◽

2014 ◽

Vol 41 (1) ◽

pp. 37-44 ◽

Cited By ~ 1

Author(s):

Bl. Yaneva ◽

E. Firkova ◽

E. Karaslavova

Keyword(s):

Chronic Periodontitis ◽

Er:Yag Laser ◽

Test Group ◽

Clinical Effectiveness ◽

Periodontal Therapy ◽

Periodontal Pocket ◽

Control Group ◽

Microbiological Analysis ◽

Periodontal Pathogens ◽

Pocket Depth

Summary Chronic periodontitis is a result of polymicrobial infection and its treatment aims removal of dental calculus and biofi lm from the periodontal pocket. Many hand and power-driven instruments are created for this purpose. In recent years, lasers are widely discussed tools for periodontal therapy. The aim of the present study is to evaluate the early microbiological and clinical effectiveness of the Er:YAG laser in the treatment of chronic periodontitis. 30 patients with moderate chronic periodontitis were enrolled in the study. Using a split-mouth design they were treated either with Er:YAG laser (chisel tip, 100 mJ, 15 Hz, 5-6 water spray)-test group or with Gracey curettes- control group. Probing pocket depth (PPD), gingival recession (GR), clinical attachment level (CAL), bleeding on probing and plaque presence were evaluated at baseline and one month after the therapy. Microbiological samples were taken from the deepest four pockets of each quadrant from 20 randomly selected patients (n = 80). They were evaluated using real time PCR for periodontal pathogens from the red complex (Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia). One month after therapy in the control group PPD decreased from 4.59 mm to 3.36 mm, the CAL gain was 1.09 mm and the reduction of bleeding and plaque - from 87.9% to 33.7% and from 75.9% to 40.9%, respectively. In the test group PPD decreased from 4.58 mm to 3.15 mm, the CAL gain was 1.37mm and the reduction of bleeding and plaque was from 85.6% to 25.9% one month after the treatment. The results were statistically significant in favour of the laser group (p < 0.05). Microbiological analysis revealed that the pathogens from the red complex decreased 3 times in the control and 6 times in the test group. Therefore, the Er:YAG laser demonstrate pronounced early effectiveness in chronic periodontitis treatment and would be appropriate alternative of the conventional periodontal therapy.

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The Increase of Periodontal Tissue in Type 2 Diabetes Mellitus Patients Based on Index CPITN

Jurnal Kesehatan Masyarakat ◽

10.15294/kemas.v12i1.5954 ◽

2016 ◽

Vol 12 (1) ◽

Author(s):

Budiman Budiman

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Periodontal Disease ◽

Periodontal Pocket ◽

Control Group ◽

Case Group ◽

Diabetic Patients ◽

Periodontal Tissue ◽

Pocket Depth

The prevalence of periodontal disease in Indonesia for all age groups has reached 96.58%. Periodontal disease has been identified as a consequence of diabetes mellitus (DM). The purpose of this study is to determine the differences of periodontal tissues in type 2 diabetes and non-diabetic patients based on CPITN index (Community periodontal index of Treatment index). This study employed case control design. The population of the study consisted of 3.544 visits in the Internal Disease Polyclinic of RSUD Cimahi Cibabat in January 2015. The samples for case group were 50 people (diabetes mellitus type 2) and control group were 50 people (non-DM). The sampling technique used accidental sampling. The study was conducted in 2015 by conducting measurement of periodontal pocket depth using CPITN index. The analysis of data was carried out with independent T test. The results show that the average pocket depth based on CPITN index in the case group of type 2 DM (4.26) is greater than control group of patients without DM (3.14). There is different condition on the periodontal tissue in the group of type 2 diabetes (value-p = 0.002 <0.05). The awareness in increasing the oral health protection is done by providing consultation related to blood glucose.

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Adjunctive Application of Systemic Antibiotics in Non-surgical Aggressive Periodontitis Treatment: Clinical and Microbiological Findings

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.6855 ◽

2021 ◽

Vol 9 (D) ◽

pp. 149-154

Author(s):

Iva Milinkovic ◽

Iva Mijailovic ◽

Aleksa Markovic ◽

Bojan Janjic ◽

Nadja Nikolic ◽

...

Keyword(s):

Test Group ◽

Aggressive Periodontitis ◽

Periodontal Treatment ◽

Adjunctive Treatment ◽

Control Group ◽

Periodontal Pathogens ◽

Periodontal Tissues ◽

Significant Difference ◽

Systemic Antibiotics

BACKGROUND: Aggressive periodontitis (AgP) is associated with an extensive and rapid destruction of periodontal tissues. Unpredictable treatment outcomes of the disease are consequences of various cross-linked factors. Antimicrobial adjunctive treatment is routinely used as a part of non-surgical periodontal treatment (NSPT) of AgP. AIM: Therefore, the aim of this study was to compare the effects of active periodontal treatment (APT) combined with systemic antibiotics with mechanical debridement alone, in patients with generalized AgP (GAgP). METHODS: Two groups, consisting of 10 participants each, were randomly formed. Both groups were clinically and microbiologically tested and monitored for 3 months. Test group received APT with antimicrobial supplementation (amoxicillin and metronidazole [AMX-MET]). Patients from the control group were treated by APT only. Clinical and microbiological parameters were recorded at baseline and 3 months following the NSPT. Clinical measurements involved probing depth, clinical attachment level, bleeding on probing, and plaque index. Samples of subgingival crevicular fluid were analyzed by qualitative polymerase chain reaction. RESULTS: Significant improvement of all clinical parameters was observed 3 months following the NSPT (p < 0.05), but significant difference between groups was not found (p > 0.05). Periodontal pathogens’ detection between baseline and 3 months follow-up was also not statistically significant in both examined groups (p > 0.05). CONCLUSION: Similarity of results obtained in both treatment groups underlined the key role of APT in the treatment of AgP. The AMX-MET supplementation did not improve clinical and microbiological outcomes, when compared to APT alone. Longer follow-up period, with larger sample, could provide a more comprehensive insight into this issue.

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