scholarly journals VASOMOTOR FUNCTION OF THE ENDOTHELIUM IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERTENSION

2017 ◽  
pp. 70-81
Author(s):  
N. V. Demikhova ◽  
M. A. Vlasenko ◽  
E. Kurshubadze ◽  
V. A. Sukhonos
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Endothelium ◽  
Vascular Tone ◽  
Hypertensive Patients ◽  
Vasomotor Function ◽  
Adaptation Mechanisms ◽  
Normal Character ◽  
Mechanisms Of Development ◽  
Constrictor Response

Investigation of the functional state of the vascular endothelium contributes to the further study of the mechanisms of development and pharmacological correction, particularly in hypertensive patients with chronic kidney disease. Material and Results. The study involved 172 patients with arterial hypertension (AH) in patients with chronic kidney disease. In the study of vascular-motor response to decompression and test with nitroglycerin in 60% of cases occur reduced vasodilatory and in 12.6% constrictor response. Normal character of vasodilation was 27.4%. Endothelium-independent vasodilation in the brachial artery decompression was reduced by 51.1% compared with the control. The growth of endothelium-independent vasoconstriction in the degree III AH was reduced to a lesser degree than the endothelium dependent - by 6.5% and 19.4% (p<0.01), respectively. Conclusion. Thus impaired endothelium-mediated autoregulation of vascular tone in hypertensive patients with chronic kidney disease is an important element in the pathogenesis of high blood pressure as one of major adaptation mechanisms.

scholarly journals Does angiotensin-converting enzyme-1 (ACE-1) gene polymorphism lead to chronic kidney disease among hypertensive patients?

Renal Failure ◽  
2016 ◽  
Vol 38 (5) ◽  
pp. 765-769 ◽  
Author(s):  
Taposh Sarkar ◽  
Narinder Pal Singh ◽  
Premashish Kar ◽  
Syed Akhtar Husain ◽  
Seema Kapoor ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Hypertensive Patients

The Relationship Between Blood Pressure Variability And Renal Progression In Hypertensive Patients With Chronic Kidney Disease

2021 ◽  
Vol 6 (14) ◽  
pp. 80-88
Author(s):  
Huseyin Duru ◽  
Ekrem KARA
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Pressure Measurement ◽  
Rapid Progression ◽  
Night Time ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
Renal Progression

Objective: To evaluate the effect of 24 hour systolic blood pressure (SBP) and diastolic blood pressure (DBP) variability (BPV) on renal progression in hypertensive patients with chronic kidney disease (CKD) Methods: A total 59 hypertensive patients (mean age: 54.2±14.6 years, 50.8% male) with CKD who underwent 24 hours ambulatory blood pressure measurement (ABPM) were included. Data on SBP, DBP, BPV coefficients (VC) for SBP (SBP-CV) and DBP (DBP-CV) were recorded. A decrease in e-GFR of <5 ml/min/year was considered as normal renal progression and a decrease in ≥5 ml/min/year was considered as rapid renal progression. Results: Overall, 40.6% of the patients had uncontrolled HT, while 45.8% had non-dipper pattern. Mean±SD daytime and night-time SBP and SBP-VC values were 135.3±17.9 mmHg, 128.6±23.0 mmHg, 11.7±2.8 and 9.5±3.6, respectively. Mean±SD daytime and nigh-time DBP and DBP-VC values were 84.5±13.4 mmHg, 77.2±16.1 mmHg, 13.8±3.8 and 12.0±3.7, respectively. Rapid renal progression was detected in 25.4% of patients with no significant difference in daytime, night-time and total SBP, SBP-VC, DBP and DBP-VC values between patients with rapid vs. natural renal progression. The regression analysis adjusted for age, gender, presence of DM, baseline e-GFR and dipping status revealed no significant impact of SBP-VC and DBP-VC in predicting rapid progression (p> 0.05). Conclusion: In conclusion, our finding revealed no significant association between BPV and renal progression in hypertensive patients with CKD. Larger scale prospective, randomized controlled trials with longer follow-up are needed to clarify this issue.

scholarly journals Non-linear progression of chronic kidney disease and associated factors in hypertensive patients: a 4-year cohort study

2020 ◽  
Author(s):  
Luciana Saraiva da Silva ◽  
Tiago Ricardo Moreira ◽  
Rodrigo Gomes da Silva ◽  
Rosângela Minardi Mitre Cotta
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Associated Factors ◽  
Multivariate Analyses ◽  
Multivariate Logistic Regression ◽  
Ckd Progression ◽  
Hypertensive Patients ◽  
Explanatory Variables ◽  
Non Linear

Abstract Background Recent studies suggest that the progression of chronic kidney disease (CKD) is not linear, but we do not have clear evidence on this issue, especially in hypertensive patients. We sought to evaluate the progression of CKD and associated factors over four years in a cohort of hypertensive patients. Methods We conducted a prospective cohort study during the years 2012 and 2016, with hypertensive patients diagnosed with CKD (n = 113). The progression of CKD was assessed through the evolution of the glomerular filtration rate (GFR) and the change in the stage of CKD between 2012 and 2016. Sociodemographic, economic, lifestyle, clinical, anthropometric, and biochemical variables were evaluated. The strength of the association between CKD progression and explanatory variables was assessed by odds ratio (OR) and their respective 95% confidence intervals using univariate and multivariate logistic regression. Results Regarding progression, 78.1% of the CKD patients did not progress over four years. When assessing the CKD trajectory (2012–2016) through the evolution of GFR, there was a mean reduction of 1.3 mL/min/1.73m² in four years. In the group that progressed, there was a reduction of 13 mL/min/1.73m², while in the group that did not progress, there was an increase of 2 mL/min/1.73m². In the multivariate analyses, age (p = 0.047), diabetes mellitus (DM) (p = 0.042), and urea (p = 0.050) were independently associated with CKD progression. Conclusions The findings of the present study showed a non-linear progression of CKD over the four years, contrary to what is traditionally expected. Age, DM and urea were independently associated with CKD progression.

scholarly journals The Vascular Endothelium in Chronic Kidney Disease

2016 ◽  
Vol 44 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Christopher R. Martens ◽  
Danielle L. Kirkman ◽  
David G. Edwards
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Endothelium
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