Is There an Association between the RENAL and PADUA Nephrometry Scores and the Trifecta and Pentafecta Achievement?

Background: RENAL and PADUA scoring systems have been designed and validated as a method to assess the complexity of renal masses and predict the risk of perioperative complications. We aimed to evaluate if there is an association between RENAL and PADUA nephrometry scores with the Trifecta and Pentafecta achievement. Materials and Methods: We retrospectively analysed the data from 102 patients with renal cell carcinoma who underwent partial nephrectomy from January 2011 to October 2018 at our institution. Radiological characteristics of the renal masses were scored according to the RENAL and PADUA classification. Trifecta and Pentafecta achievement were collected. We performed a descriptive analysis and used de χ2 test to evaluate the relationship between PADUA and RENAL scores and Trifecta and Pentafecta achievement. Result: Among 102 patients, the median tumor size was 2.7 cm (IQR 0.8-7.5), the median RENAL score was 7 (IQR 4-11) and PADUA score 8 (IQR 6-14). The overall rate of postoperative complications was 21.6% (n=22). The rates of Trifecta and Pentafecta achievement were 50% (n=51/102) and 46.1% (n=47/102), respectively. Trifecta and Pentafecta achievement were higher when the PADUA score was ≤10 (OR 3.62; IC95% (1.08-12.11); p=0.0317) and (OR 4.98; IC95% (1.32-18.7); p=0.0175), respectively. Likewise, Trifecta and Pentafecta achievement were higher in patients with RENAL score ≤ 8 (OR 4.09; IC95% (1.46-11.42); p=0.0072) and (OR 4.92; IC95% (1.66-14.51); p=0.0039), respectively. Conclusion: There is an association between the RENAL and PADUA nephrometry scores and the Trifecta and Pentafecta achievement.

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Tumor Size Predicts Synchronous Metastatic Renal Cell Carcinoma: Implications for Surveillance of Small Renal Masses

The Journal of Urology ◽

10.1016/j.juro.2007.01.029 ◽

2007 ◽

Vol 177 (5) ◽

pp. 1692-1697 ◽

Cited By ~ 76

Author(s):

David A. Kunkle ◽

Paul L. Crispen ◽

Tianyu Li ◽

Robert G. Uzzo

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Tumor Size ◽

Renal Cell ◽

Small Renal Masses ◽

Renal Masses

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506 LOW INCIDENCE OF BENIGN PATHOLOGIC LESIONS AT NEPHRECTOMY FOR RENAL MASSES PRESUMED TO BE STAGE T1N0M0 RENAL CELL CARCINOMA IN JAPANESE PATIENTS: INFLUENCE OF SEX, AGE AND TUMOR SIZE

The Journal of Urology ◽

10.1016/j.juro.2010.02.582 ◽

2010 ◽

Vol 183 (4S) ◽

Cited By ~ 1

Author(s):

Yasuhisa Fujii ◽

Yasumasa Iimura ◽

Yoshinobu Komai ◽

Kazutaka Saito ◽

Yosuke Yasuda ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Tumor Size ◽

Renal Cell ◽

Japanese Patients ◽

Renal Masses ◽

Pathologic Lesions ◽

Low Incidence

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Incidence of benign pathologic lesions at nephrectomy for renal masses presumed to be stage I renal cell carcinoma in Japanese patients: Impact of sex, age, and tumor size.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.7_suppl.374 ◽

2011 ◽

Vol 29 (7_suppl) ◽

pp. 374-374 ◽

Cited By ~ 1

Author(s):

Y. Fujii ◽

K. Saito ◽

Y. Iimura ◽

Y. Yasuda ◽

F. Koga ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Tumor Size ◽

Renal Cell ◽

Clinical Stage ◽

Japanese Patients ◽

Stage I ◽

Benign Lesions ◽

Renal Masses ◽

Pathologic Findings

374 Background: The widespread use of modern imaging techniques has resulted in the increased detection of small, asymptomatic renal tumors. Some recent studies from Western countries have reported that the incidence of benign lesions is approximately 15% in patients undergoing definitive surgery for renal masses presumed to be clinical stage I renal cell carcinoma (RCC). The high level of noncancerous lesions is, to some extent, due to the fact that no imaging feature can accurately distinguish either oncocytoma or lipid-poor angiomyolipma (AML) from RCC. This study attempts to determine the incidence of benign pathologic findings for such renal masses in Asian patients. Methods: Between 1991 and 2009, 711 consecutive patients (218 women and 493 men) underwent partial (n=206) or radical (n=505) nephrectomy for renal masses presumed to be stage T1N0M0 (T1a/T1b= 503/208) sporadic RCC on preoperative imaging in two Japanese centers. The mean size of the lesions was 3.3 cm (range 0.3-7.0). The pathologic features were reviewed by an experienced pathologist. Results: Of the 711 masses, 53 (7.5%) revealed benign pathologic findings. Twenty-two (3.1%) were AMLs, 13 (1.8%) were oncocytomas, 8 (1.1%) were complicated cysts, and 10 were others. Twenty-eight (12.8%) of the 218 females and 25 (5.1%) of the 493 males had benign lesions (p=0.0005). Of the 357 patients aged 60 years or younger, 37 (10.4%) had benign lesions while only 16 (4.5%) of the 354 patients over 60 years did (p=0.024). Forty six (9.2%) of the 503 T1a and 7 (3.4%) of the 203 T1b masses were benign (p=0.0071). A multivariate logistic regression model showed that sex, age and tumor size were all independently predictive of benign histology, particularly of AML. Conclusions: The present incidence (7.5%) of benign lesions in presumed clinical stage T1N0M0 RCC masses at nephrectomy was lower than the incidence of approximately 15% previously reported from Western countries, probably because of the low incidence of oncocytomas in Japanese patients. Female gender, young age and small tumor size are all independently predictive of benign lesions, particularly of AML in Japanese patients. No significant financial relationships to disclose.

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688 NOMOGRAM TO PREDICT MINIMAL-FAT ANGIOMYOLIPOMA AT NEPHRECTOMY FOR RENAL MASSES PRESUMED TO BE STAGE 1 RENAL CELL CARCINOMA: IMPACT OF SEX, AGE, AND TUMOR SIZE

The Journal of Urology ◽

10.1016/j.juro.2011.02.1655 ◽

2011 ◽

Vol 185 (4S) ◽

Author(s):

Yasuhisa Fujii ◽

Mizuaki Sakura ◽

Kazutaka Saito ◽

Yasumasa Iimura ◽

Yosuke Yasuda ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Tumor Size ◽

Renal Cell ◽

Renal Masses ◽

Stage 1 ◽

Minimal Fat

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Histologic Heterogeneity of Extirpated Renal Cell Carcinoma Specimens: Implications for Renal Mass Biopsy

Journal of Kidney Cancer and VHL ◽

10.15586/jkcvhl.v7i3.134 ◽

2020 ◽

Vol 7 (3) ◽

pp. 20-25

Author(s):

Lauren Nahouraii ◽

Jordan Allen ◽

Suzanne Merrill ◽

Erik Lehman ◽

Matthew Kaag ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Renal Mass ◽

Tumor Stage ◽

High Grade ◽

Renal Masses ◽

Histologic Heterogeneity ◽

Adequate Sampling ◽

Renal Mass Biopsy

Pathologic characteristics of extirpated renal cell carcinoma (RCC) specimens <7 cm were reviewed to get better information on technical nuances of renal mass biopsy (RMB). Specimens were stratified according to tumor stage, nuclear grade, size, histology, presence of lymphovas-cular invasion (LVI), necrosis, and sarcomatoid features. When considering pT1 (0–7 cm) tumors pT1b (4–7 cm), RCC masses were more likely to have necrosis (43% vs 16%, P < 0.001), LVI (6% vs 2%, P = 0.024), high-grade nuclear elements (29% vs 17%, P < 0.001), and sarcomatoid features (2% vs 0%, P = 0.006) compared with pT1a (0–4 cm) tumors. Additionally, pT3a tumors were more highly associated with necrosis (P = 0.005), LVI, sarcomatoid features, and high-grade disease (P for all < 0.001) when compared to pT1 masses. For masses <4 cm, pT3a cancers were more likely to demonstrate necrosis (38% vs 16%, P < 0.001), LVI (10% vs 2%, P = 0.037), high-grade nuclear elements (31% vs 17%, P = 0.05), and sarcomatoid features (3% vs 0%, P = 0.065) compared to pT1a tumors. Similarly, for masses 4–7 cm, pathologic T3a tumors were significantly more likely to have sarcomatoid features (16% vs 2%, P < 0.001) and LVI (28% vs 6%, P < 0.001) compared to pT1b tumors. In summary, pT3a tumors and those RCC masses >4 cm exhibit considerable histologic heterogeneity and may harbor elements that are not easily appreciated with limited renal sampling. Therefore, if RMB is considered for renal masses greater than 4 cm or those that abut sinus fat, a multi-quadrant biopsy approach is necessary to ensure adequate sampling and characterization of the mass.

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Two Cases of Sporadic Eosinophilic Solid and Cystic Renal Cell Carcinoma in Manitoba Population

International Journal of Surgical Pathology ◽

10.1177/1066896921993229 ◽

2021 ◽

pp. 106689692199322

Author(s):

Seyed Mohammad Mohaghegh Poor ◽

Shivani Mathur ◽

Karl Kassier ◽

Janetta Rossouw ◽

Robert Wightman ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Preoperative Imaging ◽

Renal Neoplasm ◽

Renal Masses ◽

Cystic Renal Cell Carcinoma ◽

Eosinophilic Cytoplasm ◽

Clear Cell Rcc

Two sporadic cases of eosinophilic solid and cystic renal cell carcinoma (ESC RCC), at our institution, are presented in this study to contribute to the growing literature on this novel renal neoplasm. The first patient was a 38-year-old female with two synchronous renal masses measuring 3.5 and 1.9 cm on preoperative imaging. The second patient was a 44-year-old female with an incidental renal mass measuring 4 cm. Both patients underwent uncomplicated radical nephrectomies. The 1.9 cm mass in the first patient was consistent with clear cell RCC. The dominant mass in the first patient and the tumor in the second patient had microscopic and macroscopic findings in keeping with ESC RCC including a tan appearance, abundant eosinophilic cytoplasm, and CK20+ and CK7− staining. Both patients had an uncomplicated course following surgery with no evidence of local recurrence or distant metastatic disease for 1 and 2 years for the first and second patient accordingly. These cases contribute to a growing body of literature regarding ESC RCC including, to our knowledge, the first reported case of synchronous ESC RCC and clear cell RCC. Further research about this novel renal neoplasm is needed.

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Genome-Wide Transcriptomic Analysis of Non-Tumorigenic Tissues Reveals Aging-Related Prognostic Markers and Drug Targets in Renal Cell Carcinoma

Cancers ◽

10.3390/cancers13123045 ◽

2021 ◽

Vol 13 (12) ◽

pp. 3045

Author(s):

Euiyoung Oh ◽

Jun-Hyeong Kim ◽

JungIn Um ◽

Da-Woon Jung ◽

Darren R. Williams ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cancer Patient ◽

Immune Cells ◽

Renal Cell ◽

Prognostic Markers ◽

Patient Survival ◽

Survival Outcome ◽

Normal Tissues ◽

Genome Wide ◽

The Relationship

The relationship between expression of aging-related genes in normal tissues and cancer patient survival has not been assessed. We developed a genome-wide transcriptomic analysis approach for normal tissues adjacent to the tumor to identify aging-related transcripts associated with survival outcome, and applied it to 12 cancer types. As a result, five aging-related genes (DUSP22, MAPK14, MAPKAPK3, STAT1, and VCP) in normal tissues were found to be significantly associated with a worse survival outcome in patients with renal cell carcinoma (RCC). This computational approach was investigated using nontumorigenic immune cells purified from young and aged mice. Aged immune cells showed upregulated expression of all five aging-related genes and promoted RCC invasion compared to young immune cells. Further studies revealed DUSP22 as a regulator and druggable target of metastasis. DUSP22 gene knockdown reduced RCC invasion and the small molecule inhibitor BML-260 prevented RCC dissemination in a tumor/immune cell xenograft model. Overall, these results demonstrate that deciphering the relationship between aging-related gene expression in normal tissues and cancer patient survival can provide new prognostic markers, regulators of tumorigenesis and novel targets for drug development.

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