Study of Quality of Life in Subjects With Chronic or High-frequency Episodic Migraine and Associated Comorbidities Treated With Erenumab

2019 ◽  
Author(s):  
Keyword(s):  
Quality Of Life ◽  
High Frequency ◽  
Episodic Migraine

Disability, burden, and symptoms related to sensitization in migraine patients associate with headache frequency

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Stefano Di Antonio ◽  
Matteo Castaldo ◽  
Marta Ponzano ◽  
Francesca Bovis ◽  
Paola Torelli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Migraine ◽  
High Frequency ◽  
Low Frequency ◽  
Episodic Migraine ◽  
Headache Frequency ◽  
Headache Attack ◽  
Burden Of Headache ◽  
The Difference

Abstract Objectives This observational study aimed to assess the difference in disability, burden, and sensitization between migraine patients with low-frequency headache attack (1–8 headache days/month), high-frequency headache attack (9–14 headache days/months), and patients with chronic migraine (>14 headache days/months). Methods Migraine patients with or without aura were divided into three groups according to headache frequency (low-frequency episodic migraine; high-frequency episodic migraine; chronic migraine). Questionnaires were used to assess the burden of headache, quality of life, phycological burden, and symptoms related to sensitization (estimated by the Central Sensitization Inventory). Differences among migraine groups were assessed using Chi-Quadro test, ANOVA, or Kruskal–Wallis as appropriate. Results 136 patients were included (68 low-frequency episodic migraine, 45 high-frequency episodic migraine, 23 chronic migraine). Patients with high frequency episodic migraine and chronic migraine differed from patients with low frequency episodic migraine showing a worse burden of headache (p=0.002; p=0.002), worse level of physical (p=0.001; p<0.001) and mental (p=0.002; p=0.001) quality of life, worse level of depression (p=0.008; p=0.003), and increase presence of symptoms related to sensitization (p<0.001; p=0.003). No differences were found in any variables between patients with high-frequency episodic migraine and patients with chronic migraine (p>0.05). Conclusions Patients with high-frequency episodic migraine and chronic migraine could be considered in the same segment of the migraine population, with similar degrees of disability and sensitization related symptoms.

scholarly journals Health-related quality of life in tension-type headache: a population-based study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sait Ashina ◽  
Dawn C. Buse ◽  
Jakob B. Bjorner ◽  
Lars Bendtsen ◽  
Ann C. Lyngberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Episodic Migraine ◽  
Tension Type Headache ◽  
Eysenck Personality Questionnaire ◽  
Health Related Quality ◽  
Self Rated Health ◽  
Related Quality ◽  
Health Related ◽  
Type Headache

Abstract Objectives Tension-type headache (TTH) is the most prevalent primary headache disorder. We assessed the cross-sectional impact of TTH on health related quality of life (HRQoL) in a general population. We also examined the association of HRQoL scores with headache frequency, disability, medication overuse, poor self-rated health, psychiatric comorbidity, and pain sensitivity in individuals with TTH. Methods A sample of 547 subjects completed a headache diagnostic interview, the SF-12 to calculate physical (PCS) and mental (MCS) health component scores, depression (major depression inventory [MDI]) and neuroticism (Eysenck Personality Questionnaire) measures. We defined the following headache diagnosis categories: pure TTH, pure migraine, and coexistent headache (TTH + migraine). Cases were further classified into chronic (≥15) or episodic (<15 headache days/month). Results Using generalized linear models (GLM) adjusted for age, sex and education, both PCS-12 and MCS-12 scores varied in groups distinguished by migraine and TTH status; scores were lower for individuals with coexistent headache (TTH + migraine; n=83), followed by pure TTH (n=97) and pure migraine (n=43) compared to the no headache group (n=324) (p≤0.001). In analyses considering chronicity, PCS-12 scores were lower in chronic coexistent headache followed by pure chronic TTH (CTTH), episodic migraine +/− episodic TTH (ETTH) and pure ETTH than in the no headache group (p≤0.001). MCS-12 scores were lower in pure CTTH, followed by chronic coexistent headache, episodic migraine +/− ETTH and pure ETTH compared to the no headache group (p≤0.001). Multiple regression models showed that in TTH, lower PCS-12 scores were associated with age (p=0.04), female sex (p=0.02), and poor self-rated health (p≤0.001). Lower MCS-12 scores in TTH were associated with depression (p≤0.001). Conclusions In a population sample, TTH, and to higher degree CTTH, are associated with decreased HRQoL.

Mind–body interactive qigong improves physical and mental aspects of quality of life in inpatients with stroke: A randomized control study

2019 ◽  
Vol 18 (8) ◽  
pp. 658-666 ◽  
Author(s):  
Ching-Hsiang Chen ◽  
Kuo-Sheng Hung ◽  
Yu-Chu Chung ◽  
Mei-Ling Yeh
Keyword(s):  
Quality Of Life ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
Standard Care ◽  
Low Frequency ◽  
Control Group ◽  
Subacute Stroke ◽  
Interactive Exercise

Background: Stroke, a medical condition that causes physical disability and mental health problems, impacts negatively on quality of life. Post-stroke rehabilitation is critical to restoring quality of life in these patients. Objectives: This study was designed to evaluate the effect of a mind–body interactive qigong intervention on the physical and mental aspects of quality of life, considering bio-physiological and mental covariates in subacute stroke inpatients. Methods: A randomized controlled trial with repeated measures design was used. A total of 68 participants were recruited from the medical and rehabilitation wards at a teaching hospital in northern Taiwan and then randomly assigned either to the Chan-Chuang qigong group, which received standard care plus a 10-day mind–body interactive exercise program, or to the control group, which received standard care only. Data were collected using the National Institutes of Health Stroke Scale, Hospital Anxiety and Depression Scale, Short Form-12, stroke-related neurologic deficit, muscular strength, heart rate variability and fatigue at three time points: pre-intervention, halfway through the intervention (day 5) and on the final day of the intervention (day 10). Results: The results of the mixed-effect model analysis showed that the qigong group had a significantly higher quality of life score at day 10 ( p<0.05) than the control group. Among the covariates, neurologic deficit ( p=0.04), muscle strength ( p=0.04), low frequency to high frequency ratio ( p=0.02) and anxiety ( p=0.04) were significantly associated with changes in quality of life. Conversely, heart rate, heart rate variability (standard deviation of normal-to-normal intervals, low frequency and high frequency), fatigue and depression were not significantly associated with change in quality of life ( p >0.05). Conclusions: This study supports the potential benefits of a 10-day mind–body interactive exercise (Chan-Chuang qigong) program for subacute stroke inpatients and provides information that may be useful in planning adjunctive rehabilitative care for stroke inpatients.

scholarly journals P174 High frequency of fatigue and sleep alterations impact on the quality of life in Mexican patients with inflammatory bowel disease

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S224-S225
Author(s):  
J K Yamamoto-Furusho ◽  
N N Parra-Holguin ◽  
A Fresán-Orellana
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Disease ◽  
Sleep Quality ◽  
Bowel Disease ◽  
High Frequency ◽  
Sleep Disturbances ◽  
Medical Attention ◽  
Severe Fatigue ◽  
Inflammatory Bowel

Abstract Background Inflammatory bowel disease (IBD) refers to ulcerative colitis (UC) and Crohn’s disease (CD). All patients with chronic diseases can have serious effects on their sleep quality and high levels of fatigue, which directly affect the quality of life of patients with IBD. It has been reported that up to 44% of patients have alterations in sleep quality and up to 72% have symptoms of fatigue The aim of the present study is the validation of the Fatigue Scale in IBD (IBD-F) in Mexican patients and to evaluate the quality of sleep and fatigue in IBD patients according to their quality of life. Methods This is a cross-sectional study which included 98 patients aged 18 to 65 years with diagnosis of IBD, during the period from March to June 2019; three evaluation instruments will be applied to them: IBD-F, Pittsburgh Sleep Quality Index (PSQI) and Quality of life in patients with IBD (IBDQ-32). The clinical variables and demographics were collected through the review of clinical records. All analyses were performed with version 22.0 of the SPSS statistical program and the level of statistical significance was set at p &lt; 0.05. Results A total of 98 patients were included in the study, 58.2% were female with an average age of 44.9 years (S.D.= 12.1, range 19–64 years). The clinical remission of IBD was 79.6%, the predominant extension in UC was pancolitis in 74.4% followed by left colitis in 12.8% (n = 11) and proctosigmoiditis in 12.8% (n = 11). For CD, the most frequent location was ileocolonic in 75%, ileal in 16.7% and colonic in 8.3%. The stricturing phenotype occurred in 75%, inflammatory in 16.7% and fistulizing in 8.3%. The clinical activity of the disease presented in 21.4% (n = 21) patients and 78.6% (n = 77) patients were in remission. Severe fatigue occurred in 28.6% (n = 28) patients, mild-moderate fatigue in 60.2%(n = 59) and 11.2% (n = 11) with no fatigue. Sleep disturbances requiring medical attention and treatment were presented in 52.1% (n = 51) patients, alterations requiring medical attention in 18.4% (n = 18) patients and 29.6% (n = 29) patients with no sleep disturbances. Patients with severe fatigue showed greater alterations in the quality of life on three dimensions of digestive (p &lt; 0.001), systemic (p &lt; 0.05) and emotional symptoms (p &lt; 0.05). Patients with sleep quality alterations also affected globally the four dimensions of quality of life. Conclusion This study demonstrates a high frequency of fatigue and sleep quality alterations that impact in the decrease of the quality of life in IBD patients

scholarly journals Severity of depressive symptoms as predictor of impairment of quality of life in chronic migraine: Comparison with episodic migraine

2008 ◽  
Vol 62 (6) ◽  
pp. 738-740 ◽  
Author(s):  
Leonides Canuet ◽  
Ryouhei Ishii ◽  
Otman Fernandez-Concepcion ◽  
Masao Iwase ◽  
Masatoshi Takeda
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
Chronic Migraine ◽  
Episodic Migraine

scholarly journals Long-Term Followup of Patients with Active J-Reservoirs after Restorative Proctocolectomy for Ulcerative Colitis with regard to Reservoir Function, Mucosal Changes, and Quality of Life

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Ola Røkke ◽  
Knut Iversen ◽  
Torill Olsen ◽  
Sølvi-May Ristesund ◽  
Geir Egil Eide ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Restorative Proctocolectomy ◽  
High Frequency ◽  
Functional Results ◽  
Favourable Result ◽  
Life Questionnaire ◽  
Calprotectin Level ◽  
Mucosal Changes

Objective. Study the functional results and mucosal changes in the ileal pouch after restorative proctocolectomy with J-reservoir for ulcerative colitis. Material and Methods. Followup study of 125 patients with J-reservoir with one disease-specific- and one general (SF-36) quality of life-questionnaire, rectoscopy with biopsies, and stool samples to evaluate inflammation, dysplasia, presence of Helicobacter pylori and calprotectin level. Results. Fourteen J-reservoirs were removed or deactivated, leaving 111 patients for followup. The followup time was 6.8 (1–15) years. 87.4% of the patients were satisfied. 93.1% had some kind of functional restriction: food- (75.5%), social- (28.9%), physical- (37%) or sexual restriction (15.3%). 18.6% had often or sometimes faecal incontinence. Low daytime faecal frequency was associated with good quality of life. 13 patients (12.6%) had a less favourable result. There was no pouch-dysplasia. Calprotectin levels were increased in patients with visible pouch inflammation or history of pouchitis. HP was diagnosed by RUT in 42.3%, but was not associated with inflammation or pouchitis. Conclusions. Most patients were satisfied with the J-reservoir in spite of a high frequency of various restrictions. 12.6% (13 patients) had a less favourable functional result, partly due to a high frequency of defecations, pain, pouchitis and inflammation.

scholarly journals Beneficial Effects of Kiatsu™ with Ki Training on Episodic Migraine: A Single Arm, Pilot, Exploratory Study

2021 ◽  
Author(s):  
Calvin Y Tabata ◽  
Philip Coppenhaver ◽  
Shirley McCartney ◽  
Saman Vazinkhoo ◽  
Terry Copperman
Keyword(s):  
Quality Of Life ◽  
Exploratory Study ◽  
Treatment Options ◽  
Episodic Migraine ◽  
Effective Treatment Option ◽  
Beneficial Effects ◽  
Migraine Frequency ◽  
Initial Session ◽  
Potential Alternative

Abstract BackgroundCurrent therapies for migraine have proven partially effective, highlighting the need for alternative treatment options. In this report, the authors conducted a single arm pilot exploratory study to evaluate the effect of Kiatsu with Ki training in adult females with episodic migraine.MethodsStudy subjects established a baseline migraine frequency over 4 weeks. During the following 4 weeks, each subject received instruction in Ki training (to improve concentration, balance, and relaxation), accompanied by Kiatsu (a focused touch method that reduces tension, swelling, and pain). Subjects then participated in one session a month for an additional 6 months. The initial session was 1 hour; subsequent sessions averaged 30 minutes. Subjects documented migraine frequency, migraine-specific quality of life scores, and medication use.ResultSixty-nine subjects met the study inclusion criteria and 21 completed the study. Subjects reported a significant reduction in migraine frequency after 1 month (from 7.2 to 3.8 migraines/month; p < 0.05), with an overall 53% reduction at 8 months (p < 0.001). Significant improvements in quality of life (QoL) were reported after 1 month, with continued improvements until study completion (p < 0.0001). A moderate reduction in medication use was also documented (p < 0.03), corresponding with improved QoL scores.ConclusionKiatsu with Ki training may be an effective treatment option for females with migraines, either in combination with medications or as a potential alternative to medications for patients who do not benefit from conventional therapies.

The clinical and public health implications and risks of widening the definition of chronic migraine

Cephalalgia ◽  
2019 ◽  
Vol 40 (4) ◽  
pp. 407-410 ◽  
Author(s):  
Martina Guglielmetti ◽  
Alberto Raggi ◽  
Raffaele Ornello ◽  
Simona Sacco ◽  
Domenico D’Amico ◽  
...  
Keyword(s):  
Public Health ◽  
Chronic Migraine ◽  
High Frequency ◽  
Episodic Migraine ◽  
Headache Frequency ◽  
Allocation Of Resources ◽  
Independent Entity ◽  
Definition Of ◽  
The Impact

Background The definition of chronic migraine has long been debated. Recently, it was suggested to define subjects with at least 8/migraine days as chronic migraine; that is, incorporating so-called high frequency episodic migraine (eight or more migraine days but less than 15 headache days per month). Methods We addressed the possible problems that might arise based on this proposal accounting for clinical, pathophysiological, impact and public health aspects. Results and conclusions Defining chronic migraine on the basis of headache frequency alone does not account for clinical and pathophysiological aspects, as well as for the impact of chronic migraine in terms of disability and quality of life. Moreover, it is potentially harmful for patients in terms of allocation of resources. These issues are discussed in the present manuscript, and we support the idea of defining high frequency episodic migraine as an independent entity as a viable path to follow.

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