704 Background: APACT did not meet the primary endpoint of independently assessed disease-free survival (DFS) with nab-P + G vs G; overall survival showed a nominal improvement. Here, we report recurrence patterns by resection status. Methods: A total of 866 treatment-naive patients (pts) with histologically confirmed pancreatic cancer, R0/R1 resection, CA19-9 < 100 U/mL, and ECOG PS ≤ 1 received 6 cycles of nab-P + G or G on days 1, 8, and 15 Q28 days. Stratification: resection (R0/R1); lymph node status (LN+/−); geographic region. Disease recurrence was per investigator review of CT/MRI scans. Results: Of 571 (66%) pts with investigator-assessed DFS events (median follow up, 35.4 mo), 543 had radiographic progression with 764 recurrent lesions (≥ 20 events: liver, 271; unspecified abdominal organ, 152; lung, 130; surgical bed, 70; mesenteric nodes, 54). Most pts (73%) had only abdominal, 61% had only distant, and 10% had only local recurrence (Table). Although more pts with R1 vs R0 status had recurrence (72% vs 60%), patterns were generally similar, and local recurrence was similarly low. Conclusions: Most recurrences in APACT were distant and in abdomen (liver). Recurrence patterns were generally similar in pts with R0 and R1 status, with low rates of local recurrence. These data may help make more informed pt management decisions. Additional data on patterns by baseline characteristics will be presented. Clinical trial information: NCT01964430 . [Table: see text]