scholarly journals The Effects of Depression in Multiple Sclerosis Patients on Their Attitude to the Disease

Doctor Ru ◽  
2020 ◽  
Vol 19 (9) ◽  
pp. 71-76
Author(s):  
N.V. Zarubina ◽  
◽  
N.N. Spirin ◽  
M.A. Bykanova ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Social Adjustment ◽  
Personality Assessment ◽  
Depressive Disorders ◽  
Assessment Tools ◽  
Assessment Scale ◽  
Study Results ◽  
Multiple Sclerosis Patients

Study Objective: To study the types of attitude to their disease in multiple sclerosis (MS) patients and the effects of depressive disorders on the internal picture of the disease. Study Design: This was a comparative prospective study. Materials and Methods: One hundred and twenty-nine patients with clinically verified MS, aged 15 to 61, participated in the study. They were divided into two groups: those who had MS without depression (n = 56) and those who had both MS and depression (n = 73). The study tools included the А. Beck Depression Inventory; a depression self-assessment scale developed at the V.M. Bekhterev Research Institute; the Khanin modification of the Spielberger State-Trait Anxiety Inventory, intended to assess personality-related and reactive anxiety; the Asthenia Assessment Scale developed by L.D. Malkova; and the “Mini-Mult” and “Attitude to Disease” personality assessment tools. Study Results: The study revealed that more than half of the MS patients had depression. The severity of their depressive disorders was consistent with a moderate depressive episode. Personality assessment of the MS patients with depression showed that women had high scores on the scales for depression and hysteria and moderate scores on the scales for paranoia and schizoid tendencies and males had high scores on the scales for psychopathy, paranoia, and psychasthenia. In the group of MS patients without depression, there were no statistically significant differences in scale scores between men and women. The MS patients without depression more often demonstrated ergopathic (р = 0.0006), anosognosic (p = 0.00003), or balanced (p = 0.01) attitudes to the disease, with a focus on maintaining their occupational status and continuing an active life, while the MS patients with depression exhibited attitudes related to particular personality traits, with signs of a disturbed social maladjustment and advantage by illness. Men with both MS and depression more often had neurasthenic and hypochondriacal attitudes and women with both MS and depression more frequently have sensitive, egocentric, paranoid or dysphoric attitudes to the disease, which are characterized by even more markedly disturbed social adjustment and various types of maladaptive behavior (using others to achieve their goals), and aggressive tendencies. Conclusion: Depressive disorders in MS patients significantly change their psychological structure and how they see the world around them, and reduce their resource capacities, making social adjustment more challenging and worsening their quality of life. When affective disorders are diagnosed in a timely manner and treated in their early stages, patients with MS choose more adaptive mechanisms of psychological defense and more adaptive attitudes to the disease, which improves their quality of life. Keywords: multiple sclerosis, type of attitude to a disease, depression, anxiety, social adjustment, internal picture of a disease.

Neuropsychiatric changes during the COVID-19 pandemic in multiple sclerosis patients

2020 ◽  
Vol 78 (9) ◽  
pp. 570-575
Author(s):  
Caner Feyzi DEMIR ◽  
Furkan BILEK ◽  
Ferhat BALGETIR
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Sleep Quality ◽  
The Body ◽  
Assessment Tools ◽  
Survey Study ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Multiple Sclerosis Patients

ABSTRACT Background: This study reported on a variety of psychological reactions related to anxiety, sleep quality, depression, fatigue, and quality of life in individuals with multiple sclerosis (MS), related to the Covid-19 quarantine experience. Objective: The aim of this study was to investigate the neuropsychiatric effects of the COVID-19 pandemic in MS patients and to analyze the risk factors contributing to psychological stress. Methods: The study was designed as a prospective, cross-sectional survey study. Multiple assessment tools that are used in neurological practice, including Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Fatigue Impact Scale (FIS), Pittsburgh Sleep Quality Index (PSQI), and Multiple Sclerosis Quality of Life-54 (MSQOL-54) were administered prospectively both during the early and the peak stages of COVID-19 outbreak (ESO and PSO, respectively). The survey forms were designed using SurveyMonkey and the participants were participating in the survey via a web link and QR code. Results: Fifty patients were included in the study. BDI scores, PSQI and FSI measurements, cognitive and social subscale scores and total FIS score, MSQOL-54 measurements, physical and mental subscale scores, and total MSQOL-54 score at PSO were significantly different than those at ESO. The body mass index values of the patients increased significantly at PSO compared to those measured at ESO. Conclusions: The results provide a basis for the development of psychological interventions that could minimize the prevalence of sleep disorders and depression and could improve patients’ quality of life during the outbreak.

scholarly journals Work experience of the demyelination pathology unit in the city of Krasnoyarsk related to investigation of the quality of life of patients with multiple sclerosis

2021 ◽  
pp. 73-79
Author(s):  
E.V. Nikonova ◽  
◽  
M.B. Abdullayev ◽  
A.V. Pervunina ◽  
M.V. Abroskina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Work Experience ◽  
Depressive Disorders ◽  
Social Activity ◽  
Control Group ◽  
Symptomatic Therapy ◽  
Study Results ◽  
The City

Aim of study. Analysis of quality of life of patients attending to the unit for multiple sclerosis in the city of Krasnoyarsk. Material and methods. A total of 54 patients with multiple sclerosis were studied. Investigation of their quality of life was performed via the SF-36 scale while revealing of anxiety-depressive disorders was carried out according to the HADS scale. Accordingly, the question of presence of employment and children was specified. The neurological status was assessed according to the EDSS disability index. Comparative analysis of patient surveying results and the data obtained from the control group formed from clinically healthy subjects. Results. MS patients were observed to have statistically significant decline in physical function and overall health status. Correlation analysis within the main studied group revealed decrease of the physical component of quality of life and lower employment rate against the background of increased EDSS score. The larger result according to the depression HADS subscale restricted social function and the larger score in the anxiety subscale restricted the role emotional functioning. Conclusion. The quality of life parameters have stronger correlation with the disability degree and negative expectations of the patients related to progression of the disease. Based on the study results, the MS unit is recommended to apply the HADS scale in its practice for rapid assessment of the emotional state of patients and prescription of relevant symptomatic therapy. The patients are recommended to support their level of social activity and adhere to regular intake of DMDs.

scholarly journals Health Management for Quality of Life of Multiple Sclerosis Patients

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 86-86
Author(s):  
Emily Weiss ◽  
Hyun Kim
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Multiple Sclerosis ◽  
Health Behaviors ◽  
Health Management ◽  
Medical Community ◽  
Physically Active ◽  
Study Results ◽  
Multiple Sclerosis Patients

Abstract Objectives The purpose of this study is to investigate the associations of health behaviors such as diet, sleep and physical activity with quality of life (QoL) for adults diagnosed with Multiple Sclerosis (MS) and other major chronic diseases. The study hypothesizes that healthier diet in addition to an increased level of physical activity is associated with improving overall quality of life for those with MS. Methods The study includes adults aged 40 and older who are registered members of the Michigan Athletic Club in East Lansing, MI, diagnosed with MS, Parkinson's Disease or Arthritis (n = 30). Data on demographic information, previous health history and health behaviors such as mental health, diet, sleep and physical activity are collected. Multivariate regression models are analyzed in order to describe how current health behaviors are associated with quality of life for those with chronic conditions. Results Study results show that physically active MS patients with proper amount and better quality of sleep are likely to have higher overall quality of life. Healthier diet in addition to an increased level of physical activity is also likely to improve overall quality of life for those with MS. Conclusions When the importance of diet, exercise and sleep on MS is understood by the medical community, MS patients can utilize this information to improve their QoL through their own habits. Therefore, this study could lead to better management of symptoms by healthcare professionals and patients, and an improved QoL for those diagnosed with MS. Funding Sources N/A.

scholarly journals The Role of Iron Metabolism in Fatigue, Depression, and Quality of Life in Multiple Sclerosis Patients

2020 ◽  
Vol 17 (18) ◽  
pp. 6818
Author(s):  
Anna Knyszyńska ◽  
Aleksandra Radecka ◽  
Paulina Zabielska ◽  
Joanna Łuczak ◽  
Beata Karakiewicz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Depressive Symptoms ◽  
Iron Metabolism ◽  
Depressive Disorders ◽  
Binding Capacity ◽  
Iron Binding ◽  
Multiple Sclerosis Patients ◽  
Iron Binding Capacity

Multiple sclerosis (MS) is a chronic inflammatory disease of autoimmune origin for which there is currently no available cure. In the course of MS, next to neurological disorders, patients often present with chronic fatigue syndrome and depressive disorders, which impact on their daily function and quality of life. The aim of study was to analyse the relationship between serum parameters of iron metabolism and the severity of fatigue, depressive symptoms, and quality of life in MS patients. Methods: The study sample consisted of 90 people with a diagnosis of multiple sclerosis, age range 19–67 years, whose functional status evaluated using the Expanded Disability Status Scale in 90% of the participants did not exceed 3.5 points. Venous blood samples were collected for blood cell count determination and for the purposes of obtaining serum analysed for the concentrations of iron, ferritin, transferrin, transferrin saturation, unsaturated iron binding capacity (UIBC), and total iron binding capacity (TIBC). The participants were also evaluated according to the Fatigue Severity Scale, Beck Depression Inventory, and Functional Assessment of Multiple Sclerosis. Results: Ferritin levels were significantly correlated with the severity of depressive symptoms (r = −0.22; p = 0.04) and quality of life assessment (r = 0.22; p = 0.04) in the MS patients. Moreover, the severity of fatigue and depressive symptoms was significantly linked to a deterioration in quality of life. Conclusions: Ferritin deficiency in MS patients is associated with an exacerbation of depressive disorders and a decline in quality of life. Symptoms of fatigue in MS patients are inversely proportional to mood and quality of life.

Quality of life in multiple sclerosis patients in Spain

2002 ◽  
Vol 8 (6) ◽  
pp. 527-531 ◽  
Author(s):  
C-H Chang ◽  
D Cella ◽  
O Fernández ◽  
G Luque ◽  
P de Castro ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Well Being ◽  
Cross Sectional Study ◽  
Self Report ◽  
Regression Analyses ◽  
Cross Sectional ◽  
Scale Scores ◽  
Multiple Sclerosis Patients

Objective: The cross-sectional study evaluated the psychometric properties of the Functional Assessment of Multiple Sclerosis (FAMS) Spanish version and its use in measuring quality of life (QOL) of multiple sclerosis (MS) patients in Spain. Methods: The FAMS is a factorially derived self-report scale designed to assess six primary aspects of QOL of patients with MS: Mobility, Symptoms, Emotional Well-Being, General Contentment, Thinking and Fatigue, and Family/Social Well-Being. Its Spanish translated version was used to assess QOL of 625 MS patients recruited in an outpatient clinic setting from 58 hospitals in Spain. Internal consistency of the Spanish FAMS was evaluated. Multiple regression analyses were performed to identify significant predictors from demographic, clinical and treatment characteristics, and Kurtzke Expanded Disability Status Scale (EDSS) scores in predicting FAMS scale scores. Results: Most of the patients are females (66%), and 74% were of the relapsing-remitting (RR) clinical subtype. Cronbach’s alpha coefficients were high (range=0.78-0.96), indicating subscale homogeneity comparable to that of the original English version. Linear multivariate regression analyses revealed that the EDSS is a dominant variable in predicting all the FAMS subscales, especially mobility (R2=0.51) and the total scores. Conclusions: The Spanish FAMS is a psychometrically valid instrument that allows clinicians and clinical researchers the ability to measure the QOL concerns of MS patients in Spain.

Fatigue, mood and quality of life improve in MS patients after progressive resistance training

2010 ◽  
Vol 16 (4) ◽  
pp. 480-490 ◽  
Author(s):  
U. Dalgas ◽  
E. Stenager ◽  
J. Jakobsen ◽  
T. Petersen ◽  
HJ Hansen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Resistance Training ◽  
Beneficial Effect ◽  
Control Group ◽  
Progressive Resistance Training ◽  
Multiple Sclerosis Patients ◽  
Progressive Resistance

Fatigue occurs in the majority of multiple sclerosis patients and therapeutic possibilities are few. Fatigue, mood and quality of life were studied in patients with multiple sclerosis following progressive resistance training leading to improvement of muscular strength and functional capacity. Fatigue (Fatigue Severity Scale, FSS), mood (Major Depression Inventory, MDI) and quality of life (physical and mental component scores, PCS and MCS, of SF36) were scored at start, end and follow-up of a randomized controlled clinical trial of 12 weeks of progressive resistance training in moderately disabled (Expanded Disability Status Scale, EDSS: 3—5.5) multiple sclerosis patients including a Control group ( n = 15) and an Exercise group ( n = 16). Fatigue (FSS > 4) was present in all patients. Scores of FSS, MDI, PCS—SF36 and MCS—SF36 were comparable at start of study in the two groups. Fatigue improved during exercise by —0.6 (95% confidence interval (CI) —1.4 to 0.4) a.u. vs. 0.1 (95% CI —0.4 to 0.6) a.u. in controls ( p = 0.04), mood improved by —2.4 (95% CI —4.1 to 0.7) a.u. vs. 1.1 (—1.2 to 3.4) a.u. in controls ( p = 0.01) and quality of life (PCS—SF36) improved by 3.5 (95% CI 1.4—5.7) a.u. vs. —1.0 (95% CI —3.4—1.4) a.u. in controls ( p = 0.01). The beneficial effect of progressive resistance training on all scores was maintained at follow-up after further 12 weeks. Fatigue, mood and quality of life all improved following progressive resistance training, the beneficial effect being maintained for at least 12 weeks after end of intervention.

Memory performance in multiple sclerosis patients correlates with central brain atrophy

2006 ◽  
Vol 12 (4) ◽  
pp. 428-436 ◽  
Author(s):  
H Hildebrandt ◽  
H K Hahn ◽  
J A Kraus ◽  
A Schulte-Herbrüggen ◽  
B Schwarze ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Motor Performance ◽  
Memory Performance ◽  
Cognitive Tests ◽  
Duration Of Symptoms ◽  
Central Brain ◽  
Multiple Sclerosis Patients

Objective To assess whole brain and central brain atrophy as well as their differential relation to memory, cognitive performance, fatigue, depression and quality of life in patients with relapsingremitting multiple sclerosis (RRMS). Methods A 3D flow compensated gradient recalled T1-weighted MRI was acquired in 45 RRMS patients. An automated analysis tool was used to calculate brain parenchymal fraction (BPF) and ventricular brain fraction (VF). All patients were assessed with neuropsychological tests focusing on memory and self-rating scales for depression, fatigue and quality of life. Age corrected partial correlations between brain atrophy, motor performance, psychological scales and test scores were calculated. Results BPF correlated moderately (0.35≤r<0.5) with duration of symptoms and disease, the Expanded Disability Status Scale (EDSS), the upper extremity motor performance, and with mental aspects of quality of life. VF correlated moderately with EDSS, upper and lower extremity motor performance and memory functions. Neither BPF nor VF correlated with fatigue and depression. Results of several cognitive tests correlated moderately with depression and fatigue, the Paced Auditory Serial Addition Test (PASAT) showing the largest correlation. Conclusions Memory performance shows a correlation with relative ventricular size in RRMS patients, indicating the strategic location of the ventricle system along the structures of the limbic system and its vulnerability in MS. The PASAT and several other cognitive tests show moderate correlations with depression and fatigue, arguing for an inter relation between the cognitive functioning and the emotional state of patients. However, this relation is independent of measurable brain atrophy.

Quality of life of multiple sclerosis patients with comorbid migraine

2011 ◽  
Vol 32 (S1) ◽  
pp. 149-151 ◽  
Author(s):  
Veronica Villani ◽  
L. Prosperini ◽  
C. Pozzilli ◽  
M. Salvetti ◽  
G. Sette
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Multiple Sclerosis Patients

Prevalence of bladder, bowel and sexual problems among multiple sclerosis patients two to five years after diagnosis

2007 ◽  
Vol 13 (1) ◽  
pp. 106-112 ◽  
Author(s):  
M W Nortvedt ◽  
T Riise ◽  
J Frugaård ◽  
J Mohn ◽  
A Bakke ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Bowel Dysfunction ◽  
Sexual Problems ◽  
Health Related Quality ◽  
Related Quality ◽  
Bowel And Bladder Dysfunction ◽  
Health Related ◽  
Multiple Sclerosis Patients

Most multiple sclerosis (MS) patients experience some sexual, bladder and/or bowel dysfunction during the course of the disease - one of MS most disabling features. This study estimated the frequency of these problems among patients, two to five years after diagnosis, and investigated how these problems are associated with health-related quality of life (using the Multiple Sclerosis Quality of Life-54 questionnaire). The study population comprised a cohort of patients (n=56), diagnosed in a three-year period, in Hordaland County, Norway. The patients were examined clinically, including scoring of the Expanded Disability Status Scale (EDSS), and completed questionnaires related to bowel and bladder dysfunction, sexual problems and health-related quality of life. More than half the patients had bladder and sexual problems. The frequency of self-reported bladder problems corresponded to the relatively high levels of residual urine found. The presence of these problems was associated with lower scores on the quality of life scales. Further, the bowel problems reported were markedly associated with the quality of life scores. Since treatments and preventive strategies can manage many of these problems, we suggest increasing the focus on these aspects of the disease when consulting patients, including at early stages.

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