Estimation of Salivary 8-Hydroxydeoxyguanosine (8-OHdG) as a Potential Biomarker in Assessing Progression towards Malignancy: A Case-Control Study

Abstract Purpose To explore changes of Telomere length (TL) and mitochondrial copy number (mtDNA-CN) in preeclampsia (PE) and to evaluatethe combined effect of maternal TL and mtDNA-CN on PE risk.Methods A case-control study of 471 subjects (130 PE cases and 341 age frequency matched controls) was conducted in Nanjing Drum Tower Hospital, Jiangsu Province of China. Relative telomere length (RTL) and mtDNA-CN were measured using quantitative polymerase chain reaction (qPCR) and PE risk was calculated between groups by logistic regression analyses.Results PE patients displayed longer RTL (0.48 versus 0.30) and higher mtDNA-CN (3.02 versus 2.00) in maternal bloodas well as longer cord blood RTL(0.61 versus 0.35) but lower mtDNA-CN (1.69 versus 5.49) in cord blood (all p<0.001). Exercise during pregnancy exerted an obvious effect of prolonging maternal telomere length. Multiparous, women with folic acid intake during early pregnancy and those delivered vaginally showed longer telomere length while those factors imposed no or opposite effect on RTL in PE cases. Furthermore, RTL and mtDNA-CN were positively correlated in controls (in maternal blood r=0.18, p<0.01; in cord blood r=0.19, p<0.001), but this correlation was disrupted in PE cases, no matter in maternal blood or in cord blood. Longer maternal RTL and higher mtDNA-CN were associated with higher risk of PE, and the ROC curve of RTL and mtDNA-CN in predicting PE risk presented an AUC of 0.755(95%CI: 0.698-0.812).Conclusions Interaction of TL and mtDNA-CN may play an important role in pathogenesis of PE and it could be a potential biomarker indicating PE risk.

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HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis in Filipino patients

Pharmacogenomics ◽

10.2217/pgs-2020-0191 ◽

2021 ◽

Author(s):

Francis Capule ◽

Pramote Tragulpiankit ◽

Surakameth Mahasirimongkol ◽

Jiraphun Jittikoon ◽

Nuanjun Wichukchinda ◽

...

Keyword(s):

Toxic Epidermal Necrolysis ◽

Medical Records ◽

Odds Ratio ◽

Genomic Dna ◽

Case Control Study ◽

Case Control ◽

Stevens Johnson Syndrome ◽

Johnson Syndrome ◽

Potential Biomarker ◽

Control Study

Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5–76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1–20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2–30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.

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Is Saliva a Potential Biomarker of Arsenic Exposure? A Case-Control Study in West Bengal, India

Environmental Science & Technology ◽

10.1021/es303756s ◽

2013 ◽

Vol 47 (7) ◽

pp. 3326-3332 ◽

Cited By ~ 14

Author(s):

Subhamoy Bhowmick ◽

Dipti Halder ◽

Amit kumar Kundu ◽

Debasree Saha ◽

Mònica Iglesias ◽

...

Keyword(s):

Case Control Study ◽

West Bengal ◽

Arsenic Exposure ◽

Case Control ◽

Potential Biomarker ◽

Control Study

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Association Between LMP-1, LMP-2, and miR-155 Expression as Potential Biomarker in Nasopharyngeal Carcinoma Patients: A Case/Control Study in Vietnam

Genetic Testing and Molecular Biomarkers ◽

10.1089/gtmb.2019.0089 ◽

2019 ◽

Vol 23 (11) ◽

pp. 815-822

Author(s):

Thuan Duc Lao ◽

Thuy Ai Huyen Le

Keyword(s):

Nasopharyngeal Carcinoma ◽

Case Control Study ◽

Case Control ◽

Potential Biomarker ◽

Control Study

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Significance of serum galactose deficient IgA1 as a potential biomarker for IgA nephropathy: A case control study

PLoS ONE ◽

10.1371/journal.pone.0214256 ◽

2019 ◽

Vol 14 (3) ◽

pp. e0214256 ◽

Cited By ~ 5

Author(s):

Soumita Bagchi ◽

Raghavendra Lingaiah ◽

Kalaivani Mani ◽

Adarsh Barwad ◽

Geetika Singh ◽

...

Keyword(s):

Iga Nephropathy ◽

Case Control Study ◽

Case Control ◽

Potential Biomarker ◽

Control Study

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A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia

Disease Markers ◽

10.1155/2017/3104180 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Wenwang Rao ◽

Na Zhou ◽

Huiping Zhang ◽

Rui Liu ◽

Shangchao Zhang ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Chain Gene ◽

Nucleotide Polymorphisms ◽

Alpha Chain ◽

Potential Biomarker ◽

Healthy Control ◽

A Minor ◽

Intron 4 ◽

Control Study

Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia. 1,145 patients with schizophrenia and 1,016 healthy volunteers from the Han population in Northeast China were recruited. The association of three tag single nucleotide polymorphisms (SNPs) (rs2070011 in the 5′UTR, rs2070016 in intron 4, and rs2070022 in the 3′UTR) in FGA and schizophrenia was examined using a case-control study design. Genotypic distributions of these three SNPs were not found to be significantly different between cases and controls (rs2070011: χ2=1.28, P=0.528; rs2070016: χ2=4.11, P=0.128; rs2070022: χ2=1.23, P=0.541). There were also no significant differences in SNP allelic frequencies between cases and controls (all P>0.05). Additionally, the frequency of haplotypes consisting of alleles of these three SNPs was not significantly different between cases and healthy control subjects (global χ2=9.27, P=0.159). Our study did not show a significant association of FGA SNPs with schizophrenia. Future studies may need to test more FGA SNPs in a larger sample to identify those SNPs with a minor or moderate effect on schizophrenia.

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Serum periostin is a potential biomarker for non-alcoholic fatty liver disease: a case–control study

Endocrine ◽

10.1007/s12020-015-0735-2 ◽

2015 ◽

Vol 51 (1) ◽

pp. 91-100 ◽

Cited By ~ 15

Author(s):

Jin-Zhou Zhu ◽

Hua-Tuo Zhu ◽

Yi-Ning Dai ◽

Chun-Xiao Li ◽

Zhi-Yun Fang ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Case Control Study ◽

Case Control ◽

Alcoholic Fatty Liver ◽

Potential Biomarker ◽

Serum Periostin ◽

Alcoholic Fatty Liver Disease ◽

Control Study

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Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Pa-tients

Iranian Journal of Public Health ◽

10.18502/ijph.v50i8.6810 ◽

2021 ◽

Author(s):

Thuan Duc Lao ◽

Minh Trong Nguyen ◽

Dung Huu Nguyen ◽

Thuy Ai Huyen Le

Keyword(s):

Nasopharyngeal Carcinoma ◽

Reverse Transcription ◽

Real Time Pcr ◽

Case Control Study ◽

Case Control ◽

Current Case ◽

Reverse Transcription Pcr ◽

Potential Biomarker ◽

Vietnamese Population ◽

Control Study

Background: The upregulation of miRNA-155 (miR-155) has been associated with oncogenesis of many human tumors, including nasopharyngeal carcinoma (NPC). However, the profile of miR-155 in Vietnamese NPC patients has not been investigated. The current study aimed to evaluate the miR-155 expression and assess whether miR-155 is a potential biomarker for diagnosis of NPC in Vietnamese patients. Methods: In current case-control study, total of RNA was isolated from 60 biopsy NPC samples and 60 non-cancerous swab samples were analyzed by Reverse-transcription PCR, qualitative Real-time PCR. Results: The frequency of miR-155 detection were 78.33%, 15.0% in NPC and non-cancerous samples (P<0.05), respectively. The miR-155 expression level was 4.92 times higher in tumor samples than non-cancerous sample. Conclusion: Taken together, miR-155 in NPC was upregulated. It may serve as a potential biomarker for NPC in the Vietnamese population.

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Novel Associations Between METTL3 Gene Polymorphisms and Pediatric Acute Lymphoblastic Leukemia: A Five-Center Case-Control Study

Frontiers in Oncology ◽

10.3389/fonc.2021.635251 ◽

2021 ◽

Vol 11 ◽

Author(s):

Xiaoping Liu ◽

Libin Huang ◽

Ke Huang ◽

Lihua Yang ◽

Xu Yang ◽

...

Keyword(s):

Protective Effect ◽

Gene Polymorphisms ◽

Case Control Study ◽

Lymphoblastic Leukemia ◽

Case Control ◽

Potential Biomarker ◽

Risk Effect ◽

Pediatric All ◽

Control Study

ObjectiveTo reveal the contributing role of METTL3 gene SNPs in pediatric ALL risk.Patients and MethodsA total of 808 pediatric ALL cases and 1,340 cancer-free controls from five hospitals in South China were recruited. A case-control study by genotyping three SNPs in the METTL3 gene was conducted. Genomic DNA was abstracted from peripheral blood. Three SNPs (rs1263801 C>G, rs1139130 A>G, and rs1061027 A>C) in the METTL3 gene were chosen to be detected by taqman real-time polymerase chain reaction assay.ResultsThat rs1263801 C>G, rs1139130 A>G, and rs1061027 A>C polymorphisms were significantly associated with increased pediatric ALL risk was identified. In stratification analyses, it was discovered that rs1263801 CC, rs1061027 AA, and rs1139130 GG carriers were more likely to develop ALL in subgroups of common B-ALL, MLL gene fusion. Rs1263801 CC and rs10610257 AA carriers were more possible to increase the risk of ALL in subgroups of low hyperdiploid, and all of these three SNPs exhibited a trend toward the risk of ALL. All of these three polymorphisms were associated with the primitive/naïve lymphocytes and MRD in marrow after chemotherapy in ALL children. Rs1263801 CC and rs1139130 AA alleles provided a protective effect on MRD ≥0.01% among CCCG-treated children. As for rs1139130, AA alleles provided a protective effect on MRD in marrow ≥0.01% on 33 days and 12 weeks among CCCG-treated children, but provided a risk effect on MRD in the marrow ≥0.01% among SCCLG-treated children. As for rs1263801 CC and rs1139130 AA, these two alleles provided a protective effect on MRD in the marrow ≥0.01% among CCCG-treated children.ConclusionIn this study, we revealed that METTL3 gene polymorphisms were associated with increased pediatric ALL risk and indicated that METTL3 gene polymorphisms might be a potential biomarker for choosing ALL chemotherapeutics.

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