scholarly journals A single nucleotide polymorphism in Prostate Stem Cell Antigen is associated with endoscopic grading in Kyoto classification of gastritis

2021 ◽  
Vol 68 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Osamu Toyoshima ◽  
Toshihiro Nishizawa ◽  
Kazuma Sekiba ◽  
Tatsuya Matsuno ◽  
Ryo Kondo ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Stem Cell ◽  
Prostate Stem Cell Antigen ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Cell Antigen

A single nucleotide polymorphism at chromosome 2q21.3 (LCT −13910C>T) associates with clinical outcome after allogeneic hematopoietic stem cell transplantation

Blood ◽  
2008 ◽  
Vol 112 (5) ◽  
pp. 2156-2159 ◽  
Author(s):  
Hanns Hauser ◽  
Otto Zach ◽  
Otto Krieger ◽  
Hedwig Kasparu ◽  
Josef Koenig ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Stem Cell ◽  
Intestinal Microflora ◽  
Median Overall Survival ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Hematopoietic Stem ◽  
Graft Versus Host ◽  
Hematopoetic Stem Cell ◽  
Related Mortality

Abstract A single nucleotide polymorphism (SNP) responsible for lactase persistence (LCT −13910C>T) changes intestinal microflora. Considering the influence of bacterial microflora on various immune effects, we tested DNA from 111 recipients/donors and analyzed whether this SNP interferes with survival and the incidence of acute graft-versus-host disease (aGVHD) after allogeneic hematopoetic stem cell tranplantations (HSCT). Median overall survival (OS) was significantly longer when donors had a CC genotype (not reached after 133 vs 11.1 months, P = .004). Multivariate analysis identified a donor T allele (hazard ratio 2.63, 95% confidence interval 1.29-5.33, P = .008) as independent risk factor for death. Surprisingly, recipient genotypes did not influence outcome and there were no differences regarding aGVHD. Transplantation-related mortality (TRM), relapse and pneumonia were significantly less frequent in patients with CC donors. These findings add to the growing list of non-HLA polymorphisms with impact on outcome after allogeneic HSCT.

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