Formulating a novel fermented soy milk functional meal replacement among overweight individuals: a preliminary weight loss clinical trial

Meal replacement is an optimising strategy in designing structured diets for weight management. In this study, a novel fermented soy-whey based beverage was fortified with dietary bioactive ingredients containing probiotic strains (Lactobacillus bulgaricus and Streptococcus thermophilus). The aim of this study was to evaluate its efficacy on the body weight loss of participants pre-and post-meal replacement. A total of 20 participants underwent the weight loss program. Over the 14-day trial, women volunteers had a body weight loss of 6.70% of their initial body weight, and men had a comparable body weight reduction of 6.18%. In comparison to the blood glucose baseline level of 3.5420 mmol/L, the meal replacement decreased the level of blood glucose by nearly 50%, reaching 1.7785 mmol/L. Total cholesterol level was reduced by the beverage with a 15.7% reduction. The functional drink also decreased the triglycerides and low-density lipoprotein significantly (p<0.001). A significantly higher level of high-density lipoprotein was obtained at Day 14 (1.73 mmol/L) compared with Day 0 (1.23 mmol/L). The meal replacement was able to provide satiety within the average of 180.7 minutes post-meal. This study supports the soy-based functional milk is of benefit for weight management, glucose homeostasis and blood cholesterol-lowering effect.

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“Discriminant Models to Estimate the Body Weight Loss after a Six-month Long Diet and Exercise-based Intervention”

Journal of Obesity & Weight loss Therapy ◽

10.4172/2165-7904.1000315 ◽

2016 ◽

Vol 6 (4) ◽

Author(s):

Miguel Angel Rojo Tirado

Keyword(s):

Weight Loss ◽

Body Weight ◽

Body Weight Loss ◽

The Body ◽

Diet And Exercise ◽

Discriminant Models

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SUN-543 Real World Evidence of Successful Weight Management for the Obese Population: Complete Reversal of Obesity Related Metabolic Co-Morbidities and Weight Loss in Patients Attending a Multidisciplinary Weight Management Clinic in Australia

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.1522 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Zoe Rock ◽

Juliana Chen ◽

Joanna Jaques ◽

Bernard L Champion ◽

Reginald V Lord ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Weight Management ◽

Exercise Physiology ◽

Body Weight Loss ◽

Total Body Weight ◽

Management Interventions ◽

Co Morbidity ◽

Total Body ◽

Total Body Weight Loss

Abstract Over 2.5 billion people worldwide are overweight or obese. Multidisciplinary weight management interventions have evolved to address the complexity of weight loss for those with one or more chronic diseases, and the trend of weight regain. The aim of these interventions is to encourage sustainable lifestyle changes, resulting in weight loss and weight maintenance and improvements in comorbidities. While some prospective clinical trials have demonstrated efficacy, results are often not reported by real life practices. The aim of this study was to evaluate the effectiveness of a Sydney based multidisciplinary weight management clinic with endocrinology, dietetics, exercise physiology, psychology, and bariatric surgical domains. All patients who attended the clinic for weight loss purposes between March 2017 and April 2019 were included (n=220). A retrospective chart review was conducted. Patient data on weight, BMI, waist circumference, body composition measurements, and selected blood test results and co-morbidities were analysed. All patient therapy included endocrinological input for co-morbidity identification and management, lifestyle intervention (dietetic and exercise physiology input) with optional adjunct pharmacotherapy or psychological counselling. Of the 220 cohort, 20 of the patients had sleeve gastrectomy. Patient retention in the clinic after the first consultation was 85% (n=186), a high rate within the weight management community. 59% of patients achieved a minimum of 5% total body weight loss, including 18% who achieved greater than 10% total body weight loss. Additionally, 31% of patients lost enough weight to decrease their BMI class by up to 2 or more classes. Of the gastric sleeve cohort average excess body weight loss was 32kg (21-56kg) enhanced by multidisciplinary care in the lead up to surgery. Across the cohort some patients completely reversed co-morbidities; including dyslipidaemia (n=1), hypertension (n=3), NAFLD (n=1), pre-diabetes (n=8) and type 2 diabetes (n=3), OSA (n=1). These results demonstrate that obesity is a chronic condition that can be successfully managed. We have demonstrated significant durable weight loss and improvement in metabolic co-morbidities with holistic coordinated care. Future directions include translating this model of care into standard practice in Australia and other countries where obesity to date not received the same coordinated approach as other chronic conditions.

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A COMPARATIVE EVALUATION OF ANTI-DIABETIC POTENTIALITY FOUND IN DIFFERENT MARKETED POLYHERBAL FORMULATION USING GLUCOCORTICOID-INDUCED HYPERGLYCAEMIA IN RABBIT

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2017v9i4.20964 ◽

2017 ◽

Vol 9 (4) ◽

pp. 83

Author(s):

Pranjal Boruah ◽

Jashabir Chakraborty ◽

Suvakanta Dash

Keyword(s):

Weight Loss ◽

Body Weight ◽

Blood Glucose ◽

Normal Saline ◽

Side Effect ◽

Body Weight Loss ◽

Control Group ◽

Therapeutic Equivalence ◽

Polyherbal Formulation ◽

Single Dosage

Objective: The aim of this study was performed to evaluate Antidiabetic potentiality found in different marketed polyherbal formulation using glucocorticoid-induced hyperglycaemia in the rabbit.Methods: The potentiality of different polyherbal formulation was investigated using dexamethasone (DEX) induced hyperglycaemia in Rabbit. Eight male rabbits were divided into four groups of two each. The first group is regarded as control group received 3 ml of normal saline daily by using the gastric tube for 15 d and remaining three group received (0.35 mg/Kg B.W. single dosage) of dexamethasone tablets which were powdered, dissolved in 3 ml of normal saline daily for 15 d. After 15 d the blood glucose estimated by using a glucometer and it is found that DXE treatment leads to significant increase in levels of glucose and a significant decrease in body weight. After that second group received metformin tablet. The third and fourth group received polyherbal formulation A and formulation B, which are powdered and dissolved in 3 ml of normal saline daily for 15 d at the dose of 0.5 gm/kg body weight orally. After completion of regular administration for 15 d, the blood glucose was again estimated and compare the results of each the group.Conclusion: The Anti-diabetic polyherbal marketed formulations were having less side effect as compared to standard metformin tablet (e. g. body weight loss). And both the polyherbal formulations were found a therapeutic equivalence to each other, also having the approximately similar potentiality to standard metformin tablet.Results: The result was found that the polyherbal marketed formulations were having less side effect as compared to standard metformin tablet (e. g. body weight loss). And both the polyherbal formulations were found significantly decreased in blood glucose level at equal potentiality, which can be consider as therapeutic equivalence to each other, and both the formulation also having the approximately similar potentiality to standard metformin tablet.

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Frequency of self-monitoring of blood glucose in relation to weight loss and A1C during intensive multidisciplinary weight management in patients with type 2 diabetes and obesity

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2019-000659 ◽

2019 ◽

Vol 7 (1) ◽

pp. e000659 ◽

Cited By ~ 2

Author(s):

Shaheen Tomah ◽

Noor Mahmoud ◽

Adham Mottalib ◽

David M Pober ◽

Mhd Wael Tasabehji ◽

...

Keyword(s):

Type 2 Diabetes ◽

Weight Loss ◽

Body Weight ◽

Blood Glucose ◽

Weight Management ◽

Average Frequency ◽

Baseline Body Mass Index ◽

Self Monitoring ◽

Median Change

ObjectiveWe evaluated the relationship between frequency of self-monitoring of blood glucose (SMBG) and body weight, A1C, and cardiovascular risk factors in patients with type 2 diabetes (T2D) and obesity enrolled in a 12-week intensive multidisciplinary weight management (IMWM) program.Research design and methodsWe conducted a retrospective analysis of 42 patients who electronically uploaded their SMBG data over 12 weeks of an IMWM program and divided them into tertiles based on their average frequency of SMBG per day. Mean (range) SMBG frequencies were 2.3 (1.1–2.9) times/day, 3.4 (3–3.9) times/day, and 5 (4–7.7) times/day in the lowest, middle, and highest tertiles, respectively. Anthropometric and metabolic parameters were measured at baseline and after 12 weeks of intervention.ResultsParticipants in the highest tertile achieved a median change (IQR) in body weight of −10.4 kg (−7.6 to −14.4 kg) compared with −8.3 kg (−5.2 to −12.2 kg), and −6.9 kg (−4.2 to −8.9 kg) in the middle and lowest tertiles, respectively (p=0.018 for trend). Participants in the highest tertile had a median change (IQR) in A1C of −1.25% (−0.6 to −3.1%) compared with −0.8% (−0.3% to −2%) and −0.5% (−0.2% to −1.2%) in the middle and lowest tertiles, respectively (p=0.048 for trend). The association between change in body weight and SMBG frequency remained significant after adjusting for age, sex, baseline body mass index, diabetes duration, and use of insulin therapy.ConclusionsIncreased frequency of SMBG during IMWM is associated with significantly better weight loss and improvement of A1C in patients with T2D and obesity. These findings may suggest future clinical recommendations aimed at increasing SMBG frequency to achieve the most favorable outcomes.

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Effect of spineless cactus intake (Opuntia ficus-indica) on blood glucose levels in lactating sows and its impact on feed intake, body weight loss, and weaning-estrus interval

Tropical Animal Health and Production ◽

10.1007/s11250-017-1295-7 ◽

2017 ◽

Vol 49 (5) ◽

pp. 1025-1033 ◽

Cited By ~ 5

Author(s):

Gerardo Ordaz-Ochoa ◽

Aureliano Juárez-Caratachea ◽

Rosa Elena Pérez-Sánchez ◽

Rafael María Román-Bravo ◽

Ruy Ortiz-Rodríguez

Keyword(s):

Weight Loss ◽

Body Weight ◽

Blood Glucose ◽

Feed Intake ◽

Body Weight Loss ◽

Opuntia Ficus Indica ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Lactating Sows

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Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice

Journal of Diabetes Research ◽

10.1155/2018/6482958 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Katsunori Nonogaki ◽

Takao Kaji

Keyword(s):

Gene Expression ◽

Weight Loss ◽

Body Weight ◽

Receptor Agonist ◽

Tryptophan Hydroxylase ◽

Intraperitoneal Administration ◽

Body Weight Loss ◽

Receptor Activation ◽

The Body ◽

Receptor Expression

A recent report suggested that brain-derived serotonin (5-HT) is critical for maintaining weight loss induced by glucagon-like peptide-1 (GLP-1) receptor activation in rats and that 5-HT2A receptors mediate the feeding suppression and weight loss induced by GLP-1 receptor activation. Here, we show that changes in daily food intake and body weight induced by intraperitoneal administration of liraglutide, a GLP-1 receptor agonist, over 4 days did not differ between mice treated with the tryptophan hydroxylase (Tph) inhibitor p-chlorophenylalanine (PCPA) for 3 days and mice without PCPA treatment. Treatment with PCPA did not affect hypothalamic 5-HT2A receptor expression. Despite the anorexic effect of liraglutide disappearing after the first day of treatment, the body weight loss induced by liraglutide persisted for 4 days in mice treated with or without PCPA. Intraperitoneal administration of liraglutide significantly decreased the gene expression of hypothalamic 5-HT2A receptors 1 h after injection. Moreover, the acute anorexic effects of liraglutide were blunted in mice treated with the high-affinity 5-HT2A agonist (4-bromo-3,6-dimethoxybenzocyclobuten-1-yl) methylamine hydrobromide 14 h or 24 h before liraglutide injection. These findings suggest that liraglutide reduces appetite and body weight independently of 5-HT synthesis in mice, whereas GLP-1 receptor activation downregulates the gene expression of hypothalamic 5-HT2A receptors.

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Some results of winter keeping of paddlefish young-of-the-year (Polyodon spathula (Walbaum, 1792)) in ponds of the Forest-Steppe and Polesye of Ukraine

Ribogospodarsʹka nauka Ukraïni ◽

10.15407/fsu2020.04.059 ◽

2020 ◽

pp. 59-67

Author(s):

B. Hankevych ◽

◽

O. Tretiak ◽

O. Kolos ◽

◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Environmental Conditions ◽

Body Weight Loss ◽

Fish Farming ◽

The Body ◽

Average Weight ◽

Forest Steppe ◽

Study Results ◽

Young Of The Year

Purpose. Assessing the results of winter keeping of paddlefish young-of-the-year in ponds of the Forest-steppe and Polesye of Ukraine. Methodology. The study was carried out using 0.05-1.0 ha ponds intended for winter keeping of carps. The stocking density of paddlefish young-of-the-year with an average weight of 94.2-147.2 g in wintering ponds was 4.10-16.63 thousand fish/ha. The study of the physicochemical parameters of the aquatic environment was carried out according to the methods generally accepted in hydrochemistry and fish farming. The main piscicultural-biological parameters during the wintering period of fish were assessed using methods commonly used in ichthyology and fish farming according to the level of survival and body weight loss of paddlefish. Findings. The environmental conditions in the ponds during most of the wintering period of fish met the biological requirements of the studied object of cultivation. The water temperature varied within 0.9-6.50C. The dissolved oxygen content in water did not fall below 3.6-3.8 mgO2/dm3 and was mainly at the level of 3.9-7.9 3.9-7.2 mgO2/dm3. Other hydrochemical parameters were within acceptable values for wintering fish in pond conditions. As a result, the survival rate of paddlefish young-of-the-year during the wintering period was 81.5-89.7%. The body weight loss of fish during the winter keeping was on average in the range of 6.41-8.17%. A conclusion was made on the need to conduct additional studies of physiological and biochemical parameters of paddlefish during the wintering period. Originality. New data were obtained on the peculiarities of wintering of paddlefish seeds in ponds of the Forest-steppe and Polesye of Ukraine. Practical value. The study results are part of the database for the development of improved technologies for sturgeon breeding in Ukraine. Key words: paddlefish, fish seeds, pond aquaculture, fish wintering, environmental conditions, piscicultural parameters.

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Therapy of obesity by sibutramin: polymorphisms of TPH2 and GNB3 genes and decrease of body weight

Obesity and metabolism ◽

10.14341/omet9646 ◽

2018 ◽

Vol 15 (2) ◽

pp. 40-45

Author(s):

Marina O. Galieva ◽

Ekaterina A. Troshina ◽

Nataliya V. Mazurina ◽

Anna P. Volynkina ◽

Andrey V. Artiushin ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Weight Loss ◽

Body Weight ◽

Genetic Factors ◽

Research Study ◽

Body Weight Loss ◽

The Body ◽

Tph2 Gene

Aims. To study of the polymorphisms of the TPN2 and GNB3 genes in obese patients and their effect on weight loss in patients on sibutramine therapy. Materials and methods. The research study included 118 patients with exogenous-constitutional obesity who received Reduxin (sibutramine + CMC) at the dose of 10 mg. Term follow-up was 3 months. A genetic study was performed to assess ТРН2 and GNB3 gene polymorphisms. The response to the therapy was evaluated after 3 months by the dynamics of body weight. Results. In the study the G703T polymorphism of the GNB3 gene showed that during 3 months of observation, carriers of the TT genotype had a greater decrease in body weight in comparison with carriers of the allele C -8 kg (-12; -5) vs. -5 kg (-8; -3), p = 0.018. In carriers of different variants of the genotype of the TPH2 gene (polymorphism C825T), there was no difference in body weight dynamics with sibutramine therapy. There was no correlation between the foresaid polymorphisms of the TPH2 and GNB3 genes with the indices of blood pressure and heart rate. Conclusions. 1. The result of sibutramin therapy may depend on genetic factors: in carriers of the TT-genotype C825T of the GNB3 gene the body weight loss was higher than among the carriers of the C allele. 2. Changes in blood pressure and heart rate did not show any statistically significant relationship with polymorphisms of the TPH2 and GNB3 genes.

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