scholarly journals Invited review: Microbiota of the bovine udder: Contributing factors and potential implications for udder health and mastitis susceptibility

2018 ◽  
Vol 101 (12) ◽  
pp. 10605-10625 ◽  
Author(s):  
Hooman Derakhshani ◽  
Kelsey B. Fehr ◽  
Shadi Sepehri ◽  
David Francoz ◽  
Jeroen De Buck ◽  
...  
Keyword(s):  
Contributing Factors ◽  
Udder Health ◽  
Mastitis Susceptibility

scholarly journals Marker assisted selection of heifers improved milk somatic cell count compared to selection on conventional pedigree breeding values

2008 ◽  
Vol 51 (1) ◽  
pp. 23-32 ◽  
Author(s):  
C. Kühn ◽  
F. Reinhardt ◽  
M. Schwerin
Keyword(s):  
Somatic Cell ◽  
Breeding Programs ◽  
Breeding Values ◽  
Udder Health ◽  
Selection Strategies ◽  
Commercial Breeding ◽  
Functional Mechanisms ◽  
Mastitis Susceptibility ◽  
Selection Of ◽  
Marker Information

Abstract. Although mastitis in cattle is an important factor for dairy economy and animal welfare and although udder health parameters have a substantial genetic variability, in many countries there is little or no improvement of udder health in the conventional commercial breeding programs. Strategies implementing information about Quantitative trait loci (QTL) via genetic marker information seem to offer new prospects to improve this situation. In a proof-of-principle approach, we show that selection of German Holstein heifers prior to first calving based on marker information regarding a confirmed QTL affecting somatic cell score (SCS) on bovine chromosome 18 (BTA18) (MAS strategy) indeed enabled prediction of halfsibs with a high (q) or a low (Q) number of somatic cells in milk already early in the first lactation. Compared to a strategy relying on conventional breeding values only (CON strategy), selection including marker information resulted in a stronger discrimination between and a higher uniformity within the MAS-Q and -q groups compared to the CON-Q and – q groups selected by conventional selection strategies. The selected heifers, which are clinically unaffected, however genetically different in their capacity of mammary gland protection against pathogens, will serve as tools for a comprehensive expression analysis to highlight molecular processes underlying a different genetic predisposition to mastitis susceptibility. Thus, functional mechanisms resulting in a decreased susceptibility of the Q individuals can be identified to further improve selection on udder health in cattle.

Pathogen-group specific association betweenCXCR1polymorphisms and subclinical mastitis in dairy heifers

2012 ◽  
Vol 79 (3) ◽  
pp. 341-351 ◽  
Author(s):  
Joren Verbeke ◽  
Sofie Piepers ◽  
Luc Peelman ◽  
Mario Van Poucke ◽  
Sarne De Vliegher
Keyword(s):  
Subclinical Mastitis ◽  
Missense Mutations ◽  
Early Lactation ◽  
Coding Region ◽  
Coagulase Negative Staphylococci ◽  
Phenotypic Data ◽  
Udder Health ◽  
Dairy Heifers ◽  
Experimental Trials ◽  
Mastitis Susceptibility

The chemokine (C-X-C motif) receptor 1 (CXCR1) gene encodes the homonymous receptor for interleukin 8 (IL8) on polymorphonuclear neutrophilic leucocytes (PMNL). Binding causes migration from blood to milk, activation and prolonged survival of PMNL, a crucial process in the innate immune defence of the bovine mammary gland against invading mastitis-causing pathogens. The main objective of this study was to screen the entire coding region of theCXCR1gene for polymorphisms and to analyse their association with udder health of dairy heifers. One-hundred-and-forty Belgian Holstein heifers originating from 20 commercial dairy farms were genotyped by DNA sequencing. Detailed phenotypic data on udder health was available including quarter bacteriological culture results and somatic cell count (SCC) in early lactation and composite milk SCC during first lactation. In total, 16 polymorphisms (including 8 missense mutations) were detected. Polymorphism c.980A>G was associated with pathogen-group specific IMI: heifers with genotype AG were less likely to have an IMI due to major mastitis pathogens compared with heifers with genotype GG but did not have less IMI by coagulase-negative staphylococci, so-called minor pathogens.CXCR1genotype was neither associated with quarter SCC in early lactation nor with composite SCC during lactation. Although mastitis susceptibility is influenced by many factors, some genetic polymorphisms potentially have major effects on udder health of heifers, as was shown here. These results trigger us to further study the relationship betweenCXCR1polymorphisms and mastitis susceptibility in both observational and experimental trials.

The Influence of Language Context on Repetitive Speech Use in Children With Autism Spectrum Disorder

2020 ◽  
Vol 29 (1) ◽  
pp. 327-334 ◽  
Author(s):  
Allison Gladfelter ◽  
Cassidy VanZuiden
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Individual Characteristics ◽  
Receptive Vocabulary ◽  
Spectrum Disorder ◽  
School Age Children ◽  
Social Responsiveness ◽  
Contributing Factors ◽  
Children With Asd ◽  
Language Context

Purpose Although repetitive speech is a hallmark characteristic of autism spectrum disorder (ASD), the contributing factors that influence repetitive speech use remain unknown. The purpose of this exploratory study was to determine if the language context impacts the amount and type of repetitive speech produced by children with ASD. Method As part of a broader word-learning study, 11 school-age children with ASD participated in two different language contexts: storytelling and play. Previously collected language samples were transcribed and coded for four types of repetitive speech: immediate echolalia, delayed echolalia, verbal stereotypy, and vocal stereotypy. The rates and proportions of repetitive speech were compared across the two language contexts using Wilcoxon signed-ranks tests. Individual characteristics were further explored using Spearman correlations. Results The children produced lower rates of repetitive speech during the storytelling context than the play-based context. Only immediate echolalia differed between the two contexts based on rate and approached significance based on proportion, with more immediate echolalia produced in the play-based context than in the storytelling context. There were no significant correlations between repetitive speech and measures of social responsiveness, expressive or receptive vocabulary, or nonverbal intelligence. Conclusions The children with ASD produced less immediate echolalia in the storytelling context than in the play-based context. Immediate echolalia use was not related to social skills, vocabulary, or nonverbal IQ scores. These findings offer valuable insights into better understanding repetitive speech use in children with ASD.

1118: The Incidence and Duration of Postoperative Ileus in Patients Undergoing Radical Cystectomy. A Multivariate Analysis of Contributing Factors

2005 ◽  
Vol 173 (4S) ◽  
pp. 303-303
Author(s):  
Diana Wiessner ◽  
Rainer J. Litz ◽  
Axel R. Heller ◽  
Mitko Georgiev ◽  
Oliver W. Hakenberg ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Radical Cystectomy ◽  
Postoperative Ileus ◽  
Contributing Factors

Blood Pressure and Contributing Factors in Inhabitants of Estonia: 15-year Trends

2003 ◽  
Vol 12 (2) ◽  
pp. 1-1
Author(s):  
JELENA ABINA ◽  
OLGA VOLOZH ◽  
ELEONORA SOLODKAYA ◽  
MERILEID SAAVA
Keyword(s):  
Blood Pressure ◽  
Contributing Factors

Efficacy of Crisis Intervention

Crisis ◽  
1999 ◽  
Vol 20 (2) ◽  
pp. 78-85 ◽  
Author(s):  
Thomas Reisch ◽  
Petra Schlatter ◽  
Wolfgang Tschacher
Keyword(s):  
Crisis Intervention ◽  
Intervention Program ◽  
Suicide Ideation ◽  
Indirect Evidence ◽  
Well Being ◽  
Term Therapy ◽  
Contributing Factors ◽  
Step Therapy ◽  
Long Term Therapy ◽  
The Impact

This study assesses the efficacy of the treatment approach implemented in the Bern Crisis Intervention Program, where particular emphasis is placed on the remediation of suicide ideation and suicidal behavior, and depression, fear, and phobia are generally considered to be contributing factors. Four questionnaires addressing psychopathology, emotional well-being, social anxiety, and personality were administered prior to and after the treatment of 51 patients over a period of 2 to 3 weeks. The reduction of symptoms contributing to suicidal ideation and behavior was interpreted as indirect evidence of an antisuicidal effect of the program. Significant improvements were found in the psychopathology ratings, with depression and anxiety showing the largest reductions. The impact on personality and social phobia, however, was only moderate, and on average patients still exhibited symptoms after attending the program. This residual symptomatology points to the necessity of introducing a two-step therapy approach of intensive intervention targeted at the precipitating causes of the crisis, augmented by long-term therapy to treat underlying problems.

Differences in Suicidal Thoughts and Behaviors Among Three Racial Groups

Crisis ◽  
2020 ◽  
Vol 41 (3) ◽  
pp. 172-178
Author(s):  
Brooke A. Ammerman ◽  
Martha K. Fahlgren ◽  
Kristen M. Sorgi ◽  
Michael S. McCloskey
Keyword(s):  
Suicide Attempts ◽  
Health Concern ◽  
Future Research ◽  
Racial Groups ◽  
Contributing Factors ◽  
Suicidal Thoughts ◽  
Final Sample ◽  
And Behaviors ◽  
Assessment Procedures ◽  
Suicidal Thoughts And Behaviors

Abstract. Background: Despite being a major public health concern, it is unclear how suicidal thoughts and behaviors differentially impact separate racial groups. Aims: The aim of the current study was to examine the occurrence of nonlethal suicide events, in addition to suicide attempt characteristics and factors contributing to suicide attempts. Method: A final sample of 7,094 undergraduates from a large northeastern university, identifying as members of three racial groups (White [67.30%], Black [17.30%], and Asian [15.40%]), completed online questionnaires. Results: White participants reported increased likelihood of endorsing lifetime suicidal ideation and plan, whereas Black participants reported decreased likelihood of these events; no differences were found in rates of lifetime suicide attempts. Black participants' suicidal behavior may involve greater ambivalence of intent. A higher proportion of Asian participants endorsed interpersonal factors as contributing to their suicide attempts, whereas a greater percentage of White participants reported internal contributing factors. Limitations: Findings are limited by the sample size and assessment of lifetime suicidal thoughts and behaviors. Conclusion: The findings present a more nuanced look at attitudes and actions related to suicidal thoughts and behaviors that may inform future research and risk assessment procedures.

Suicide after Deployment in UN Peacekeeping Missions—A Danish Pilot Study

Crisis ◽  
2002 ◽  
Vol 23 (2) ◽  
pp. 55-58 ◽  
Author(s):  
J. Hansen-Schwartz ◽  
G. Jessen ◽  
K. Andersen ◽  
H.O. Jørgensen
Keyword(s):  
Pilot Study ◽  
Future Research ◽  
Prevention Strategies ◽  
Contributing Factors ◽  
Un Peacekeeping ◽  
Peacekeeping Missions

Summary: This pilot study looks at the frequency of suicide among Danish soldiers who took part in the UN mandated forces (UNMF) during the 1990's. In a contingent of nearly 4000 Danish UN soldiers four suicides were documented, two of whom committed suicide less than one month before deployment and two who committed suicide within a year after discharge from mission. Contributing factors, prevention strategies, and implications for future research are discussed.

Child and Adolescent Suicide Deaths in New Mexico, 1990-1994

Crisis ◽  
2000 ◽  
Vol 21 (1) ◽  
pp. 36-44 ◽  
Author(s):  
DD Werenko ◽  
LM Olson ◽  
L Fullerton-Gleason ◽  
AW Lynch ◽  
RE Zumwalt ◽  
...  
Keyword(s):  
New Mexico ◽  
Cause Of Death ◽  
American Indians ◽  
Adolescent Suicide ◽  
Suicide Attempts ◽  
Medical Examiner ◽  
Contributing Factors ◽  
Targeted Interventions ◽  
And Gender ◽  
Youth Activity

The suicide death rate in New Mexico is consistently higher than the national rate. Among adolescents, suicide is the third leading cause of death nationally, but in New Mexico it is the second leading cause of death. This study describes the pattern of adolescent suicide deaths in New Mexico. We conducted a retrospective review of all medical examiner autopsies for adolescent suicides (ages 20 years and younger) in New Mexico from 1990-1994. Records were reviewed for demographics and possible contributing factors such as depression, previous attempts, and alcohol and drug use. We identified 184 suicide deaths among children and adolescents ages 9-20 years for an overall rate of 12.9 per 100,000. Our rates for ages 5-9 years (0.2), 10-14 years (3.8), and 15-19 years (22.3) are over twice the U.S. rates. Suicide deaths resulted primarily from firearms (67%), hanging (16%), poisoning (6%), inhalation (4%), and other methods (7%). Method varied by ethnicity (p = .01) and gender (p = .03); males and non-Hispanic Whites were overrepresented among firearm deaths. Firearm ownership was known in 60 (48%) of the firearm deaths. Of these, 53% of the firearms belonged to a family member, 25% to the decedent, and 22% to a friend. Over one-third of decedents (41%) experienced mental disorders, primarily depressed mood and clinical depression. Previous suicide attempts were noted for 15% of the decedents. Some 50% of the decedents had alcohol or drugs present at the time of death; among American Indians/Alaska Natives, 74% had drugs or alcohol present (p = .003). Targeted interventions are needed to reduce adolescent suicide in New Mexico. We suggest raising awareness about acute and chronic contributing factors to suicide; training physicians to look for behavioral manifestations of depression; and involving physicians, teachers, and youth activity leaders in efforts to limit firearm accessibility, such as advising parents to remove firearms from their households.

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