Diffuse villous hyperplasia of the choroid plexus and its surgical management

2010 ◽  
Vol 5 (5) ◽  
pp. 518-522 ◽  
Author(s):  
Oguz Cataltepe ◽  
Deborah Liptzin ◽  
Lindsey Jolley ◽  
Thomas W. Smith

Diffuse villous hyperplasia of the choroid plexus (DVHCP) is a very rare cause of hydrocephalus in children. Only 12 cases of DVHCP have been reported in the literature. In this report the authors describe a new case of a patient with DVHCP who was diagnosed prenatally with hydrocephalus. In a comprehensive literature review and discussion, the authors also discuss radiological and histological characteristics of the reported cases, treatment approaches, and surgical modalities that have been used in the treatment of these patients.

2019 ◽  
Vol 129 (4) ◽  
pp. 394-400 ◽  
Author(s):  
Narmien Haddad ◽  
Pratima Agarwal ◽  
Jessica R. Levi ◽  
Jeremiah C. Tracy ◽  
Lauren F. Tracy

Objective: To examine the clinical presentation, diagnostic evaluation, and management of Killian–Jamieson diverticula (KJD) through literature review. Methods: A comprehensive literature review was conducted through December 2018 using keywords Killian–Jamieson diverticula/diverticulum. Data extracted included clinical presentation, imaging characteristics, surgical management, and postoperative care. Sources: PubMed and Google Scholar. Results: Sixty-eight cases of KJD in 59 reports (29M:39F; median 58 years old) were identified for review. The most common presentation was dysphagia (n = 39), suspected thyroid nodule (n = 24) and globus (n = 14). The majority of KJD (n = 51) occur on the left, with rare reports of right side (n = 11) and bilateral (n = 5) presentation. Thirty-two cases describe surgical management: 22 utilizing a transcervical approach, with (n = 13) or without (n = 9) cricopharyngeal myotomy; and 10 reported endoscopic surgery. Diverticula managed transcervically averaged 3.8 cm in size in comparison to average 2.8 cm in the endoscopic group. Time to diet initiation after transcervical surgery averaged 4 days versus 2 days after endoscopic surgery. Complications were reported in 2/68 cases; both were diverticula recurrence after endoscopic surgery. Conclusion: Killian–Jamieson diverticula is a rare diagnosis that should be considered in the evaluation of dysphagia, globus, and also suspected thyroid nodule. When patient symptoms warrant intervention, a transcervical approach, with or without cricopharyngeal myotomy, is most commonly utilized. In recent years, an endoscopic approach has been presented as an alternative for smaller diverticula. Further understanding of the optimal treatment and postoperative management for KJD requires larger cohorts. Level of Evidence: 4


Pituitary ◽  
2013 ◽  
Vol 17 (5) ◽  
pp. 399-413 ◽  
Author(s):  
Ming Feng ◽  
John D. Carmichael ◽  
Vivien Bonert ◽  
Serguei Bannykh ◽  
Adam N. Mamelak

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Binbin Jiao ◽  
Zhenshan Ding ◽  
Zhenkai Luo ◽  
Shicong Lai ◽  
Xin Xu ◽  
...  

Objective. To assess current evidence on the effectiveness and safety of single- versus multiple-tract percutaneous nephrolithotomy in the surgical management of complex caliceal calculi or staghorn stones through a comprehensive literature review. Methods. A comprehensive literature review of articles investigating the clinical efficacy and safety of single- versus multiple-tract percutaneous nephrolithotomy was performed. Relevant literature was obtained by systematically searching PubMed, EMBASE, and the Cochrane Library through May 2020. We followed the search strategy based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The primary outcomes, including the stone-free rate (SFR), and secondary outcomes (peri- and postoperative complications and operative data) were evaluated using RevMan 5.3 statistical software. Results. Ten studies involving 1844 patients with complex caliceal calculi or staghorn stones met the inclusion criteria. Single-tract percutaneous nephrolithotomy (STPCNL) had noninferior clinical efficacy with respect to the immediate SFR ( odds   ratio   OR = 0.80 , 95% confidence interval (CI) (0.46 to 1.38), p = 0.42 ) and 3-month SFR ( OR = 1.22 , 95% CI (0.38 to 3.92), p = 0.74 ) compared with multiple-tract percutaneous nephrolithotomy (MTPCNL). In addition, pooled analyses showed that STPCNL resulted in significantly lower hemoglobin decreases ( MD = − 0.46 , 95% CI (-0.68 to -0.25), p < 0.0001 ), fewer blood transfusions ( OR = 0.48 , 95% CI (0.34 to 0.67), p < 0.0001 ), and fewer pulmonary complications ( OR = 0.28 , 95% CI (0.09 to 0.83), p = 0.02 ) than MTPCNL. However, the overall evidence was insufficient to suggest a statistically significant difference for other adverse events. Conclusion. This meta-analysis indicated that STPCNL is an effective method for treating complex caliceal calculi or staghorn stones. Compared with MTPCNL, STPCNL not only yields similarly high SFRs but also is associated with many advantages, less blood loss, fewer blood transfusions, and fewer pulmonary complications without an increase in other complications. However, the findings of this study should be further confirmed by well-designed prospective randomized controlled trials (RCTs) with a larger patient series.


Author(s):  
Adam Lee ◽  
Adam Bajinting ◽  
Abby Lunneen ◽  
Colleen M. Fitzpatrick ◽  
Gustavo A. Villalona

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.


Oikos ◽  
2016 ◽  
Vol 19 (40) ◽  
pp. 137
Author(s):  
Roberto Horta

RESUMENEl objetivo de este artículo es el de analizar el concepto “desempeño exportador”, concepto muy usado en la literatura relacionada con los negocios internacionales, a los efectos de aportar a su conceptualización y medición. Para ello, se efectúa una amplia revisión de la literatura y se analizan los avances realizados por los investigadores a los efectos de aportar a las dimensiones y formas de medir este concepto. Se concluye que se trata de un concepto en el cual siguen existiendo diversos enfoques, aunque existen avances importantes en la forma de operacionalizar el desempeño exportador.Palabras clave: conceptualización, desempeño exportador, negocios internacionales.Conceptualization of export performance: analysis of developments in the literature of international business ABSTRACTThe aim of this paper is to analyze the concept of "export performance" concept very use in the literature of international business, in order to contribute to its conceptualization and measurement. For this, a comprehensive literature review is performed and the progress made by researchers to contribute to the dimensions and ways of measuring this concept is discussed. Concluded that it is a concept which still exist several approaches, although there are significant advances in how to operationalize export performance.Keywords: conceptualization, export performance, international business.Conceptualização do desempenho exportador: a análise dos avanços na literatura dos negócios internacionais RESUMO O objetivo deste artigo é analisar o conceito de "desempenho exportador", conceito utilizado amplamente na literatura sobre negócios internacionais, aos efeitos de contribuir para a conceituação e medição. Para fazer isso, se faz uma extensa revisão da literatura e analisam-se os avanços realizados pelos pesquisadores aos efeitos de contribuir nas dimensões e formas de medir este conceito. Conclui-se que se trata de um conceito no qual continuam existindo diversas abordagens, apesar dos avanços significativos na forma de operacionalizar o desempenho exportador.Palavras-chave: conceituação, desempenho exportador, negócios internacionais.


2020 ◽  
Vol 02 ◽  
Author(s):  
Masood Ghori ◽  
Nadya O. Al Matrooshi ◽  
Samir Al Jabbari ◽  
Ahmed Bafadel ◽  
Gopal Bhatnagar

: Infective Endocarditis (IE), a known complication of hemodialysis (HD), has recently been categorized as Healthcare-Associated Infective Endocarditis (HAIE). Single pathogen bacteremia is common, polymicrobial endocardial infection is rare in this cohort of the patients. We report a case of endocarditis caused by Enterococcus faecalis (E. faecalis) and Burkholderia cepacia (B. cepacia), a first ever reported combination of a usual and an unusual organism, respectively, in a patient on HD. Clinical presentation of the patient, its complicated course ,medical and surgical management ,along with microbial and echocardiographic findings is presented herein. The authors believe that presentation of this case of HAIE may benefit and contribute positively to cardiac science owing to the rare encounter of this organism as a pathogen in infective endocarditis and the difficulties in treating it.


2019 ◽  
Vol 19 (16) ◽  
pp. 1298-1368 ◽  
Author(s):  
Ankit Jain ◽  
Poonam Piplani

: Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives has also been incorporated. The objective of the review is to provide insights to designing and synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.


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