Oncotic aneurysm

1976 ◽  
Vol 45 (1) ◽  
pp. 98-100 ◽  
Author(s):  
Fredric A. Helmer
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Intracranial Aneurysm ◽  
Tumor Cells ◽  
Vessel Wall ◽  
Metastatic Tumor ◽  
Content Type ◽  
Arterial Circulation ◽  
Aneurysm Formation ◽  
Oncotic Aneurysm ◽  
Fine Print

✓ The author describes a case of intracerebral and subarachnoid hemorrhage associated with an intracranial aneurysm caused by a metastatic tumor. The aneurysm formation is explained as being a result of tumor cells invading the vessel wall while still preserving the arterial circulation.

Intracranial aneurysm in infancy

1977 ◽  
Vol 46 (6) ◽  
pp. 832-834 ◽  
Author(s):  
Robert J. Morelli ◽  
Frederick Laubscher
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Surgical Treatment ◽  
Intracranial Aneurysm ◽  
Anterior Cerebral Artery ◽  
Content Type ◽  
Long Term Follow Up ◽  
Surgical Cure ◽  
Fine Print

✓ Angiography demonstrated an aneurysm of the left anterior cerebral artery in a 4-month-old baby who was admitted for subarachnoid hemorrhage. A surgical cure with long-term follow-up course was achieved. Clinical and pathogenetic aspects are presented. The rarity of such lesions in childhood and their successful surgical treatment are discussed briefly.

Radiographic and histologic demonstration of an aneurysm developing on the infundibulum of the posterior communicating artery

1970 ◽  
Vol 33 (5) ◽  
pp. 591-595 ◽  
Author(s):  
J. Timothy Stuntz ◽  
George A. Ojemann ◽  
Ellsworth C. Alvord
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Histological Examination ◽  
Posterior Communicating Artery ◽  
Content Type ◽  
Aneurysm Formation ◽  
Fine Print

✓ In this case an aneurysm of the posterior communicating artery developed 9 years after an infundibular dilatation of this posterior communicating artery, without aneurysm formation, had been radiographically demonstrated. Histological examination, after a fatal subarachnoid hemorrhage from the aneurysm, demonstrated that it arose exactly at the site of narrowing of the funnel-shaped infundibulum.

Subarachnoid hemorrhage caused by a fungal aneurysm of the vertebral artery as a complication of intracranial aneurysm clipping

1990 ◽  
Vol 73 (6) ◽  
pp. 962-964 ◽  
Author(s):  
Wolfgang Peter Piotrowski ◽  
Peter Pilz ◽  
I-Hsing Chuang
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Intracranial Aneurysm ◽  
Fungal Infection ◽  
Vertebral Artery ◽  
Immunosuppressive Therapy ◽  
Intracranial Aneurysms ◽  
Content Type ◽  
Aneurysm Clipping ◽  
Long Period ◽  
Fine Print

✓ Intracranial aneurysms are an uncommon manifestation of fungal infection. A case is described in which the formation of an aneurysm followed an intracranial intraoperative Aspergillus infection attributable to a long period of preoperative antibiotic medication and immunosuppressive therapy with steroids.

Pathological and radiological correlation of subarachnoid hemorrhage in phencyclidine abuse

1987 ◽  
Vol 67 (3) ◽  
pp. 446-448 ◽  
Author(s):  
Orest B. Boyko ◽  
Peter C. Burger ◽  
E. Ralph Heinz
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Vessel Wall ◽  
Pharmacological Action ◽  
Cerebral Vasculature ◽  
Pathological Findings ◽  
Content Type ◽  
Arterial Vessel ◽  
Chromatographic Evidence ◽  
Fine Print

✓ Although hypertension can be associated with phencyclidine (PCP) use, subarachnoid hemorrhage (SAH) is a rare result. The radiological and pathological findings are reported of a patient with acute SAH who had chromatographic evidence of PCP in his blood. The occurrence of SAH in a patient who uses PCP may be caused by a disrupted arterial vessel wall and/or vasospasm due to the pharmacological action of the drug on the cerebral vasculature.

Hemorrhage from a previously undemonstrated intracranial aneurysm as a late complication of carotid artery ligation

1977 ◽  
Vol 46 (5) ◽  
pp. 654-658 ◽  
Author(s):  
William M. Klemme
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Carotid Artery ◽  
Intracranial Aneurysm ◽  
Late Complication ◽  
Artery Ligation ◽  
Content Type ◽  
Carotid Artery Ligation ◽  
Ruptured Intracranial Aneurysm ◽  
The Common ◽  
Fine Print

✓ A case is reported in which the patient underwent ligation of the common carotid artery as treatment for a ruptured intracranial aneurysm. Nine years later a second subarachnoid hemorrhage occurred from a new or previously undemonstrated intracranial aneurysm. Recannulation of the ligated carotid artery was demonstrated by arteriography. Similar cases are cited from the literature.

Prostatic adenocarcinoma metastatic to chronic subdural hematoma membranes

1988 ◽  
Vol 68 (4) ◽  
pp. 642-644 ◽  
Author(s):  
Charles L. Y. Cheng ◽  
Jonathan Greenberg ◽  
Lola A. Hoover
Keyword(s):  
Tumor Cells ◽  
Subdural Hematoma ◽  
Relevant Literature ◽  
Chronic Subdural Hematoma ◽  
Metastatic Tumor ◽  
Prostatic Adenocarcinoma ◽  
Content Type ◽  
Adenocarcinoma Of The Prostate ◽  
Fine Print

✓ A case of adenocarcinoma of the prostate metastatic to chronic subdural hematoma membranes is presented. The relevant literature is reviewed and the mechanism of transdural invasion by metastatic tumor cells is discussed.

Early versus late intracranial aneurysm surgery in subarachnoid hemorrhage

1988 ◽  
Vol 69 (3) ◽  
pp. 326-331 ◽  
Author(s):  
Douglas Chyatte ◽  
Nicolee C. Fode ◽  
Thoralf M. Sundt
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Intracranial Aneurysm ◽  
Surgical Intervention ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Direct Result ◽  
Aneurysm Surgery ◽  
Content Type ◽  
Surgical Group ◽  
Fine Print

✓ The management results in 244 patients admitted to one institution within 3 days of aneurysmal subarachnoid hemorrhage (SAH) from January, 1979, to December, 1985, were analyzed with respect to the timing of surgical intervention. Twenty-six patients died prior to surgery. Patients surviving to surgery were divided into three groups according to the interval between preadmission SAH and surgery: 0 to 3 days (85 cases), 4 to 9 days (83 cases), and 10 or more days (50 cases). Of the patients who were categorized neurologically into Botterell Grades 1 and 2 (Hunt and Hess Grades I to III) on admission, 87% had an excellent or good result on follow-up evaluation. Patients undergoing surgery 0 to 3 days after SAH had a statistically significant increase in the incidence of postoperative ischemic symptoms (p < 0.005), which was balanced by similar complications preoperatively in the 10-day post-SAH surgical group. Most rebleeds occurred before admission but delaying surgery did increase the risk of rebleeding in the hospital (p < 0.0005). Management morbidity and mortality occurred primarily as a direct result of a severe initial hemorrhage; thus, the measured benefits of early surgery were less than might have been predicted.

Presence and significance of NK cells in glioblastomas

1989 ◽  
Vol 70 (5) ◽  
pp. 728-731 ◽  
Author(s):  
Jesús Vaquero ◽  
Santiago Coca ◽  
Santiago Oya ◽  
Roberto Martínez ◽  
Josefa Ramiro ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Nk Cells ◽  
Survival Time ◽  
Tumor Cells ◽  
Lymphocytic Infiltration ◽  
Surface Marker ◽  
Content Type ◽  
Hematoxylin And Eosin ◽  
Hematoxylin And Eosin Staining ◽  
Fine Print

✓ A monoclonal antibody against the surface marker IOT-10 of natural killer (NK) cells was used to investigate the presence of these cells in a series of 25 glioblastomas. In 40% of the tumors, IOT-10-positive NK cells were found in small numbers scattered among the tumor cells. The presence of IOT-10-positive NK cells was not related to the degree of lymphocytic infiltration in the tumor as demonstrated by hematoxylin and eosin staining, nor did it appear to influence the survival time of the patients studied.

Aneurysm-induced third nerve palsy

1972 ◽  
Vol 36 (5) ◽  
pp. 548-551 ◽  
Author(s):  
Iftikhar A. Raja
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Functional Recovery ◽  
Poor Prognosis ◽  
Nerve Palsy ◽  
Nerve Function ◽  
Content Type ◽  
Third Nerve Palsy ◽  
Carotid Ligation ◽  
Third Nerve ◽  
Fine Print

✓ Forty-two patients with aneurysm-induced third nerve palsy are described. After carotid ligation, 58% showed satisfactory and 42% unsatisfactory functional recovery. In some patients the deficit continued to increase even after carotid ligation. Early ligation provided a better chance of recovery of third nerve function. Patients in whom third nerve palsy began after subarachnoid hemorrhage had a poor prognosis. No relationship was noted between the size of the aneurysm and the recovery of third nerve function.

Thymidine kinase-mediated killing of rat brain tumors

1993 ◽  
Vol 79 (5) ◽  
pp. 729-735 ◽  
Author(s):  
David Barba ◽  
Joseph Hardin ◽  
Jasodhara Ray ◽  
Fred H. Gage
Keyword(s):  
Gene Therapy ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Wild Type ◽  
Cns Disorders ◽  
Content Type ◽  
Potential Applications ◽  
Ganciclovir Treatment ◽  
The Brain ◽  
Fine Print

✓ Gene therapy has many potential applications in central nervous system (CNS) disorders, including the selective killing of tumor cells in the brain. A rat brain tumor model was used to test the herpes simplex virus (HSV)-thymidine kinase (TK) gene for its ability to selectively kill C6 and 9L tumor cells in the brain following systemic administration of the nucleoside analog ganciclovir. The HSV-TK gene was introduced in vitro into tumor cells (C6-TK and 9L-TK), then these modified tumor cells were evaluated for their sensitivity to cell killing by ganciclovir. In a dose-response assay, both C6-TK and 9L-TK cells were 100 times more sensitive to killing by ganciclovir (median lethal dose: C6-TK, 0.1 µg ganciclovir/ml; C6, 5.0 µg ganciclovir/ml) than unmodified wild-type tumor cells or cultured fibroblasts. In vivo studies confirmed the ability of intraperitoneal ganciclovir administration to kill established brain tumors in rats as quantified by both stereological assessment of brain tumor volumes and studies of animal survival over 90 days. Rats with brain tumors established by intracerebral injection of wild-type or HSV-TK modified tumor cells or by a combination of wild-type and HSV-TK-modified cells were studied with and without ganciclovir treatments. Stereological methods determined that ganciclovir treatment eliminated tumors composed of HSV-TK-modified cells while control tumors grew as expected (p < 0.001). In survival studies, all 10 rats with 9L-TK tumors treated with ganciclovir survived 90 days while all untreated rats died within 25 days. Curiously, tumors composed of combinations of 9L and 9L-TK cells could be eliminated by ganciclovir treatments even when only one-half of the tumor cells carried the HSV-TK gene. While not completely understood, this additional tumor cell killing appears to be both tumor selective and local in nature. It is concluded that HSV-TK gene therapy with ganciclovir treatment does selectively kill tumor cells in the brain and has many potential applications in CNS disorders, including the treatment of cancer.

Sign in / Sign up

Export Citation Format

Share Document