scholarly journals Asymptomatic Bacteriuria in Pregnant Women

2013 ◽  
Vol 52 (192) ◽  
Author(s):  
Achala Thakur ◽  
Ratna Baral ◽  
Pritha Basnet ◽  
Rubina Rai ◽  
Ajay Agrawal ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Urine Culture ◽  
Asymptomatic Bacteriuria ◽  
Signs And Symptoms ◽  
Acinetobacter Species ◽  
Significant Difference ◽  
Culture Sensitivity ◽  
Pregnancy Urine ◽  
A Prospective Study ◽  
In Pregnancy

Introduction: Asymptomatic bacteriuria is the significant presence of bacteria in urine of an individual without symptoms. The aim of the study is to determine the prevalence of asymptomaticbacteriuria in pregnant women. Methods: This study was a prospective study conducted in the department of Obstetrics and Gynaecology at B. P. Koirala Institute of Health Sciences. The duration of the study was six monthsfrom January to June 2012. A total of 600 pregnant women were enrolled. All women were clinically identified to have no signs and symptoms of UTI. Clean catch midstream urine sample was collectedfrom each patient into a sterile vial. The urine samples were examined for microscopic and culture sensitivity test. Results: Out of 600 pregnant women, 52 were positive for significant bacteriuria with a prevalence rate of 8.7%. There was a significant difference in prevalence of asymptomatic bacteriuria withrespect to trimester (p=0.005). Age did not show any significant difference in the prevalence of asymptomatic bacteriuria (p=0.807). There was not any significant difference in the prevalence ofasymptomatic bacteriuria with respect to parity (p=0.864) and booking status (p=0.397). Escherichia coli (35%), Acinetobacter species (15%), Enterococcus species (12%) and Klebsiella pneumoniae (10%)were the common isolates. Most of the isolates were sensitive either to Nitrofurantoin, Norfloxacin or Amikacin. Conclusions: Asymptomatic bacteriuria is common in pregnancy. Urine culture sensitivity should be carried out routinely on all pregnant patients in order to prevent the dangerous complicationsassociated with it. Keywords: asymptomatic bacteriuria in pregnancy; urine culture and sensitivity.

scholarly journals Role of routine urine culture in predicting asymptomatic bacteriuria in pregnancy and the prevalence of asymptomatic bacteriuria in pregnant women - Our experience

2021 ◽  
Vol 8 (4) ◽  
pp. 513-517
Author(s):  
Aparna Krishnamurthy ◽  
Shazia Khan ◽  
Tina Singh
Keyword(s):  
Pregnant Women ◽  
Urine Culture ◽  
Asymptomatic Bacteriuria ◽  
Renal Calculi ◽  
Culture Sensitivity ◽  
History Of ◽  
Sensitivity Standard ◽  
Or History ◽  
In Pregnancy

Asymptomatic bacteriuria (ASB) in pregnancy can flare into frank pyelonephritis and sepsis if untreated due to the low immunity. Apart from causing morbidity in mothers it affects the foetus by increasing the incidence of prematurity and IUGR. The present study was undertaken to determine the prevalence of ASB in the pregnant women attending Ante natal clinic and the significance of routine urine culture. : Total 310 pregnant women attending the antenatal OPD were enrolled in the study over a period of 10 months. Inclusion criteria included all pregnant women attending antenatal OPD without any urinary symptoms or history of fever. Exclusion criteria included frank UTI symptoms like fever, dysuria, increased frequency of urine, any history of intake of antibiotics, any urinary tract anomaly or renal calculi. Their midstream urine sampling was collected and subjected to both microscopy and culture sensitivity; standard microbiological method was used. The prevalence of ASB was found to be 11.29% and was maximum in second trimester (54.2%). The study revealed routine urine culture is a sensitive test to diagnose ASB. The commonest bacterium isolated was Escherichia coli (51.4% cases) and the most effective antibiotic was Nitrofurantoin. The neonatal outcomes are discussed in the text while no perinatal deaths were recorded during the period of study. No direct association of asymptomatic bacteriuria with anaemia and preeclampsia was found, but odds ratio was more than one. The study highlights that asymptomatic bacteriuria is a common occurrence in pregnant women, including urine culture as a part of routine investigation in antenatal patients can help diagnose this condition. Prompt treatment of ASB can prevent any obstetric complication arising from the flareup of asymptomatic bacteriuria in pregnancy and thus reduce maternal and foetal morbidity.

scholarly journals The Rate of Asymptomatic Bacteriuria is Similar in Term and Preterm Delivery

2016 ◽  
Author(s):  
Riska Amelia
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Preterm Labor ◽  
Obstet Gynecol ◽  
Urine Analysis ◽  
Urine Culture ◽  
Asymptomatic Bacteriuria ◽  
Significant Difference ◽  
Term Delivery ◽  
The Subject

Objectives: To show the prevalence of asymptomatic bacteriuria in pregnant women and to find its correlation with preterm labor. Methods: This research was performed in Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. A total of 78 subjects joined this research. The first group consisted of 39 subjects that were having preterm delivery and the second group consisted of 39 subjects that were having term delivery. Urine analysis and culture were done in both groups. The subject was being considered to have asymptomatic bacteriuria if the urine culture showed a minimum of 100,000 bacteria/ml without any symptoms or signs of urinary tract infection. The number was then analyzed to reveal the correlation of asymptomatic bacteriuria with preterm delivery. Results: There were a significantly higher number of preterm deliveries in subjects whose age ranged between 15-19 year-old (28.20% vs 12.8%; p=0.033). While on the contrary, there was a significantly lower number of preterm delivery in subjects whose age ranged between 30-34 year-old (25.6% vs 5.12%; p=0.020).The incidence number of asymptomatic bacteriuria among all subjects is 21.79%. There was no significant difference of asymptomatic bacteriuria between preterm and a term delivery (23.07% vs 20.51%; p=0.784). Conclusions: There was no significant difference of asymptomatic bacteriuria between the subject with preterm delivery and term delivery, but the incidence of asymptomatic bacteriuria in pregnant women in this study was quite high, reaching eight times higher than those stated in other study. Thus, routine urine culture screening policy in early pregnancy still cannot be omitted, considering that asymptomatic bacteriuria can lead to pyelonephritis which can cause maternal and fetal morbidity. [Indones J Obstet Gynecol; 37-1: 8-11] Keywords: asymptomatic bacteriuria, urine analysis, urine culture, preterm delivery

scholarly journals Asymptomatic bacteriuria in pregnancy

2019 ◽  
Vol 14 (2) ◽  
pp. 31-35
Author(s):  
Tripti Shrestha ◽  
Gehanath Baral
Keyword(s):  
Pregnant Women ◽  
Antimicrobial Agents ◽  
Asymptomatic Bacteriuria ◽  
Urine Samples ◽  
Urine Specimen ◽  
Sensitivity Testing ◽  
Microbiological Methods ◽  
Sensitivity Pattern ◽  
Significant Difference ◽  
In Pregnancy

Aims: To estimate the prevalence of asymptomatic bacteriuria, its causative agents and their antimicrobial susceptibility pattern; and to determine the relationship of asymptomatic bacteriuria and pyuria in pregnant women. Methods: A cross sectional study was conducted in a total of 240 asymptomatic pregnant women in Paropakar Maternity and Women’s Hospital from August 2016 to January 2017. Clean catch midstream urine samples were collected from each participant. Urine samples were cultured using standard microbiological methods. Identification of isolates and antibiotic sensitivity testing were done. Results: Out of 240 pregnant women, 17 (7.1%) were positive for asymptomatic bacteriuria [colony forming unit (CFU) >10 5 /ml]. There was no any significant difference in the prevalence of asymptomatic bacteriuria with respect to age, gestational age and parity. The prevalence of asymptomatic bacteriuria was significantly different with respect to education level (p=0.01) and number of pus cells in urine specimen (p=0.04). The most frequently isolated microorganisms were E.coli (70.6 %) followed by Klebsiella spp (11.8%). Ciprofloxacin followed by Nitrofurantoin and Norfloxacin had the highest sensitivity to all the isolates. Conclusions: Asymptomatic bacteriuria is common in pregnancy. Routine urine culture should be done on all pregnant women to detect asymptomatic bacteriuria. Treatment should be based on antimicrobial sensitivity pattern due to increased antibiotic resistance to commonly used antimicrobial agents.

scholarly journals A study on bacterial vaginosis in pregnancy and its effect on pregnancy outcome

2019 ◽  
Vol 8 (7) ◽  
pp. 2826
Author(s):  
Sai Deepthi Chikicherla ◽  
V. Sitalakshmi
Keyword(s):  
Bacterial Vaginosis ◽  
Pregnant Women ◽  
Sampling Technique ◽  
Exclusion Criteria ◽  
Chi Square ◽  
Medical College ◽  
Significant Difference ◽  
Adverse Pregnancy ◽  
A Prospective Study ◽  
In Pregnancy

Background: Bacterial vaginosis is an extremely prevalent vaginal condition and one of the causes of vaginitis among both pregnant and non pregnant women and associated with severe sequelae. Fifty percent of the women are asymptomatic. Current studies have found that the prevalence of BV ranges from 15% to 30% among non-pregnant women and 10% to 41% among pregnant women.Methods: This is a prospective study conducted among 150 pregnant women who attended the antenatal outpatient and inpatient clinic in the Department of Obstetrics and Gynaecology at Narayana Medical College and Hospital, Nellore over a period of two years from Oct 2016 to Oct 2018. Obstetric cases fulfilling the inclusion and exclusion criteria were enrolled in the study by convenient sampling technique. They were followed till the outcome of pregnancy. The data was subjected to usual statistical analysis by employing the chi-square tests.Results: Prevalence of the bacterial vaginosis was 20% in the present study. BV was significantly (p<0.05) associated with preterm delivery, PPROM, low birth weight, low APGAR and neonatal jaundice. Neonatal sepsis and congenital abnormalities showed no statistically significant difference (p>0.05) between BV positive and negative women.Conclusions: Considering the vast spectrum of maternal and fetal morbidity associated with this infection, and the availability of rapid inexpensive diagnostic tests it may be prudent to screen BV in pregnancy, so that it may be treated early and hence prevent the adverse pregnancy outcomes.

scholarly journals A study of prevalence of asymptomatic bacteriuria in pregnant women from rural areas attending to Obstetric Department in Akash Hospital, Karnataka, India

2019 ◽  
Vol 8 (7) ◽  
pp. 2845
Author(s):  
Rohini N. S. ◽  
Ravishankar S. N. ◽  
Kala K. ◽  
Rakshith N. R.
Keyword(s):  
Pregnant Women ◽  
Urine Culture ◽  
Screening Method ◽  
Asymptomatic Bacteriuria ◽  
Significant Risk ◽  
Screening Tests ◽  
Rapid Screening ◽  
Screening Methods ◽  
Gram Staining ◽  
In Pregnancy

Background: Asymptomatic bacteriuria (ASB) in pregnancy is a significant risk factor for developing upper urinary tract infection and pyelonephritis which is associated with significant maternal and fetal risks. The aim of this study was to know the prevalence of asymptomatic bacteriuria in pregnancy, to identify the organisms and their antibiotic susceptibility patterns and to formulate a single or combined rapid screening method as an acceptable alternative to urine culture.Methods: A total of 375 pregnant women aged between 18 to 45 years were included in this study. Clean catch mid-stream urine samples were collected. Screening tests done were gram staining of uncentrifuged urine, pus cell count, nitrite test and leukocyte esterase test. Identification of pathogens and antibiotic sensitivity tests were performed as per standard urine culture and sensitivity methods.Results: Out of the 375 pregnant women, 31 (8.4%) had significant bacteriuria. High percentage of women with ASB were primigravidas (51.38%) and in 2nd trimester (43.86%). The most common organism isolated was E.coli (56.14%). In screening tests, gram staining of uncentrifuged urine had a sensitivity of 85.71%. Sensitivity of 71.42% was found in Nitrite and leucocyte esterase tests. However, the combination of these two tests, with either test positive, showed sensitivity and negative predictive value of 90.47% and 99.09% respectively.Conclusions: Early detection and treatment of ASB in pregnancy can prevent complications. ASB can be identified by simple and combined rapid screening methods and urine culture along with antibiogram. Therefore, screening and treatment of ASB may be incorporated as routine antenatal care for safe motherhood and healthy newborn.

scholarly journals Incidence of Asymptomatic Bacteriuria in Pregnant Women

2021 ◽  
pp. 215-219
Author(s):  
S. Roshini ◽  
R. Shruta Lakshanaa ◽  
M. Sivasankar ◽  
M. Griffin ◽  
T. Suhas ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Tamil Nadu ◽  
Urine Culture ◽  
Age Groups ◽  
Asymptomatic Bacteriuria ◽  
Signs And Symptoms ◽  
Culture Method ◽  
First Trimester ◽  
Antenatal Clinic ◽  
Medical College

Background: Asymptomatic bacteriuria is the presence of bacteria in the properly collected urine of a patient that has no signs and symptoms of urinary tract infection. Aim: This study was carried out to determine the incidence of asymptomatic bacteriuria in pregnant women in Saveetha medical college, Thandalam, Tamil Nadu. Materials and Methods: A total of 250 pregnant women attending antenatal clinic at civil hospital, Saveetha medical college, over a period of 3 months, with age groups between 18 to 30 years agreed to enter the study and were clinically evaluated. All these women were asked to submit clean catch midstream urine samples and it was examined under the microscope and by culture method. Results: A total of 250 pregnant women included in our study, with varying age groups between 18 to 30 years and the highest incidence was seen in between the 26 to 30 age group. Asymptomatic bacteriuria was seen in 27.2% of the pregnant women. The prevalence of Escherichia coli was among the most dominant organism, followed by Staphylococcus aureus ,klebsiella and proteus species. Conclusion: The study showed 27.2% of the pregnant women to have asymptomatic bacteriuria. This can be reduced by screening the mothers in first trimester and routine urine culture test must be carried out.

scholarly journals The content of matrix metalloproteinase-12 in pregnancy complicated by preeclampsia

2017 ◽  
Vol 66 (6) ◽  
pp. 66-72
Author(s):  
Natalia Yu. Yakovleva ◽  
Elena Yu. Vasileva ◽  
Lubov’ V. Kuznetsova ◽  
Ekaterina S. Shelepova ◽  
Elena L. Khazova ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Pregnant Women ◽  
Sharp Decrease ◽  
First Trimester ◽  
Pathological Process ◽  
Significant Difference ◽  
Single Idea ◽  
A Prospective Study ◽  
In Pregnancy ◽  
Matrix Metalloproteinase 12

Relevance. Pre-eclampsia is the most difficult and important problem in obstetrics, it ranks third in the structure of maternal mortality. Until now, there is no single idea of the mechanisms of development of this pathological process. The study of the concentration of MMP-12 in pregnancy will determine its possible role in the development of pre-eclampsia. Aim. Сompare the dynamics of the concentration of matrix metalloproteinase-12 (MMP-12) in pregnancy complicated and not complicated by preeclampsia. Materials and methods. A prospective study of two groups of women: the main group is pregnant (n = 17) with preeclampsia (moderate (n = 11) and severe (n = 6)), the comparison group is women whose pregnancy was not complicated by preeclampsia (n = 83). The concentration of matrix metalloproteinase-12 was determined by the method of enzyme immunoassay in serum at 11-13, 22-24, 32-34 weeks of gestation. Results. In the group of pregnant women without preeclampsia, there was a sharp decrease in the concentration of MMP-12 from the I trimester to II (p = 0.0001), followed by a slight increase to the III trimester. In the group of pregnant women with preeclampsia, an increase in the concentration from the I trimester to II (p = 0.0001) was established. A significant difference in the concentration of MMP-12 between groups in the first trimester of pregnancy was shown (p = 0.0001). Conclusion. Thus, the results of the study indicate the role of MMP-12 in the initial stages of placentation.

scholarly journals Differences in pregnancy and perinatal outcomes among symptomatic versus asymptomatic COVID-19-infected pregnant women: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Durray Shahwar A. Khan ◽  
La-Raib Hamid ◽  
Anna Ali ◽  
Rehana A. Salam ◽  
Nadeem Zuberi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Pregnant Women ◽  
Low Birthweight ◽  
Meta Analysis ◽  
Perinatal Outcomes ◽  
Respiratory Disorder ◽  
Significant Difference ◽  
The Mean ◽  
In Pregnancy

Abstract Background There is dearth of information on COVID-19’s impact on pregnant women. However, literature reported trends of COVID-19 differ, depending on the presence of clinical features upon presentation. Objective This systematic review aimed to assess differences in risk factors, management, complications, and pregnancy and perinatal outcomes in symptomatic vs. asymptomatic pregnant women with confirmed SARS-CoV-2 infection. Methods A search was run on electronic databases to identify studies reporting COVID-19 in pregnancy. Meta-analysis was performed and odds ratios and mean difference with 95% confidence intervals were calculated using Review Manager 5.4. Review Prospero registration number CRD42020204662. Results We included ten articles reporting data from 3158 pregnancies; with 1900 symptomatic and 1258 asymptomatic pregnant women. There was no significant difference in the mean age, gestational age, and body mass index between the two groups. The meta-analysis suggested that pregnant women who were obese (OR:1.37;95%CI:1.15 to 1.62), hypertensive (OR:2.07;95%CI:1.38 to 3.10) or had a respiratory disorder (OR:1.64;95%CI:1.25 to 2.16), were more likely to be symptomatic when infected with SARS-CoV-2. Pregnant women with Black (OR:1.48;95%CI:1.19 to 1.85) or Asian (OR:1.64;95%CI:1.23 to 2.18) ethnicity were more likely to be symptomatic while those with White ethnicity (OR:0.63;95%CI:0.52 to 0.76) were more likely to be asymptomatic. Cesarean-section delivery (OR:1.40;95%CI:1.17 to 1.67) was more likely amongst symptomatic pregnant women. The mean birthweight(g) (MD:240.51;95%CI:188.42 to 293.51), was significantly lower, while the odds of low birthweight (OR:1.85;95%CI:1.06 to 3.24) and preterm birth (< 37 weeks) (OR:2.10;95%CI:1.04 to 4.23) was higher amongst symptomatic pregnant women. Symptomatic pregnant women had a greater requirement for maternal ICU admission (OR:13.25;95%CI:5.60 to 31.34) and mechanical ventilation (OR:15.56;95%CI:2.96 to 81.70) while their neonates had a higher likelihood for Neonatal Intensive Care Unit admission (OR:1.96;95%CI:1.59 to 2.43). The management strategies in the included studies were poorly discussed, hence could not be analyzed. Conclusion The evidence suggests that the presence of risk factors (co-morbidities and ethnicity) increased the likelihood of pregnant women being symptomatic. Higher odds of complications were also observed amongst symptomatic pregnant women. However, more adequately conducted studies with adjusted analysis and parallel comparison groups are required to reach conclusive findings.

Competence of medical and obstetric registrars in the management of systemic lupus erythematosus in pregnancy

2020 ◽  
pp. 1753495X2096467
Author(s):  
Jarrod Zamparini ◽  
Stuart Pattinson ◽  
Kavita Makan
Keyword(s):  
South Africa ◽  
Systemic Lupus Erythematosus ◽  
Pregnant Women ◽  
Lupus Erythematosus ◽  
Pass Rate ◽  
Childbearing Age ◽  
Systemic Lupus ◽  
Significant Difference ◽  
General Physicians ◽  
In Pregnancy

Introduction Systemic lupus erythematosus has a predilection for women of childbearing age. Globally a shortage of rheumatologists exists resulting in general physicians and obstetricians treating systemic lupus erythematosus in pregnancy. Methods We conducted a survey amongst medical and obstetric registrars in South Africa to assess their subjective and objective competence in managing pregnant women with systemic lupus erythematosus. Results The pass rate for the objective section was 70.8% with no statistically significant difference in the pass rate between medical and obstetric registrars. Participants felt unprepared to manage pregnant women with systemic lupus erythematosus, with a mean overall score of 3.4 out of 7 for the subjective section, based on four Likert scale type questions. Conclusion Trainees are not able to accurately assess their own levels of competence in order to identify their learning needs. Due to the shortage of rheumatologists and lack of obstetric physicians in South Africa, general physicians and obstetricians must be equipped to provide adequate care to pregnant women with systemic lupus erythematosus.

scholarly journals Asymptomatic bacteriuria in pregnancy: what is the validity of urine sediment microscopy as a screening tool in a low resource setting?

2020 ◽  
Vol 9 (6) ◽  
pp. 2442
Author(s):  
Rashmi Polnaya ◽  
Amritha Bhandary
Keyword(s):  
Predictive Value ◽  
Urine Culture ◽  
Asymptomatic Bacteriuria ◽  
Urine Sediment ◽  
Predictive Values ◽  
Low Resource ◽  
Resource Setting ◽  
Low Resource Setting ◽  
Urine Microscopy ◽  
In Pregnancy

Background: Asymptomatic bacteriuria in pregnancy should be screened and treated to reduce the risk of morbidity and mortality. Urine culture is the recommended test. In low resource setting with large patient load urine culture in all pregnant patients is not feasible. In this study authors have assessed the validity of urine microscopy in the screening of asymptomatic bacteriuria in pregnancy.Methods: Midstream clean catch urine specimen collected from 675 pregnant women was subjected to urine sediment microscopy and culture. It was considered screen positive if pus cells were >5/HPF. Asymptomatic bacteriuria was diagnosed if there were >/=100000 CFU of a single uropathogen per ml. Results obtained were statistically analysed for the prevalence of asymptomatic bacteriuria, sociodemographic and medical risk factors, causative organisms, antibiotic sensitivity and validity of urine sediment microscopy in detecting asymptomatic bacteriuria.Results: The incidence of asymptomatic bacteriuria in our study was 10.2%. The incidence was higher in the age group between 20-30 years, in gravida 3 and above, in upper lower and lower socioeconomic status, in women with hyperglycemia in pregnancy and anaemia. E. coli was the commonest bacterial isolate in culture positive cases. Bacterial isolates had poor sensitivity for Ampicillin, amoxicillin and nitrofurantoin and good sensitivity for cephalosporins and aminoglycosides. The sensitivity, specificity, positive and negative predictive values for urine microscopy was 43%, 85%, 25% and 93% respectively.Conclusions: This study shows poor sensitivity and positive predictive value and good specificity and negative predictive value.

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