scholarly journals CATARACT SURGERY AND PROGRESSION OF DIABETIC RETINOPATHY

2003 ◽  
Vol 41 (143) ◽  
pp. 433-437
Author(s):  
Sudesh Subedi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Cataract Surgery ◽  
Cataract Extraction ◽  
Extracapsular Cataract Extraction ◽  
Vitreous Loss ◽  
Clinically Significant Macular Edema ◽  
Clinically Significant ◽  
Form Type

Patient with diabetes mellitus have a higher prevalence of lens opacity 1and cataractdevelopment at an earlier age than non diabetic.2Cataract in diabetes mellitus decreasesthe visual acuity, makes posterior segment evaluation and laser treatment difficult.Several studies have shown that there is progression of diabetic retinopathy after cataractsurgery. In all studies, criteria for progression of diabetic retinopathy are:a) progression of any form/type or stage of diabetic eye (DE), nonproliferative diabeticretinopathy (NPDR) or proliferative diabetic retinopathy (PDR) to any advanced,recurrent form/ type or stage of NPDR or PDR andb) development of new clinically significant macular edema (CSME) and/or worsening/recurrent of preexisting CSME defined by Early Treatment Diabetic RetinopathyStudy (ETDRS).• More severe the preexisting diabetic retinopathy (DR), much worse the DR aftercataract extraction. The progression of DR after cataract extraction is severe inIntracapsular Cataract Extraction (ICCE) than Extracapsular Cataract Extraction(ECCE) with Intraocular Lens (IOL) and Sutureless Small Incision CataractSurgery (SICS) and Phacoemulcification.• Progression of DR increases with complicated cataract surgery, like posteriorcapsular rupture (PCR), vitreous loss and prolonged surgery.• The first 6 months period is crucial as a minimum period of follow up to detectprogression of DR.• There are other several local and systemic risk factors for the progression of DR,like hypertension, renal failure, ischemic heart disease, high cholesterol andtriglyceride level, pregnancy etc.Key Words: Diabetic retinopathy, cataract surgery, risk factors

scholarly journals Prophylaxis of Macular Edema with Intravitreal Ranibizumab in Patients with Diabetic Retinopathy after Cataract Surgery: A Pilot Study

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Patricia Udaondo ◽  
Maria Garcia-Pous ◽  
Salvador Garcia-Delpech ◽  
David Salom ◽  
Manuel Diaz-Llopis
Keyword(s):  
Diabetic Retinopathy ◽  
Cataract Surgery ◽  
Macular Edema ◽  
San Francisco ◽  
Case Series ◽  
Control Group ◽  
Intravitreal Ranibizumab ◽  
Previous Diagnosis ◽  
Clinically Significant Macular Edema ◽  
Clinically Significant

The purpose of this study was to evaluate the effectiveness of intravitreal ranibizumab (Lucentis, Genentech, South San Francisco, Calif, USA) combined with cataract surgery for the prevention of clinically significant macular edema (CSME) in patients with diabetic retinopathy (DR). This prospective interventional case series included fifty-four eyes of 54 patients with a previous diagnosis of nonproliferative diabetic retinopathy (NPDR) without macular edema preoperatively. Subjects were assigned in a 1 : 1 ratio to receive an intraoperative intravitreal ranibizumab injection (n=27) or not (control group,n=27) associated with standardised phacoemulsification surgery. The main outcome measure was the incidence of CSME one and three months after surgery. One month after surgery the incidence of CSME in the control group was 25.92% and 3.70% in the treatment group and at three months was 22.22% and 3.70%, respectively. Short-term results suggest that intravitreal ranibizumab immediately after phacoemulsification prevents CS ME in patients with NPDR.

scholarly journals Delay in seeking medical care after the onset of symptoms in patients with sight-threatening diabetic retinopathy

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110132
Author(s):  
Yan Wei ◽  
Fenghua Mi ◽  
Yan Cui ◽  
Ying Li ◽  
Xinyi Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Medical Care ◽  
Diabetic Complications ◽  
Multivariate Logistic Regression Analysis ◽  
Routine Examination ◽  
Clinically Significant Macular Edema ◽  
Clinically Significant ◽  
Poor Outcomes ◽  
Associated Risk Factors

Objective To investigate the reasons for delays in seeking medical care in patients with diabetic retinopathy and associated risk factors. Methods We retrospectively reviewed data for patients with sight-threatening diabetic retinopathy (STDR) who attended a hospital in China. Various forms of STDR were identified, including severe non-proliferative DR, clinically significant macular edema and proliferative DR. Demographic, clinical and socioeconomic information was collected and the associated risk factors were evaluated. Results Of the 127 patients with STDR, 89.2% sought medical care within 1 month of developing symptoms. Those who sought treatment ≥6 months after symptoms developed had significantly lower income and less knowledge of diabetic complications than those who attended earlier. Multivariate logistic regression analysis showed that no or infrequent routine examination for diabetic complications were associated with long delays in seeking medical care (odds ratio (OR) 3.06, 95% confidence interval (CI) 1.05–9.19; and OR 2.91, 95% CI 1.04–8.40, respectively). Conclusions Most patients with STDR sought medical care within 1 month of symptoms developing, but no or infrequent routine examination for diabetic complications was associated with long delays. These results stress the importance of educational programs regarding diabetic complications to encourage timely medical care and prevent poor outcomes.

Pseudophakic Retinal Detachment; Risk Factors, Pathogenesis, Clinical Characteristics, and Management

2020 ◽  
pp. 153-159
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Retinal Detachment ◽  
Cataract Surgery ◽  
Clinical Characteristics ◽  
Rhegmatogenous Retinal Detachment ◽  
Cataract Extraction ◽  
Common Risk Factor ◽  
Vitreous Loss ◽  
Pseudophakic Retinal Detachment

Since cataract surgery is the most common intraocular procedure, it also is the most common risk factor for rhegmatogenous retinal detachment. It has been realized that 20-40% of rhegmatogenous retinal detachments occur in eyes that have undergone cataract extraction. The risk of pseudophakic retinal detachment can be increased in myopic patients, in those patients in whom vitreous loss had occurred at the time of cataract surgery, and in patients undergoing Nd: YAG laser posterior capsulotomy. This review mentions about the risk factors, pathogenesis, clinical and management of pseudophakic retinal detachment.

scholarly journals Cross Talk between Lipid Metabolism and Inflammatory Markers in Patients with Diabetic Retinopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Roxanne Crosby-Nwaobi ◽  
Irini Chatziralli ◽  
Theodoros Sergentanis ◽  
Tracy Dew ◽  
Angus Forbes ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Inflammatory Markers ◽  
Multinomial Logistic Regression ◽  
Significant Risk ◽  
Metabolic Markers ◽  
Apo B ◽  
Multinomial Logistic Regression Analysis ◽  
Clinically Significant Macular Edema ◽  
Clinically Significant

Purpose. The purpose of this study was to examine the relationship between metabolic and inflammatory markers in patients with diabetic retinopathy (DR).Methods. 208 adult patients with type 2 diabetes participated in this study and were categorized into (1) mild nonproliferative diabetic retinopathy (NPDR) without clinically significant macular edema (CSME), (2) NPDR with CSME, (3) proliferative diabetic retinopathy (PDR) without CSME, and (4) PDR with CSME. Variable serum metabolic markers were assessed using immunoassays. Multinomial logistic regression analysis was performed.Results. Diabetes duration and hypertension are the most significant risk factors for DR. Serum Apo-B and Apo-B/Apo-A ratio were the most significant metabolic risk factors for PDR and CSME. For every 0.1 g/L increase in Apo-B concentration, the risk of PDR and CSME increased by about 1.20 times. We also found that 10 pg/mL increase in serum TNF-αwas associated with approximately 2-fold risk of PDR/CSME while an increase by 100 pg/mL in serum VEGF concentration correlated with CSME.Conclusions. In conclusion, it seems that there is a link between metabolic and inflammatory markers. Apo-B/Apo-A ratio should be evaluated as a reliable risk factor for PDR and CSME, while the role of increased systemic TNF-αand VEGF should be explored in CSME.

scholarly journals The prevalence of diabetic retinopathy, risk factors, visual impairment and ocular status among patients with diabetes mellitus presenting to Berhan Aini National Referral Hospital, Eritrea: A hospital based study

2017 ◽  
Vol 6 (4) ◽  
pp. 37-46
Author(s):  
P Bastola ◽  
F Kahsay ◽  
S Zewengiel ◽  
M M Muguleta
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Visual Impairment ◽  
Glycosylated Hemoglobin ◽  
Referral Hospital ◽  
Patients With Diabetes ◽  
Working Age ◽  
Clinically Significant ◽  
National Referral Hospital

Diabetic Retinopathy (DR) is the most common ocular complication in the diabetic population and the leading cause of blindness amongst working age group. There is a paucity of data about DR and various factors in Eritrea. The study aimed to find the prevalence of diabetic retinopathy, risk factors, visual impairment and ocular status among patients with diabetes mellitus in Asmara, Eritrea. This was a hospital based, Mixed method, descriptive study, all the consecutive patients attending the retina clinic of the hospital were enrolled in the study from January, 2014 to October, 2016. Early Treatment Diabetic Retinopathy Study (ETDRS) and Modified Airlie House classification were followed to evaluate the various stages of diabetic retinopathy and clinically significant macular edema (CSME). The guidelines developed by International Council of Ophthalmology (ICO) were followed to determine the need for interventions. Of the 506 diabetic subjects attending Berhan Aini National Referral Hospital; 435 (86.0%) subjects had type 2 Diabetes Mellitus (DM). 425 (84.0%) subjects had diabetic retinopathy. Moderate visual impairment, severe visual impairment and blindness due to diabetic retinopathy was observed in 139 (27.1%), 57 (11.1%), 76 (15%) subjects respectively while 234 subjects (46.2%) had normal vision. Hypertension 309 (61%) was the most common risk factor followed by duration of diabetes, occupation and the level of glycosylated Hemoglobin. 481 (95%) of the literate subjects were aware about diabetic retinopathy (P=<0.01). 277 (54.7%) subjects needed prompt treatment. There is a high prevalence of DR in patients attending Berhan Aini National Referral Hospital (BANRH). Awareness about diabetic retinopathy was good still the knowledge about primary prevention was not good enough.

scholarly journals Diabetic retinopathy with or without clinically significant macular edema: The influencing factors

2016 ◽  
Vol 7 (2) ◽  
pp. 142-147
Author(s):  
Barsha Suwal ◽  
Jeevan Kumar Shrestha ◽  
Sagun Narayan Joshi ◽  
Ananda Kumar Sharma
Keyword(s):  
Diabetic Retinopathy ◽  
Glycemic Control ◽  
Macular Edema ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Clinically Significant Macular Edema ◽  
Clinically Significant

Introduction: Diabetic retinopathy is the commonest micro vascular complication in patients with diabetes and remains a leading cause of blindness in people of working age group. Objective: to determine the prevalence of clinically significant macular edema (CSME) and the influence of systemic risk factors Materials and methods: It is a hospital based comparative study conducted in 220 eyes of 110 diabetic patients. DR was graded according to International Clinical Diabetic Retinopathy Severity Scale and CSME was defined according to Early Treatment Diabetic Retinopathy Study (ETDRS) system. The patients were grouped as 1) CSME group (DR and CSME in one or both eyes) and 2) Non- CSME group(CSME in none of the eyes but with any grade of DR).Level of glycosylated hemoglobin (HbA1C), serum total cholesterol, triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and urine for albumin were studied in both groups. Results: CSME was present in 36% of 110 patients. Poor glycemic control and high total cholesterol level showed positive association with CSME (p<0.05). LDL and TG levels were higher and HDL lower in CSME group. However, no statistical significance was found. Conclusion: The CSME is significantly associated with poorer glycemic control and elevated total cholesterol level.

scholarly journals Vitreous loss in planned extracapsular cataract extraction does lead to a poorer visual outcome

Eye ◽  
1995 ◽  
Vol 9 (4) ◽  
pp. 446-451 ◽  
Author(s):  
N A Frost ◽  
J M Sparrow ◽  
N P Strong ◽  
A R Rosenthal
Keyword(s):  
Visual Outcome ◽  
Cataract Extraction ◽  
Extracapsular Cataract Extraction ◽  
Vitreous Loss
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