Reproductive Tract and Pancreatic Norepinephrine Levels in Pre- and Overt-Diabetic C57BL/KsJ Mice: Relationship to Body Weight, Blood Glucose, Serum Insulin, and Reproductive Dysfunction

1988 ◽  
Vol 189 (1) ◽  
pp. 79-83 ◽  
Author(s):  
D. R. Garris
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Reproductive Tract ◽  
Serum Insulin ◽  
Reproductive Dysfunction

Studies on hypoglycaemic effects of polyherbal preparation in streptozotocin-induced diabetic male albino rats

2009 ◽  
Vol 28 (11) ◽  
pp. 679-687
Author(s):  
A. Ismail Khan ◽  
S. Yuvaraj ◽  
E. Suthagar ◽  
C. Parthasarathy ◽  
K. Balasubramanian
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Skeletal Muscles ◽  
Glucose Oxidation ◽  
Serum Insulin ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Vehicle Group ◽  
Albino Rats ◽  
Serum Insulin Level

Many traditional treatments have been recommended in the alternative system of medicine for diabetes mellitus. However, the mode of action of most of the herbals used has not been defined. It has been reported that sex hormones are important regulators of insulin-mediated events in skeletal muscles. In view of this, a novel herbal preparation containing antidiabetic and aphrodisiac plants was used in the present study. Adult male albino rats were divided into following groups after induction of diabetes. Rats were given an intraperitoneal (i.p.) injection of streptozotocin (STZ), at a dose of 65 mg/kg body weight after overnight fasting, to induce diabetic state with blood glucose levels >250 mg/dL. Group 1—Control rats treated with single i.p. injection of vehicle, Group 2—Rats treated with polyherbal preparation (PHP; 500 mg/kg body weight by oral intubation, morning and evening for 30 days), Group 3—STZ-diabetic rats treated orally with equal volumes of vehicle (water) alone and Group 4—STZ-diabetic rats treated with PHP after 10 days of diabetic induction. STZ-diabetes decreased the body weight, serum insulin level and glucose oxidation in liver and skeletal muscles but increased the fasting blood glucose level. After polyherbal treatment, body weight and glucose oxidation were completely restored to control level while serum insulin level was restored partially and the glucose tolerance was significantly improved. There was a significant decrease in total haemoglobin (Hb) level of diabetic rats when compared to control but polyherbal treatment significantly improved the same. However, the other parameters studied (red blood cell [RBC], white blood corpuscle [WBC], packed cell volume [PCV], mean corpuscular volume [MCV] and mean corpuscular haemoglobin [MCH]) were unaltered. In conclusion, the anti-diabetic properties of PHP appear to be mediated through pancreatic β-cell regeneration, resulting in maintenance of optimal blood glucose and its oxidation in liver and skeletal muscles.

scholarly journals Antidiabetic and Antilipidemic activity of Poly herbal formulation (PHF) in STZ-NA induced diabetes in rats

2021 ◽  
Vol 12 (3) ◽  
pp. 2239-2247
Author(s):  
Uma P ◽  
Venkatachalam V V ◽  
Mani Chandrika P ◽  
Sorabh Kumar Agrawal
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Normal Control ◽  
Moringa Oleifera ◽  
Serum Insulin ◽  
Lipid Level ◽  
Raphanus Raphanistrum ◽  
C Peptide ◽  
Polyherbal Formulation ◽  
Group I

The effects of polyherbal formulations were studied in the streptozotocin-nicotinamide (STZ-NA) induced diabetes rat model. The present study was undertaken to assess the effects of polyherbal formulations on the blood sugar level (BSL) as well as blood lipid level(BLL) of STZ-NA diabetic rats. The leaves of Moringa oleifera and roots of Raphanus raphanistrum were used for the study due to the presence of various phytoconstituents such as alkaloids, saponins, tannins, steroids, phenolic acids, flavonoids. Three polyherbal formulations were prepared from different portions of leaves of Moringa oleifera and roots of Raphanus raphanistrum and titled PHF-I, PHF-II and PHF-III. Diabetes in experimental animals was induced by STZ injection intraperitoneally (i. p) after 30 min of Nicotinamide injection i. p in all animal groups except normal control group animals. Group, I served as normal control received no treatment. Group II served as negative control received streptozotocin-nicotinamide. Group III rats were treated with Metformin, Group IV, Group V and Group VI rats treated with PHF-I, PHF-II and PHF-III respectively. Physical parameters (body weight, feed and water intake), Biochemical parameters (Blood Glucose, Serum Insulin, Serum C-Peptide Level, Serum Leptin, Serum Total cholesterol, Serum Triglycerides, LDL and VLDL) were measured on 0th, 14th and 28th day. The study results and histopathology of the pancreas indicate that oral administration of polyherbal formulation- II proved as a more effective, safe anti-diabetic agent in comparison to Polyherbal formulation I and III by Decrease in body weight, fasting blood glucose, serum glucose level. Increase in serum insulin level, serum C-peptide with a significant decrease in blood serum lipid level.

scholarly journals Effects of Omega-3 Fatty Acids on Insulin Resistance in an Ovariectomized Mouse Model of Diet-Induced Obesity Treated with Chemotherapy

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 345-345
Author(s):  
Kate Ormiston ◽  
Zihan Zhang ◽  
Kelly Murphy ◽  
A Courtney DeVries ◽  
Maryam Lustberg ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Blood Glucose ◽  
Body Fat ◽  
High Fat Diet ◽  
Serum Insulin ◽  
Model Assessment ◽  
Omega 3 ◽  
High Fat ◽  
Body Weights

Abstract Objectives Our objective was to examine effects of dietary enrichment of eicosapentaenoic acid + docosahexaenoic acid (EPA + DHA) on high fat diet-induced insulin resistance during chemotherapy. Methods Adult, female C57Bl/6 mice (n = 48) were assigned to 1 of 3 diets; low-fat diet (LF; 10% kcals fat), high-fat diet (HF; 45% kcals fat), or HF diet with omega-3 s (HF n-3; 2% kcals EPA + DHA) for 7 weeks. Mice received vehicle or chemotherapy injections (doxorubicin + cyclophosphamide), by tail vein at week 4 and 6. Food intake and body weights were recorded. Fasted blood glucose and serum insulin were measured weekly.  Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Body composition was measured using Echo MRI. Data were analyzed using ANOVA; p < 0.05 was considered significant. Results Total kilocalories significantly differed by group (p < 0.001); HF and HF n-3 groups consumed more than the LF group (p < 0.001, p < 0.0001; respectively). Obesity was induced prior to first injection with body weights being significantly different (p < 0.01); the LF group weighed less than the HF n-3 group (p < 0.01), and there was a similar trend between LF and HF groups (p = 0.0519). Body weights at sacrifice significantly differed (p < 0.0001); chemotherapy mice weighed less than vehicle (p < 0.0001). Percent body fat at sacrifice significantly differed (p < 0.0001); chemotherapy mice had less fat than vehicle (p < 0.0001), and the LF group had less fat than HF  (p < 0.01) and HF n-3 group (p < 0.01). Blood glucose significantly differed at sacrifice (p < 0.01); chemotherapy mice had lower glucose than vehicle (p < 0.05) and HF group had higher glucose than LF group (p < 0.01). HOMA-IR scores at sacrifice significantly differed (p < 0.05); chemotherapy mice had lower scores than vehicle  (p < 0.05) and mice on the LF and HF n-3 diets had lower scores than the HF diet (p < 0.01; p < 0.05 respectively). Conclusions Chemotherapy lowered body weight and body fat in mice, potentially contributing to decreases in blood glucose and insulin resistance. EPA + DHA enrichment of a HF diet reduced insulin resistance in mice comparable to a LF diet group. This occurred in both chemotherapy and vehicle treated mice, despite LF diet-fed mice having lower body weight and adiposity. Underlying mechanisms are being investigated. Funding Sources NIH #5R01CA18994.

scholarly journals Antidiabetic and Antilipidemic activity of Poly herbal formulation (PHF) in STZ-NA induced diabetes in rats

2020 ◽  
Vol 11 (4) ◽  
pp. 8092-8100
Author(s):  
Uma P ◽  
Venkatachalam V V ◽  
Mani Chandrika P ◽  
Sorabh Kumar Agrawal
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Normal Control ◽  
Moringa Oleifera ◽  
Serum Insulin ◽  
Lipid Level ◽  
Raphanus Raphanistrum ◽  
C Peptide ◽  
Polyherbal Formulation ◽  
Group I

The effects of polyherbal formulations were studied in the streptozotocin-nicotinamide (STZ-NA) induced diabetes rat model. The present study was undertaken to assess the effects of polyherbal formulations on the blood sugar level (BSL) as well as blood lipid level(BLL) of STZ-NA diabetic rats. The leaves of Moringa oleifera and roots of Raphanus raphanistrum were used for the study due to the presence of various phytoconstituents such as alkaloids, saponins, tannins, steroids, phenolic acids, flavonoids. Three polyherbal formulations were prepared from different portions of leaves of Moringa oleifera and roots of Raphanus raphanistrum and titled PHF-I, PHF-II and PHF-III. Diabetes in experimental animals was induced by STZ injection intraperitoneally (i. p) after 30 min of Nicotinamide injection i. p in all animal groups except normal control group animals. Group, I served as normal control received no treatment. Group II served as negative control received streptozotocin-nicotinamide. Group III rats were treated with Metformin, Group IV, Group V and Group VI rats treated with PHF-I, PHF-II and PHF-III respectively. Physical parameters (body weight, feed and water intake), Biochemical parameters (Blood Glucose, Serum Insulin, Serum C-Peptide Level, Serum Leptin, Serum Total cholesterol, Serum Triglycerides, LDL and VLDL) were measured on 0th, 14th and 28th day. The study results and histopathology of the pancreas indicate that oral administration of polyherbal formulation- II proved as a more effective, safe anti-diabetic agent in comparison to Polyherbal formulation I and III by Decrease in body weight, fasting blood glucose, serum glucose level. Increase in serum insulin level, serum C-peptide with a significant decrease in blood serum lipid level.

scholarly journals Protective role of nano-selenium-enriched Bifidobacterium longum in delaying the onset of streptozotocin-induced diabetes

2018 ◽  
Vol 5 (12) ◽  
pp. 181156 ◽  
Author(s):  
Yan Lin ◽  
Yongzhe Ren ◽  
Yan Zhang ◽  
Junjie Zhou ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Insulin Signalling ◽  
Serum Insulin ◽  
Bifidobacterium Longum ◽  
Model Group ◽  
Insulin Signalling Pathway ◽  
Onset Of Diabetes ◽  
Related Proteins ◽  
Intake Water

Bifidobacterium longum (B. longum) could accumulate Selenium (Se) and nano-Se in the form of Se-B. longum and Nano-Se-B. longum, respectively . In this study, the effect of Nano-Se-B. longum in diabetic mice was evaluated. Physiological and metabolic parameters such as blood glucose, body weight, serum insulin level, intraperitoneal glucose tolerance test (IPGTT), food intake, water consumption and urine output were evaluated. The expression of insulin signalling pathway-related proteins was evaluated by western blotting. Haematoxylin and eosin (H&E) was used for histological examination of the liver, pancreas and kidney sections. Creatinine levels in serum (SCr) and blood urea nitrogen (BUN) were measured. Nano-Se-B. longum was the best in terms of delaying the onset of diabetes. Nano-Se-B. longum decreased blood glucose and body weight compared with those noted for the model group. IPGTT, food intake, water consumption and urine output significantly increased and serum insulin levels significantly decreased in the model group compared with those in all the Nano-Se-B. longum -treated mice. Histological results showed that the Nano-Se-B. longum -treated mice were better than the model group mice in terms of pathological changes. The expression of insulin signalling pathway-related proteins was upregulated in the Nano-Se-B. longum -treated groups. A significant increase in SCr and BUN levels was noted in the model group. This study for the first time reported the dose-dependent preventive effect of Nano-Se-B. longum on the onset of diabetes and renal damage. The mechanism may be related to changes in insulin signalling.

scholarly journals A Low Glycemic Index Diet Slows Prostate Cancer Growth (P05-018-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Gloria Cecilia Galvan ◽  
Everardo Macias ◽  
Sergio Sanders ◽  
Adela Ramirez-Torres ◽  
Stephen Freedland
Keyword(s):  
Prostate Cancer ◽  
Body Weight ◽  
Blood Glucose ◽  
Glycemic Index ◽  
Tumor Volume ◽  
Serum Insulin ◽  
The Other ◽  
Glucose Levels ◽  
Carbohydrate Quality ◽  
Low Carbohydrate

Abstract Objectives Carbohydrates are the main source of energy in older adults in the US. Moreover, they increase insulin and insulin-like growth factor-1 (IGF1), which are implicated in tumor growth by increasing cell survival. Previously, we found low carbohydrate (LC) diets slow prostate cancer (PC) growth and increase survival vs. a Western diet (WD) in mice. However, long-term adherence to a LC diet can be difficult for cancer patients. Thus, we aimed to determine whether modifying carbohydrate quality without changing quantity could result in the same outcome as when quantity is reduced. Carbohydrate quality was based on a glycemic index (GI), which indicates how carbohydrates affect blood glucose levels. Low GI carbohydrates are absorbed more slowly and result in a lower and slower increase in glucose levels and insulin demand than high GI carbohydrates. We hypothesized that high carbohydrate intake but with a low GI would slow PC growth, by reducing insulin levels. Methods A xenograft mice study compared the effect on PC growth of 3 diets: HiGI WD (48% carbohydrate: sucrose), HiGI LC (20% carbohydrate: sucrose), and LoGI WD (48% carbohydrate: amylose, amylopectin, maltodextrin). Male SCID mice were fed an ad lib HiGI WD. At day 14, they were injected with 5 × 105 LAPC-4 cells. When tumors reached ∼200 mm3, mice were single-housed and randomized to their diets (n = 33/group). Mice were pair-fed to ensure all had the same weight throughout the study. Tumor volume and body weight were measured 2X per week. Body composition was determined by Echo-MRI. The outcomes of the study were tumor volume, survival, glucose, insulin, IGF-1 and IGFBP-3 levels, and tumor tissue analysis. Results LoGI WD mice had lower tumor volumes, insulin, IGF1, and IGF1: IGFBP3 ratio, and higher IGF-BP3 levels, than the other two groups. Blood glucose was similar across arms. Even though body weight was similar across arms, LoGI WD mice had lower body fat. In a meal tolerance test, glucose was higher in HiGI WD mice with comparable results between the other two diets. Conclusions Feeding mice a low GI diet delayed PC growth and decreased serum insulin, IGF1 and IGF1: IGFBP3 ratios vs. a high GI diet. These data suggest carbohydrate quality is important for PC growth. Whether a low-carbohydrate and low GI diet would have additive benefits remains to be tested. Funding Sources American Institute for Cancer Research.

Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat

2011 ◽  
Vol 301 (3) ◽  
pp. E527-E538 ◽  
Author(s):  
Yi Lin ◽  
Jie Wei ◽  
Yuanyuan Li ◽  
Jun Chen ◽  
Zhao Zhou ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Glucose Homeostasis ◽  
Endocrine Pancreas ◽  
Serum Insulin ◽  
Β Cell ◽  
Developmental Exposure ◽  
Ethylhexyl Phthalate ◽  
Dehp Exposure

—Di(2-ethylhexyl) phthalate (DEHP), a typical endocrine-disrupting chemical (EDC), is widely used as plasticizer. DEHP exposure in humans is virtually ubiquitous, and those undergoing certain medical procedures can be especially high. In this study, we investigated whether developmental DEHP exposure disrupted glucose homeostasis in the rat and whether this was associated with the early impairment in endocrine pancreas. Pregnant Wistar rats were administered DEHP (1.25 and 6.25 mg·kg−1·day−1) or corn oil throughout gestation and lactation by oral gavage. Body weight, glucose and insulin tolerance, and β-cell morphometry and function were examined in offspring during the growth. In this study, developmental DEHP exposure led to abnormal β-cell ultrastructure, reduced β-cell mass, and pancreatic insulin content as well as alterations in the expression of genes involved in pancreas development and β-cell function in offspring at weaning. At adulthood, female DEHP-exposed offspring exhibited elevated blood glucose, reduced serum insulin, impaired glucose tolerance, and insulin secretion. Male DEHP-exposed offspring had increased serum insulin, although there were no significant differences in blood glucose at fasting and during glucose tolerance test. In addition, both male and female DEHP-exposed offspring had significantly lower birth weight and maintained relatively lower body weight up to 27 wk of age. These results suggest that developmental exposure to DEHP gives rise to β-cell dysfunction and the whole body glucometabolic abnormalities in the rat. DEHP exposure in critical periods of development can be a potential risk factor, at least in part, for developing diabetes.

scholarly journals Effect of high-protein meal replacement on weight and cardiometabolic profile in overweight/obese Asian Indians in North India

2017 ◽  
Vol 117 (11) ◽  
pp. 1531-1540 ◽  
Author(s):  
Seema Gulati ◽  
Anoop Misra ◽  
Rajneesh Tiwari ◽  
Meenu Sharma ◽  
Ravindra M. Pandey ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Blood Glucose ◽  
Asian Indians ◽  
Serum Insulin ◽  
Meal Replacement ◽  
Protein Meal ◽  
Inflammatory Parameters ◽  
High Protein Meal ◽  
Hs Crp

AbstractThe aim of the present study was to evaluate the impact of a high-protein meal replacement (HPMR) on weight and metabolic, lipid and inflammatory parameters in overweight/obese Asian Indians. In this 12-week open-label, parallel-arm randomised controlled trial, 122 overweight/obese men and women were administered either a HPMR or a control diet after 2 weeks of diet and exercise run-in. Body weight, waist circumference (WC), percentage body fat (%BF), fasting blood glucose, post-oral glucose tolerance test (post-OGTT) blood glucose, fasting and post-OGTT serum insulin, lipid profile, high-sensitivity C-reactive protein (hs-CRP), kidney function and hepatic aminotransferases were assessed before and after the intervention. Additional improvement in mean values for the following parameters in the HPMR group compared with the control group was observed: body weight, 4·9 % (95 % CI 3·8, 6·1; P<0·001); WC, 3·8 % (95 % CI 2·5, 5·1; P<0·001); %BF, 6·3 % (95 % CI 4·3, 8·2; P<0·001); systolic blood pressure, 2·8 % (95 % CI 0·4, 5·1; P=0·002); diastolic blood pressure, 3·5 % (95 % CI 0·7, 6·3; P= 0·01); post-OGTT blood glucose, 7·3 % (95 % CI 1·4, 13·1; P=0·02); total cholesterol, 2·5 % (95 % CI 1·6, 3·5; P<0·001); LDL-cholesterol, 7·3 % (95 % CI 1·7, 12·9; P<0·01); alanine aminotransferase, 22·0 % (95 % CI 2·1, 42; P=0·03) and aspartate aminotransferase, 15·2 % (95 % CI 0·9, 29·5; P=0·04). The absolute reduction in BMI was 0·9 units in the intervention arm compared with the control arm (–0·9 %, 95 % CI –1·4, –0·5; P<0·001) and in serum TAG was 11·9 mg/dl (–11·9 mg/dl, 95 % CI –21·1, –2·7; P<0·01). The reduction in fasting serum insulin in the intervention v. the control arm was 3·8 v. 0 % (P=0·002); post-OGTT serum insulin was 50·3 v. 77·3 mU/l (P=0·005); and hs-CRP, 16·7 % v. 0 % (P=0·002). These findings show that intervention with HPMR may lead to significant weight loss and improvement in obesity measures, metabolic, lipid and inflammatory parameters and hepatic transaminases in overweight/obese Asian Indians.

Abstract MP18: Mutagenesis Of Protease-mediated Cleavage Site In (pro)renin Receptor Induces Obesity And Type 2 Diabetes In Mice

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Fei Wang ◽  
Yan-ting Chen ◽  
Chang-jiang Zou ◽  
Renfei Luo ◽  
Brittin Hekking ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Fat Mass ◽  
Therapeutic Potential ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Mutant Mice ◽  
Chow Diet ◽  
Multiple Substrates

Soluble (pro)renin receptor (sPRR), the extracellular domain of PRR, is generated by multiple proteases, including furin or ADAM19, and recently site-1 protease (S1P). We have previously reported that the therapeutic potential of histidine-tagged recombinant soluble (pro)renin receptor (sPRR), termed as sPRR-His, in a mouse obesity model induced by high-fat diet (DIO) for management of obesity and hyperglycemia. Conversely, inhibition of endogenous sPRR production by PF429242, an inhibitor of S1P in DIO mice aggravated diabetes and insulin resistance (Wang F et al. JCI Insight In press). However, the existence of the multiple substrates for S1P may impose confounding influence on the function of sPRR. The goal of the present study was to employ CRISPR strategy to mutagenize the overlapping recognition site for S1P and furin in PRR (termed as mutant mice) to examine its impact on metabolism. Mutant mice were fertile and developed normally with a 50% reduction plasma and tissue sPRR. 12-wk-old male mutant mice fed chow diet exhibited increased body weight (45.6 ± 4.8 g vs. 34.8 ± 2.7 g, n = 9, p < 0.05) and fat mass percentage ( fat mass/ body weight: 26% ± 4% vs. 12% ± 3%, n =9, p < 0.01) accompanied by reduced energy expenditure (0.35 ± 0.02 Kcal/kg/h vs. 0.54 ± 0.04 Kcal/kg/h, n = 4, p < 0.05) as assessed by calorimetry. The mutant mice developed hyperglycemia (fasting blood glucose: 172 ± 6.8 in mutant vs. 118 ± 5.4 mg/dL in WT, n = 15, p < 0.01), hyperinsulinemia (serum insulin: 48.7 ± 12.9 ng/ml vs. 3.7 ± 0.4 ng/ml, n = 6, p < 0.01), and impaired GTT and ITT. Additionally, sPRR-His supplement in the mutant mice nearly normalized blood glucose (132.4 ± 12.2 mg/dL) and insulin level (14.1 ± 5.9 ng/ml). Overall, these results support sPRR as an essential regulator of energy metabolism.

scholarly journals Anti-diabetic effect of metformin combined with peanut (Arachis hypogaea L.) on streptozotocin induced diabetic rats

2018 ◽  
Vol 13 (2) ◽  
pp. 59-67
Author(s):  
Shehrina Nazmin ◽  
Nayma Sultana
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Arachis Hypogaea ◽  
Serum Insulin ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Glycemic Status ◽  
Final Body Weight ◽  
Arachis Hypogaea L

Background: Diabetes mellitus (DM) is a common metabolic disorder. Metformin is the initial drug of choice for treatment of type 2 DM. In many cases, metformin mono-therapy cannot effectively achieve the targeted glycemic control. However, metformin along with peanut (Arachis hypogaea L.) may reduce blood glucose level more effectively. Objective: To evaluate the anti-diabetic effect of metformin in combination with peanut on streptozotocin induced diabetic rats. Methods: This experimental study was conducted in the Department of Physiology, Sir Salimullah Medical College, in 2016. Forty (40) Wistar Albino male rats, 90-120 days old, weighing 225-240 g (initial body weight) were taken and divided into four groups containing 10 rats in each group, i.e. Non-diabetic group (ND), Streptozotocin induced diabetic group (STZ), Diabetic group treated with metformin (STZ-M) and Diabetic group treated with metformin and peanut (STZ-MP). Diabetic model was developed by giving single intraperitoneal injection of streptozotocin (50mg/kg body weight) to STZ, STZ-M and STZ-MP groups on day-1. In addition, STZ-M group received metformin (500mg/kg body weight) orally and STZ-MP group received both metformin and peanut extract orally (both 500mg/kg body weight) once daily in the morning for 21 days (day-4 to day-24). After measuring the final body weight, rats were sacrificed on day-25. To observe glycemic status, Fasting Blood Glucose (FBG), serum insulin levels were estimated and HOMA-IR was calculated. Statistical analyses were done by one way ANOVA and Bonferroni test as applicable. Results: Mean FBG level and HOMA-IR were significantly (p<0.001) higher and serum insulin level and final body weight were significantly (p<0.001) lower in STZ group when compared to those of ND group. Whereas, FBG level and HOMA-IR were significantly (p<0.001) lower and insulin level and final body weight were significantly higher (p<0.001) in both STZ-M and STZ-MP groups in comparison to those of STZ group but more profound effects were found in STZ-MP group than those of STZ-M group. Conclusion: The present study revealed that, metformin combined with peanut was more effective to control glycemic status in diabetic rats than metformin alone. J Bangladesh Soc Physiol. 2018, December; 13(2): 59-67

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