scholarly journals Frontotemporal dementia to Alzheimer's disease

2007 ◽  
Vol 9 (2) ◽  
pp. 153-160
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Behavioral Changes ◽  
Neural Damage ◽  
Personality Changes ◽  
The Social ◽  
Long Time ◽  
And Behavior ◽  
The Relationship

Behavioral manifestations may dominate the clinical picture of the frontal variant of frontotemporal dementia (fv-FTD) for a long time before the appearance of true cognitive deficits. On the other hand, a deficit in the episodic memory domain represents the main manifestation of Alzheimer's disease (AD). Many behavioral disorders have been described in the clinical course of both FTD and AD; however, apathy and personality changes characterize frontal dementias, while depression dominates in AD, at least in the earlier stages. Depending on the distribution of neural damage, different patterns of noncognitive manifestations may be expected in different subtypes of FTD. Recent research on the social cognition deficit in FTD has offered new insights into the relationship between cognition and behavior, suggesting that some aspects of the behavioral changes in dementia may be generated by impairment in this domain.

Distinct social-behavioral changes in frontotemporal dementia and early onset Alzheimer's disease

2014 ◽  
Author(s):  
Joseph P. Barsuglia ◽  
Michelle J. Mather ◽  
Hemali V. Panchal ◽  
Aditi Joshi ◽  
Elvira Jimenez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
Behavioral Changes ◽  
Early Onset Alzheimer’S Disease

scholarly journals Different Apathy Profile in Behavioral Variant of Frontotemporal Dementia and Alzheimer's Disease: A Preliminary Investigation

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Davide Quaranta ◽  
Camillo Marra ◽  
Concettina Rossi ◽  
Guido Gainotti ◽  
Carlo Masullo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Sleep Disturbances ◽  
Preliminary Investigation ◽  
Univariate Analysis ◽  
Behavioral Changes ◽  
Neuropsychiatric Inventory ◽  
Multivariate Logistic Regression ◽  
Clinical Expression

Apathy is one of the most common behavioral symptoms of dementia; it is one of the salient features of behavioral variant of frontotemporal dementia (bvFTD) but is also very frequent in Alzheimer's disease. This preliminary investigation was aimed at assessing the type of apathy-related symptoms in a population of bvFTD and AD subjects showing comparable apathy severity. Each patient underwent a comprehensive neuropsychological assessment; behavioral changes were investigated by the neuropsychiatric inventory (NPI), using the NPI-apathy subscale to detect apathetic symptoms. At univariate analysis, bvFTD subjects showed lack of initiation (χ2=4.602,p=0.032), reduced emotional output (χ2=6.493,p=0.008), and reduced interest toward friends and family members (χ2=4.898,p=0.027), more frequently than AD subjects. BvFTD displayed higher scores than AD on NPI total score (p=0.005) and on subscales assessing agitation (p=0.004), disinhibition (p=0.007) and sleep disturbances (p=0.025); conversely, AD subjects were more impaired on memory, constructional abilities, and attention. On multivariate logistic regression, reduced emotional output was highly predictive of bvFTD (OR=18.266;p=0.008). Our preliminary findings support the hypothesis that apathy is a complex phenomenon, whose clinical expression is conditioned by the site of anatomical damage. Furthermore, apathy profile may help in differentiating bvFTD from AD.

scholarly journals Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study

2019 ◽  
Vol 13 (3) ◽  
pp. 356-360
Author(s):  
Leonardo Cruz de Souza ◽  
Luciano Inácio Mariano ◽  
Renata Freire de Moraes ◽  
Paulo Caramelli
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Csf Biomarkers ◽  
Positron Emission ◽  
Personality Changes ◽  
Clinical Presentations ◽  
History Of ◽  
Executive Deficits

ABSTRACT Alzheimer's disease (AD) has heterogeneous clinical presentations. Amnestic progressive disorder leading to dementia is the most typical, but non-amnestic presentations are also recognized. Here we report a case of frontal variant of AD. A right-handed woman, aged 68 years, was referred for progressive behavioral disorders and personality changes. She had a corroborated history of dietary changes, hyperorality, impulsivity, affective indifference and apathy, with functional impairment. Cognitive assessment yielded severe executive deficits. Positron emission tomography with fluorodeoxyglucose showed marked hypometabolism in frontotemporal regions, with relative preservation of parietal regions. CSF AD biomarkers showed low Aβ42, high Tau and high P-Tau. The patient fulfilled criteria for probable behavioral variant frontotemporal dementia. However, considering the AD pathophysiological signature on CSF biomarkers, a diagnosis of frontal variant of AD was established. In the perspective of disease-modifying therapies, it is important to identify atypical Alzheimer presentations, as these patients may be candidates for specific treatments.

scholarly journals The Association betweenC9orf72Repeats and Risk of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis: A Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Li Shu ◽  
Qiying Sun ◽  
Yuan Zhang ◽  
Qian Xu ◽  
Jifeng Guo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyotrophic Lateral Sclerosis ◽  
Frontotemporal Dementia ◽  
Meta Analysis ◽  
Sporadic Als ◽  
Repeat Expansions ◽  
Positive Correlations ◽  
The Relationship ◽  
Lateral Sclerosis

C9orf72is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in Caucasian populations. However, the relationship betweenC9orf72repeats and Alzheimer’s disease (AD) was not clear. Additionally, there were few articles assessingC9orf72in other ethnicities with ALS. In this meta-analysis, we aimed to investigate the relationship betweenC9orf72repeat expansions (≥30 repeats) and intermediate repeat copies (20–29 repeats) and AD or ALS. The results suggested positive correlations betweenC9orf72repeat expansions and the risk of Alzheimer’s disease (OR = 6.36, 95% CI = 3.13–12.92, andp<0.00001), while intermediate repeat copies ofC9orf72gene were not associated with the risk of the disease.C9orf72repeat expansions were positively correlated with the risk of familial and sporadic ALS (OR = 293.25, 95% CI = 148.17–580.38, andp<0.00001; OR = 35.57, 95% CI = 19.61–64.51, andp<0.00001). There was a positive correlation between the gene variations and ALS risk among Caucasians and Asians (OR = 57.56, 95% CI = 36.73–90.22, andp<0.00001; OR = 6.35, 95% CI = 1.39–29.02, andp=0.02).

scholarly journals Recognizing Late Onset Frontotemporal Dementia with the DAPHNE scale: A case report

2018 ◽  
Vol 12 (1) ◽  
pp. 75-79
Author(s):  
Leonardo Tafarello Martins ◽  
Ivan Abdalla Teixeira ◽  
Jerson Laks ◽  
Valeska Marinho
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Report ◽  
Frontotemporal Dementia ◽  
Late Onset ◽  
Behavioral Changes ◽  
Csf Biomarkers ◽  
Atypical Alzheimer’S Disease ◽  
Characteristic Features ◽  
Structured Means

ABSTRACT Frontotemporal dementias are classically described as early onset dementias with personality and behavioral changes, however, late onset forms can also be found. Considering the paucity of information about late onset behavioral variant frontotemporal dementia and its challenging diagnosis, we present a case report of an 85-year-old woman with behavioral changes and slow progression to dementia who was first diagnosed as having bipolar disorder and then Alzheimer's disease. The Daphne scale provided a structured means to improve clinical diagnosis, also supported by characteristic features on MRI and SPECT, while CSF biomarkers ruled out atypical Alzheimer's disease.

scholarly journals OXIDATIVE STRESS IN ALZHEIMER’S DISEASE–EVALUATING THE AMYLOID BETA HYPOTHESIS

2021 ◽  
pp. 32-38
Author(s):  
SWETHA G. ◽  
ANJALI RAJ ◽  
SANIYA TABASSUM ◽  
DOUGLAS ZORINMAWIA CHHAKCHHUAK
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pyramidal Neurons ◽  
Senile Plaques ◽  
Redox Balance ◽  
Tau Proteins ◽  
Significant Component ◽  
And Behavior ◽  
The Relationship

Dementia is defined by the debilitation of cognition and behavior of individuals more than 65 y. Alzheimer's disease (AD) is the most pervasive pervasive form of dementia, afflicting around 47 million individuals worldwide. Oxidative damage is a significant component in the pathophysiology of Alzheimer's disease (AD). Assessment of Alzheimer's disease mind has shown a lot of oxidative harm, related with both trademark pathologies (senile plaques and neurofibrillary tangles) just as in typical seeming pyramidal neurons. By the by, the process that eventually causes disruption of redox balance and furthermore the origin of the free radicals are as yet hazy. There is likewise the accessibility of proof that oxidative stress may enhance the conglomeration and production of Aβ and furthermore help the polymerization just as phosphorylation of tau, subsequently making a pernicious cycle that invigorates the development and even commencement of Alzheimer's. These neurotic trademarks have complex proportional collaborations with cholinergic abrasions. This review may give complemental data for understanding the relationship between oxidative stress, amyloid plaques, tau proteins and cholinergic system in processing of AD.

scholarly journals Devotion and Commitment in A Contradictory Conditionsas Seen in The Notebook by Nicholas Spark

2020 ◽  
Vol 3 (2) ◽  
pp. 17-31
Author(s):  
Helmita Helmita ◽  
Elsa Mayora Putri
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Qualitative Method ◽  
Descriptive Analysis ◽  
The Novel ◽  
Analysis Method ◽  
Personality Psychology ◽  
Long Time ◽  
First Time ◽  
The Relationship

The problem in this thesis is Devotion and commitment in a contradictory conditions in the relationship between Noah and Allie who have differences in social status. Until their relationship was opposed by Allie's mother, even so Allie remained devotion to choose Noahh. Devotion and commitment to the contradictory conditions between Noah and Allie also occur when they are old. Noah remained loyal to Allie when she suffered from Alzheimer's disease. The object of this study was The Notebook novel by Nicholas Sparks. This research uses Sigmund Freud's theory of personality psychology. The results of this study are the figures Noah and Alli have personality aspects that refer to Sigmund Freud's theory of id, ego, superego. The writer uses descriptive analysis method and qualitative method. The author carries out a systematic procedure with an understanding of the novel, figures Noah and Allie, and also structural theory. This research aims : (1) to analyze the importance of loyalty and commitment in contradictory conditions. (2) to describe the loyalty and commitment contained in the Novel The notebook. (3) to explain the loyalty and commitment shown by Noah and Allie after marriage. Based on the results of this analysis it can be concluded that the problem faced by the main character is his deep love and loyalty to his wife, Noah did everything for Allie, including writing to him for two years even though his letter was never responded by Allie. But when they met for the first time after being separated for quite a long time their love for each other was still there. Until they married and aged together and Allie contracted Alzheimer's disease, but Noah remained faithful with her.

Dementia 1: Defining Dementia, Alzheimer’s Disease and Frontotemporal Dementia (DRAFT)

2018 ◽  
Author(s):  
Tamara Kaplan ◽  
Tracey Milligan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Behavior ◽  
Frontotemporal Dementia ◽  
Neurofibrillary Tangles ◽  
Repetitive Behaviors ◽  
Behavioral Changes ◽  
Cognitive Domains ◽  
Pathologic Features ◽  
Visuospatial Processing

The video in this chapter explores dementia, and focuses on definitions of dementia, Alzheimer’s disease and Frontotemporal Dementia. Dementia is defined as a cognitive decline in one or more cognitive domains including memory, language, attention, visuospatial processing and social behavior. Two hallmark pathologic features of Alzheimer’s disease (AD) are plaques, which are formed from amyloid and neurofibrillary tangles, which involve tau, whereas symptoms of Frontotemporal Dementia (FTD) may include behavioral changes, apathy and disinhibition and ritualistic or repetitive behaviors. Language may also be affected, and this can be a presenting symptom.

Social Cognition Tests Can Discriminate Behavioral Variant Frontotemporal Dementia From Alzheimer’s Disease Independently of Executive Functioning

2020 ◽  
Author(s):  
Millena Vieira Brandão Moura ◽  
Luciano Inácio Mariano ◽  
Antônio Lúcio Teixeira ◽  
Paulo Caramelli ◽  
Leonardo Cruz de Souza
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Cognition ◽  
Frontotemporal Dementia ◽  
Area Under The Curve ◽  
Facial Emotion ◽  
Short Version ◽  
Executive Performance ◽  
Social And Emotional ◽  
The Social

Abstract Objective To investigate the accuracy of the Social and Emotional Assessment-short version (Mini-SEA) to differentiate subgroups of behavioral variant of frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD) defined according to executive performance. Methods bvFTD (n = 21), AD (n = 20), and healthy controls (HC, n = 23) underwent the Mini-SEA, comprising the Facial Emotion Recognition Test (FERT) and the faux-pas test. AD and bvFTD patients were classified according to their performance in the Frontal Assessment Battery into dysexecutive and nondysexecutive subgroups. Results The area under the curve (AUC) values for the faux-pas test were 0.87 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.96 (non-dysexecutive-bvFTD vs. nondysexecutive-AD). The AUC values for FERT were 0.99 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.65 (nondysexecutive-bvFTD vs. nondysexecutive-AD); the AUC values for the Mini-SEA (total-score) were 0.95 (dysexecutive-bvFTD vs. dysexecutive-AD) and 0.88 (nondysexecutive-bvFTD vs. nondysexecutive-AD). Discussion Social Cognition tests accurately distinguish bvFTD from AD regardless of the executive profile.

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