scholarly journals Complicated grief therapy as a new treatment approach

2012 ◽  
Vol 14 (2) ◽  
pp. 159-166 ◽  
Keyword(s):  
Prolonged Exposure ◽  
Behavioral Therapy ◽  
Complicated Grief ◽  
Future Research ◽  
Interpersonal Therapy ◽  
Research Directions ◽  
Grief Therapy ◽  
Future Research Directions ◽  
New Treatment

Complicated grief therapy (CGT) is a relatively new psychotherapy model designed to address symptoms of complicated grief. Drawn from attachment theory and with roots in both interpersonal therapy (IPT) and cognitive-behavioral therapy, CGT includes techniques similar to prolonged exposure (repeatedly telling the story of the death and in vivo exposure activities). The treatment also involves focusing on personal goals and relationships. CGT has been demonstrated to be effective in a trial in which participants with complicated grief were randomly assigned to CGT or IPT; individuals receiving CGT responded more quickly and were more likely to respond overall (51% vs 28%). This article briefly summarizes the conceptual underpinnings of CGT, discusses the empirical evidence for its efficacy, describes its techniques, and presents a case example of a client treated in a 16-session manualized CGT protocol. The article concludes with a description of future research directions for CGT.

Treating Trauma-Related Symptoms in Children and Adolescents

2020 ◽  
Author(s):  
Elisabeth Pollio ◽  
Felicia Neubauer ◽  
Esther Deblinger
Keyword(s):  
Children And Adolescents ◽  
Randomized Trials ◽  
Behavioral Therapy ◽  
Trauma Treatment ◽  
Future Research ◽  
Controlled Trials ◽  
Research Directions ◽  
Randomized Controlled ◽  
Future Research Directions ◽  
Scientific Questions

The significant impact of trauma on children is well documented. This chapter focuses on trauma-specific treatments for children and adolescents that have at least two randomized controlled trials in which one or more standardized outcome measures were used. These treatments address varying traumas, including sexual abuse, physical abuse, exposure to violence or loss, and disasters. The efficacy of one such treatment, trauma-focused cognitive behavioral therapy (TF-CBT), has been documented in over 50 scientific studies, including 22 randomized trials. A more detailed description of TF-CBT is presented in the chapter. Also discussed are future research directions, including specific scientific questions, to advance our knowledge about trauma treatment for children and adolescents.

scholarly journals Managing Sleep in Adults with ADHD: From Science to Pragmatic Approaches

2021 ◽  
Vol 11 (10) ◽  
pp. 1361
Author(s):  
Craig B. H. Surman ◽  
Daniel M. Walsh
Keyword(s):  
Adult Adhd ◽  
Sleep Problems ◽  
Behavioral Therapy ◽  
Light Therapy ◽  
Preliminary Evidence ◽  
Future Research ◽  
Evidence Based ◽  
Research Directions ◽  
Evidence Based Treatments ◽  
Future Research Directions

Background: Sleep disorders and sleep problems commonly occur in adults with ADHD and add to functional impairment. Evidence-based treatments for sleep could improve function in the adult ADHD population. Methods: A literature review was conducted to present the clinical science informing treatment of sleep in adults with ADHD. Results: Six systematic prospective studies of sleep intervention in adults with ADHD were identified. Three of these, all including well-characterized ADHD patients, offered evidence for a significant effect of morning light therapy. Across the studies, preliminary evidence for melatonin, behavioral therapy, and weighted blankets were also found. Implication: Low-risk interventions such as light therapy may improve sleep in adults with ADHD, but many sleep interventions currently in use remain unstudied in the ADHD population. Considerations for evidence-informed practice and future research directions are discussed.

Interpersonal Psychotherapy for the Treatment of Eating Disorders

2017 ◽  
Author(s):  
Natasha L. Burke ◽  
Anna Karam ◽  
Marian Tanofsky-Kraff ◽  
Denise E. Wilfley
Keyword(s):  
Eating Disorders ◽  
Behavioral Therapy ◽  
Clinical Care ◽  
Risk Groups ◽  
Interpersonal Psychotherapy ◽  
Future Research ◽  
Dissemination And Implementation ◽  
Research Directions ◽  
Future Research Directions

Interpersonal psychotherapy (IPT) is a focused, time-limited treatment that targets interpersonal problem(s) associated with the onset and/or maintenance of eating disorders. It is supported by substantial empirical evidence documenting the role of interpersonal factors in the onset and maintenance of eating disorders. Interpersonal psychotherapy is a viable alternative to cognitive-behavioral therapy for the treatment of bulimia nervosa and binge eating disorder. The effectiveness of IPT for the treatment of anorexia nervosa requires further investigation. The utility of IPT for the prevention of obesity is promising. Future research directions include enhancing the delivery of IPT for eating disorders, increasing the availability of IPT in routine clinical care settings through dissemination and implementation efforts, exploring IPT adolescent and parent-child adaptations in diverse and high-risk groups, and further exploring IPT for the prevention of eating and weight-related problems that may promote full-syndrome eating disorders or obesity.

scholarly journals Glioma-on-a-Chip Models

Micromachines ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 490
Author(s):  
Merve Ustun ◽  
Sajjad Rahmani Dabbagh ◽  
Irem Sultan Ilci ◽  
Tugba Bagci-Onder ◽  
Savas Tasoglu
Keyword(s):  
Future Research ◽  
Cell Behavior ◽  
Therapeutic Approaches ◽  
Term Survival ◽  
Research Directions ◽  
Metabolic Functions ◽  
Future Research Directions ◽  
On Chip

Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months). Glioma-on-chip platforms, with continuous perfusion, mimic in vivo metabolic functions of cancer cells for analytical purposes. This offers an unprecedented opportunity for understanding the underlying reasons that arise glioma, determining the most effective radiotherapy approach, testing different drug combinations, and screening conceivable side effects of drugs on other organs. Glioma-on-chip technologies can ultimately enhance the efficacy of treatments, promote the survival rate of patients, and pave a path for personalized medicine. In this perspective paper, we briefly review the latest developments of glioma-on-chip technologies, such as therapy applications, drug screening, and cell behavior studies, and discuss the current challenges as well as future research directions in this field.

scholarly journals Vascularized Lower Respiratory-Physiology-On-A-Chip

2020 ◽  
Vol 10 (3) ◽  
pp. 900 ◽  
Author(s):  
Hyoryung Nam ◽  
Yoo-mi Choi ◽  
Jinah Jang
Keyword(s):  
Treatment Options ◽  
Respiratory Physiology ◽  
Future Research ◽  
Research Directions ◽  
Disease Mechanisms ◽  
Chip Technology ◽  
Future Research Directions ◽  
Respiratory Systems

Recently, respiratory systems are increasingly threatened by high levels of environmental pollution. Organ-on-a-chip technology has the advantage of enabling more accurate preclinical experiments by reproducing in vivo organ physiology. To investigate disease mechanisms and treatment options, respiratory-physiology-on-a-chip systems have been studied for the last decade. Here, we delineate the strategic approaches to develop respiratory-physiology-on-a-chip that can recapitulate respiratory system in vitro. The state-of-the-art biofabrication methods and biomaterials are considered as key contributions to constructing the chips. We also explore the vascularization strategies to investigate complicated pathophysiological phenomena including inflammation and immune responses, which are the critical aggravating factors causing the complications in the respiratory diseases. In addition, challenges and future research directions are delineated to improve the mimicry of respiratory systems in terms of both structural and biological behaviors.

scholarly journals Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4796
Author(s):  
Anna E. Kaiser ◽  
Mojdeh Baniasadi ◽  
Derrek Giansiracusa ◽  
Matthew Giansiracusa ◽  
Michael Garcia ◽  
...  
Keyword(s):  
Human Cancer ◽  
Health Benefits ◽  
Mechanisms Of Action ◽  
Future Research ◽  
Research Directions ◽  
Chemopreventive Agent ◽  
Future Research Directions ◽  
Major Mediator

There is substantial and promising evidence on the health benefits of consuming broccoli and other cruciferous vegetables. The most important compound in broccoli, glucoraphanin, is metabolized to SFN by the thioglucosidase enzyme myrosinase. SFN is the major mediator of the health benefits that have been recognized for broccoli consumption. SFN represents a phytochemical of high interest as it may be useful in preventing the occurrence and/or mitigating the progression of cancer. Although several prior publications provide an excellent overview of the effect of SFN in cancer, these reports represent narrative reviews that focused mainly on SFN’s source, biosynthesis, and mechanisms of action in modulating specific pathways involved in cancer without a comprehensive review of SFN’s role or value for prevention of various human malignancies. This review evaluates the most recent state of knowledge concerning SFN’s efficacy in preventing or reversing a variety of neoplasms. In this work, we have analyzed published reports based on in vitro, in vivo, and clinical studies to determine SFN’s potential as a chemopreventive agent. Furthermore, we have discussed the current limitations and challenges associated with SFN research and suggested future research directions before broccoli-derived products, especially SFN, can be used for human cancer prevention and intervention.

Cognitive behavioral therapy: Current status and future research directions

2015 ◽  
Vol 25 (3) ◽  
pp. 321-329 ◽  
Author(s):  
Shelley McMain ◽  
Michelle G. Newman ◽  
Zindel V. Segal ◽  
Robert J. DeRubeis
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Current Status ◽  
Future Research ◽  
Research Directions ◽  
Future Research Directions

Treating Trauma-related Symptoms in Children and Adolescents

2012 ◽  
pp. 472-490
Author(s):  
Esther Deblinger ◽  
Elisabeth Pollio ◽  
Felicia Neubauer
Keyword(s):  
Children And Adolescents ◽  
Behavioral Therapy ◽  
Controlled Trial ◽  
Trauma Treatment ◽  
Future Research ◽  
Trauma Symptoms ◽  
Research Directions ◽  
Medical Trauma ◽  
Future Research Directions ◽  
Scientific Questions

The significant impact of trauma on children is well documented. This chapter focuses on trauma-specific treatments for children and adolescents that have at least one randomized controlled trial in which one or more standardized outcome measures of trauma symptoms were used. These treatments address varying traumas, including sexual abuse, physical abuse, exposure to violence or loss, medical trauma, and disasters. Many of the treatments demonstrate promising results, but the research is often hampered by methodological limitations. The efficacy of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) has been documented in over 17 scientific studies, including 10 randomized trials. A more detailed description of TF-CBT is presented in the chapter. Also discussed are future research directions, including specific scientific questions, to advance our knowledge about trauma treatment for children and adolescents.

Sign in / Sign up

Export Citation Format

Share Document