scholarly journals Neuroendocrine models of social anxiety disorder

2015 ◽  
Vol 17 (3) ◽  
pp. 287-293 ◽  

Social anxiety disorder (SAD) is a highly prevalent and disabling disorder with key behavioral traits of social fearfulness, social avoidance, and submissiveness. Here we argue that hormonal systems play a key role in mediating social anxiety, and so may be important in SAD. Hormonal alterations, often established early in development through the interaction between biological and psychological factors (eg, genetic predisposition x early trauma), predispose to socially fearful, avoidant, and submissive behavior. However, whereas gene variants and histories of trauma persist, hormonal systems can be remodeled over the course of life. Hormones play a key role during the periods of all sensitive developmental windows (ie, prenatal, neonatal, puberty, aging), and are capable of opening up new developmental windows in adulthood. Indeed, the developmental plasticity of our social brain, and thus of social behavior in adulthood, critically depends on steroid hormones such as testosterone and peptide hormones such as oxytocin. These steroid and peptide hormones in interaction with social experiences may have potential for reprogramming the socially anxious brain. Certainly, single administrations of oxytocin and testosterone in humans reduce socially fearful, avoidant, and submissive behavior. Such work may ultimately lead to new approaches to the treatment of SAD.

2021 ◽  
pp. 153465012110278
Author(s):  
Erika S. Penney ◽  
Alice R. Norton

Social Anxiety Disorder (SAD) is a condition defined by an excessive and persistent fear of negative evaluation in social or performance situations. Whilst Cognitive Behaviour Therapy (CBT) is the gold standard treatment, not all individuals with SAD respond to CBT. The Schema Therapy Mode Model is frequently applied to chronic and hard-to-treat conditions and therefore may be applicable for SAD individuals who are non-responders to CBT. This case study describes how the Mode Model was successfully used to treat a woman in her 20s who presented with excessive fears of negative evaluation and pervasive social avoidance. Experiential techniques, such as chair dialogues and imagery rescripting, resulted in cognitive modification of negative core beliefs, reduced experiential discomfort and increased engagement in social and relational activities. This case offers a preliminary indication that the Schema Therapy Mode Model may be an effective treatment for socially anxious individuals and that further theoretical and empirical study in this area is warranted.


2005 ◽  
Vol 96 (2) ◽  
pp. 411-421
Author(s):  
Hani Raoul Khouzam ◽  
Bita Ghafoori ◽  
Emma E. A. Nichols

This case report described a veteran with social anxiety disorder who reported fears of negative evaluation by others, social avoidance, and accompanying physiological symptoms of heart palpitations, gastrointestinal discomfort, muscle tension and mental confusion. The symptoms of social anxiety disorder subsided with the use of a Christian hymn “Be Still My Soul” and its accompanying musical poem, in Finlandia. The veteran attributed the symptom remission to the feeling of stillness and surrender to God conveyed by the words and music of the hymn. Although previous studies have shown that both music and religious beliefs can affect mental health, the findings in this case cannot be generalized without conducting further prospective empirical studies.


2020 ◽  
Vol 3 (1) ◽  
pp. 17-27
Author(s):  
Louise F. Carey ◽  
Giles M. Anderson ◽  
Sanjay Kumar

AbstractBackgroundAttention bias modification (ABM) can reduce anxiety and attentional bias towards threatening stimuli, but evidence of its usefulness as a potential intervention for socially anxious individuals has been mixed. Eye contact avoidance, a maladaptive attentional strategy in social anxiety disorder (SAD), has yet to be targeted by ABM research.AimsThis study sought to establish whether a new ABM training paradigm could increase attentional deployment towards eyes and what effect this would have on social and gaze-related anxiety.MethodParticipants (n = 23) recruited through adverts calling for people who felt anxious in social situations completed either a novel ABM training task designed to induce attentional bias towards images of eyes over images of noses, or control training. Data on response times (RTs), accuracy of responses, gaze behaviour (using an eye tracker) and scores on clinical measures of social and gaze-related anxiety were collected before and after both training tasks.ResultsABM training produced a greater number of initial saccades towards eye images than did the control task, indicating an induced shift in early attentional deployment. ABM training was also associated with a marginal increase in fixation durations on eye images. No effect was observed on RTs or social and gaze-related anxiety.ConclusionsOur results indicate that ABM can alter the gaze behaviour of socially anxious individuals. They also highlight the importance of eye tracking to ABM research, because it was more sensitive than analyses of RTs to changes in early attentional deployment.


1999 ◽  
Vol 175 (2) ◽  
pp. 120-126 ◽  
Author(s):  
David Baldwin ◽  
Julio Bobes ◽  
Dan J. Stein ◽  
Ingebor Scharwächter ◽  
Michel Faure

BackgroundPreliminary studies have suggested that paroxetine may be effective in social phobia/social anxiety disorder.AimsTo assess the efficacy and tolerability of paroxetine in the acute (12-week) treatment of social phobia.MethodTwo-hundred and ninety patients with social phobia were assigned randomly to paroxetine (20–50 mg/day flexible dose) or placebo for 12 weeks of double-blind treatment. Primary efficacy outcomes were the Liebowitz Social Anxiety Scale (LSAS) total score (patient-rated) and the Clinical Global Impression (GGI) scale global improvement item. The secondary efficacy variables included CGI scale severity of illness score and the patient-rated Social Avoidance and Distress Scale.ResultsParoxetine produced a significantly greater reduction in LSAS total score (mean change from baseline: –29.4 v. –15.6; P 0.001) and a greater proportion of responders (score $2 on CGI global improvement) (65.7% v. 32.4%; P < 0.001) compared with placebo at the end of the 12-week study period. Both primary efficacy variables were statistically significant compared with placebo from week 4 onwards. Paroxetine was generally well tolerated.ConclusionsParoxetine is an effective, well-tolerated treatment for patients with social phobia.


2017 ◽  
Vol 20 ◽  
Author(s):  
Ivan Blanco ◽  
Jutta Joormann

AbstractDepression and Social Anxiety Disorder are commonly conceptualized by the presence of negative affect. However, these disorders are also characterized by lack of positive affect, presence of negative cognitions, and emotion dysregulation which may play an important role in the onset and maintenance of these disorders. The present study explored differences among these variables in 189 clinical patients diagnosed with Major Depression, Social Anxiety Disorder, or both. Results showed differences in lack of positivity F(2, 185) = 18.92, p = .0001, η2 = .17, presence of negative cognitions F(2, 185) = 13.97, p = .0001, η2 = .13, and the use of rumination F(2, 185) = 14.63, p = .0001, η2 = .14 and punishment F(2, 181) = 7.64, p = .001, η2 = .08 among groups. Overall, lack of positivity, negative cognitions, and emotion dysregulation were elevated in the comorbid group, whereas lack of positivity and negative cognitions were specifically found for patients diagnosed with depression compared to socially anxious patients. In addition, the study examined the relation of both, lack of positivity and negative cognitions, to emotion regulation processes among groups. Overall, lack of positivity was associated with fear and avoidance in the social anxiety group (all r > .417, p < .01), whereas lack of positivity and negative cognitions were associated with rumination across the three groups (all r > .370, p < .01). Limitations of the present study and future directions are discussed.


2019 ◽  
Vol 8 (1) ◽  
pp. 99-110 ◽  
Author(s):  
Maya Asher ◽  
Idan M. Aderka

Individuals with social anxiety disorder (SAD) have substantial difficulties in romantic relationships. The aim of the present study was to examine initial, opposite-sex interactions of individuals with SAD and their interaction partners. Specifically, we investigated gender and social context (small talk vs. closeness-generating conversations) and their effects on momentary social anxiety during the interaction, as well as on participants’ desire for future interaction. Participants in this study ( N = 160) formed 42 experimental dyads, each comprising one individual with SAD and another non–socially anxious (NSA) individual, and 38 control dyads of two NSA individuals. We found that men with SAD benefitted significantly from closeness-generating interactions such that levels of momentary social anxiety were greatly reduced and both members of the dyad reported increased desire for future interaction. This effect was not found in small-talk conversations and not found for women with SAD. Implications for psychopathology and treatment are discussed.


2020 ◽  
Vol 8 (2) ◽  
pp. 280-294
Author(s):  
Maya Asher ◽  
Amitay Kauffmann ◽  
Idan M. Aderka

We examined nonverbal synchrony during opposite-sex interactions of individuals with social anxiety disorder (SAD). Participants were 156 individuals: 38 diagnosed with SAD and 118 individuals who were not socially anxious (NSA). Participants formed 78 dyads of either 2 NSA individuals (control dyads; n = 40) or 1 individual with SAD and 1 NSA individual (SAD dyads; n = 38). Dyads were randomly assigned to either a closeness-generating conversation or a small-talk conversation, and nonverbal synchrony was derived from computer analysis of videos. We found that for control dyads, closeness-generating conversations led to increased nonverbal synchrony compared with small-talk conversations but did not find the same outcome in SAD dyads. We also found a positive association between social anxiety and nonverbal synchrony in small-talk conversations but a negative association in closeness-generating conversations. Thus, we found evidence for impaired nonverbal synchrony in SAD using objective measures. Implications for psychopathology and treatment are discussed.


2017 ◽  
Vol a4 (3) ◽  
pp. 244-262 ◽  
Author(s):  
Rachel A. Sluis ◽  
Mark J. Boschen ◽  
David L. Neumann ◽  
Karen Murphy

Cognitive models of social anxiety disorder (SAD) emphasize anticipatory processing as a prominent maintaining factor that occurs before social-evaluative events. Anticipatory processing occurs when a socially anxious individual is expecting a social event and can be described as a mode of repetitive negative thinking dominated by past failures, negative images of oneself, predictions of poor performance and rejection. The present review examined the literature on anticipatory processing in social anxiety in an effort to highlight important findings pertaining to this construct. Correlational and experimental studies have investigated the relationship between anticipatory processing and the behavioural, physiological, cognitive and affective outcomes for socially anxious individuals. Studies investigating the characteristics, causes, and consequences of anticipatory processing according to models of social anxiety were included for review. The majority of study designs include those investigating anticipatory processing prior to social-evaluative threat. Directions for future research are discussed and an overview of a framework for explaining anticipatory processing biases in social anxiety is presented.


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