An improved YOLOv3 model for detecting location information of ovarian cancer from CT images

2021 ◽  
Vol 25 (6) ◽  
pp. 1565-1578
Author(s):  
Xun Wang ◽  
Hanlin Li ◽  
Lisheng Wang ◽  
Yongzhi Yu ◽  
Hao Zhou ◽  
...  

Ovarian cancer is a malignant tumor that poses a serious threat to women’s lives. Computer-aided diagnosis (CAD) systems can classify the type of ovarian tumors, but few of them can provide exactly the location information of ovarian cancer cells. Recently, deep learning technology becomes hot for automatic detection of cancer cells, particularly for detecting their locations. In this work, we propose a novel end-to-end network YOLO-OC (Ovarian cancer) model, which can extract the characteristics of ovarian cancer more efficiently. In our method, deformable convolution is used to enhance the model’s ability to learn geometric deformation in space. Squeeze-and-Excitation (SE) module is proposed to automatically learn the importance of different channel features. Data experiments are conducted on datasets collected from The Affiliated Hospital of Qingdao University Medical College, China. Experimental results show that our YOLO-OC model achieves 91.83%, 85.66% and 73.82% on mean average precision [email protected], [email protected] and mAP@[.5,.95], respectively, which performs better than Faster R-CNN, SSD and RetinaNet on both accuracy and efficiency.

2018 ◽  
Author(s):  
F Guo ◽  
Z Yang ◽  
J Xu ◽  
J Sehouli ◽  
AE Albers ◽  
...  

2020 ◽  
Vol 19 (2) ◽  
pp. 206-210
Author(s):  
Feng Chen ◽  
Bei Zhang

Lupeol exhibits multiple pharmacological activities including, anticancerous, anti-inflammatory, and antioxidant. The aim of this study was to explore the anticancerous activity of lupeol on ovarian cancer cells and examine its mechanism of action. To this end, increasing concentrations of lupeol on cell viability, cell cycle, and apoptosis in Caov-3 cells were evaluated. Lupeol inhibited cell viability, induced G1 phase arrest in cell cycle, increased cell apoptosis, and inhibited the ratio of phospho-Akt/protein kinase B and phospho-mammalian target of rapamycin/mammalian target of rapamycin. In conclusion, these data suggest that lupeol may play a therapeutic role in ovarian cancer.


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