Autobiographical Memory Performance in Alzheimer’s Disease Depends on Retrieval Frequency

ABSTRACTLogopenic Progressive Aphasia is a rare language disorder characterised by repetition and naming difficulties, reflecting the progressive degeneration of left-lateralized peri-sylvian temporal and inferior parietal regions. Mounting evidence suggests that cognitive impairments in this syndrome extend beyond the language domain to include episodic encoding and retrieval disturbances. To date, it remains unknown whether autobiographical memories from across the lifespan are also subject to decline, yet this information is critical to arrive at a comprehensive understanding of the Logopenic syndrome. The objective of this study was to provide the first in depth examination of autobiographical memory function in Logopenic Progressive Aphasia using the Autobiographical Interview, a validated semi-structured interview which assesses recollection of the past under free and probed recall conditions. Autobiographical memory performance in 10 well-characterised Logopenic Progressive Aphasia patients was contrasted with that of 18 typical amnestic Alzheimer’s disease and 16 healthy Control participants. Relative to Controls, Logopenic Progressive Aphasia cases showed marked impairment in the free recall of episodic details, scoring comparably to disease-matched cases of Alzheimer’s disease. This impairment was evident across all time periods and persisted even when formal structured probing was provided. Importantly, controlling for overall level of language disruption failed to ameliorate the autobiographical memory impairment in the Logopenic Progressive Aphasia group, suggesting a genuine amnesia spanning recent and remote memories. Whole-brain voxel-based morphometry analyses revealed that total episodic information retrieved in Logopenic Progressive Aphasia was associated with decreased grey matter intensity predominantly in a bilateral posterior parietal network. Taken together, our findings reveal for the first time the presence of marked remote and recent autobiographical memory impairments in Logopenic Progressive Aphasia, that cannot be explained solely due to their language difficulties or disease staging. Our findings hold important clinical implications for the accurate characterization of Logopenic Progressive Aphasia, and suggest that episodic memory difficulties should be considered as one of the core clinical features of this syndrome.

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Are Deficits in Social Cognition Linked to Autobiographical Memory in Patients with Alzheimer’s Disease?

Zeitschrift für Neuropsychologie ◽

10.1024/1016-264x/a000187 ◽

2016 ◽

Vol 27 (4) ◽

pp. 257-264 ◽

Cited By ~ 3

Author(s):

Johannes H. Scheidemann ◽

Franz Petermann ◽

Marc Schipper

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Social Cognition ◽

Theory Of Mind ◽

Autobiographical Memory ◽

Positive Relationship ◽

Neuropsychological Test ◽

Clinical Group ◽

Neuropsychological Test Battery ◽

Fluency Task

Abstract. We investigated theory of mind (ToM) deficits in Alzheimer‘s disease (AD) and its possible connection to autobiographical memory (ABM). Patients and matched controls were evaluated and compared using a video-based ToM test, an autobiographical fluency task, and a neuropsychological test battery. We found that ToM deficits were positively associated with semantic ABM in the clinical group, whereas a positive relationship appeared between ToM and episodic ABM in controls. We hypothesize that this reflects the course of the disease as well as that semantic ABM is used for ToM processing, being still accessible in AD. Furthermore, we assume that it is also less efficient, which in turn leads to a specific deficit profile of social cognition.

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Impact of Comorbid Depression on Serial Position Effects in Alzheimer’s Disease

GeroPsych ◽

10.1024/1662-9647/a000115 ◽

2014 ◽

Vol 27 (4) ◽

pp. 161-169 ◽

Cited By ~ 1

Author(s):

Nienke A. Hofrichter ◽

Sandra Dick ◽

Thomas G. Riemer ◽

Carsten Schleussner ◽

Monique Goerke ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Serial Position ◽

Episodic Memory ◽

Memory Performance ◽

Memory Function ◽

Word List ◽

Position Effects ◽

Serial Position Effects ◽

List Memory

Hippocampal dysfunction and deficits in episodic memory have been reported for both Alzheimer’s disease (AD) and major depressive disorder (MDD). Primacy performance has been associated with hippocampus-dependent episodic memory, while recency may reflect working memory performance. In this study, serial position profiles were examined in a total of 73 patients with MDD, AD, both AD and MDD, and healthy controls (HC) by means of CERAD-NP word list memory. Primacy performance was most impaired in AD with comorbid MDD, followed by AD, MDD, and HC. Recency performance, on the other hand, was comparable across groups. These findings indicate that primacy in AD is impaired in the presence of comorbid MDD, suggesting additive performance decrements in this specific episodic memory function.

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Research of autobiographical memory: The Autobiographical Interview (AI) Method (Healthy memory and Alzheimer’s disease)

Magyar Pszichológiai Szemle ◽

10.1556/mpszle.66.2011.4.2 ◽

2011 ◽

Vol 66 (4) ◽

pp. 587-603 ◽

Cited By ~ 1

Author(s):

Ágnes Szőllősi ◽

Anikó Kónya

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Autobiographical Memory

Levine, Svoboda és munkatársai (2002) olyan félig strukturált Önéletrajzi Interjút fejlesztettek ki az egyedi, specifikus önéletrajzi emlékek vizsgálatára, amely képes kiemelni az emlék elbeszéléséből az eseményspecifikus tartalmakat. Jelen vizsgálat célja e módszer magyar nyelvű adaptációja. Az eljárás segítségével három egészséges életkori csoport került összehasonlításra: fiatalok (20–27 év: 25 fő), középkorúak (45–55 év: 25 fő) és idősek (60–79 év: 16 fő), valamint egy emlékezetsérült klinikai betegcsoport: kezdeti stádiumú Alzheimer-kórban szenvedő betegek (60–80 év: 16 fő). Megerősítést kapott, hogy egészséges személyeknél a kor előrehaladtával romlik az önéletrajzi események elbeszélésének epizodikus gazdagsága. Továbbá, hogy az Alzheimer-kór kezdeti stádiumában sokkal nagyobb mértékben sérül az epizodikus emlékezés képessége, mint hasonló életkorú egészséges idős személyeknél.

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Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer’s disease

Scientific Reports ◽

10.1038/s41598-021-94992-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Christina F. de Veij Mestdagh ◽

Jaap A. Timmerman ◽

Frank Koopmans ◽

Iryna Paliukhovich ◽

Suzanne S. M. Miedema ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Memory Performance ◽

Long Term Potentiation ◽

Fear Memory ◽

Contextual Fear ◽

Contextual Fear Memory ◽

Model Of Alzheimer’S Disease ◽

Term Potentiation

AbstractHibernation induces neurodegeneration-like changes in the brain, which are completely reversed upon arousal. Hibernation-induced plasticity may therefore be of great relevance for the treatment of neurodegenerative diseases, but remains largely unexplored. Here we show that a single torpor and arousal sequence in mice does not induce dendrite retraction and synapse loss as observed in seasonal hibernators. Instead, it increases hippocampal long-term potentiation and contextual fear memory. This is accompanied by increased levels of key postsynaptic proteins and mitochondrial complex I and IV proteins, indicating mitochondrial reactivation and enhanced synaptic plasticity upon arousal. Interestingly, a single torpor and arousal sequence was also sufficient to restore contextual fear memory in an APP/PS1 mouse model of Alzheimer’s disease. Our study demonstrates that torpor in mice evokes an exceptional state of hippocampal plasticity and that naturally occurring plasticity mechanisms during torpor provide an opportunity to identify unique druggable targets for the treatment of cognitive impairment.

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Subjective Cognitive Decline and its Relation to Verbal Memory and Sex in Cognitively Unimpaired Individuals from a Colombian Cohort with Autosomal-Dominant Alzheimer’s Disease

Journal of the International Neuropsychological Society ◽

10.1017/s1355617721000801 ◽

2021 ◽

pp. 1-9

Author(s):

Jairo E. Martinez ◽

Enmanuelle Pardilla-Delgado ◽

Edmarie Guzmán-Vélez ◽

Clara Vila-Castelar ◽

Rebecca Amariglio ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Sex Differences ◽

Cognitive Decline ◽

Verbal Memory ◽

Autosomal Dominant ◽

Memory Performance ◽

Subjective Cognitive Decline ◽

Mutation Carriers ◽

Study Partner

Abstract Objective: Subjective Cognitive Decline (SCD) may be an early indicator of risk for Alzheimer’s disease (AD). Findings regarding sex differences in SCD are inconsistent. Studying sex differences in SCD within cognitively unimpaired individuals with autosomal-dominant AD (ADAD), who will develop dementia, may inform sex-related SCD variations in preclinical AD. We examined sex differences in SCD within cognitively unimpaired mutation carriers from the world’s largest ADAD kindred and sex differences in the relationship between SCD and memory performance. Methods: We included 310 cognitively unimpaired Presenilin-1 (PSEN-1) E280A mutation carriers (51% females) and 1998 noncarrier family members (56% females) in the study. Subjects and their study partners completed SCD questionnaires and the CERAD word list delayed recall test. ANCOVAs were conducted to examine group differences in SCD, sex, and memory performance. In carriers, partial correlations were used to examine associations between SCD and memory performance covarying for education. Results: Females in both groups had greater self-reported and study partner-reported SCD than males (all p < 0.001). In female mutation carriers, greater self-reported (p = 0.02) and study partner-reported SCD (p < 0.001) were associated with worse verbal memory. In male mutation carriers, greater self-reported (p = 0.03), but not study partner-reported SCD (p = 0.11) was associated with worse verbal memory. Conclusions: Study partner-reported SCD may be a stronger indicator of memory decline in females versus males in individuals at risk for developing dementia. Future studies with independent samples and preclinical trials should consider sex differences when recruiting based on SCD criteria.

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Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer’s disease

10.1101/2020.05.11.089383 ◽

2020 ◽

Author(s):

Xiong Jiang ◽

James H. Howard ◽

G. Wiliam Rebeck ◽

R. Scott Turner

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Medial Temporal Lobe ◽

Inhibition Of Return ◽

Memory Performance ◽

Brain Regions ◽

List Type ◽

Older Individuals

ABSTRACTSpatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here we provide evidence supporting that spatial IOR is mildly impaired in individuals with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD), and the impairment is readily detectable using a novel double cue paradigm. Furthermore, reduced spatial IOR in high-risk healthy older individuals is associated with reduced memory and other neurocognitive task performance, suggesting that the novel double cue spatial IOR paradigm may be useful in detecting MCI and early AD.SIGNIFICANCE STATEMENTNovel double cue spatial inhibition of return (IOR) paradigm revealed a robust effect IOR deficits in individuals with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD)Spatial IOR effect correlates with memory performance in healthy older adults at a elevated risk of Alzheimer’s disease (with a family history or APOE e4 allele)The data suggests that double cue spatial IOR may be sensitive to detect early AD pathological changes, which may be linked to disease progress at the posterior brain regions (rather than the medial temporal lobe)

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Emotional Working Memory and Alzheimer’s Disease

International Journal of Alzheimer s Disease ◽

10.1155/2014/207698 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Nicola Mammarella ◽

Beth Fairfield

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Working Memory ◽

Memory Performance ◽

Memory Task ◽

Emotional Information ◽

Healthy Older Adults ◽

Affective Stimuli ◽

Age Related ◽

Dementia Of Alzheimer’S Type

A number of recent studies have reported that working memory does not seem to show typical age-related deficits in healthy older adults when emotional information is involved. Differently, studies about the short-term ability to encode and actively manipulate emotional information in dementia of Alzheimer’s type are few and have yielded mixed results. Here, we review behavioural and neuroimaging evidence that points to a complex interaction between emotion modulation and working memory in Alzheimer’s. In fact, depending on the function involved, patients may or may not show an emotional benefit in their working memory performance. In addition, this benefit is not always clearly biased (e.g., towards negative or positive information). We interpret this complex pattern of results as a consequence of the interaction between multiple factors including the severity of Alzheimer’s disease, the nature of affective stimuli, and type of working memory task.

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ODor-evoked Autobiographical Memory in Alzheimer’s disease?

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acab074 ◽

2021 ◽

Author(s):

Mohamad El Haj

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Autobiographical Memory ◽

Personal Information ◽

Disease Model ◽

Olfactory Stimulation ◽

Autobiographical Memories ◽

Comprehensive Overview ◽

Memory Decline ◽

Stimulation Of

Abstract Objective Because memory decline is the hallmark of Alzheimer’s disease (AD), an important endeavor for both clinicians and researchers is to improve memory performances in AD. This can be pursued by olfactory stimulation of memory in patients with AD and by studying the effects of olfactory stimulation on autobiographical memory (i.e., memory for personal information). The effects of olfactory stimulation on autobiographical memory in patients with mild AD have been reported by recent research. We thus provide the first comprehensive overview of research on odor-evoked autobiographical memory in AD. We also establish the basis for solid theoretical analysis concerning the memory improvement reported by research on odor-evoked autobiographical memory in AD. Method We examined literature on odor-evoked autobiographical memories in AD and propose the “OdAMA” (Odor-evoked Autobiographical Memory in Alzheimer’s disease) model. Results and discussion According to OdAMA model, odor exposure activates involuntary access to specific autobiographical memories, which promotes enhanced experience subjective of retrieval in patients with AD and improves their ability to construct not only recent and remote events but also future ones. The OdAMA model could serve as a guide for researchers and clinicians interested in odor-evoked autobiographical memory in AD.

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