scholarly journals APOE Genotype and Entorhinal Cortex Volume in Non-Demented Community-Dwelling Adults in Midlife and Early Old Age

2012 ◽  
Vol 30 (4) ◽  
pp. 935-942 ◽  
Author(s):  
David Bunce ◽  
Kaarin J. Anstey ◽  
Nicolas Cherbuin ◽  
Prapti Gautam ◽  
Perminder Sachdev ◽  
...  
Keyword(s):  
Old Age ◽  
Entorhinal Cortex ◽  
Apoe Genotype ◽  
Community Dwelling ◽  
Early Old Age

scholarly journals Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study

2016 ◽  
Vol 42 (5-6) ◽  
pp. 297-309 ◽  
Author(s):  
Pia Horvat ◽  
Ruzena Kubinova ◽  
Andrzej Pajak ◽  
Abdonas Tamosiunas ◽  
Ben Schöttker ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Cognitive Function ◽  
Old Age ◽  
Verbal Fluency ◽  
Community Dwelling ◽  
Cognitive Test ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Early Old Age

Background/Aims: Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age. Methods: Subjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample. Linear regression was used to estimate associations of biomarkers with cognitive test scores cross-sectionally (n = 4,304) and prospectively (n = 2,882). Results: Increased d-ROM levels were inversely associated with global cognition and verbal fluency cross-sectionally and in prospective analysis; observed effects corresponded to 3-4 years' higher age. TTL was inconsistently associated with memory. BAP was not related to cognitive function. Conclusion: This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults.

scholarly journals Concurrent and Predictive Associations between the Life's Simple 7 & Brain Structure in Middle-Age and Early-Old Age

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 1005-1006
Author(s):  
Teresa Warren ◽  
McKenna Williams ◽  
Christine Fennema-Notestine ◽  
Jeremy Elman ◽  
Jennifer de Anda ◽  
...  
Keyword(s):  
White Matter ◽  
Old Age ◽  
Cortical Thickness ◽  
Cardiovascular Health ◽  
Brain Aging ◽  
Apoe Genotype ◽  
Mean Diffusivity ◽  
Life’S Simple 7 ◽  
Life's Simple 7 ◽  
Early Old Age

Abstract American Heart Association’s (AHA) Life’s Simple 7 (LS7), an index of cardiovascular health risks, has been associated with worse brain outcomes but few examined this relationship in midlife. We examined whether LS7 scores at midlife were associated with brain morphometry in early old age. Participants were 471 men who participated in the Vietnam Era Twin Study of Aging. The LS7 index was assessed at mean age 62 (range 55-66) and 68 (range 61-71) and included smoking, physical activity, diet, body mass index, cholesterol, glucose, and blood pressure. Each factor was coded, per AHA criteria, on a 3-point scale (0/poor-2/ideal) and summed to create a composite score (0-14). At mean age 68, participants underwent structural magnetic resonance imaging, which was used to create the previously validated brain measures. Scores included: the ratio of abnormal white matter to white matter, and two Alzheimer’s disease brain signatures (cortical thickness/volume signature and a mean diffusivity (MD) signature). Analyses controlled for age, education, income, ethnicity, and APOE genotype. Concurrently at mean age 68, the LS7 was associated with cortical thickness/volume (F=4.85, p = .028), MD (F=10.89, p = .001) signatures and abnormal white matter ratio (F=14.04, p < .001). Prospectively, the LS7 at mean 62 was significantly associated with age 68 cortical thickness/volume (F=5.08, p = .025) and MD (F=5.54, p = .019) signatures but not with abnormal white matter ratio. These results suggest that prevention strategies that promote heart healthy behaviors could have implications for healthy brain aging.

scholarly journals Self-compassion as predictor of daily physical symptoms and chronic illness across older adulthood

2021 ◽  
pp. 135910532110023
Author(s):  
Heather Herriot ◽  
Carsten Wrosch
Keyword(s):  
Older Adults ◽  
Longitudinal Study ◽  
Chronic Illness ◽  
End Of Life ◽  
Old Age ◽  
Physical Symptoms ◽  
Older Adulthood ◽  
Self Compassion ◽  
Early Old Age

This study examined whether self-compassion could benefit daily physical symptoms and chronic illness in early and advanced old age. The hypotheses were evaluated in a 4-year longitudinal study of 264 older adults. Results showed that self-compassion predicted lower levels of daily physical symptoms across the study period in advanced, but not early, old age ( T-ratio = −1.93, p = 0.05). In addition, self-compassion was associated with fewer increases in chronic illness in advanced, but not early, old age ( T-ratio = − 2.45, p < 0.02). The results of this study suggest that self-compassion may be particularly adaptive towards the end of life.

scholarly journals Likelihood of Participation in Home-Based Cognitive Assessment: The Role of Subjective Cognitive Decline and Age

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 293-294
Author(s):  
Moriah Splonskowski ◽  
Holly Cooke ◽  
Claudia Jacova
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Old Age ◽  
Cognitive Assessment ◽  
Community Dwelling ◽  
Subjective Cognitive Decline ◽  
Cognitive State ◽  
Home Based ◽  
Increased Risk

Abstract Home-based cognitive assessment (HBCA) services are emerging as a convenient alternative to in-clinic cognitive assessment and may aid in mitigating barriers to detecting cognitive impairment (CI). It is unknown which older adults would be likely to participate in HBCA. Here we investigated the role of age and Subjective Cognitive Decline (SCD). SCD has demonstrated an increased risk for progression to CI/dementia. A nation-wide community-dwelling sample of 494 adults age 50+ were recruited via Amazon Mechanical Turk to complete an online survey assessing perceptions around HBCA and SCD. Our sample was 91.9% White and 66.8% female. It consisted of 174 respondents aged 50-60, 265 aged 61- 70, and 55 aged 71-79. Age groups were comparable with respect to their acceptance of cognitive assessment (Range 4-20, higher score=higher acceptance, 7.9±3.3, 8.15±3.2, 8.05±3.43) and SCD-Q total (43.1±5.8, 43.2±5.7, 43.3±5.7). Correlation analysis revealed a relationship between SCD-QSCD total and perceived likelihood of participation in HBCA for those ages 61-70 (r(263) = .222 p = .000), but not for ages 50-60 or 71-79 (r(172) = .102 p = .152; r(53) = -.102 p = .458). Our findings suggest that SCD influences the likelihood of participation in HBCA for older adults’ transitioning to old age (61-70). Findings show that for adults transitioning into old age (61-70), perceived cognitive state influences their likelihood of participation in HBCA. Importantly, concerns about CI/dementia may generate more favorable perceptions of HBCA for this group.

Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men

GeroScience ◽  
2021 ◽  
Author(s):  
Megan M. Marron ◽  
Steven C. Moore ◽  
Stacy G. Wendell ◽  
Robert M. Boudreau ◽  
Iva Miljkovic ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Black Men ◽  
Apoe Genotype ◽  
Community Dwelling ◽  
Lipid Profiling

scholarly journals Benefits of Sustained Physical Activity From Middle-Age To Early Old Age On Quality Of Life In Early Old Age

2022 ◽  
Author(s):  
Mikyung Lee ◽  
Hyeonkyeong Lee ◽  
Ki Jun Song ◽  
Young-Me Lee
Keyword(s):  
Quality Of Life ◽  
Old Age ◽  
Secondary Data ◽  
Activity Levels ◽  
Related Quality ◽  
Health Related ◽  
Using Data ◽  
Middle Aged Adults ◽  
Early Old Age

Abstract This secondary data analysis study aimed to examine the changes in physical activities (PAs) over time (2009-2017) in the same participants and to determine an association between changes in PA and health-related quality of life (HRQoL) in early older adults (n=994) using data from the Korea Health Panel Survey. The HRQoL was measured using the EuroQol quality-of-life system and the amount of PA were grouped to 4 activity levels (remained inactive, became inactive, became active, and remained active). The association of changes in PA over 8 years with HRQoL was examined using logistic regression analysis while controlling for socioeconomic and behavioral factors. The total PA decreased from 1,859.72±1,760.01 MET-minutes in 2009 to 1,264.80 ±1,251.14 MET-minutes in 2017 (P < 0.001). In 2017, 142 (14.3%) remained inactive, whereas 419 (42.2%) remained active. The participants who remained inactive at early old age were more likely to be at the lowest 10% HRQoL of the sample (odds ratio = 1.95, 95% confidence interval = 1.09–3.48). This indicates that educating middle-aged adults who are relatively inactive must be a priority in order to maintain and improve PA, enhance HRQoL, and maximize the benefits of PA in old age.

scholarly journals Physical activity types and risk of dementia in community-dwelling older people: the Three-City cohort.

2020 ◽  
Author(s):  
Caroline Dupré ◽  
Bienvenue Bongue ◽  
Catherine Helmer ◽  
Jean François Dartigues ◽  
David Hupin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older People ◽  
Sport Activity ◽  
Apoe Genotype ◽  
Community Dwelling ◽  
Activity Level ◽  
Activity Levels ◽  
Dementia Risk ◽  
Sport Activities ◽  
Activity Types

Abstract Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observational Three-city cohort and included 1550 community-dwelling individuals aged 72 to 87 without dementia at baseline. Physical activity was assessed with the Voorrips questionnaire. Two sub-scores were calculated to assess household/transportation activities and leisure/sport activities. Restricted cubic spline and proportional hazard Cox models were used to estimate the non-linear exposure-response curve for the dementia risk and the appropriate activity level thresholds. Models were adjusted for possible confounders, including socio-demographic variables, comorbidities, depressive symptoms and APOE genotype. Results The median age was 80 years, and 63.6% of participants were women. After a median follow-up of 4.6 years, dementia was diagnosed in 117 participants (7.6%). An inverse J-shaped association was found between household/transportation physical activity sub-score and dementia risk, which means that the risk is lowest for the moderately high values and then re-increases slightly for the highest values. The results remained significant when this sub-score was categorized in three classes (low, moderate, and high), with hazard ratios (95% confidence interval) of 0.55 (0.35-0.87) and 0.62 (0.38-1.01) for moderate and high activity levels, respectively. No significant effect was found for leisure/sport activities. Conclusions The 5-year risk of dementia was significantly and negatively associated with the household/transportation activity level, but not with the leisure and sport activity sub-score. This highlights the importance of considering all physical activity types in 72 years or older people.

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