scholarly journals The Relationship Between Cardiovascular Health and Rate of Cognitive Decline in Young-Old and Old-Old Adults: A Population-Based Study

2021 ◽  
pp. 1-15
Author(s):  
Andreja Speh ◽  
Rui Wang ◽  
Bengt Winblad ◽  
Milica G. Kramberger ◽  
Lars Bäckman ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Verbal Fluency ◽  
Cardiovascular Health ◽  
National Study ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Old Adults ◽  
Ideal Cardiovascular Health ◽  
Global Cognition ◽  
Young Old

Background: Modifiable vascular risk factors have been associated with late-life cognitive impairment. The Life Simple 7 (LS7) score comprises seven cardiovascular health metrics: smoking, diet, physical activity, body mass index, plasma glucose, total serum cholesterol, and blood pressure. Objective: To investigate the association between individual and composite LS7 metrics and rate of cognitive decline, and potential differences in these associations between young-old and old-old individuals. Methods: This cohort study included 1,950 participants aged≥60 years (M = 70.7 years) from the Swedish National Study on Aging and Care-Kungsholmen (SNAC-K), who underwent repeated neuropsychological testing (episodic and semantic memory, verbal fluency, processing speed, global cognition) across 12 years. The LS7 score was assessed at baseline and categorized as poor, intermediate, or optimal. Level and change in cognitive performance as a function LS7 categories were estimated using linear mixed-effects models. Results: Having an optimal LS7 total score was associated with better performance (expressed in standard deviation units) at baseline for perceptual speed (β= 0.21, 95%CI 0.12–0.29), verbal fluency (β= 0.08, 0.00–0.16), and global cognition (β= 0.06, 0.00–0.12) compared to the poor group. Age-stratified analyses revealed associations for cognitive level and change only in the young-old (<  78 years) group. For the specific metrics, diverging patterns were observed for young-old and old-old individuals. Conclusion: Meeting the LS7 criteria for ideal cardiovascular health in younger old age is associated with slower rate of cognitive decline. However, the LS7 criteria may have a different meaning for cognitive function in very old adults.

scholarly journals Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort

2021 ◽  
pp. 1-12
Author(s):  
Rachael A. Lawson ◽  
Caroline H. Williams-Gray ◽  
Marta Camacho ◽  
Gordon W. Duncan ◽  
Tien K. Khoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Verbal Fluency ◽  
Neuropsychological Tests ◽  
Visual Memory ◽  
Attention And Memory ◽  
Memory And Attention ◽  
Global Cognition

Background: Cognitive impairment is common in Parkinson’s disease (PD), with 80% cumulatively developing dementia (PDD). Objective: We sought to identify tests that are sensitive to change over time above normal ageing so as to refine the neuropsychological tests predictive of PDD. Methods: Participants with newly diagnosed PD (n = 211) and age-matched controls (n = 99) completed a range of clinical and neuropsychological tests as part of the ICICLE-PD study at 18-month intervals over 72 months. Impairments on tests were determined using control means (<1-2SD) and median scores. Mild cognitive impairment (PD-MCI) was classified using 1-2SD below normative values. Linear mixed effects modelling assessed cognitive decline, while Cox regression identified baseline predictors of PDD. Results: At 72 months, 46 (cumulative probability 33.9%) participants had developed PDD; these participants declined at a faster rate in tests of global cognition, verbal fluency, memory and attention (p <  0.05) compared to those who remained dementia-free. Impaired baseline global cognition, visual memory and attention using median cut-offs were the best predictors of early PDD (area under the curve [AUC] = 0.88, p <  0.001) compared to control-generated cut-offs (AUC = 0.76–0.84, p <  0.001) and PD-MCI (AUC] = 0.64–0.81, p <  0.001). Impaired global cognition and semantic fluency were the most useful brief tests employable in a clinical setting (AUC = 0.79, p <  0.001). Conclusion: Verbal fluency, attention and memory were sensitive to change in early PDD and may be suitable tests to measure therapeutic response in future interventions. Impaired global cognition, attention and visual memory were the most accurate predictors for developing a PDD. Future studies could consider adopting these tests for patient clinical trial stratification.

scholarly journals Serum Non-esterified Fatty Acids and Risk of Incident Stroke in Older Adults: The Cardiovascular Health Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1416-1416
Author(s):  
Neil Huang ◽  
Nirupa Matthan ◽  
Mary Biggs ◽  
W T Longstreth ◽  
David Siscovick ◽  
...  
Keyword(s):  
Cardiovascular Health ◽  
Cox Regression ◽  
Positive Association ◽  
Cholesterol Concentration ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Fasting Serum ◽  
Total N

Abstract Objectives Significant associations between plasma total non-esterified fatty acid (NEFA) concentrations and incident ischemic stroke have been reported in some but not all prospective cohort studies. Given the functional and structural diversity among circulating NEFA, the association of individual or sub-groups of circulating NEFAs may provide additional insight into their relationship with incident stroke. We hypothesized fasting serum monounsaturated, n-6 polyunsaturated (PUFA) and n-3 PUFA NEFA are inversely associated, and saturated and trans NEFA are positively associated with incident stroke. Methods We analyzed the incidence of stroke among Cardiovascular Health Study (CHS) participants who were free of stroke in 1996–1997 (baseline) and had an archived fasting serum sample (N = 2028). At baseline, mean age was 77.8 ± 4.5, body mass index (BMI) was 26.7 ± 4.4 and 61% were female. A total of 38 individual NEFAs were measured using gas chromatography. Cox regression was used to evaluate the association of individual and 5 sub-group (saturated, monounsaturated, n-6 PUFA, n-3 PUFA and trans) NEFAs with incident stroke, adjusting for age, sex, race and field center (model 1); model 1 covariates plus serum albumin, smoking, education, physical activity, alcohol consumption, eGFR, BMI, aspirin use, waist circumference, hypertension, prevalent diabetes and total serum cholesterol concentration (model 2). Results A total of 338 cases of incident stroke occurred during median follow-up of 10.5 years. In the fully adjusted model 2, individuals in the highest quartile of serum 16:1n-7 had a 56% higher risk of stroke (quartiles 4 versus 1, hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.08–2.25; P-trend = 0.02); highest quartile of total n-6 PUFA NEFA had a 40% higher risk (HR, 1.40; 95% CI, 0.99–1.98; P-trend = 0.03); and highest quartile of 20:3n-6 had a 53% higher risk (HR, 1.53; 95% CI, 1.09–2.14; P-trend = 0.01). No significant associations were observed between saturated, n-3 PUFA, and trans NEFAs with incident stroke. Conclusions These data suggest a positive association between fasting serum 16:1n-7, 20:3n-6 and total n-6 PUFA NEFAs with incident stroke in CHS participants. No significant associations were observed for the other individual or sub-groups of NEFAs. Funding Sources NIH and USDA.

P2-594: IDEAL CARDIOVASCULAR HEALTH, COGNITIVE DECLINE AND RISK OF DEMENTIA IN OLDER PERSONS FROM THE COMMUNITY: THE THREE-CITY STUDY

2006 ◽  
Vol 14 (7S_Part_17) ◽  
pp. P965-P965
Author(s):  
Cecilia Samieri ◽  
Marie-Cécile Perier ◽  
Catherine Helmer ◽  
Claudine Berr ◽  
Christophe Tzourio ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Older Persons ◽  
Cardiovascular Health ◽  
Ideal Cardiovascular Health

scholarly journals Lipolytic Postbiotic from Lactobacillus paracasei Manages Metabolic Syndrome in Albino Wistar Rats

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 472
Author(s):  
Ali Osman ◽  
Nashwa El-Gazzar ◽  
Taghreed N. Almanaa ◽  
Abdalla El-Hadary ◽  
Mahmoud Sitohy
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Lipolytic Activity ◽  
Control Level ◽  
Serum Triglyceride ◽  
Positive Control ◽  
Lactobacillus Paracasei ◽  
Total Serum ◽  
Albino Rats ◽  
Total Serum Cholesterol

The current study investigates the capacity of a lipolytic Lactobacillus paracasei postbiotic as a possible regulator for lipid metabolism by targeting metabolic syndrome as a possibly safer anti-obesity and Anti-dyslipidemia agent replacing atorvastatin (ATOR) and other drugs with proven or suspected health hazards. The high DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS [2,2′-azino-bis (3-ethyl benzothiazoline-6-sulphonic acid)] scavenging activity and high activities of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-px) of the Lactobacillus paracasei postbiotic (cell-free extract), coupled with considerable lipolytic activity, may support its action against metabolic syndrome. Lactobacillus paracasei isolate was obtained from an Egyptian cheese sample, identified and used for preparing the postbiotic. The postbiotic was characterized and administered to high-fat diet (HFD) albino rats (100 and 200 mg kg−1) for nine weeks, as compared to atorvastatin (ATOR; 10 mg kg−1). The postbiotic could correct the disruption in lipid metabolism and antioxidant enzymes in HFD rats more effectively than ATOR. The two levels of the postbiotic (100 and 200 mg kg−1) reduced total serum lipids by 29% and 34% and serum triglyceride by 32–45% of the positive control level, compared to only 25% and 35% in ATOR’s case, respectively. Both ATOR and the postbiotic (200 mg kg−1) equally decreased total serum cholesterol by about 40% and 39%, while equally raising HDL levels by 28% and 30% of the positive control. The postbiotic counteracted HFD-induced body weight increases more effectively than ATOR without affecting liver and kidney functions or liver histopathology, at the optimal dose of each. The postbiotic is a safer substitute for ATOR in treating metabolic syndrome.

scholarly journals Cardiovascular Health, Functional Disability, and Leisure Activities Profiles in Relation to Mental Aging

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 663-663
Author(s):  
Dorina Cadar ◽  
Celine De Looze ◽  
Christine McGarrigle
Keyword(s):  
Longitudinal Study ◽  
Cognitive Aging ◽  
Representative Sample ◽  
Cardiovascular Health ◽  
Functional Disability ◽  
Physiological Stress ◽  
Leisure Activities ◽  
Functional Decline ◽  
Functional Impairments ◽  
Ideal Cardiovascular Health

Abstract We investigated cardiovascular health, functional disability and leisure activities profiles independently and in relation to cognitive decline and dementia in high and low-medium income countries using data from the English Longitudinal Study of Ageing, Irish Longitudinal Study on Ageing and Brazilian Bambui Cohort Study of Aging. Functional loss among older Brazilians has shown a hierarchical sequence over the 15-year follow-up, with the highest incidence in functional disability reported for dressing, followed by getting out of bed, bathing/showering, walking across a room, using the toilet and eating (de Oliveira). Using the Life’s Simple 7, an ideal cardiovascular health scoring system evaluating the muscular strength, mobility and physiological stress, we showed a reliable prediction of cognitive trajectories in a representative sample of Irish individuals (De Looze). Within the same cohort, we report discrepancies between men and women in functional decline driven by domestic tasks, rather than determining differential cognitive trajectories (McGarrigle). In an English representative sample, we found that participants with an increasing number of functional impairments over almost a decade were more likely to be classified with subsequent dementia compared with those with no impairments and this may imply a more comprehensive ascertainment during the prodromal stage of dementia (Cadar). In contrast, a reduced risk of dementia was found for individuals with higher levels of engagement in cognitively stimulating activities, that may preserve cognitive reserve until later in life (Almeida). Identifying factors that influence cognitive aging and dementia risk in a multifactorial perspective is critical toward developing adequate intervention and treatment.

Long-Term Exposure to PM2.5 and Cognitive Decline: A Longitudinal Population-Based Study

2021 ◽  
pp. 1-9
Author(s):  
Giulia Grande ◽  
Jing Wu ◽  
Petter L.S. Ljungman ◽  
Massimo Stafoggia ◽  
Tom Bellander ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cognitive Decline ◽  
Population Based ◽  
Cerebrovascular Diseases ◽  
Air Pollutant ◽  
National Study ◽  
Piecewise Regression ◽  
Risk Increase ◽  
Restricted Cubic Splines

Background: A growing but contrasting evidence relates air pollution to cognitive decline. The role of cerebrovascular diseases in amplifying this risk is unclear. Objectives: 1) Investigate the association between long-term exposure to air pollution and cognitive decline; 2) Test whether cerebrovascular diseases amplify this association. Methods: We examined 2,253 participants of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K). One major air pollutant (particulate matter ≤2.5μm, PM2.5) was assessed yearly from 1990, using dispersion models for outdoor levels at residential addresses. The speed of cognitive decline (Mini-Mental State Examination, MMSE) was estimated as the rate of MMSE decline (linear mixed models) and further dichotomized into the upper (25%fastest cognitive decline), versus the three lower quartiles. The cognitive scores were used to calculate the odds of fast cognitive decline per levels of PM2.5 using regression models and considering linear and restricted cubic splines of 10 years exposure before the baseline. The potential modifier effect of cerebrovascular diseases was tested by adding an interaction term in the model. Results: We observed an inverted U-shape relationship between PM2.5 and cognitive decline. The multi-adjusted piecewise regression model showed an increased OR of fast cognitive decline of 81%(95%CI = 1.2–3.2) per interquartile range difference up to mean PM2.5 level (8.6μg/m3) for individuals older than 80. Above such level we observed no further risk increase (OR = 0.89;95%CI = 0.74–1.06). The presence of cerebrovascular diseases further increased such risk by 6%. Conclusion: Low to mean PM2.5 levels were associated with higher risk of accelerated cognitive decline. Cerebrovascular diseases further amplified such risk.

scholarly journals Ideal Cardiovascular Health in Racially and Ethnically Diverse People with Serious Mental Illness

2020 ◽  
Vol 31 (4) ◽  
pp. 1669-1692
Author(s):  
Mark R. Hawes ◽  
Kimberly B. Roth ◽  
Xiaoyan Wang ◽  
Ana Stefancic ◽  
Christopher Weatherly ◽  
...  
Keyword(s):  
Mental Illness ◽  
Serious Mental Illness ◽  
Cardiovascular Health ◽  
Ethnically Diverse ◽  
Ideal Cardiovascular Health
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