scholarly journals Arthroplasty Using Autologous Multipotent Mesenchymal Cells and Collagen Membrane Chondro-Gide

2014 ◽  
pp. 62-66 ◽  
Author(s):  
A. I. Bryanskiy ◽  
T. A. Kulyaba ◽  
N. N. Kornilov ◽  
V. P. Rumakin ◽  
V. S. Gornostaev
Keyword(s):  
Surgical Treatment ◽  
Fat Body ◽  
Articular Surface ◽  
Femoral Condyle ◽  
Cartilage Regeneration ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Collagen Membrane ◽  
Slowing Down ◽  
Body Tissues ◽  
Diagnostic Arthroscopy

Surgical treatment results for 13 patients with local deep defects of the articular surface of femoral condyle are presented. Surgical treatment was performed in two steps. At first step diagnostic arthroscopy with removal of loose intraarticular bodies, resection of injured menisci and harvesting of fat body tissues for multipotent mesenchymal stromal cells (MMSC) isolation were applied. Second step consisted of knee arthroplasty; zone of defect was covered with collagen membrane Chondro-Gide under which MMSC were implanted. Control arthroscopy with biopsy of articular surface fragment in the zone of defect restoration was performed to four patients (30.8%) 2 years after arthroplasty. It is shown that after surgical intervention cartilage regeneration goes on owing to fibrillar cartilage formation. In 2 years follow up good results were achieved in 92.3% of cases that proved the efficacy of the elaborated technique for restoration of knee joint function and slowing down of degenerative-dystrophic changes development

scholarly journals Arthroplasty Using Autologous Multipotent Mesenchymal Cells and Collagen Membrane Chondro-Gide

2014 ◽  
Vol 21 (1) ◽  
pp. 62-66
Author(s):  
A. I Bryanskiy ◽  
T. A Kulyaba ◽  
N. N Kornilov ◽  
V. P Rumakin ◽  
V. S Gornostaev
Keyword(s):  
Surgical Treatment ◽  
Fat Body ◽  
Articular Surface ◽  
Femoral Condyle ◽  
Cartilage Regeneration ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Collagen Membrane ◽  
Slowing Down ◽  
Body Tissues ◽  
Diagnostic Arthroscopy

Surgical treatment results for 13 patients with local deep defects of the articular surface of femoral condyle are presented. Surgical treatment was performed in two steps. At first step diagnostic arthroscopy with removal of loose intraarticular bodies, resection of injured menisci and harvesting of fat body tissues for multipotent mesenchymal stromal cells (MMSC) isolation were applied. Second step consisted of knee arthroplasty; zone of defect was covered with collagen membrane Chondro-Gide under which MMSC were implanted. Control arthroscopy with biopsy of articular surface fragment in the zone of defect restoration was performed to four patients (30.8%) 2 years after arthroplasty. It is shown that after surgical intervention cartilage regeneration goes on owing to fibrillar cartilage formation. In 2 years follow up good results were achieved in 92.3% of cases that proved the efficacy of the elaborated technique for restoration of knee joint function and slowing down of degenerative-dystrophic changes development

scholarly journals Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Hagen Schmal ◽  
Justyna M. Kowal ◽  
Moustapha Kassem ◽  
Michael Seidenstuecker ◽  
Anke Bernstein ◽  
...  
Keyword(s):  
Stem Cells ◽  
Femoral Condyle ◽  
Rabbit Model ◽  
Cartilage Regeneration ◽  
Collagen Membrane ◽  
Defect Model ◽  
Tissue Quality ◽  
Repair Tissue ◽  
Significant Difference

Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in a rabbit, a collagen membrane was seeded with either culture-expanded allogenic chondrocytes or SMSC and then transplanted into the lesion. A tailored piece synovium served as a control. Rabbit SMSC formed typical cartilage in vitro. Macroscopic evaluation of defect healing and the thickness of the regenerated tissue did not reveal a significant difference between the intervention groups. However, instantaneous and shear modulus, reflecting the biomechanical strength of the repair tissue, was superior in the implantation group using allogenic chondrocytes (p<0.05). This correlated with a more chondrogenic structure and higher proteoglycan expression, resulting in a lower OARSI score (p<0.05). The repair tissue of all groups expressed comparable amounts of the collagen types I, II, and X. Cartilage regeneration following matrix-associated implantation using allogenic undifferentiated synovium-derived stem cells in a defect model in rabbits showed similar macroscopic results and collagen composition compared to amplified chondrocytes; however, biomechanical characteristics and histological scoring were inferior.

Patellofemoral Cartilage Restoration: Indications, Techniques, and Outcomes of Autologous Chondrocytes Implantation, Matrix-Induced Chondrocyte Implantation, and Particulated Juvenile Allograft Cartilage

2017 ◽  
Vol 31 (03) ◽  
pp. 212-226 ◽  
Author(s):  
Betina Hinckel ◽  
Andreas Gomoll
Keyword(s):  
Surgical Treatment ◽  
First Generation ◽  
Collagen Membrane ◽  
Type I ◽  
Generation Technique ◽  
Chondral Defects ◽  
Diagnostic Arthroscopy ◽  
Cartilage Restoration ◽  
Chondrocyte Implantation ◽  
Autologous Chondrocytes Implantation

AbstractFocal chondral defects are common in the patellofemoral (PF) joint and can significantly impair the quality of life. The autologous chondrocytes implantation (ACI) technique has evolved over the past 20 years: the first-generation technique involves the use of a periosteal patch, the second-generation technique (collagen-cover) uses a type I/III collagen membrane, and the newest third-generation technique seeds and cultivates the collagen membrane with chondrocytes prior to implantation and is referred to as matrix-induced autologous chondrocyte implantation. Particulated juvenile allograft cartilage (PJAC) (DeNovo NT) is minced cartilage allograft from juvenile donors. A thorough physical exam is important, especially for issues affecting the PF joint, to isolate the location and source of pain, and to identify associated pathologies. Imaging studies allow further characterization of the lesions and identification of associated pathologies and alignment. Conservative management should be exhausted before proceeding with surgical treatment. Steps of surgical treatment are diagnostic arthroscopy and biopsy, chondrocytes culture and chondrocyte implantation for the three generations of ACI, and diagnostic arthroscopy and implantation for PJAC. The techniques and their outcomes will be discussed in this article.

scholarly journals Improvement of Surgical Treatment with Combined Sculoorbital Injuries

2020 ◽  
pp. 13-16
Author(s):  
Rizaev J. A ◽  
Agzamova S. S ◽  
Yuldashov. S. A
Keyword(s):  
Surgical Treatment ◽  
Plastic Surgery ◽  
Collagen Membrane ◽  
Orbital Fractures ◽  
Membrane Material ◽  
Common Criteria ◽  
Fractures In Children ◽  
Orbital Wall

Purpose of the research: Improving surgical treatment of bottom orbital fractures in children, with the use of auto-cartilaginous block, without destroying the integrity of the rib and collagen membrane. Material and methods: We performed 12 operations according the proposed methods. During analyzing the results of the restoration of the orbital bottom published by most authors, the obvious problem is a lack of common criteria for evaluating the effectiveness of surgical treatment. Perhaps, this circumstance explains it and significantly differences presented in the data when different authors use the same methods of plastic surgery of the lower orbital wall.

Estimation of Non-Fat Body Tissues from Measurements of Skinfold Thickness, total Body Potassium and Total Body Nitrogen

1983 ◽  
Vol 65 (4) ◽  
pp. 407-414 ◽  
Author(s):  
D. B. Morgan ◽  
L. Burkinshaw
Keyword(s):  
Fat Body ◽  
Skinfold Thickness ◽  
Statistical Technique ◽  
Fat Free Mass ◽  
Variable Component ◽  
Total Body Potassium ◽  
Tissue Mass ◽  
Body Tissues ◽  
Total Body ◽  
The Relationship

1. Many previous reports have shown that the ratio of total body potassium to fat-free tissue mass is, on average, higher in men than in women. 2. In an attempt to explain this finding we have re-examined our own data and data taken from the literature. Our own data comprise measurements on 333 healthy people (196 men and 137 women). In all subjects we measured total body potassium and estimated fat-free mass from body weight and skinfold thickness; in 91 of them (62 men and 29 women) we measured, in addition, total body nitrogen. 3. We have used the statistical technique of factor analysis to obtain unbiased estimates of the relationships between the three quantities measured in the smaller group. The validity of the relationships is supported by the results from the larger group and by data from the literature. 4. The average values of total body potassium and fat-free mass are greater in men than in women, but the relationship between the two variables is identical in men and women. The relationship has a positive intercept on the axis of fat-free mass, so that the ratio of total body potassium to fat-free mass increases with fat-free mass. The higher ratio in men compared with women can therefore be explained by a difference in size alone. 5. The relationship between total body potassium and total body nitrogen has a negligible intercept. Therefore the ratio of total body potassium to total body nitrogen does not change with size. 6. These findings suggest that, on average, the fat-free mass is made up of a fixed component of approximately 9 kg of tissue containing no potassium or nitrogen, and a variable component with a potassium to nitrogen ratio of about 1.81 mmol/g.

Fate of differentiated fat body tissues during metamorphosis of Helicoverpa zea

1992 ◽  
Vol 38 (3) ◽  
pp. 199-213 ◽  
Author(s):  
Zhixiang Wang ◽  
Norbert H. Haunerland
Keyword(s):  
Helicoverpa Zea ◽  
Fat Body ◽  
Body Tissues

Salter-Harris Type III Fracture of the Medial Femoral Condyle in an Adolescent Football Player

1994 ◽  
Vol 3 (3) ◽  
pp. 239-244
Author(s):  
Thomas W. Kaminski ◽  
Thomas L. Schildwachter
Keyword(s):  
Sports Medicine ◽  
Articular Surface ◽  
English Literature ◽  
Femoral Condyle ◽  
Football Player ◽  
Fracture Site ◽  
Type Iii ◽  
Special Challenge ◽  
Salter Harris ◽  
Type Of Injury

Epiphyseal injuries present a special challenge to the sports medicine professional Salter-Harris Type III fractures involving the physis, epiphysis, and articular surface are uncommon (1). Because of the proximity of this fracture site to the knee joint, it is especially important that the clinician be aware of this type of injury when working with the adolescent athlete. This case adds to others previously reported in the English literature.

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