scholarly journals THE EFFECT OF SILODOSIN AND SODIUM DICLOFENAC TO REDUCE PAIN AFTER DJ STENT REMOVAL IN SOETOMO HOSPITAL: DOUBLE-BLINDED RANDOMIZED-CONTROLLED TRIAL

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Hasroni Fathurrahman ◽  
Doddy M Soebadi ◽  
Lukman Hakim
Keyword(s):  
Controlled Trial ◽  
Diclofenac Sodium ◽  
Pain Scale ◽  
Test Results ◽  
Group Iii ◽  
Stent Removal ◽  
Group I ◽  
Dj Stent ◽  
Group Ii ◽  
Double Blinded

Objective: To analyze, measure, compare, prove, and evaluate effectiveness of silodosin, diclofenac sodium, and the combination of both drugs in pain management after stent removal. Materials & Methods: Thirty-three patients were divided into three groups. Group I was given diclofenac Sodium 50 mg, group II was given silodosin 8 mg and group III was given the combination of diclofenac sodium 50 mg and silodosin 8 mg. The Wong Baker Pain Scale (WBPS) was assessed serially: two hours before the DJ stent removal, during DJ stent removal, and after the DJ stent removal (2 hours and 24 hours after). The data was analyzed by ANOVA and Kruskal-Wallis test. Results: In this study, 33 patients who underwent DJ stent removal were obtained. Wong Baker was presented in median (min-max) form. The WBPS study in each group did not differ statistically significant. Lowest WBPS during DJ stent removal was found in group III. Group III was better and statistically significant in reducing pain compared to group I and group II (p<0.05). WBPS two hours after removal in each group decreased and group III was better and statistically significant in reducing pain compared to group II, whereas group III compared to group I had an equivalent effectiveness. While the WBPS 24 hours after removal had the same value and did not differ significantly. No side effects or adverse events were found in the use of diclofenac sodium, silodosin, and their combinations. Conclusion: Single oral dose of diclofenac sodium combined with silodosin is effective to reduce pain after DJ stent removal.

scholarly journals THE EFFECTIVENESS OF TAMSULOSIN, SOLIFENACIN, AND COMBINATIONS THERAPY TAMSULOSIN ADDED SOLIFENACIN ON LOWER URINARY TRACT SYMPTOMS AFTER DOUBLE J STENT INSERTION

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Ida Bagus Putra Pramana ◽  
Fikri Rizaldi ◽  
Tarmono Djojodimedjo
Keyword(s):  
Quality Of Life ◽  
Combination Therapy ◽  
Controlled Trial ◽  
Psychosocial Health ◽  
Stent Insertion ◽  
Group Iii ◽  
International Prostatic Symptom Score ◽  
Group I ◽  
Dj Stent

Objective: Insertion of DJ Stent is a procedure that is often done by urologist. Insertion of DJ Stent can cause LUTS complaints and greatly affect the physical and psychosocial health of patients. The aim of this study was to determine the effectiveness difference of tamsulosin therapy 0.4 mg/day, solifenacin 5 mg/day and the combination of tamsulosin therapy 0.4 mg/day added solifenacin 5 mg/day to manage LUTS complaint after DJ Stent insertion. Material & Methods: This study was a randomized placebo-controlled trial. There were 4 groups, group I received placebo, group II received tamsulosin 0.4 mg/day, group III received solifenacin 5 mg/day, and group IV received combination therapy of tamsulosin 0.4 mg/day added solifenacin 5 mg/day. Evaluation based on International Prostatic Symptom Score (IPSS) and Ureteral Stent Symptom Questioner (USSQ) score. Data were analyzed using SPSS 21.0. It is said to be significant if p<0.05. Results: There were a total of 32 samples consist of 19 (59.3%) men and 13 (40.6%) women. There were significant improvements in the score of total IPSS, IPSS storage and IPSS quality of life score in patients who received combination therapy (p<0.05) when compared with patients who received monotherapy. The highest decrease in USSQ scores 1, 2, 3, 4, 5 and 6 were in the group that received combination therapy when compared with the monotherapy group. Conclusion: The combination therapy is safe and effective to improve IPSS total, IPSS storage and IPSS Quality of Life scores compared with monotherapy.

scholarly journals Comparison of postoperative analgesic effects of two doses of dexamethasone in ultrasound-guided transversus abdominis plane block for inguinal hernia repair: a randomized controlled trial

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Amani H. Abdel-wahab ◽  
Ekram A. Osman ◽  
Abubakr Y. Ahmed
Keyword(s):  
Inguinal Hernia ◽  
Hernia Repair ◽  
Inguinal Hernia Repair ◽  
Controlled Trial ◽  
Transversus Abdominis ◽  
Tap Block ◽  
Group Iii ◽  
Randomized Controlled ◽  
Group I ◽  
Group Ii

Abstract Background Ninety patients American Society of Anesthesiologists (ASA) I–II, aged (18–60 years), were enrolled in this randomized controlled trial. All enrolled patients had undergone elective primary unilateral open inguinal hernia repair under spinal anesthesia; at the end of the surgery, transversus abdominis plane (TAP) block was done by bupivacaine combined with 4 mg dexamethasone in (group I), 8 mg dexamethasone in (group II), or saline in (group III.). We aimed to compare the analgesic efficacy of two different doses of dexamethasone (4 mg and 8 mg) added to bupivacaine in a unilateral single-injection (TAP) block. The first outcome measure was the time of the first analgesic request, and the secondary outcome measure was the VAS scale in the first postoperative 24 h. Results There was no need for any analgesia in group I and group II in the first postoperative 24 h. The time of the first analgesic request in group III was 720 ± 90 min. VAS scores were significantly lower in group I and group II than in group III, with no significant difference between group I and group II. Conclusions There is no difference in the first postoperative 24 h analgesic effect of the two doses of dexamethasone when added to a long-acting local anesthetic mixture in TAP blocks in patients undergoing inguinal hernia repair. Trial registration ClinicalTrials.gov, NCT03863977

scholarly journals Effect of Herbal and Fluoride Mouth Rinses onStreptococcus mutansand Dental Caries among 12–15-Year-Old School Children: A Randomized Controlled Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Vinej Somaraj ◽  
Rekha P. Shenoy ◽  
Ganesh Shenoy Panchmal ◽  
Vijaya Kumar ◽  
Praveen S. Jodalli ◽  
...  
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Controlled Trial ◽  
Group Iii ◽  
Intention To Treat ◽  
Group I ◽  
Mouth Rinses ◽  
Significant Difference ◽  
Group Ii ◽  
Glucan Synthesis

To assess and compare the effect of herbal and fluoride mouth rinses onStreptococcus mutanscount and glucan synthesis byStreptococcus mutansand dental caries, a parallel group placebo controlled randomized trial was conducted among 240 schoolchildren (12–15 years old). Participants were randomly divided and allocated into Group I (0.2% fluoride group), Group II (herbal group), and Group III (placebo group). All received 10 ml of respective mouth rinses every fortnight for a period of one year. Intergroup and intragroup comparison were done forStreptococcus mutanscount and glucan synthesis byStreptococcus mutansand dental caries.Streptococcus mutanscount showed a statistically significant difference between Group I and Group III (p=0.035) and also between Group II and Group III (p=0.039). Glucan concentration levels showed a statistically significant difference (p=0.024) between Group II and Group III at 12th month. Mean DMF scores showed no statistical difference between the three groups (p=0.139). No difference in the level of significance was seen in the intention-to-treat and per-protocol analysis. The present study showed that both herbal and fluoride mouth rinses, when used fortnightly, were equally effective and could be recommended for use in school-based health education program to control dental caries. Trial registration number isCTRI/2015/08/006070.

scholarly journals Antiinflammatory therapy of neurotrophic corneal diseases

2019 ◽  
Vol 12 (4) ◽  
pp. 77-82
Author(s):  
E. V. Yani ◽  
E. N. Orlova ◽  
V. A. Golikova
Keyword(s):  
Combined Treatment ◽  
Eye Drops ◽  
Test Results ◽  
Antiinflammatory Therapy ◽  
Group Iii ◽  
Group I ◽  
New Directions ◽  
Neurotrophic Keratitis ◽  
Anti Inflammatory ◽  
Group Ii

Clinical data on new directions in combined treatment of neurotrophic keratitis, including anti-inflammatory therapy are presented.Purpose. To compare the effectiveness of bromfenac 0.09 %, nepafenac 0.1 % and indomethacin 0.1 % eye drops in the treatment of neurotrophic keratitis (NK).Materials and methods. 22 NK patients, aged 34 to 78, were divided into three groups. Group I received bromfenac 0.09 %, group II, nepafenac 0.1 %, and group III, indomethacin 0.1 %. Ophthalmic tests included visometry, biomicroscopy, corneal sensitivity determination, as well as diagnostic tests to determine indicators of tear production (Schirmer test, Norn test, LIPCOF test), and measuring lacrimal meniscus height.Results. Between visits V2 and V3, patients of group III showed an increase in conjunctival irritation to an average of 2.3 points, while groups I and II revealed the condition of the conjunctiva at 0.9 and 1.1 points, respectively. The lesion area was evaluated in points (max = 20) and averaged on V1 6.8 points in group I, 5.9 points in group II and 7.2 points in group III. Keratopathy in group I which was estimated at 3.8 points before V2, dropped to 1.4 points by V3. In group III it was 1.7 points by V3. In group II, keratopathy showed only 4.1 points by V3. The average Norn test on the day of treatment showed 2.7 seconds in group I, 2.5 seconds in group II, and 3.1 seconds in group III. No significant increase in Schirmer's test results in all groups was recorded.Conclusion. The use of non-steroidal anti-inflammatory eye drops of various groups — bromfenac 0.09%, nepafenac 0.1 % and indomethacin 0.1 % — gave a positive result in NK therapy. However, bromfenac 0.09% instillations administered once a day produce a higher anti-inflammatory effect then the same quantity of nepafenac 0.1% and indomethacin 0.1 % instillations.

scholarly journals Study on Efficacy of Nalbuphine Hydrochloride as Pre-Emptive Analgesic – Comparison With Diclofenac Sodium after Open Cholecystectomy

2009 ◽  
Vol 20 (2) ◽  
pp. 39-44
Author(s):  
Md Quamrul Islam ◽  
Hasina Begum ◽  
AKM Akhtaruzzaman ◽  
UH Shahera Khatun
Keyword(s):  
Muscle Relaxation ◽  
Open Cholecystectomy ◽  
Diclofenac Sodium ◽  
Randomized Study ◽  
Afferent Input ◽  
P Value ◽  
Group Iii ◽  
Central Processing ◽  
Group I ◽  
Group Ii

Preemptive analgesia is an antinociceptive treatment that prevents establishment of altered central processing of afferent input from sites of injury. The aim of this study was to evaluate the effects of preemptively used nalbuphine and diclofenac on postoperative pain and opioid consumption. Seventy five patients scheduled for open cholecystectomy were investigated by randomized study. Patients were divided into three groups. In group I, patients received Inj. Nalbuphine Hydrochloride (0.3 mg/kg bw IV) before induction. In group II, patients received Inj. Diclofenac Sodium (1 mg/kg bw IV) before induction and in group III patients received placebo before induction. General Anesthesia was given in all groups with Inj. Thiopental sodium 5mg/kg and Inj. Succninylcholine 1.5mg/kg to facilitate endotracheal intubation. Anesthesia was maintained with halothane 0.5% and nitrous oxide 66% in oxygen. Muscle relaxation was maintained by Inj.Vecuronium 0.1 mg/kg. Intraoperative proper hydration was maintained by lactate ringer's solution.In post operative period patients in all three groups received Inj. Pethidine 10mg IV till the patients got relieved from pain. The minimum interval of giving pethidine was 10 minutes. Through our study we have found that, pethidine consumption in 24 hours in group-I (Nalbuphine group) was 54.00±1.0, in group-II (Diclofenac group) was 74.00±1.0 and in group-III (Placebo group) was 112.0±2.0 and p-value <0.001, which is highly significant (measured in mg). Time of first pethidine demand in group-I was 45.83±10.93, in group-II was 34.20±5.44and in group-III was 16.21±3.62 and p-value<0.001 which is also highly significant (measured in minute). Overall patients satisfaction was high in nalbuphine group. Under the condition of present study, we can conclude that preemptively used nalbuphine hydrochloride decreases post operative pain and opioid demand. Journal of BSA, Vol. 20, No. 2, July 2007 p.39-44

Mechanisms of Platelet Dysfunction and Response to DDAVP in Patients with Congenital Platelet Function Defects

1995 ◽  
Vol 74 (04) ◽  
pp. 1071-1078 ◽  
Author(s):  
A Koneti Rao ◽  
Sikha Ghosh ◽  
Ling Sun ◽  
Xu Yang ◽  
Jyoti Disa ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Dense Granule ◽  
Double Blind ◽  
Group Iii ◽  
Group I ◽  
Production Group ◽  
Group Ii ◽  
Platelet Defects ◽  
Deficiency Group ◽  
The Impact

SummaryTo examine the impact of the underlying defective platelet mechanism on the response to 1-desamino-8-D-arginine vasopressin (DDAVP, Desmopressin), we studied the effect of intravenous infusion of 0.3 μg/kg of DDAVP in a randomized double blind placebo-controlled trial with cross-over in 18 carefully characterized patients with congenital platelet defects (CPD) and BT ≥9 min. Eleven patients had normal dense granule stores and normal thromboxane A2 (TxA2) production (Group I), 3 patients had normal granule stores but impaired TxA2 production (Group II), and 4 had δ-storage pool deficiency (Group III). DDAVP shortened BT at 50 min (DDAVP 14.6 ± 2.2 vs placebo 19.6 ± 2.3 min; n = 18; mean ± SE; p = 0.003) and 4h (17.0 ± 2.2 vs 19.6 ±2.1 min, p = 0.055), and raised plasma FVIIIC and von Willebrand factor (vWF). At 50 min DDAVP shortened BT by ≥5 min in 8 of 11 Group I patients (mean 9.7 ± 1.3 vs 16.3 ± 2.8 min; p <0.008), 1 of 3 Group II patients (11.9 ± 3.9 vs 17.7 ± 6.6; p = NS) and none of Group III patients (mean 30 min both arms). Ten patients (Group I or II) were managed successfully during surgical procedures with DDAVP alone. We conclude that DDAVP shortens BT in majority of CPD patients with normal dense granule stores and suggest that BT response may be dependent on the underlying platelet defect. DDAVP is a useful modality in management of selected patients, particularly those with normal dense granule stores.

scholarly journals Local Bupivacaine Infiltration to Reduce Pain after Tonsillectomy: A Low Cost Approach

2021 ◽  
Vol 28 (3) ◽  
pp. 228-233
Author(s):  
Rakesh B S ◽  
Bharathi M B ◽  
Thanzeemunisa U ◽  
Kumar Shankar De ◽  
Nitish Aggarwal
Keyword(s):  
Rating Scale ◽  
Low Cost ◽  
Major Drawback ◽  
Group Iii ◽  
Pain Scores ◽  
Group I ◽  
Significant Difference ◽  
Average Pain ◽  
Group Ii ◽  
Double Blinded

Introduction Tonsillectomy is one of the most commonly performed surgical procedures worldwide, with the major drawback of significant post operative pain.There is no consensus regarding topical application or local infiltration of anesthetics post operatively to reduce pain. The present study was performed to evaluate the effect of bupivacaine infiltration in the tonsillar fossae after tonsillectomy. Materials and Methods A double-blinded clinical trial was performed on 75 patients undergoing tonsillectomy between January 2019 and January 2020. All patients underwent tonsillectomy under general anesthesia and were then randomly divided into 3 groups of 25 patients each. For Group I, a swab soaked in normal saline was applied to the tonsillar fossae for 5 minutes just before extubation. In Group II, a swab soaked in 5 ml of 0.5% bupivacaine was placed for 5 minutes, while in Group III, 5ml of 0.5% bupivacaine was infiltrated in the tonsillar fossae. The intensity of pain for each group was measured in the immediate post op period, at6 hours, 24 hours and 1 week by Wong Baker Faces Pain Rating Scale. Results There was a significant difference in the mean level of pain between groups I and III in the immediate post op period, at 6 hours and 24 hours. Although the average pain scores of group III were better than those of group II, the results were significant only in the 6 hour post op period. Conclusion To reduce post-tonsillectomy pain,0.5% bupivacaine can be infiltrated into the tonsillar fossa.

scholarly journals [NO TITLE AVAILABLE]

1998 ◽  
Vol 13 (1) ◽  
pp. 37-43 ◽  
Author(s):  
José Guilherme Minossi ◽  
Celso Vieira de Souza Leite ◽  
Luiz Eduardo Naresse ◽  
Maria Aparecida M. Rodrigues ◽  
Paulo Roberto Curi ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Wistar Rats ◽  
Diclofenac Sodium ◽  
Group Iv ◽  
Clinical Parameters ◽  
Control Groups ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Tensile Strenght

The effect of the diclofenac sodium (DS) on the healing of anastomosis carried- out in the ileum of rats was studied. Five- hundred and nineteen Wistar rats were randomly assigned to the 4 experimental groups: Group I included 52 rats treated with 3 mg/kg/day of saline, administered intramusculary during 4 days, group II included 110 rats submitted to ileal anastomosis and treated with saline as described previously, group III included 52 rats treated with DS in a dose of 3 mg/kg/day, administered IM during 4 days, and group IV included 295 rats submitted to ileal anastomosis and treated with DS as prior described. In all rats from the 4 experimental groups clinical parameters and measurements of tensile strength, tissue collagen and histological analyses were documented at 4, 7, 14, and 21 postoperative days. There are no clinical alterations in group I rats all over the study. Diarrhoea was observed in 8 rats (15,4%) from group III. In this group both tensile strenght and tissue collagen were descrease when compared with group I rats. Mortality in DS treated rats submitted to ileal anastomosis was higher than those of control groups. In group IV we also observed reard in the healing, with intense PMN inflamatory response, decrease of macrophages and of tissue collagen, and mucosae regeneration. We concluded that DS is deleterious on the healing of anastomosis performed in the ileum of rats

scholarly journals Conservative Treatment for Plantar Fasciitis

2018 ◽  
Vol 3 (2) ◽  
pp. 2473011418S0000
Author(s):  
Carlos Jasmin Alfredo Lobo
Keyword(s):  
Plantar Fasciitis ◽  
Diclofenac Sodium ◽  
Randomized Study ◽  
Local Infiltration ◽  
Group Iii ◽  
Muscle Stretching ◽  
Group I ◽  
Evaluation Group ◽  
Group Ii ◽  
Night Splints

Category: Hindfoot Introduction/Purpose: The objective of this study was to compare the results obtained in the treatment of plantar fasciitis, by: group I, muscle stretching (plantar and gastrocnemius); Group II, use of the dorsiflexion night splints; and group III, permanent elevation use of shoe heel, 2 cm or more, in relation to forefoot. Methods: One hundred and fifty patients participated in the prospective and randomized study. After randomizing the method, the patients received treatment orientation. Prescription: 150 mg diclofenac sodium, single daily dose, for 7 days. Group II, they underwent daily physiotherapy with plantar stretching and electrotherapy, associated to the use of the night splints. The evaluations were at 30 and 60 days. In the first evaluation, eight patients underwent local infiltration of betamethasone dipropionate, betamethasone disodium phosphate: five from Group I and three from Group II. All patients were evaluated on the AOFAS score of the hindfoot. Results: First evaluation: group I, 52% showed little improvement (AOFAS: initial 53.5, 30 days 56.6); Group II, 38% were dissatisfied and uncomfortable with the night splints (AOFAS: initial 55.6, 30 days 63.3). In group III, 22% of the patients reported pain arising in the morning and after periods of sitting (AOFAS: initial 57.7, 30 days 81.6). Second evaluation: Group I, AOFAS 56.9; Group II AOFAS 72.2; group III AOFAS 88.6. Conclusion: heel elevation presented a satisfactory result, superior to the other methods used; difficulty for patient’s adhesion because it eliminates usage of shoes with no heels; AOFAS / scale close to all patients treated.

scholarly journals The Comparison of the Effects of Ellagic Acid and Diclofenac Sodium on Intra-Abdominal Adhesion: An In Vivo Study in the Rat Model

2014 ◽  
Vol 99 (5) ◽  
pp. 543-550 ◽  
Author(s):  
Tulay Diken Allahverdi ◽  
Ertuğrul Allahverdi ◽  
Sadık Yayla ◽  
Turgay Deprem ◽  
Oğuz Merhan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ellagic Acid ◽  
Diclofenac Sodium ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesions ◽  
Group Iii ◽  
Group I ◽  
Anti Inflammatory ◽  
Group Ii

Abstract Peritoneal adhesions are seen frequently after abdominal surgery and can cause serious complications. We aimed to evaluate the effects of the oral use of diclofenac sodium and ellagic acid on formation of postoperative adhesions in rats Studies have shown that agents with anti-inflammatory properties and antioxidant substances can prevent adhesion by decreasing oxidative stress. We compared and evaluated the effects of ellagic acid that has strong antioxidant and anti-inflammatory properties and the nonsteroidal anti-inflammatory diclofenac sodium on peritoneal adhesion development in our experimental study. Laparotomy was performed with a midline incision under general anesthesia and an adhesion model was created on the antimesenteric side of the cecum in Groups I, II, and III. Group I received 85 mg/kg ellagic acid and Group II, 50 mg/kg diclofenac sodium through the nasogastric catheter while Group III received no medication. Only laparotomy was performed in Group IV. The rats were sacrificed at the end of the 14th day. Following macroscopic scoring, tissue samples were removed and subjected to biochemical and histopathologic evaluation. The degree of adhesion and the malondialdehyde level were decreased (P &lt; 0.05), and glutathione level increased (P &lt; 0.05) in Group I compared to Group II and Group III. The effects of ellagic acid on the prevention of peritoneal adhesion were found to be stronger than diclofenac sodium. This can be explained by the fact that ellagic acid is a strong antioxidant and decreases oxidative stress with anti-inflammatory and anti-angiogenic effects.

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