scholarly journals Serotonin transporter polymorphism and stress effects on gut microbiota at various time points in pregnancy

2017 ◽  
Author(s):  
◽  
Briana M. Kille
Keyword(s):  
Prenatal Stress ◽  
Gut Microbiome ◽  
Good Evidence ◽  
Potential Mechanism ◽  
Time Points ◽  
Stress Effects ◽  
Serotonin Transporter Polymorphism ◽  
Poor Outcomes ◽  
Stress Susceptibility ◽  
In Pregnancy

Prenatal stress (stress experienced by the mother while pregnant) has been shown to greatly affect the health of a child. Still, not all off05 who experience prenatal stress will suffer poor outcomes. Maternal genetics and the timing of adverse events have been shown to interact to affect the likelihood that a child will be affected by prenatal stress. However, the mechanisms behind this interaction are not fully understood. One potential mechanism is the maternal gut microbiome (the community of bacteria residing in the mother's gut). The current study used a mouse model of genetic stress susceptibility, combined with a daily restraint stress during pregnancy to examine alterations in the maternal gut microbiome due to an interaction between genes and stress. While pregnancy was found to alter the microbiome differently at various time-points in pregnancy, there was no significant interaction between genes and stress. However, as the sample size was quite small and there were trending results, we believe there is good evidence to continue exploration of the effects of stress and genetics on the maternal microbiome.

Poor Outcomes Seen in Pregnancy-Tied Breast Ca

Ob Gyn News ◽  
2008 ◽  
Vol 43 (2) ◽  
pp. 15
Author(s):  
BRUCE JANCIN
Keyword(s):  
Poor Outcomes ◽  
In Pregnancy

scholarly journals Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

2021 ◽  
Author(s):  
Anurag Singh ◽  
Davide D’Amico ◽  
Pénélope A. Andreux ◽  
Gillian Dunngalvin ◽  
Timo Kern ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Dietary Exposure ◽  
Food Product ◽  
Pomegranate Juice ◽  
Healthy Population ◽  
Plasma Samples ◽  
Time Points ◽  
Natural Exposure ◽  
Microbiome Diversity ◽  
Urolithin A

Abstract Background Urolithin A (UA) is produced by gut microflora from foods rich in ellagitannins. UA has been shown to improve mitochondrial health preclinically and in humans. Not everyone has a microbiome capable of producing UA, making supplementation with UA an appealing strategy. Objective This is the first detailed investigation of the prevalence of UA producers in a healthy population and the ability of direct UA supplementation to overcome both microbiome and dietary variability. Dietary intake of a glass of pomegranate juice (PJ) was used to assess UA producer status (n = 100 participants) and to characterize differences in gut microbiome between UA producers from non-producers. Methods Subjects were randomized (1:1) to either PJ or a food product containing UA (500 mg). Prevalence of UA producers and non-producers were determined in the PJ group. Diet questionnaires and fecal samples were collected to compare differences between UA producers and non-producers along with plasma samples at different time points to assess levels of UA and its conjugates between the interventions. Results Only 12% of subjects had detectable levels of UA at baseline. Following PJ intake ~40% of the subjects converted significantly the precursor compounds into UA. UA producers were distinguished by a significantly higher gut microbiome diversity and ratio of Firmicutes to Bacteroides. Direct supplementation with UA significantly increased plasma levels and provided a >6-fold exposure to UA vs. PJ (p < 0.0001). Conclusions Differences in gut microbiome and diet that dictate natural exposure to UA can be overcome via direct dietary UA supplementation.

scholarly journals Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Livio Provenzi ◽  
Fabiana Mambretti ◽  
Marco Villa ◽  
Serena Grumi ◽  
Andrea Citterio ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Collective Trauma ◽  
Transporter Gene ◽  
Stress Exposure ◽  
Buccal Cells ◽  
Stress Effects ◽  
Cpg Sites ◽  
Stress Related Genes ◽  
Related Stress ◽  
Epigenetic Signatures

AbstractThe COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months.

scholarly journals Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

2008 ◽  
Vol 1 ◽  
pp. CMBD.S823
Author(s):  
Juliane Menezes ◽  
Mariana Emerenciano ◽  
Flávia Pimenta ◽  
Gilson Guedes Filho ◽  
Isis Q. Magalhães ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Women ◽  
Acute Leukaemia ◽  
Myeloid Leukemia ◽  
Leukemic Cells ◽  
Fusion Genes ◽  
Life Threatening ◽  
Poor Outcomes ◽  
Acute Myeloid ◽  
In Pregnancy

Although acute leukaemia is rare in pregnancy its importance lies in its life-threatening potential, both to the child and the mother. The possibility of vertical transmission of leukemic cells increases the attention devoted to these patients and their offspring. Three cases of pregnant young women (15-17 years of age) with AML are presented. This series of cases is the first report where gene abnormalities such as ITD mutations of the FLT3 gene and AML1/ETO fusion genes were screened in pregnant AML patients and their babies, so far. Unfortunately, very poor outcomes have been associated to similar cases described in literature, and the same was true to the patients described herein. Although very speculative, we think that the timing and possible similar exposures would be involved in all cases.

Prenatal stress effects on exploratory activity and stress-induced analgesia in rats

1991 ◽  
Vol 24 (5) ◽  
pp. 361-372 ◽  
Author(s):  
T. Szuran ◽  
E. Zimmerman ◽  
V. Pliska ◽  
H. P. Pfister ◽  
H. Welzl
Keyword(s):  
Prenatal Stress ◽  
Exploratory Activity ◽  
Stress Effects

scholarly journals Moderate prenatal stress may buffer the impact of Superstorm Sandy on placental genes: Stress in Pregnancy (SIP) Study

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0226605
Author(s):  
Wei Zhang ◽  
Jacob Ham ◽  
Qian Li ◽  
Maya A. Deyssenroth ◽  
Luca Lambertini ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Superstorm Sandy ◽  
The Impact ◽  
In Pregnancy

scholarly journals Maternal Gut Microbiome Biodiversity in Pregnancy

2017 ◽  
Vol 35 (01) ◽  
pp. 024-030 ◽  
Author(s):  
Nitasha Ricks ◽  
Alexis Panzer ◽  
Amber Mccoy ◽  
M. Azcarate-Peril ◽  
Temitope Keku ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
High Throughput Sequencing ◽  
White Women ◽  
Phase 1 ◽  
Rrna Gene ◽  
Fecal Samples ◽  
Gestational Weight ◽  
Biodiversity Changes ◽  
In Pregnancy

Objective To measure maternal gut microbiome biodiversity in pregnancy. Materials and Methods In phase 1, maternal fecal samples were collected by rectal swab in 20 healthy pregnant women (14–28 weeks gestation) to measure bacterial abundance. In phase 2, fecal samples were collected from 31 women at enrollment (<20 weeks gestation, baseline) and at 36 to 39 weeks of gestation (follow-up). We assessed cluster analysis to assess bacterial community profiles at the phylum level longitudinally through pregnancy. DNA was extracted from swabs, followed by PCR of the bacterial 16s rRNA gene and multiplex high-throughput sequencing (Ion Torrent). Results In phase 1, 16 of 20 samples yielded usable data. White women (n = 10) had greater abundance of Firmicutes (23 ± 0.15 vs. 16% ± 0.75, p = 0.007) and Bacteroidetes (24 ± 0.14 vs. 19% ± 0.68, p = 0.015) compared with non-White women (n = 6). In the 11 paired specimens, Bacteroidetes increased in abundance from baseline to follow-up. Compared with women who gained weight below the median gestational weight gain (GWG, <15.4 kg), those who gained above the median GWG had increased abundance of Bacteroidetes (p = 0.02) and other phyla (p = 0.04). Conclusion Maternal microbiome biodiversity changes as pregnancy progresses and correlates with GWG.

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