scholarly journals Identifying bioactive phytochemicals in spent coffee grounds for cosmetic application through global metabolite analysis

2017 ◽  
Author(s):  
◽  
Jihyun Park
Keyword(s):  
Bioactive Compounds ◽  
Raw Materials ◽  
Costa Rican ◽  
Raw Material ◽  
Spent Coffee Grounds ◽  
Metabolite Analysis ◽  
Coffee Grounds ◽  
Chemical Profiles ◽  
Anti Oxidant ◽  
Anti Inflammatory

Annually, more than 6 million tons of spent coffee grounds (SCG) are generated worldwide. The present study explores the possible use of spent coffee grounds as the raw materials for cosmetics industry. The main objective of this project are to investigate the chemical profiles and identify the bioactive compounds for cosmetics application through global metabolite analysis. The compounds extracted from SCG of Ethiopia coffee (Yirgacheffe), Costa Rican coffee (Tarrazu) and Hawaiian coffee (Kona) were analyzed by ultra-high pressure liquid chromatography coupled with mass spectrometry (UPLC-MS). The ion chromatograms were submitted to XCMS platform operated by Center for Metabolomics at the Scripps Research Institute. The peak detection, peak grouping, spectra extraction, and retention alignment were processed by XCMS. The spectra were annotated and the compounds were identified and categorized by integration with METLIN, the world's largest metabolite database. Multivariate and univariate statistical analysis including PCA and cloud-plot were performed by XCMS to compare the chemical profiles between the three coffee cultivars. These analyses indicated that each cultivar showed a specific cluster. Over 200 compounds related to anti-oxidant, anti-inflammatory, anti-tyrosinase and anti-tumor for skin care application were identified by XCMS. Therefore, the presence of bioactive compounds in SCG makes it a potential source of raw material for cosmetic application (e.g., anti-oxidant, anti-inflammatory, skin-whiting, and anti-aging).

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

Analysis of Extraction Kinetics of Bioactive Compounds from Spent Coffee Grounds (Coffea arábica)

2018 ◽  
Vol 9 (12) ◽  
pp. 2381-2389 ◽  
Author(s):  
Ashley Sthefanía Caballero-Galván ◽  
Daissy Lorena Restrepo-Serna ◽  
Mariana Ortiz-Sánchez ◽  
Carlos Ariel Cardona-Alzate
Keyword(s):  
Bioactive Compounds ◽  
Coffea Arabica ◽  
Spent Coffee Grounds ◽  
Extraction Kinetics ◽  
Coffee Grounds ◽  
Kinetics Of

The influence of brewing method on bioactive compounds residues in spent coffee grounds of different roasting degree and geographical origin

2019 ◽  
Vol 54 (11) ◽  
pp. 3008-3014 ◽  
Author(s):  
Rita Głowacka ◽  
Agata Górska ◽  
Magdalena Wirkowska‐Wojdyła ◽  
Rafał Wołosiak ◽  
Ewa Majewska ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Geographical Origin ◽  
Spent Coffee Grounds ◽  
Coffee Grounds ◽  
Brewing Method

scholarly journals Using biochar from spent coffee grounds to treat pollution in livestock wastewater

2020 ◽  
Vol 61 (5) ◽  
pp. 135-144
Author(s):  
Huong Thu Thi Tran ◽  
Tong Xuan Nguyen ◽  
Yen Hai Thi Trinh ◽  
Hang Thi To ◽  
Huyen Thanh Thi Dang ◽  
...  
Keyword(s):  
Interplanar Spacing ◽  
Reaction Times ◽  
Raw Material ◽  
Lattice Plane ◽  
Treatment Efficiency ◽  
Spent Coffee Grounds ◽  
Technical Regulation ◽  
Livestock Wastewater ◽  
Coffee Grounds ◽  
Material Sample

Four types of biochar material synthesized from spent coffee grounds by slow pyrolysis process CF1 (500(C/0.5h); CF2 (500(C/1.5h); CF3 (500(C/3h); CF4 (500(C/6h) is studied to treat two pollution parameters (COD and TSS) in livestock wastewater. Material characteristics were determined by SEM, EDX and BET methods. The results showed that the 4 samples of biochar materials were structured fiber clearly, the interplanar spacing which corresponds to the lattice plane. The C content in the biochar sample is higher than the initial raw material sample; the highest value recorded reaches 90.61% C (CF2). 100 mL of the original livestock waster water is filtered through columns with 4g of biochar CF1-CF4 during reaction times varied from 0h, 1h, 4h and 8h, the COD treatment efficiency and adsorption content of CF4 sample is highest of 96.41% and 188 mg/g after 8h, and the lowest value is 76.67% and 149.5 mg/g after 1h recorded in CF3 sample, however the COD value after treatment is still higher from 1.2 to 1.46 times than Vietnamese standard 62: 2016/MONRE - national technical regulation on the effluent of livestock. The CF3 material samples have the highest TSS treatment efficiency and adsorption content of 95.19% and 6.425 mg/g after 8h and the lowest of 66.78% and 4.575 mg/g recorded in CF1 samples after 1h, response the requirements of QCVN 62: 2016/MONRE. The results showed that biochar is a potential sorbent to removed pollutants from waste water.

Food waste biorefinery: A case study for spent coffee grounds (SCGs) into bioactive compounds across the European Union

2021 ◽  
pp. 459-473
Author(s):  
Georgeio Semaan ◽  
Sutha Shobana ◽  
Sundaram Arvindnarayan ◽  
Neha Bhatt ◽  
Jeyaprakash Dharmaraja ◽  
...  
Keyword(s):  
European Union ◽  
Bioactive Compounds ◽  
Food Waste ◽  
The European Union ◽  
Spent Coffee Grounds ◽  
Coffee Grounds

scholarly journals Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4444
Author(s):  
Joanna Kolniak-Ostek ◽  
Dagmara Kłopotowska ◽  
Krzysztof P. Rutkowski ◽  
Anna Skorupińska ◽  
Dorota E. Kruczyńska
Keyword(s):  
Bioactive Compounds ◽  
Antiproliferative Activity ◽  
Fruits And Vegetables ◽  
Raw Materials ◽  
Reducing Ability ◽  
Pyrus Communis L ◽  
Health Promoting ◽  
Anti Inflammatory ◽  
Excellent Source ◽  
Cox 1

Consuming food that is rich in antioxidants reduces the risk of developing chronic diseases and oxidative stress. Fruits and vegetables are an excellent source of substances with antioxidant and pro-health properties. Such raw materials, characterized by a high content of polyphenolic compounds and antioxidant capacity, include pear fruits. In this study, the concentrations of bioactive compounds, as well as the antioxidant, anti-inflammatory, and antiproliferative activity in fruits of five selected pear cultivars were determined and compared. LC–MS and UPLC–PDA methods were used to determine the polyphenolic, carotenoid, chlorophyll, and triterpenoid profiles and content, and the antioxidant activity was analyzed using DPPH and ferric-reducing ability of plasma (FRAP) tests. The anti-inflammatory activity was determined against COX-1 and COX-2 enzymes. The cytotoxic activity of the test compounds was assessed against six tumor cell lines. The results showed that the major group of phenolic compounds in all cultivars was phenolic acids. In the group of chromoplastic pigments, chlorophyllide a and 9-cis-β-carotene were the major compounds, while in the triterpene group, ursolic acid was dominant. The antioxidant potential correlated with the content of polyphenols and carotenoids, and was the strongest for the ‘Radana’ cultivar. The highest antiproliferative activity in all varieties was established for bladder cancer.

scholarly journals Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Annona muricata By-Products and Pulp

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 904 ◽  
Author(s):  
Gabriela Aguilar-Hernández ◽  
María García-Magaña ◽  
María Vivar-Vera ◽  
Sonia Sáyago-Ayerdi ◽  
Jorge Sánchez-Burgos ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Bioactive Compounds ◽  
Raw Materials ◽  
Raw Material ◽  
Ultrasound Assisted Extraction ◽  
Total Polyphenols ◽  
Assisted Extraction ◽  
Ultrasound Assisted ◽  
Conventional Extraction ◽  
By Products

Ultrasound-assisted extraction (UAE) is widely used; however, the efficiency of extraction depends on the raw materials. Therefore, optimization of UAE must be investigated for each type of plant material. By-products from soursop fruit have not been studied as a source of bioactive compounds. In this work, the optimization of UAE conditions (extraction time (5, 10, and 15 min), pulse cycle (0.4, 0.7, and 1 s), and sonication amplitude (40%, 70%, and 100%)) for the extraction of phenolic compounds (soluble, hydrolyzable, condensed tannins, and total polyphenols) from soursop by-products (seed, peel, and columella) and pulp was evaluated using response surface methodology. The optimal conditions for UAE to obtain the highest total polyphenol content from by-products and pulp was dependent on the raw material. Peel resulted in the highest content of total polyphenols (187.32 mg/g dry matter [DM]) followed by columella (164.14 mg/g DM), seed (36.15 mg/g DM), and pulp (33.24 mg/g DM). The yield of polyphenolic content from peel and columella obtained with UAE was higher (32–37%) than conventional extraction for 2 h under stirring (14–16%). The contents of gallic acid (0.36–15.86 µg/g DM), coumaric acid (0.07–1.37 µg/g DM), and chlorogenic acid (9.18–32.67 µg/g DM) in the different parts of the fruit were higher in the extracts obtained by UAE compared with a conventional extraction method (0.08–0.61, 0.05–0.08, 3.15–13.08 µg/g DM, respectively), although it was dependent on the raw materials. Soursop by-products can be functionally important if they are used to extract bioactive compounds by UAE; a technology with high potential for commercial extraction on a large scale.

scholarly journals Polyphenols composition, antioxidant and antimicrobial properties of Pinus sylvestris L. shoots extracts depending on different drying methods

2020 ◽  
pp. 229 ◽  
Author(s):  
Marcin Dziedziński ◽  
Joanna Kobus-Cisowska ◽  
Daria Szymanowska- Powałowska ◽  
Kinga Stuper- Szablewska ◽  
Marlena Baranowska
Keyword(s):  
Pinus Sylvestris ◽  
Bioactive Compounds ◽  
Raw Materials ◽  
Antimicrobial Properties ◽  
Raw Material ◽  
Drying Methods ◽  
Active Components ◽  
Antioxidant Power ◽  
Freeze Dried ◽  
Ferric Reducing Antioxidant Power

Scots pine (Pinus sylvestris L.) shoots have been increasingly commonly used as functional food or its component, the shoots contain various active components, unknown from other raw materials. The objective of the study was to assess the influence of the drying method on the content of bioactive compounds and antioxidative and antimicrobial activity of pine shoots. It was demonstrated that freeze drying (PSL), vacuum drying (PSP) and natural drying (PSN) have significant impact on the physicochemical properties, content of bioactive compounds and antioxidative activity of the prepared ethanol-water extracts. The content of the studied compounds varied significantly in the tested shoots. In spectrophotometric testing the highest total flavonoid content was demonstrated in the PSP sample, at 5.51 mg quercetin/g dw. On the other hand, the reducing capacity was as follows: PSN>PSP>PSL in the range from 13.4 to 5.73 mg gallic acid/g dw. However in assay conducted using HPLC methods the highest content of polyphenols characterized extract from freeze-dried raw material (9151.15 µg/g), followed by vacuum-dried (8264.57 µg/g), and the lowest content of phenolic compounds was found in convection-dried shoots (7621.76 µg/g). The studied extracts demonstrated antioxidative properties, both in ferric reducing antioxidant power assay (FRAP) as well as in free radical quenching measurement (DPPH). All of the studied extracts demonstrated antimicrobial and fungicidal properties, and they were particularly efficient in the case of gram-negative bacteria.

scholarly journals DEVELOPMENT OF A DRUG BASED ON THE FRUITS OF CHOKEBERRY (ARÓNIA MELANOCÁRPA (MICHX.) EL-LIOT) IMPROVING THE EFFICIENCY OF CANCER CHEMOTHERAPY

2020 ◽  
pp. 219-226
Author(s):  
Valeriya Yur'yevna Andreyeva ◽  
Vladimir Viktorovich Sheykin ◽  
Galina Il'inichna Kalinkina ◽  
Tat'yana Georgiyevna Razina ◽  
Yelena Petrovna Zuyeva ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Raw Materials ◽  
Combined Treatment ◽  
Latin Square ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
New Drugs ◽  
Raw Material ◽  
Black Chokeberry ◽  
Active Substances

Black chokeberry is an official drug raw material and is used as a multivitamin drug. Black chokeberry guarantees the supply of raw materials as it grows all over the Russian Federation end is a promising sourse of phenolic compounds for new drugs. Objective: to develop the most favorable conditions for extraction of bioactive compounds from black chokeberry and to assess its anti-metastatic activity. To extract bioactive compounds from black chokeberry the method of multistep repercolation with completed cycle was used. To assess the factors controlling the raw material extraction the technique of mathematic simulation for latin square. The technique of liquid anthocyanins and catechins rich black chokeberry extraction was given with the following parameters: extragent – 95% acidified alcohol, phase relation – 1 : 5, number of percolators – 5. The content of biologically active substances in the extract obtained with 95% acidified ethyl alcohol was determined by conventional methods. In the composition of the extract, the content of anthocyanins (5.83±0.25%), catechins (0.22±0.02%), tannins (4.65±0.30%), phenolic acids (0.27±0.01%) and other biologically active substances was determined. To assess the antitumor properties of the chokeberry fruit extract, the Lewis lung carcinoma model was used. It was found that the proposed extract reliably inhibits the development of metastases and increases the antimetastatic activity of cyclophosphamide in combined treatment, is of interest as a means for increasing the effectiveness of tumor chemotherapy.

scholarly journals Analysis of the possibility for obtaining oil from the spend coffee grounds as potential raw material for biodiesel production

2012 ◽  
Vol 66 (4) ◽  
pp. 581-586 ◽  
Author(s):  
Zoran Ilickovic ◽  
Eldin Redzic ◽  
Franc Andrejas ◽  
Gordan Avdic ◽  
Vedran Stuhli
Keyword(s):  
Petroleum Ether ◽  
Process Parameters ◽  
Raw Material ◽  
Biodiesel Production ◽  
Oil Yield ◽  
Solvent Ratio ◽  
Spent Coffee Grounds ◽  
Weight Percentage ◽  
Soxhlet Apparatus ◽  
Coffee Grounds

The aim of this paper was to investigate the possibility of obtaining oil from spent coffee grounds, which are left behind after the coffee is prepared, as the potential feedstock for biodiesel production. The effect of process parameters, such as are the type of solvent, the ratio of spent coffee grounds/solvent and the extraction time on oil yielded from coffee grounds was examined. The oil was obtained by maceration and extraction in the Soxhlet apparatus. The obtain results show that the spent coffee grounds could be used as an alternative raw material for biodiesel production, because it contains a significant amount of oil that can be extracted. The oil yield depends on the extraction (maceration) process parameters. The maximum oil yield obtained by the Soxhlet extraction with the n-hexane for the period of 5 h was 11.85% (the weight percentage of oil on dry mater), whereas with petroleum ether the oil yield was slightly lower and amounted to 10.44%. The yield of the oil extracted by maceration increases with the decrease of spent coffee grounds/solvent ratio from 1/3 to 1/7 g/cm3, and other parameters being constant. The oil yield increases with the duration of the maceration. Greater oil yield, ranging from 3 to 8.5%, can be obtained with n-hexane compared to the extraction with petroleum ether. Furthermore, n-hexane is less volatile and flammable, compared to petroleum ether, so it is more convenient to use.

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